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Case Report
Misdiagnosis of fetus-in-fetu as meconium peritonitis
Yoon Joo Kim, Se Hyung Sohn, Ju Young Lee, Jin A Sohn, Eun Hee Lee, Ee Kyung Kim, Chang Won Choi, Han Suk Kim, Beyong Il Kim, Jung Hwan Choi
Clin Exp Pediatr. 2011;54(3):133-136.   Published online March 31, 2011

Fetus-in-fetu (FIF) is a rare congenital condition in which a fetiform mass is detected in the host abdomen and also in other sites such as the intracranium, thorax, head, and neck. This condition has been rarely reported in the literature. Herein, we report the case of a fetus presenting with abdominal cystic mass and ascites and prenatally diagnosed as meconium...

Original Article
Interpretation of screening for congenital adrenal hyperplasia in preterm infants
Hye Rim Chung, Choong Ho Shin, Sei Won Yang, Kyong Ah Yun, Young Ah Lee, So Eun Park, Chang Won Choi, Byung Il Kim, Jung Hwan Choi, Junghan Song
Clin Exp Pediatr. 2008;51(6):616-621.   Published online June 15, 2008
Purpose : This study was undertaken to identify factors that influence 17-OHP levels in preterm infants and to suggest a reasonable follow-up schedule of screening for congenital adrenal hyperplasia (CAH) in preterm infants. Methods : The 17-OHP concentrations in filter paper blood spots of 427 preterm infants were obtained. The effects of gestational age (GA), systemic diseases, and antenatal dexamethasone...
Risk Factors of Nephrocalcinosis in Very Low Birth Weight(VLBW) Infants
Gyu Hong Shim, Jin A Lee, Yun Jung Shin, Ee Kyung Kim, June Dong Park, Beyong Il Kim, Jung Hwan Choi
Clin Exp Pediatr. 2004;47(3):275-281.   Published online March 15, 2004
Purpose : Nephrocalcinosis in very low birth weight(VLBW) infants were known to be caused by a longer duration of furosemide use. However, etiologies, pathogenesis and risk factors remain unclear. Therefore, we examined the incidence and risk factors of nephrocalcinosis in VLBW infants retrospectively. Methods : Inborn babies of birth weights less than 1,500 gm were examined retrospectively. Data were reviewed on...
A Nationwide Survey on the Causative Organisms of Neonatal Sepsis in Korea
Kyung Ah Kim, Son Moon Shin, Jung Hwan Choi
Clin Exp Pediatr. 2002;45(1):55-63.   Published online January 15, 2002
Purpose : A nationwide survey was conducted to investigate the most common causative organisms in neonatal sepsis in Korea. Methods : By reviewing medical records of newborn infants who were confirmed as neonatal sepsis by isolating organisms from blood culture during a one year study period from January to December in 1997, data for causative organisms, risk factors, accompanying focal infections and combinations of antibiotics...
Etiologic Agents and Clinical Features of Acute Pyogenic Osteoarthritis in Children
Young Ho Kwak, Su Eun Park, Jung Youn Hong, He Sun Jung, Jin Young Park, Jung Hwan Choi, Hoan Jong Lee, In Ho Choi
Clin Exp Pediatr. 2000;43(4):506-513.   Published online April 15, 2000
Purpose : Though acute pyogenic infections of musculoskeletal system are infrequent in children, delayed diagnosis or inadequate management may cause serious chronic sequelae. We analysed 40 cases of children who were affected by acute septic osteomyelitis and/or septic arthritis to find etiologic agents and to establish proper initial antimicrobial therapy. Methods : Medical records of 40 cases of microbiologically confirmed acute...
Re-Evaluation of Neonatal Screening Tests for Inborn Errors of Metabolism with Dried Filter Paper Blood Spots
Kye Shik Shim, Jin Soon Hwang, Jung Sub Lim, Se Young Kim, Choong Ho Shin, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Jung-Han Song
Clin Exp Pediatr. 1999;42(12):1639-1644.   Published online December 15, 1999
Purpose : There have been high rates of false positive and recall in neonatal screening test using the cut-off points set by the manufacturing company. So, it is necessary to re-evaluate the cut off values to minimize the false positive rates. Methods : We collected capillary blood in dry filter paper from 996 healthy neonates on the third day in cases...
