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Original Article
Distribution of CD4＋CD25＋ T cells and graft-versus-host disease in human hematopoietic stem cell transplantation
Dae Hyoung Lee, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
Clin Exp Pediatr. 2008;51(12):1336-1341.   Published online December 15, 2008
Purpose : This study aimed to determine the frequencies of CD4＋CD25＋ T cells in donor graft and peripheral blood CD4＋CD25＋ T cells in recipients after hematopoietic stem cell transplantation (HSCT) and their association with graft-versus-host disease (GVHD). Methods : Seventeen children who underwent HSCT were investigated. CD4＋CD25＋ T cells in samples from donor grafts and recipient peripheral blood were assessed...
Study on the diagnostic utility of serum levels of insulin-like growth Factor-I and insulin-like growth factor binding protein-3 in growth hormone deficiency
Geun Ha Chi, Jeong Nyeo Lee, Woo Yeong Chung
Clin Exp Pediatr. 2008;51(12):1329-1335.   Published online December 15, 2008
Purpose : This study aimed to determine the best cutoff line for insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-3 to discriminate between growth hormone deficiency (GHD) patients and the control group. Methods : Two hundred thirty subjects with normal controls (129 boys and 101 girls, aged 7-15 years), 14 patients with complete GHD (12 boys and...
Epidemiologic study of Kawasaki disease in 6 months old and younger infants
Yong Won Park, Ji Whan Han, In Sook Park, Chang Hwi Kim, Sung Ho Cha, Jae Sook Ma, Joon Sung Lee, Tae Chan Kwon, Sang Bum Lee, Chul Ho Kim, Heung Jae Lee, Yong Soo Yun
Clin Exp Pediatr. 2008;51(12):1320-1323.   Published online December 15, 2008
Purpose : The aim of this study was to investigate the epidemiologic status of Kawasaki disease (KD) in infants ≤6 months of age. Methods : For the epidemiologic study of KD in Korea, data from 22,674 KD patients were collected from 1997 to 2005 on a 3-year basis by a retrospective survey. From this survey, data of 1,739 KD patients ≤6...
The effect of rooming-in care on the emotional stability of newborn infants
So Yoon Ahn, Sun Young Ko, Kyung Ah Kim, Yeon Kyung Lee, Son Moon Shin
Clin Exp Pediatr. 2008;51(12):1315-1319.   Published online December 15, 2008
Purpose : We aimed to examine the effect of rooming-in care on newborn infants emotional stability by comparing them with those cared for in a nursery. Methods : Forty-eight full-term newborn infants born at Cheil General Hospital between July 1 and October 31, 2007, were enrolled. Twenty-four newborn infants were roomed-in in their mothers rooms (rooming-in group), and 24 newborns...
Prevalence of obesity, hypertension, and hyperlipidemia in Gunpo children of low economic status
Kyung Hee Yi
Clin Exp Pediatr. 2008;51(12):1310-1314.   Published online December 15, 2008
Purpose : This study aimed to assess the prevalence of obesity, hypertension, and hyperlipidemia in children from low-income families in Gunpo and to evaluate whether economic status affects the prevalence of obesity. Methods : Between October 2007 and March 2008, 341 children (167 girls and 174 boys; age, 6 to 13 years) were enrolled in this study. All these children came...
Preliminary analysis of metabolic syndrome components in Korean adolescents by using Korean national health and nutrition examination Survey pooling data (1998, 2001, and 2005)
Kyoung Huh, Mi Jung Park
Clin Exp Pediatr. 2008;51(12):1300-1309.   Published online December 15, 2008
Purpose : This study aimed to estimate age- and gender-specific cut points for metabolic syndrome (MS) components, including body mass index (BMI), blood pressure (BP), triglycerides, high-density lipoprotein (HDL) cholesterol, and glucose. Methods : Data from the 1998, 2001, and 2005 Korean NHANES (National Health and Nutrition Examination Survey) were analyzed (n=4164; 2,139 boys and 2,025 girls, aged 10-19 years)....
Review Article
Neuromuscular disorders in children : Diagnosis and treatment
Jong Hee Chae
Clin Exp Pediatr. 2008;51(12):1295-1299.   Published online December 15, 2008
Inherited muscle diseases are heterogeneous with varying genetic etiologies and present with common symptoms and signs, including weakness, motor developmental delay, and hypotonia. To diagnose these various diseases, a meticulous family and clinical history, physical and neurological examinations, laboratory findings with electromyography, muscle biopsy, and genetic testing are needed. Here, I review several inherited muscle diseases, with a focus on...
Epilepsy in various metabolic disorders
Young-Mock Lee
Clin Exp Pediatr. 2008;51(12):1290-1294.   Published online December 15, 2008
Seizures are a frequent symptom in metabolic disorders, although metabolic disorders are rarely found to be the cause of epilepsy. A precise diagnosis might not only influence treatment, but it might also call for counseling of the family, even if there are no direct therapeutic consequences. We review the main characteristics of epilepsy in metabolic disorders with regard to energy...
