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Original Article
Nephrology (Genitourinary)
Changes in the thyroid hormone profiles in children with nephrotic syndrome
Sun Hee Jung, Jeong Eun Lee, Woo Yeong Chung
Clin Exp Pediatr. 2019;62(3):85-89.   Published online October 4, 2018

Purpose: We compared thyroid hormone profiles in children with nephrotic syndrome (NS) during the nephrotic phase and after remission. Methods: This study included 31 pediatric NS patients. The thyroid hormone profiles included serum levels of triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), and free T4. Results: Of the 31 patients, 16 (51.6%) showed abnormal thyroid hormone profiles: 6 had overt hypothyroidism, 8...
Study on the diagnostic utility of serum levels of insulin-like growth Factor-I and insulin-like growth factor binding protein-3 in growth hormone deficiency
Geun Ha Chi, Jeong Nyeo Lee, Woo Yeong Chung
Clin Exp Pediatr. 2008;51(12):1329-1335.   Published online December 15, 2008
Purpose : This study aimed to determine the best cutoff line for insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-3 to discriminate between growth hormone deficiency (GHD) patients and the control group. Methods : Two hundred thirty subjects with normal controls (129 boys and 101 girls, aged 7-15 years), 14 patients with complete GHD (12 boys and...
Serum levels of free insulin-like growth factor-I and clinical value in healthy children
Young Hee Chung, Woo Yeong Chung
Clin Exp Pediatr. 2008;51(1):47-53.   Published online January 15, 2008
Purpose : The serum levels of total insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)- 3 reflect endogenous growth hormone (GH) secretion in healthy children. Free form of IGF-I which is suggested to have more potent biological action than complex form of IGF-I. The aim of this study is to investigate the serum levels of free IGF-I and its...
Analysis of cytosine adenine(CA) repeat polymorphism of the IGF-I gene and influence on serum IGF-I levels in healthy children and adolescents
Myung Jin Ko, Tae Gyu Hwang, Jeong Nye Lee, Woo Yeong Chung
Clin Exp Pediatr. 2006;49(12):1340-1347.   Published online December 15, 2006
Purpose : The aim of the present study was to investigate the role of polymorphic cytosine adenine (CA) repeat of the IGF-I gene in the age-related alterations of serum IGF-I levels in healthy children. Methods : Two hundred and forty three normal healthy children (136 boys; 107 girls) aged between 7 and 15 years were enrolled in the present study. The...
The Usefulness of Spot Urine Protein/Creatinine Ratio in Evaluating Proteinuria in Children and the Correlation between 24-hour Urinary Protein Amount and Spot Urine Protein/Creatinine Ratio
Seon Young Hong, Ji Young Kim, Woo Yeong Chung
Clin Exp Pediatr. 2003;46(2):173-177.   Published online February 15, 2003
Purpose : Recently, different results about factors affecting accurate quantitation of 24-hr urinary protein(24UP) amount using spot urine protein/creatinine ratio(PCR) have been reported. The current study was designed to evaluate correlation between 24UP amounts and PCR in children, and the effect of 24UP amounts, age, sex, and glomerular filtration rate(GFR) on this correlation. Methods : Among 94 patients who visited the...
Renal Anomalies in Children with Turner Syndrome
Ji Young Kim, Sun Young Hong, Young Mi Park, Yong Hoon Park, Woo Yeong Chung
Clin Exp Pediatr. 2002;45(7):891-895.   Published online July 15, 2002
Purpose : The prevalence of renal anomalies in Turner syndrome(TS) has been reported to vary from 33% to 60%. The purpose of this study was to clarify the true incidence of renal malformations in Korean TS. Methods : We evaluated 33 patients with Turner syndrome diagnosed by karyotype in Inje University Busan Paik hospital and Youngnam University from January 1995....
The Effect of Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura Nephritis
Chang Woo Ha, Ji Young Kim, Jeong Nyeo Lee, Jeong Hwa Lee, Woo Yeong Chung
Clin Exp Pediatr. 2002;45(7):884-890.   Published online July 15, 2002
Purpose : Henoch-Schonlein purpura(HSP) nephritis has been reported to vary from 25 to 50% among HSP patients and is a common cause of chronic glomerulonephritis in children. In our study, we evaluated the distribution and the association of the Insertion/Deletion(I/D) polymorphism of angiotensin converting enzyme(ACE) gene with clinical manifestations, particularly proteinuria in children with HSP nephritis, compared with that in...
Radiologic Findings of Hands in Turner Syndrome
Young Sim Han, Moo Young Oh, Young Joon Lee, Woo Yeong Chung
Clin Exp Pediatr. 2001;44(7):817-822.   Published online July 15, 2001
Purposes : Radiologic findings of hands in Turner syndrome(TS) which have been reported were metacarpal sign(MS), carpal sign(CS), phalangeal sign(PS), osteopenia, and delayed bone maturation. The aim of this study is to evaluate the difference of radiologic findings in TS, idiopathic short stature(ISS), and growth hormone deficiency(GHD). Methods : Sixty girls with short stature were studied for chromosome analysis, and...
Study on Hepatitis B Virus Pre-S/S Gene Mutations in Children with Chronic Hepatitis B Infection
Byeong Hee Son, Yeong Hong Park, Woo Yeong Chung
Clin Exp Pediatr. 2001;44(7):741-751.   Published online July 15, 2001
Purpose : Hepatitis B virus(HBV) with various mutations has been reported. The aims of this study were to investigate the frequency and manifestation of HBV pre-S/S mutations in children with chronic hepatitis B infection. Methods : Sera from 17 children with chronic hepatitis B infection were analyzed by direct sequencing of polymerase chain reaction amplification of HBV DNA. Results : Seventeen...