Comparison of Continuous versus Intermittent Infusion of Indomethacin in PDA of Preterm Infants
Yun Kyoung Lee, Hee Seok Kim, Kyoung Ran Park, Chan Hu Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(5):599-605.   Published online May 15, 1998
Purpose : Patent ductus arteriosus(PDA) of prematurity is very important disease to study because it causes many cases of perinatal morbidity and its incidence is now increasing. Nowadays indomethacin is the drug of choice for PDA closure, but its use has been limited due to its side effects. Therefore, we compared the effect and side effects of indomethacin according to...
Comparison of Continuous Versus Intermittent Infusion of Indomethacin in PDA of Preterm Infants
Yun Kyoung Lee, Hee Seok Kim, Kyoung Ran Park, Chan Hu Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(4):464-470.   Published online April 15, 1998
Purpose : Patent ductus arteriosus(PDA) of prematurity is very important disease to study because it causes many cases of perinatal morbidity and its incidence is now increasing. Nowadays indomethacin is the drug of choice for PDA closure, but its use has been limited due to its side effects. Therefore, we compared the effect and side effects of indomethacin according to the infusion method, continuous...
The Efficacy of Fetal Ultrasonography and Postnatal Abdominal Ultrasonography for the Diagnosis of Neonatal Abdominal Mass
Hee Eun Lee, Ee Kyung Kim, Hee Seok Kim, Yun Kyoung Lee, Chan Hwu Park, Kyung Ran Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Gui Won Park, Hwang Choi, Yong Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(3):299-306.   Published online March 15, 1998
Purpose : Most neonatal abdominal masses are benign in nature, but early detection and management is important to avoid the development of complications. So, we studied the causes of neonatal abdominal masses and the efficacy of ultrasonography for early detection and diagnosis. Methods : We reviewed 36 newborn infants with abdominal masses who had been admitted to the nursery and Neonatal...
Study on the Thyroid Function of Neonate Born to Mother with Hyperthyroidism
Choong Ho Shin, Se Young Kim, Sei Won Yang, Jung Hwan Choi, Chong Ku Park
Clin Exp Pediatr. 1996;39(1):106-114.   Published online January 15, 1996
Purpose : In newborns from mothers with Graves' disease, neonatal transient hyperthyroidism or hypothyroidism may develop early in life. We evaluated the incidence and prognosis of neonatal thyroid dysfunction in neonates born to mothers with hyperthyroidism during pregnancy. Methods : We measured blood T4, T3, TSH levels and TSH-R-Ab titer in 48 hyperthyroid mothers and their babies between 1988 and 1994. Results :...
Congenital cystic diseases of the lung.
Won Soon Park, Young Pyo Chang, Hee Ju Kim, Young Yull Koh, Jung Hwan Choi, Chong Ku Yun, Joo Hyun Kim
Clin Exp Pediatr. 1991;34(12):1671-1677.   Published online December 31, 1991
Congenital cystic diseases of the lung (CCDL) is a clinical group of disorders characterized by a cystic appearance of pulmonary tissue. It can be classified into four distinct categories: 1) Congenital lobar emphysema (CLE), 2) Congenital cystic adenomatoid malformation (CCAM), 3) Pulmonary sequeestration (PS), and ^Bronchogenic cyst (BC). 24 patients with CCDL admitted to the Seoul National University Children’s Hospital from January 1984 to June...
Mechanical ventilator care in the newborn infants.
Young Pyo Chang, Yong Won Park, Won Soon Park, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1991;34(11):1526-1533.   Published online November 30, 1991
The widespread introduction of mechanically assisted ventilation into the neonatal intensive care during the 1960s substantially improved the outcome of sick newborn infants, particularly those with respiratory disorders. We studied the clinical features of 82 neonates, who were treated with mechanically assisted ventilation in Neonatal Intensive Care Unit (NICU) at Seoul National Univer- sity Children’s Hospital from January 1986 to August 1989 (the second...