Pediatric cerebrovascular disease
Ji Hoon Phi, Kyu-Chang Wang, Byung-Kyu Cho, Seung-Ki Kim
Clin Exp Pediatr. 2008;51(12):1282-1289.   Published online December 15, 2008
Recently, accumulated clinical experience and advanced neuroradiological techniques have led to a better understanding of pediatric cerebrovascular disease (CVD), which was once considered rare. Approximately 10% of pediatric neurosurgical patients have CVD; therefore, it is no longer uncommon to pediatricians and pediatric neurosurgeons. Furthermore, children with CVD tend to recover better than adults after stroke because the immature brain is...
Erratum
An overview and preparation of Korean pediatrician according to the expansion of national immunization program coverage
In Sung Cho
Clin Exp Pediatr. 2008;51(12):1275-1281.   Published online December 15, 2008
National Immunization Program (NIP) in korea is regulated by government for effective prevention of infectious diseases since 1954. But the program is only performed in public health center, so many people had various complaints such as inconvenience to use public center, high cost when vaccinated in private medical organization and lack of speciality and registration etc. In this reason, it...
ERRATUM: Neurons by oxygen-glucose deprivation in organotypic hippocampal slice cultures
Clin Exp Pediatr. 2008;51(12):1-1.   Published online December 15, 2008
The title changed from "Neurons by oxygen-glucose deprivation in organotypic hippocampal slice cultures" to "Injury of neurons by oxygen-glucose deprivation in organotypic hippocampal slice culture" in Korean J Pediatr 2008;51(10):1112. And added the statement of "The present research was conducted by the research fund of Dankook University in 2006(No. 46217)".
Kim Ki-Ho: Comment on tuberculosis chemotherapy and its theoretical backgrounds (1), (II). (Soakwa 1959;3:171-4)
Clin Exp Pediatr. 2008;51(11):1245-1246.   Published online November 15, 2008
Case Report
The clinical phenotype of the derivative (8)t(7;8)(q22;p23.3) in two siblings
Young Ok Kim, Young Kuk Cho, En Song Song, Dong Kyun Han, Ic Sun Choi, Hee Jo Baek, Chan Jong Kim, Young Jong Woo, Young Youn Choi
Clin Exp Pediatr. 2008;51(11):1241-1244.   Published online November 15, 2008
We report on 2 siblings with a partial trisomy of 7q (7q22→qter) and concomitant partial monosomy of 8p (8p23.3→pter), which were shown by FISH using probes located at the telomere region of each chromosome. All the balanced translocation carriers (father and a sister) in this family had a normal phenotype. The 2 siblings with the same abnormal karyotype had similar...
A case of Smith-Lemli-Opitz syndrome diagnosed by identification of mutations in the 7-dehydrocholesterol reductase (DHCR7) gene
Mee Rim Park, Jung Min Ko, Chong-Keun Cheon, Gu-Hwan Kim, Han-Wook Yoo
Clin Exp Pediatr. 2008;51(11):1236-1240.   Published online November 15, 2008
Smith-Lemli-Opitz syndrome (SLOS) is a rare, autosomal recessive disease caused by an inborn error in cholesterol synthesis. Patients with this disease suffer from multiple malformations due to reduced activity of 7-dehydrocholesterol reductase (DHCR7), which increases 7-dehydrocholesterol (7DHC) and 8-dehydrocholesterol (8DHC) concentrations and decreases cholesterol concentration in body fluids and tissue. The SLOS phenotypic spectrum ranges from a mild disorder with...
A case of imipramine induced toxicity with Brugada electrocardiographic pattern in a toddler
Woo-Yeon Choi, Soo-Min Park, Ui-Jeong Han, Young-Nam Kim, Young-Kuk Cho, Jae-Sook Ma
Clin Exp Pediatr. 2008;51(11):1232-1235.   Published online November 15, 2008
Imipramine, a tricyclic antidepressant (TCA), is used for the treatment of non-polar depression and nocturnal enuresis in children in whom an organic pathology has been excluded, anxiety disorders, and neuropathic pain. Clinical toxicity following the treatment of TCAs, including imipramine, is well known. The anticholinergic effects initially present include a dry mouth, ileus, dilated pupils, urinary retention, and mild sinus...
