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Original Article
The usefulness of soluble transferrin receptor in the diagnosis and treatment of iron deficiency anemia in children
Se Hoon Yoon, Dong Sup Kim, Seung Taek Yu, Sae Ron Shin, Du Young Choi
Clin Exp Pediatr. 2015;58(1):15-19.   Published online January 31, 2015
Purpose

Soluble transferrin receptor (sTfR) is a truncated extracellular form of the membrane transferrin receptor produced by proteolysis. Concentrations of serum sTfR are related to iron status and erythropoiesis in the body. We investigated whether serum sTfR levels can aid in diagnosis and treatment of iron deficiency anemia (IDA) in children.

Methods

Ninety-eight patients with IDA were enrolled and were classified according to...

Relationship between iron deficiency anemia and febrile convulsion in infants
Youn Soo Jun, Ho Il Bang, Seung Taek Yu, Sae Ron Shin, Du Young Choi
Clin Exp Pediatr. 2010;53(3):392-396.   Published online March 15, 2010
Purpose : The association between iron deficiency anemia and febrile convulsion in infants has been examined in several studies with conflicting results. Therefore, the authors aimed to evaluate the precise relationship involved. Methods : In this case-control study, the authors assessed 100 children with a diagnosis of febrile convulsion, aged between 9 months and 2 years, during January 2007 to...
Anti-tumor effect of new compound, 127, through the induction of apoptosis
Ki Hwan Baek, A Lum Han, Sae Ron Shin, Chun Mae Jin, Young Wook Yoon, Seung Taek Yu, Jong Duk Kim, Du Young Choi
Clin Exp Pediatr. 2009;52(6):696-700.   Published online June 15, 2009
Purpose : We screened more than 350 compounds with an endoperoxide ring structure in search of an anti-leukemic drug and found that compound 127 (c-127) could induce significant cytotoxicity in HL-60 cells. In this study, we investigated the molecular mechanisms of compound 127-induced antitumor activity on HL-60 cells. Methods : HL-60 cells were cultured in Rosewell Park Memorial Institute 1640...
Weaning food practice in children with iron deficiency anemia
Joo Hee Chang, Woo Sik Cheong, Yong Hoon Jun, Soon Ki Kim, Hung Sik Kim, Sang Kyu Park, Kyung Ha Ryu, Eun Sun Yoo, Chuhl Joo Lyu, Kun soo Lee, Kwang Chul Lee, Jae Young Lim, Du Young Choi, Byung Kyu Choe, Eun Jin Choi, Bong Soon Choi
Clin Exp Pediatr. 2009;52(2):159-166.   Published online February 15, 2009
Purpose : Iron deficiency anemia (IDA) is one of the most common nutritional deficiencies in children on a weaning diet. We investigated weaning practices in infants and children, as well as their mothers' knowledge about weaning. Methods : We investigated 129 children with IDA and 166 without IDA (aged 6-36 months) who had visited 10 university hospitals between March 2006...
Clinical features of vaccination-associated thrombocytopenic purpura in children
Wan Soo Lee, Seung Taek Yu, Sae Ron Shin, Du Young Choi
Clin Exp Pediatr. 2008;51(6):610-615.   Published online June 15, 2008
Purpose : Idiopathic thrombocytopenic purpura (ITP) is a relatively common hematological disease in children. It generally occurs after exposure to a common viral infection episode; however, it may occasionally follow immunization with measles, measles-mumps-rubella (MMR), hepatitis B (HBV), influenza, diphtheria tetanus-pertussis (DTP), or chickenpox vaccines. In this study, the incidence, clinical characteristics, and treatment outcome of vaccination-associated ITP were investigated...
Case Report
A case of dapsone syndrome
Yoo Jong Won, Ok Lan Kim, Seung Taek Yu, Young Wook Yoon, Du Young Choi
Clin Exp Pediatr. 2007;50(5):493-496.   Published online May 15, 2007
Diamino-diphenyl-sulfone (Dapsone) is widely used in the treatment of leprosy and a variety of blistering skin diseases. It sometimes has adverse side effects with common usual doses, such as skin, nervous system, gastrointestinal tract, liver, kidney and hematologic toxicity. One of these side effects is a rare but serious hypersensitivity reaction called dapsone syndrome, which occurs several weeks after the...
