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"Most downloaded" Articles are from the articles published in 2023 during the last six months.
- Review Article
- Cardiology
- Research trends on causes of Kawasaki disease in the COVID-19 era: focus on viral infections
(16 times)
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Young Hwan Lee
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Clin Exp Pediatr. 2023;66(1):1-11. Published online June 22, 2022
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· The etiology of Kawasaki disease (KD) is unclear, but its clinical, epidemiological, and pathophysiological characteristics are strongly associated with infectious diseases.
· In the coronavirus disease 2019 pandemic era, viruses are attracting the most attention. Sudden acute respiratory syndrome coronavirus 2 infection causes various hyperinflammation in children that require differentiation from KD.
· Immune responses in patients with KD may be induced by host cell damage. To effectively prevent and treat KD, the genetic background and immune responses of KD patients and triggering pathogens require identification. |
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- Critical Care Medicine
- Ferritin in pediatric critical illness: a scoping review
(16 times)
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Ivy Cerelia Valerie, Anak Agung Sagung Mirah Prabandari, Dyah Kanya Wati
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Clin Exp Pediatr. 2023;66(3):98-109. Published online September 16, 2022
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The number of studies on ferritin predictive ability in pediatric critical illness has grown exponentially over the past 2 decades. However, among the 66 of 1,580 studies analyzed here, summary statistics for overall and condition-specific studies were only reported in 45.4% and 71.2%, respectively. In contrast, ferritin as a categorical variable with a preset threshold was a significant predictor in 84.6% of studies. |
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- Other
- Children’s health affected by parent’s behavioral characteristics: a review
(16 times)
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Sung Eun Kim, Jongin Lee
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Clin Exp Pediatr. 2024;67(5):232-239. Published online August 21, 2023
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· Parents’ occupational hazards, long working hours, and smoking behaviors should be modified adequately to minimize adverse health effects on their children.
· As of 2023, several diseases from fetal exposure to occupational hazards can be compensated with Industrial Accident Compensation Insurance in South Korea.
· A directed acyclic graph is recommended for medical research to control the effects of parents’ behaviors on children’s health. |
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- Original Article
- Gastroenterology
- Assessing indicators and clinical differences between functional and organic childhood constipation: a retrospective study in pediatric gastroenterology clinics
(15 times)
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Hasan M. Isa, Fatema A. Alkharsi, Fatema A. Salman, Maryam S. Ali, Zahra K. Abdulnabibi, Afaf M. Mohamed
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Clin Exp Pediatr. 2023;66(7):296-306. Published online June 14, 2023
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Question: What causes childhood constipation, and what can predict organic constipation?
Finding: Constipation represents 14.7% of gastroenterology visits. Functional constipation is more common among constipation types, while organic constipation is more common in young children and those with a low body weight, stunted growth, mucus in the stool, and associated diseases.
Meaning: Younger children and those with lower growth or mucus in the stool should be assessed for underlying organic causes of constipation. |
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- Neurology
- Need for palliative care from birth to infancy in pediatric patients with neurological diseases
(15 times)
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Raffaele Falsaperla, Silvia Marino, Carla Moscheo, Lucia Giovanna Tardino, Simona Domenica Marino, Concetta Sciuto, Piero Pavone, Giovanna Vitaliti, Federica Sullo, Martino Ruggieri
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Clin Exp Pediatr. 2023;66(8):350-356. Published online June 14, 2023
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Question: What are the current palliative care protocols, palliative course, and implementable palliative care programs for hospitalized pediatric patients with neurological diseases in Italy?
Finding: We studied 34 newborns with nervous system diseases, all of whom had a poor prognosis.
Meaning: Despite current legislation in Italy, no palliative care network has been implemented. Given the vast number of patients with neurological conditions, standardized palliative care guidelines and protocols are required. |
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- Allergy
- Association between dyslipidemia and asthma in children: a systematic review and multicenter cohort study using a common data model
(15 times)
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Ji Eun Lim, Hye Min Kim, Ju Hee Kim, Hey Sung Baek, Man Yong Han
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Clin Exp Pediatr. 2023;66(8):357-365. Published online June 14, 2023
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Question: Is dyslipidemia a risk factor for asthma in children?
Finding: This was a comprehensive systematic review and retrospective multicenter study of the association between dyslipidemia and asthma in children. In a multicenter cohort analysis using the Observational Medical Outcomes Partnership Common Data Model, elevated total cholesterol levels were associated with increased risk of asthma development.