A case of pulmonary vascular air embolism in the newborn.
Won Soon Park, Beom Soo Park, Hye Kyung Han, Jung Hwan Choi, Chong Ku Yun, Kyoung Mo Yeon, Je Geun Chi
Clin Exp Pediatr. 1991;34(10):1422-1427.   Published online October 31, 1991
Pulmonary vascular air embolism is a rare, and almost invariably fatal complication of positive pressure ventilation of newborn infants. There have only been 53 cases described in the world literature to date. We have experienced a case of pulmonary vascular air embolism in a premature newborn as a complication of mechanical ventilation during the course of respiratory distress syndrome. The pathophysiology and clinical characteristics of...
Indomethacin therapy in premature infants with patent ductus arteriosus.
Dug Ha Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1991;34(10):1381-1390.   Published online October 31, 1991
Patent ductus arteriosus (PDA) is a common disease that occurred in 20 〜 40 percent of premature infants. The incidence of PDA is inversely related to the gestational age and birth weight. Hemodynamically significant PDA increases the morbidity and mortality of premature infants. So, the management of PDA is one of the major problems in neonatal intensive care unit. Based on experimental animal studies,...
A clinical study on neonatal bacterial meningitis.
Yong Won Park, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1991;34(6):763-770.   Published online June 30, 1991
Clinical courses of 12 neonates who were confirmed as neonatal bacterial meningitis by CSF culture or CSF latex agglutination test from January, 1986 to June, 1990, emphasizing on their complications and treatments, were evaluated. The results were summarized as follows; 1) The most common etiologic organism was E. coli (33.3%). 2) Two most common complications were ventriculitis (66.7%) and hydrocephalus (66.7%). 3) EVD with intraventricular antibiotics therapy was only...
Clinical analysis on fetal and neonatal arrhythmia.
Young Ah Lee, Chung Il Noh, Jung Hwan Choi, Jung Yun Choi, Yong Soo Yun, Chong Ku Yun
Clin Exp Pediatr. 1991;34(4):507-514.   Published online April 30, 1991
저자들은 최근 5년 8개월 동안 서울대학교병원 소아과에서 경험한 태아 및 신생아기의 심부정맥 24 례에 대하여, 이들의 심전도, 심초음파도, 24시간 심전도 소견 및 임상 기록을 통하여，부정맥의 유 형과 여러 연관 요소에 대한 임상적 분석을 시행하였다. 발견된 부정맥은 심실조기수축 7례, 심방조 기수축 5례，상실성 빈맥 7례，동성서맥 2례, 심방조동 1례, 지속적인 1도 방실 블록 1례, 심실 빈맥 1례였다. 심장 이상은 10례（2 ASD : 4례, PDA : 1례，ASD+VSD :...
A clinical observation on chylothorax in childhood.
Mi Jin Jung, Joon Jai Kim, Young Ah Lee, Chung Il Noh, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1991;34(4):497-506.   Published online April 30, 1991
Fourteen patients who had developed a chylothorax in childhood during a ten year period, from Jan. 1979 to July 1989, were reviewed by their hospital records. The chylothoraces occurred most frequently as complications of cardiothoracic surgeries in eight patients(57%). Four cases followed extrapericardial operations such as ligation of PDA and take-down of Blalock-Taussig shunt, and four cases followed intrapericardial operations such as corrective operations...
Acute pyogenic arthritis of hip in neonate and infant.
Mi Jung Kim, Young Ah Lee, Young Pyo Chang, Hoan Jong Lee, Jung Hwan Choi, Chong Ku Yun, Hak Jin Min, In Ho Choi
Clin Exp Pediatr. 1991;34(2):197-205.   Published online February 28, 1991
Acute pyogenic arthritis of hip is a serious infection that can lead to truly devastating complica- tions especially in neonatal period and infancy. Clinical survey on twelve neonates and infants (14 hip joints) with acute pyogenic arthritis of hip who were admitted to the Departments of Pediatrics and Orthopedic Surgery, Seoul National University Hospital from Jan. 1980 to Dec. 1989 were done. The results...