Original Article
Clinical factors causing hyperbilirubinemia in patients with Kawasaki disease
Kyung Hee Moon, Ok Ran Kim, Seung Taek Yu, Myung Eun Hong, Chang Woo Lee, Du Young Choi, Yeon Kyun Oh, Jong Duk Kim, Hyang Suk Yoon
Clin Exp Pediatr. 2007;50(1):52-55.   Published online January 15, 2007
Purpose : Hyperbilirubinemia, jaundice and gallbladder hydrops are unusual manifestations of Kawasaki disease (KD). In this case, abdominal pain, anorexia and abdominal distension may follow eventfully. We reviewed the clinical and laboratory data to investigate the causative factors of hyperbilirubinemia in patients with KD. Methods : Two-hundred eighty two children diagnosed and hospitalized with KD were identified by searching patients' charts....
The study on cytotoxicity of cytokines produced by the activated human NKT cells on neuroblastoma
Jin Young Cho, Young Wook Yoon, Hyang Suk Yoon, Jong Duk Kim, Du Young Choi
Clin Exp Pediatr. 2006;49(4):439-445.   Published online April 15, 2006
Purpose : α-Galactosylceramide (α-GalCer)-stimulated human Vα24 natural killer T (NKT) cells exert antitumor activity against some leukemia in a CD1d dependent and TCR-mediated manner, but could not kill CD1d - negative neuroblastoma (NB) cells. There are few reports about the direct antitumor effect of highly secreted cytokines by these cells on activation. In this study, using a cell-free supernatant (SPN)...
Lower respiratory tract infection of positive antigen test for respiratory syncytial virus on children under 2 years of age
Jea Heon Jeong, Kyoung Hee Moon, Chang Woo Lee, Du Young Choi, Yeun Geun Oh, Hyang Suk Yoon, Ji Hyun Cho, Jong Duck Kim
Clin Exp Pediatr. 2006;49(4):394-400.   Published online April 15, 2006
Purpose : This study was design and performed for evaluations of resent clinical pattern of bronchiolitis caused by RSV infection with children under 2 year of age for 5 years, who were admitted to pediatric ward. Methods : The inclusion criteria of the patients were children under 24 month-of-age, clinical manifestations of lower respiratory tract infection, and RSV antigen that...
Case Report
A Case of Retroperitoneal Extrarenal Wilms' Tumor with Metastasis to Lung and Bone
Jea Heon Jeong, Weon Cheol Han, Du Young Choi
Clin Exp Pediatr. 2005;48(1):112-115.   Published online January 15, 2005
Extrarenal Wilms' tumor is a very exceptional tumor which is defined as Wilms' tumor found anywhere other than in the kidneys. Until now less than 60 cases have been reported in the English literature. The tumor can be located in the retroperitoneum, inguinal canal, uterus, cervix, testes, skin and even in the thorax. The diagnosis is almost always made after...
Original Article
Clinical Significance of Gastrointestinal Symptoms and Abdominal Ultrasonographic Findings in Henoch-Schönlein Purpura
Eun Jung Choi, Chang Woo Lee, Du Young Choi
Clin Exp Pediatr. 2005;48(1):63-67.   Published online January 15, 2005
Purpose : Henoch-Sch nlein purpura(HSP) is a systemic vasculitis, characterized by cutaneous palpable purpura, gastrointestinal(GI) symptoms, arthritis and renal involvement. In general, the prognosis is determined by GI complication as well as the severity of nephritis. In this study, we analyzed the statistical relationship between the GI symptom and other clinical findings for assessing the prognosis, and evaluated abdominal ultrasonographic...
Synergistic Cytotoxicity of Arsenic Trioxide and Sulindac Against Neuroblastoma
Du Young Choi
Clin Exp Pediatr. 2004;47(9):1002-1007.   Published online September 15, 2004
Purpose : Recent clinical studies have shown that arsenic trioxide(As2O3) at low concentrations induces complete remission without significant toxicity in patients with refractory acute promyelocytic leukemia(APL). Like APL cells, neuroblastoma(NB) cells are thought to be arrested at an early stage of differentiation, and can respond with retinoic acid treatment. Sulindac, a nonsteroidal antiinflammatory drug, was reported to induce antitumor activity...