Meaning: These findings suggest an association between dyslipidemia and asthma in children. |
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- Review Article
- Nephrology (Genitourinary)
- Kidney complications associated with COVID-19 infection and vaccination in children and adolescents: a brief review
(15 times)
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Hee Sun Baek, Min Hyun Cho
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Clin Exp Pediatr. 2023;66(10):424-431. Published online June 28, 2023
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Several observational studies have shown that acute kidney injury affects up to 46% of children and adolescents who develop severe postinflammatory responses, such as multisystem inflammatory syndrome in childhood, due to coronavirus disease 2019 (COVID-19). Although causality has not been established, some cases of glomerulopathy or nephrotic syndrome occurring after COVID-19 infection or vaccination have been reported. Therefore, kidney complications associated with these conditions in children and adolescents warrant attention. |
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- Original Article
- Neurology
- Changes in frequency of benign convulsions with mild gastroenteritis and their viral causes before and during the COVID-19 pandemic: a single-center study
(15 times)
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Hyejin Na, Sanghoon Lee, Seo Hee Kim, Young Ok Kim
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Clin Exp Pediatr. 2024;67(4):213-220. Published online March 19, 2024
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Question: Did coronavirus disease 2019 (COVID-19) affect the frequency, seasonal variation, or virus type of benign convulsions with mild gastroenteritis (CwG)?
Findings: We compared 41 cases of CwG before and during the COVID-19 pandemic. After March 2020, frequency did not change significantly (18 patients vs. 23 patients), seasonal variation was lost, and number of cases of enteric adenovirus-associated CwG increased (1 cases vs. 7 cases).
Meaning: The COVID-19 pandemic affected CwG. |
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- Review Article
- Endocrinology
- Lifelong medical challenges and immunogenetics of Turner syndrome
(15 times)
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Won Kyoung Cho
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Clin Exp Pediatr. 2024;67(11):560-568. Published online July 31, 2024
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· This summary emphasizes the importance of the early diagnosis of Turner syndrome (TS) and presents a multidisciplinary approach to its prevention and management, high-lighting the need for customized care.
· Advancements in immunogenetic research may improve our understanding of TS and improve its outcomes.
· TS encompasses a wide array of medical challenges, including cardiovascular, endocrine, autoimmune, and mental health issues, as well as a heightened cancer risk. |
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- Original Article
- Hematology
- Changes and correlations of T-cell coinhibitory molecule programmed death-1 and interferon-γ in pediatric immune thrombocytopenia
(14 times)
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Fady Mohamed El-Gendy, Amira M.F. Shehata, Esam Awad Abd El-Kawy, Mahmoud Ahmed El-Hawy
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Clin Exp Pediatr. 2023;66(3):127-133. Published online February 24, 2023
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Question: What are the PD-1+ CD4+ T cells percentages and serum interferon gamma (IFN-γ) levels of pediatric patients with immune thrombocytopenia (ITP)?
Finding: Compared with healthy controls, the PD-1+ CD4+ T cells percentages and IFN-γ levels were significantly higher in ITP patients before and 1 month after therapy.
Meaning: Our findings suggest that PD-1+ CD4+ T cells and IFN-γ are involved in the pathophysiological process of ITP. |
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- Editorial
- Other
- Advancing pediatric health: the multifaceted scope of Clinical and Experimental Pediatrics
(14 times)
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Jin Hee Oh, Man Yong Han
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Clin Exp Pediatr. 2023;66(4):171-172. Published online March 29, 2023
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Clinical and Experimental Pediatrics (CEP) is a journal that specializes in pediatric research topics. It covers a wide range of research areas, including basic research, translational research, and research related to improving pediatric health and diseases. CEP also focuses on the coordination of societal structures and processes that orchestrate pediatric health and disease throughout society, and the parallel relationship between regional characteristics and globalization. The journal intends to continue promoting pediatric health through relentless efforts and the discovery of new research areas. |
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- Original Article
- Developmental and Behavioral Medicine
- Neonatal risk factors associated with attention-deficit/hyperactivity disorder: an umbrella review
(14 times)
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Ensiyeh Jenabi, Erfan Ayubi, Sajjad Farashi, Saeid Bashirian, Fereshteh Mehri
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Clin Exp Pediatr. 2023;66(10):441-446. Published online July 14, 2023
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Question: The risk factors for attention deficit hyperactivity disorder (ADHD), such as breastfeeding, congenital heart disease, and low birth weight, in neonates are not well understood.