A Clinical Study of Periventricular-Intraventricular Hemorrhage in Very Low Birth Weight Infants.
Myoung Jae Chey, Young Pyo Chang, Jung Hwan Choi, Yong Seung Hwang, Chong Ku Yun, In One Kim, Kyung Mo Yeon
Clin Exp Pediatr. 1990;33(10):1341-1352.   Published online October 31, 1990
34 very low birth weight infants weighing 1,500 gms or less, who were admitted to the neonatal intensive care unit of Seoul National University Children’s Hospital, were routinely studied with serial real-time brain ultrasonography from August 1, 1986 to July 31, 1988. Their medical records and the results of brain ultrasonography were analyzed to evaluate propor- tion, severity, timing, clinical findings, outcome, associated periventricular...
Effect of Position Change on TcPO2 in the Newborns.
Young Pyo Chang, Yong Joon Shin, Myoung Jae Choey, Beyong Il Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1990;33(4):448-455.   Published online April 30, 1990
To determine the optimal position for the neonatal intensive care, transcutaneous oxygen tension (TCPO2) was monitored in 20 healthy preterm infants and 20 healthy term infants using the Radiometer Tc Oxgen Monitor in both supine and prone position. Also, transcutaneous oxygen tension (TcPO2) was monitored with tilting change in each position. When the infants were prone, TcPO2 rose by a mean of 7.36 mmHg...
Study on the Temperature Measurement in the Newborn Infants.
Eun Saing Jee, Young Pyo Chang, Jung Hwan Choi, Chong Ku Yun, Yong Ran Kim, Myoung Sook Lee
Clin Exp Pediatr. 1989;32(12):1632-1636.   Published online December 31, 1989
We measured body temperatures and stabilization times of 100 term and 52 preterm infants at four sites. The sites were core, aural, rectal and axilla in order of degree of temperature. There was significant difference between term and preterm infants (term infant higher, p<0.001). Mean difference between axillary and rectal temperatures was 0.501C(rectal higher). Mean difference between rectal and core temperatures was 0.10lC(core higher)....
A Clinical Survey of Abdominal Masses in the Neonate.
Beyong Il Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1989;32(7):926-932.   Published online July 31, 1989
We reviewed 22 newborn patients with palpable abdominal mass among 9, 834 newborn infants admitted to nursery and NICU of Seoul Natinal University Children’s Hospital from Jan. 1, 1983 to Dec. 31, 1987. The results were summarized as follows: 1) The incidence was 2.2/1,000 admission. The difference of incidence was not significant between preterm infants and term infants. 2) The most common etiology of neonatal abdominal masses is...
Clinical Application of Shake test od Gastric Aspiretes for the Prediction od Respiratory Distress Syndrome in the Newborn infants.
In Sang Jeon, Hann Tchah, Myoung Jae Choi, Beyng Il Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1989;32(3):349-358.   Published online March 31, 1989
To study the predictive value of gastric aspirates shake test on respiratory distress syndrome (RDS) in the newborn infants, we carried out the shake test on gastric aspirates of all newborn who admitted to NICU of Seoul National University Hospital from July 1986 to December 1987. We successfully carried out gastric aspirates shake test on 96 newborn infants and analyzed the relation between gastric...
Normal TSH Levels in Neonates by TSH Screening test.
Jae Won Song, Jong Lin Rhi, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Hyung Ro Moon, Bo Youn Cho, Chang Soon Koh
Clin Exp Pediatr. 1988;31(6):754-761.   Published online June 30, 1988
In 110 term neonates without perinatal problems who were bom in SNUH, blood TSH levels were measured by TSH screening test for congenital hypothyroidism. The results are as follows 1) Normal TSH level was 14.8±7.8 µU/ml, 8.8±4.7 µU/ml, and 6.5±2.7 µU/ml in neonates of age 0 〜24 hours, 24—48 hours, and 48〜72 hours respectively, and all TSH values in neonates of age 48〜72 hours were...