A case of vancomycin-induced drug hypersensitivity syndrome
Kyung Sun Min, Woo Yeon Choi, Eun Song Song, Dong Kyun Han, Young Kuk Cho, Jae Sook Ma
Clin Exp Pediatr. 2008;51(11):1228-1231.   Published online November 15, 2008
Drug hypersensitivity syndrome (DHS) has rarely been reported in association with vancomycin treatment. Here, we describe an 11-year-old girl who developed fever and a maculopapular rash on day 18 of intravenous vancomycin for treatment of infective endocarditis. The patient presented with fever, a maculopapular skin rash, hepatitis, and acute renal failure caused by vancomycin-induced DHS. The symptoms resolved in less...
A case of restless legs syndrome in a child presenting with growing pains
Dong Soon Kim, Hong Beom Shin, Young Min Ahn
Clin Exp Pediatr. 2008;51(11):1222-1227.   Published online November 15, 2008
Restless legs syndrome (RLS) is a common neurological sleep disorder in adults characterized by the following diagnostic criteria: an urge to move that is usually associated with unpleasant sensations and symptoms that are worse at rest, relieved by movement, and most severe at night. The definite diagnosis of RLS in children is stricter and consists of self-description of leg discomfort...
Original Article
Prevalence and clinical significance of the positive antinuclear antibody in children with idiopathic thrombocytopenic purpura
So Eun Jun, Seong Sik Park, Young Tak Lim
Clin Exp Pediatr. 2008;51(11):1217-1221.   Published online November 15, 2008
Purpose : An association between idiopathic thrombocytopenic purpura (ITP) and systemic lupus erythematosus (SLE) has been recognized for decades because thrombocytopenia is the first manifestation in some patients with SLE. However, the risk of later development of SLE in childhood ITP is currently unknown. We retrospectively evaluated the incidence and clinical significance of the positive antinuclear antibody (ANA) in children...
Diamond-Blackfan anemia: long-term follow-up of six cases
Young Jun Son, Hee Jo Baek, Hoon Kook
Clin Exp Pediatr. 2008;51(11):1211-1216.   Published online November 15, 2008
Purpose : Diamond-Blackfan anemia (DBA) is a rare heterogeneous genetic disorder of infancy and early childhood. It is characterized by red cell aplasia, congenital anomalies, and a predisposition to cancer. Corticosteroids and red cell transfusions are the mainstays of therapy. We describe our experience of 6 cases of DBA that were encountered over a period of 16 years. Methods :...
The significance of corpus callosal size in the estimation of neurologically abnormal infants
Seung Taek Yu, Chang Woo Lee
Clin Exp Pediatr. 2008;51(11):1205-1210.   Published online November 15, 2008
Purpose : The development of the corpus callosum occupies the entire period of cerebral formation. The myelination pattern on magnetic resonance imaging (MRI) is very useful to evaluate neurologic development and to predict neurologic outcome in high risk infants. The thickness of the corpus callosum is believed to depend on the myelination process. It is possible to calculate the length...
Analysis of disease mechanism of subacute necrotizing lymphadenitis in children
Hyun Jung Kim, Jung Suk Yeom, Ji Suk Park, Eun Sil Park, Ji Hyun Seo, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Jae Min Cho, Jeong Hee Lee, Hee Shang Youn
Clin Exp Pediatr. 2008;51(11):1198-1204.   Published online November 15, 2008
Purpose : The cause of subacute necrotizing lymphadenitis, a rare disease in children, has not been completely clarified. This study was aimed to investigate the disease mechanism by examining clinical, radiologic, and immunohistochemical findings in children diagnosed with subacute necrotizing lymphadenitis after an excisional biopsy. Methods : We examined 19 lymph node tissue specimens from 17 children diagnosed with subacute...
Clinical characteristics of Epstein-Barr virus infection detected by polymerase chain reaction in children less than 15 years old
Jong-In Na, Ok Lan Kim, Do-kyoung Seoung, Seong-Taek Yoo, Chang Woo Lee, Doo-Young Choi, Yeon-Kyun Oh, Ji-Hyun Cho, Jong-Duck Kim
Clin Exp Pediatr. 2008;51(11):1191-1197.   Published online November 15, 2008
Purpose : Previously, Epstein-Barr virus (EBV) infection was diagnosed by serological examination; currently, many EBV antigen detection methods have been developed and applied clinically for diagnosing EBV infection. To delineate the clinical characteristics of EBV infection, clinical and laboratory findings were evaluated for patients who tested positive in EBV polymerase chain reaction (PCR). Methods : EBV PCR was conducted in 352...
The immunogenicity and reactogenicity of Td booster vaccination in Korean preadolescents, aged with 11-12 years old
Soo Young Lee, Ga Young Kwak, Hye Rin Mok, Jong Hyun Kim, Jae Kyun Hur, Kyung Il Lee, Park Joon Su, Sang Hyuk Ma, Hwang Min Kim, Jin Han Kang
Clin Exp Pediatr. 2008;51(11):1185-1190.   Published online November 15, 2008
Purpose : This study was undertaken to evaluate the immunogenicity and reactogenicity of Td booster immunization in early preadolescents of Korea. Methods : Healthy preadolescents, who had been vaccinated with 4 or 5 doses of DTaP vaccines until 6 years old age, were enrolled in this study from August 2006 to April 2007. Diphtheria and tetanus anti-toxoid antibodies in sera were...