Study on the Correlation between Clinical Classification according to Hemorrhagic Symptoms and Platelet Counts in Childhood Idiopathic Thrombocytopenic Purpura
Ho Il Bang, Sae Ron Shin, Du Young Choi
Clin Exp Pediatr. 2004;47(4):412-416.   Published online April 15, 2004
Purpose : Idiopathic thrombocytopenic purpura(ITP) is a relatively common hematologic disease in children. The optimal strategy for treating ITP during childhood is a matter of controversy. In general, platelet count has been the primary, if not the sole measure, on which treatment decisions have been made and outcomes determined. In this study, we tried to find out the correlation between...
Sensitization of TNFα and Agonistic FAS/CD95 Antibody-Induced Apoptosis by INFγ on Neuroblastoma Cells
Ho Il Bang, Jong Duck Kim, Du Young Choi
Clin Exp Pediatr. 2003;46(7):702-709.   Published online July 15, 2003
Purpose : IFNγ sentitizes many tumor cells to TNFα and FASL-mediated apoptosis by enhancing the expression of TNF or FAS/CD95 receptor and modulating the activation of caspase and Bcl-2 family. It has been reported that IFNγ and TNFα synergistically caused differentiation and growth inhibition of neuroblastoma cells. Even though some neuroblastoma cell express FASR/FASL on the cell surface, they could...
Milk Feeding Methods and the Changes of Serum Lactate Level in Infants with Iron Deficiency Anemia
Du Young Choi, Jong Duck Kim
Clin Exp Pediatr. 1998;41(4):514-520.   Published online April 15, 1998
Purpose : Infants undergo critical and rapid stages of growth. Optimal nutrition during this period is therefore essential. Iron deficiency is especially impotant and common. The aim of this study was to determine the present status and problems of milk feeding methods in infants with iron deficiency anemia and, futhermore, to develop appropriate feeding guidelines for adequate iron nutrition. Latate is the end product...
Erratum
Echocardiographic Evaluation of the Natural Processes in Uncomplicated Ventricular Septal Defect
Hyang Suk Yoon, Du Young Choi
Accepted January 1, 1970  
We studied, with echocardiography as a main tool, the natural processes of 211 patients with uncomplicated ventricular septal defect(VSD)(incidence, 5.33 per 1,000 live births); 146(69.2%) had a perimembranous VSD and 32 (15.2%) had a subarterial, 25(11.8%) had a muscular type of VSD. Cumulative rate of spontaneous closure was 26.1%. In the closure processes, about three-fourth of perimembranous VSd showed a...
Original Article
Transcutaneous Oxygen and Carbon Dioxide Monitoring in Critically Ill Neonates.
Du Young Choi, Yong Kweon Kim, Yeon Kyun Oh
Clin Exp Pediatr. 1990;33(9):1202-1208.   Published online September 30, 1990
We studied the correlation of 85 paired arterial, transcutaneous P02 and 50 paired arterial, trans- cutaneous PCO2, which were obtained from 9 sick preterm infants within first week of their life, who were bom at the Wonkwang University Hospital from March. 1, 1988 to Feb. 28, 1989. And we also analysed the affect of the pH, body temperature, hematocrit and birth weight to...
The Estimation of Pressure Gradients of the various Cardiac Chambers Using Conbtinuos-Wave Doppler Echocardiography in Congenital Heart Disease.
Du Young Choi, Yeon Sim Kim, Hyung Suk Yoon
Clin Exp Pediatr. 1990;33(3):324-331.   Published online March 31, 1990
Continuous-Wave doppler echocardiography was used to estimate the Pressure gradient in 55 children with congenital heart disease. To test whether the Doppler method would be useful for evaluation and management of pediatric patients with ventricular septal defect (VSD)), pulmonic stenosis (PS), tricuspid regurgitation (TR), we recorded the maximal velocity (Vmax) of transseptal, pulmonary and regurgitant tricuspid jet flows and calculated the pressure gradients used by...