A Clinical Observation on Esolhageal Atresia and Tracheoesophageal Fistula.
In Sang Jeon, Jung Hwan Choi, Jeong Kee Seo, Chong Ku Yun, Sung Chul Lee, Kwi Won Park, Woo ki Lee
Clin Exp Pediatr. 1988;31(6):691-699.   Published online June 30, 1988
To study the clinical characteristics of esophageal atresia and tracheoesophageal fistula, we carried out a retrospective review on medical records of 39 patients who were diagnosed as that by the operation, autopsy or radiolgy at the department of Pediatrics and Pediatric Surgery, Seoul National University Hospital between January 1980 and June 1987. The results were summarized as follows; 1) Type A was most common (94.8%) among...
A Case of Type A Niemann Pick Disease.
Hyo Nam Cho, Hong Jin Lee, Jae Won Song, Jung Hwan Choi, Hyung Ro Moon, Je Geun Ji, Myeong Hee Park
Clin Exp Pediatr. 1987;30(12):1461-1467.   Published online December 31, 1987
We experienced a case of type A Niemann Pick disease in 13 month female baby. She showed marked hepatosplenomegaly, developmental regression and apathy. Fundoscopic examination revealed a cherry red spot in the macula. Numerous foamy histiocyte were seen in bone marrow. Autopsy finding revealed that liver, spleen, thymus, lymph node, lung and brain were involved. Liver showed fatty change. Generalized muscular atrophy and patch...
A Case of Potter Syndrome with Bilateral Polycystic Kidneys.
Chun Hwa Lee, Jung Hwan Choi, Yong Choi, Chong Ku Yun, Yeon Lim Suh, Je G Chi, Son Moon Shin
Clin Exp Pediatr. 1987;30(11):1282-1286.   Published online November 30, 1987
In 1946, Potter described a series of 20 cases of infants in whom bilateral absence of the kidneys was associated with hypoplasia of the lungs and characteristic faces. Afterwards it has been known that any condition that causes significant reduction in urine formation or excretion will result in oligohydramnios accounts for many of the nonrenal features of Potter syndorme. We report a case...
Blood Pressure Change in the Neonates during Abdominal Examination.
Young Sun Kim, Yoon Deok Kim, Jung Hwan Choi, Chong Ku Yun, Son Moon Shin
Clin Exp Pediatr. 1987;30(11):1201-1206.   Published online November 30, 1987
During abdominal palpation in the 50 full term neonates, blood pressure changes were measured by automatic oscillometric blood pressure monitor. The systolic blood pressure value at resting stage was 61.2 ±2.9 mmHg, and during the liver, the left kidney and the bladder palpation, it was signifi- cantly elevated to 67.2±4.7 mmHg, 68.1 ±4.8 mmHg, 69.0±4.6 mmHg respectively (P< 0.005). The diastoloic pressure value at...
Risk Factors for Retinopathy of Prematurity (Retrolental Fibroplasia)
Beyong Il Kim, Jung Hwan Choi, Chong Ku Yun, Jae Heung Lee, Son Moon Shin
Clin Exp Pediatr. 1987;30(10):1092-1099.   Published online October 31, 1987
We studied 51 premature babies who were admitted to the N.I.C.U. of S.N.U.H., managed with oxygen with or without artificial ventilation due to respiratory distress, and examined by indirect ophthalmoscopy between April 1, 1982 and March 31, 1986. The results were as follows; 1. Among 51 premature babies, retinopathy of prematurity developed in 12 cases (24%). 2. The high distribution of retinopathy of prematurity was observed in...
Study on the Korean Infant Development Screening Test.
Jong Lin Rhi, Jung Hwan Choi, Hyung Ro Moon, Sechin Cho
Clin Exp Pediatr. 1987;30(8):852-867.   Published online August 31, 1987
Developmental problems are relatively prevalent and often treatable if early interventions are to be given. Much better prognosis will also be given if they are treated early & properly by early detection through the use of the developmental screening test. Developmental screening is the application of relatively quick and simple procedures to an asymptomatic population to select out those individuals who are highly likely...