Finding: This umbrella review obtained significant effect sizes for ADHD for congenital heart disease (odds ratio [OR], 3.04), low birth weight (OR, 2.25), never breastfed (OR, 1.55), and Apgar score (OR, 1.30).
Meaning: Congenital heart disease, low birth weight, lack of breastfeeding, and Apgar scores were significant factors for ADHD. |
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- Gastroenterology
- Inferior vena cava to aorta ratio in dehydrated pediatric patients: a systematic review and meta-analysis
(14 times)
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Gilbert Sterling Octavius, Michelle Imanuelly, Johan Wibowo, Nadia Khoirunnisa Heryadi, Melanie Widjaja
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Clin Exp Pediatr. 2023;66(11):477-484. Published online June 14, 2023
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Question: The inferior vena cava to aorta (IVC/Ao) ratio measured via ultrasound has been touted as a promising noninvasive technique to assess clinically significant dehydration in pediatric patients.
Finding: Our meta-analysis found that IVC/Ao ratio had a positive likelihood ratio of 3.2 (95% confidence interval [CI], 2.1–5.1) and negative likelihood ratio of 0.18 (95% CI, 0.12–0.28).
Meaning: Hence, IVC/Ao ratio is insufficient to exclude or confirm significant dehydration in pediatric patients. |
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- Developmental and Behavioral Medicine
- Attention-deficit/hyperactive-impulsive disorder symptoms among grade 1 students with reading disorder in Thailand
(14 times)
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Patcharapun Sarisuta, Issarapa Chunsuwan, Tippawan Hansakunachai, Paskorn Sritipsukho
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Clin Exp Pediatr. 2023;66(11):485-492. Published online October 24, 2023
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Question: Would students with reading disorder have a significantly higher prevalence of attention-deficit/hyperactiveimpulsive disorder (ADHD) symptoms than neurotypical students?
Finding: Students at risk of reading disorder exhibited significant ADHD symptoms compared with those not at risk of reading disorder according to all presentations of teacher assessments versus only for predominantly inattentive presentations of the parental assessments.
Meaning: Students with reading disorder have a significantly higher prevalence of ADHD symptoms than neurotypical students. Sex, parental education level, average family income, and children’s school affiliation significantly influenced reading disorder prevalence. |
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- Neonatology (Perinatology)
- Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center study
(14 times)
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Sung Hee Lee, Ju Hyun Jin, Jong Ha Yoo, Shin Won Yoon
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Clin Exp Pediatr. 2023;66(11):493-500. Published online October 24, 2023
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Question: What are the adverse clinical outcomes of neonates of coronavirus disease 2019 (COVID-19)–infected mothers?
Finding: Infants of mothers with COVID-19 were at significantly increased risk of transient tachypnea of the newborn (TTN), use of noninvasive ventilation, and need for supplemental oxygen (P<0.05).
Meaning: Neonates of mothers with COVID-19 are at risk of TTN and require respiratory support. Close monitoring is essential to ensuring timely intervention if required. |
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- Review Article
- Nutrition
- Macronutrients modified dietary intervention in the management of overweight/obese children and adolescents: a systematic review
(14 times)
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Jihyun Park, Oh Yoen Kim
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Clin Exp Pediatr. 2024;67(4):191-200. Published online July 11, 2023
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· Dietary macronutrient modifications affect the body composition of and metabolic markers in children and adolescents.
· Hypocaloric diets, regardless of macronutrient composition, are reportedly effective for weight loss in obese children.
· Future interventional studies with meta-analyses that include Korean children and adolescents are needed to provide basic information applicable to this population. |
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- Original Article
- Adolescence Medicine
- Relationship between inflammatory biomarkers and insulin resistance in excess-weight Latin children
(14 times)
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Mariano Nicolás Aleman, María Constanza Luciardi, Emilce Romina Albornoz, María Cristina Bazán, Adela Victoria Abregú
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Clin Exp Pediatr. 2024;67(1):37-45. Published online December 21, 2023
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Question: What is the prevalence of insulin resistance (IR) in excess-weight Latin children, and can proinflammatory biomarkers predict it?
Finding: IR prevalence was elevated and tumor necrosis factor- α, interleukin-6, monocyte chemoattractant protein- 1, soluble CD40 ligand, and high-sensitivity C-reactive protein levels were increased in excess-weight Latin children. However, none predicted IR status.