Study of the risk factors for pulmonary interstitial emphysema related to mechanical ventilator care
Sang Yeob Kim, Pil Sang Lee, Sang Geel Lee
Clin Exp Pediatr. 2008;51(11):1179-1184.   Published online November 15, 2008
Purpose : Pulmonary interstitial emphysema (PIE) primarily occurs in preterm infants suffering from respiratory distress syndrome (RDS) and kept under mechanical ventilator care. Therefore, this study aimed to examine various risk factors for PIE, to identify conditions that can decrease the possibility of PIE development. Methods : PIE classification was conducted for 183 patients diagnosed to have RDS and receiving mechanical...
A clinical study of congenital chylothorax and octreotide therapy
Ung Geon Oh, Kyoung Eun Choi, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin
Clin Exp Pediatr. 2008;51(11):1172-1178.   Published online November 15, 2008
Purpose : Congenital chylothorax is an accumulation of lymphatic fluid within the pleural space. It is a common cause of unidentified hydrops fetalis. We examined the perinatal history, clinical manifestation, diagnosis, treatment, and outcome in 6 newborns diagnosed to have congenital chylothorax with hydrops fetalis. We also studied the effect of octreotide therapy for congenital chylothorax in relation to conservative...
Comparison of the seroconversion rate after primary hepatitis B vaccination and after revaccination of non-responders in full-term infants according to mother's HBsAg seropositivity
Jang Hee Kang, Jae Won Moon, Seung Hyun Kong, Kwang Su Hwang, Ji Sun Mok, Hyeon Jung Lee
Clin Exp Pediatr. 2008;51(11):1165-1171.   Published online November 15, 2008
Purpose : This study aimed to identify the true extent of non-responsiveness in full-term infants born from HBsAg-negative or HBsAg-positive mothers and vaccinated against hepatitis B virus (HBV) at 0, 1, and 6 months of age and to evaluate the effect of revaccination among non-responders. Methods : The study included 716 full-term infants born in 2004-2007. Of 716, 662 infants...
Performance effectiveness of pediatric index of mortality 2 (PIM2) and pediatricrisk of mortality III (PRISM III) in pediatric patients with intensive care in single institution: Retrospective study
Hui Seung Hwang, Na Young Lee, Seung Beom Han, Ga Young Kwak, Soo Young Lee, Seung Yun Chung, Jin Han Kang, Dae Chul Jeong
Clin Exp Pediatr. 2008;51(11):1158-1164.   Published online November 15, 2008
Purpose : To investigate the discriminative ability of pediatric index of mortality 2 (PIM2) and pediatric risk of mortality III (PRISM III) in predicting mortality in children admitted into the intensive care unit (ICU). Methods : We retrospectively analyzed variables of PIM2 and PRISM III based on medical records with children cared for in a single hospital ICU from January 2003...
Analysis of online breast-feeding consultation on the website of the Korean Pediatric Society
Jung Yun Kim, Seoug Jae Hwang, Hyun Kyung Park, Ha-beck Lee, Nam Su Kim
Clin Exp Pediatr. 2008;51(11):1152-1157.   Published online November 15, 2008
Purpose : Since the infant formula milk has been produced in Korea, it has faced a low rate of breast milk feeding, though breast milk feeding is a little increasing. Therefore, the Korean Pediatric Society launched its website for breast-feeding consultation to provide information to the general public and enhance the health of growing infants. The consultation results were analyzed...
Review Article
Diagnosis and therapy for functional urinary incontinence in childhood
Ju Hyung Kang
Clin Exp Pediatr. 2008;51(11):1147-1151.   Published online November 15, 2008
Functional urinary incontinence, the absence of any neurologic or structural abnormality as a cause of urinary incontinence in children, is one of the most common clinical problems encountered in pediatric and urologic departments, and it can be socially and emotionally distressing for the affected children. The prevalence rates of functional urinary incontinence in school-aged children are not very high and...
Diagnosis and treatment of nocturnal enuresis in children
Chang Hee Hong, Minki Baek, Seong Ho Lee, Jeong Won Lee, Ki-Soo Pai
Clin Exp Pediatr. 2008;51(11):1140-1146.   Published online November 15, 2008
Nocturnal enuresis is a heterogeneous disorder with various underlying pathophysiological mechanisms and causes a mismatch between the nocturnal bladder capacity and the amount of urine produced during sleep at night. It is associated with a simultaneous failure of conscious arousal in response to the sensation of bladder fullness. Generally, a complete history and physical examination, with a specific focus on...
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