Meaning: These inflammatory biomarkers were unable to predict IR status. Therefore, further investigations are necessary. |
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- Review Article
- Neonatology (Perinatology)
- Quantifying myelin in neonates using magnetic resonance imaging: a systematic literature review
(14 times)
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Nabila Hanem Arshad, Hasyma Abu Hassan, Nur Farhayu Omar, Zurina Zainudin
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Clin Exp Pediatr. 2024;67(8):371-385. Published online December 6, 2023
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Question: This systematic review attempts to discover the best magnetic resonance imaging (MRI) technique for myelin quantification in neonates by evaluating various MRI parameters and their reproducibility.
Finding: Since the benefits of using synthetic MRI for quantifying myelin in neonates outweigh the very minor draw- backs, it is recommended.
Meaning: The findings suggest the importance of identifying noninvasive MRI techniques available to assess myelin tissue in neonates, which aid in diagnosing neurodevelopmental disorders.
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- Original Article
- Cardiology
- Echocardiographic reference z scores of right ventricular dimension and systolic function of children aged 5–12 years
(13 times)
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Alaba Busola Oladimeji, Moriam Omolola Lamina, Peter Odion Ubuane, Motunrayo Oluwabukola Adekunle, Omolara Adeolu Kehinde, Barakat Adeola Animasahun, Olisamedua FidelisNjokanma
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Clin Exp Pediatr. 2023;66(5):215-222. Published online April 18, 2023
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Question: Z score reference values for right ventricular size and systolic function in children using echocardiography are available in several countries. Despite the high burden of diseases involving the right ventricle in Nigeria, these reference values have limited applicability.
Finding: The right ventricular sizes of Nigerian children differed from those published elsewhere.
Meaning: These reference values will aid the treatment, monitoring, and pre- and postintervention for Nigerian children. |
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- Editorial
- Neonatology (Perinatology)
- Does cord blood cortisol have a mediating effect on maternal prepregnancy body mass index and birth weight?
(13 times)
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Gyu Hong Shim
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Clin Exp Pediatr. 2023;66(1):24-25. Published online November 30, 2022
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· A high prepregnancy body mass index (pre-BMI) is associated with large for gestational age (LGA) and macrosomia, whereas a low pre-BMI is associated with small for gestational age (SGA) and low birth weight (LBW).
· The identification of the role of the hypothalamus-pituitary-adrenal axis in the effect of pre-BMI and maternal gestational weight gain on birth weight could reduce the frequency of LGA, macrosomia, SGA, or LBW through maternal diet optimization. |
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- Original Article
- Infection
- Predicting COVID-19 transmission in a student population in Seoul, South Korea, 2020–2021
(12 times)
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Young Hwa Lee, Han Ho Kim, Young June Choe
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Clin Exp Pediatr. 2023;66(4):173-178. Published online December 22, 2022
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Question: What is the spatial distribution and determinants of coronavirus disease 2019 (COVID-19) infection among students in Korea?
Finding: The community population was closely associated with the risk of COVID-19, and the number of students per school class were inversely associated with COVID-19 rates in students.
Meaning: Our finding suggests that controlling the community-level burden of COVID-19 can help prevent sudden acute respiratory syndrome coronavirus 2 infection in school-aged children. |
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- Editorial
- Gastroenterology
- Noninvasive and simple, but accurate? Meta-analysis of evidence-based point-of-care ultrasound for assessing dehydration in children
(12 times)
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Jin-Hee Oh
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Clin Exp Pediatr. 2023;66(11):475-476. Published online July 11, 2023
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· Point-of-care ultrasound imaging, including measurement of the inferior vena cava/aorta ratio, is powerful for evaluating the hemodynamic status of pediatric patients.
· Owing to the limited feasibility of randomized clinical trials and insufficient data in children, imaging tools require validation.
· Objective validity meta-analyses of imaging studies can affect clinical decision-making and serve as a cornerstone for evidence-based practice in pediatrics. |
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- Perspective
- Other
- New public-centered child protection system in Korea
(11 times)
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We Sun Shim
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Clin Exp Pediatr. 2023;66(5):179-181. Published online April 18, 2023
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Korea’s child abuse response system was transformed under policy change in April 2020, from what was previously operated on a private-centered basis to a focus on the public sector with expanded role of local governments. Promising outcomes are expected with new system as greater governmental intervention will effectively protect at-risk children with acceleration in institutional collaboration and expertise in information management and administration. |
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