Hepatitis B Virus Pre-S Gene Mutations in Children with Chronic Hepatitis B Infection
Jae Young Kim, Woo Yeong Chung, Chul Ho Kim
Clin Exp Pediatr. 2000;43(9):1232-1240.   Published online September 15, 2000
Purpose : The envelope of HBV consists of three polypeptides which are encoded in pre-S/S open reading frame. Three translation initiation sites are present within this pre-S/S open reading frame, i.e. pre-S1, pre-S2, and S, allowing the expression of large, middle and small HBs proteins. The pre-S1 is thought to carry the receptor binding site for viral entry into hepatocyte...
Mutations in Hepatitis B Virus Precore and Core Promotor in Children with Chronic Hepatitis B Infection - Comparison Between Vertical and Non-vertical Transmission -
Jin Kuk Kim, Yeong Hong Park, Woo Yeong Chung, Chul Ho Kim
Clin Exp Pediatr. 2000;43(6):779-791.   Published online June 15, 2000
Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 46 children with chronic hepatitis B infection were analyzed by direct sequencing of polymerase chain reaction product of HBV DNA. In this study, the patients were divided...
Hepatitis B Virus Precore and Core Promotor Mutations in Children with Chronic Hepatitis B Infection
Woo Yeong Chung, Jin Kuk Kim, Yeong Hoon Kim, Yeong Hong Park, Chul Ho Kim
Clin Exp Pediatr. 1999;42(10):1392-1402.   Published online October 15, 1999
Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 31 children with chronic HBV infection were analyzed by direct sequencing of polymerase chain reaction amplification of HBV DNA. Results : Twenty-nine adr type were analyzed. The mutations...
Effects of Growth Hormone Treatment on Alterations of Growth and Bone Metabolism in Rats Induced by Dexamethasone Administration
Woo Yeong Chung, Jeong Nyu Lee, Hye Kyoung Yoon
Clin Exp Pediatr. 1999;42(7):991-1002.   Published online July 15, 1999
Purpose : The aim of this study was to investigate the alterations of growth and bone metabolism in SDR induced by dexa administration and to evaluate the effects of GH treatment in dexamethasone(dexa) induced growth and bone metabolism in SDR. Methods : Forty-five female Sprague-Dawley rats(weight 150-170gm) were divided in 3 groups: Group 1(n=15) received normal saline as control, Group 2(n=15)...
Medical Lecture Course
Diagnostic Evaluation and Treatment of Children with Hematuria
Woo Yeong Chung
Clin Exp Pediatr. 1998;41(6):729-733.   Published online June 15, 1998
Original Article
The Concentration of Insulin Like Growth Factor-I(IGF-I) and IGF-Binding Protein-3 (IGFBP-3) in the Serum of Children with Growth Hormone Deficiency and the Alterations after Growth Hormone Treatment
Woo Yeong Chung, Dae-Yeol Lee
Clin Exp Pediatr. 1996;39(6):846-855.   Published online June 15, 1996
Purpose : The insulin like growth factors (IGFs) circulate complexed to IGF-binding proteins(IGFBPs). IGFBP-3 is the major circulating IGFBP and is found primarily as a 150 kDa complex which contains an acid labile subunit(ALS), IGFBP-3, and IGF-I or IGF-II and is considered to be growth hormone(GH) dependent. In this study, we measured serum IGF-I, IGFBP-3 and 150 kDa levels in sera of growth hormone...
Effect of Steroid Therapy on Bone Mineral Density in Children with Minimal Change Nephrotic Syndrome
Byeong Hee Son, Woo Yeong Chung, Chul Ho Kim
Clin Exp Pediatr. 1996;39(6):822-828.   Published online June 15, 1996
Purpose : Osteoporosis and growth failure have been known one of the serious side effects of corticosteroid therapy especially in children. This study was designed to evaluate the effect of long-term administration of steroids on bone mineral density(BMD) in children with nephrotic syndrome and its relationship to cumulative steroid dose, the duration of the rapy and sex. Methods : The BMD of...
Case Report
A Case of Idiopathic Crescentic Glomerulonephritis
Jung Keum Park, Sang Il Goo, Woo Yeong Chung, Chul Ho Kim
Clin Exp Pediatr. 1996;39(1):131-135.   Published online January 15, 1996
We experienced a case of idiopathic crescentic glomerulonephritis in a 10-year-old girl who was admitted to our hospital due to gross hematuria and oliguria for 2 months. The diagnosis was based on the rapidly progressive clinical course to chronic renal failure, positive p-ANCA test and light microscopic findings of diffuse crescents formation in about 80% glomeruli of renal tissue obtained...
Original Article
Diagnostic Significance of Urinary Growth Hormone Measurement in Patients with Growth Hormone Deficiency
No Hyun Kim, Woo Yeong Chung, Soon Yong Lee
Clin Exp Pediatr. 1995;38(8):1124-1131.   Published online August 15, 1995
Purpose : To investigate the diagnostic significance of urinary growth hormone measurement and compare with the urinary GH values in different methods of urine collection, this study was performed in patients with short stature. Methods : Measurement of urinary GH excretion was performed in 9 children with complete growth hormone deficiency (GCD), in 19 children with partial growth hormone deficiency (GPD)...
Study on Anti-neutrophil Cytoplasmic Antibodies in Children with Henoch-Schölein Purpura
Shin Jong Lee, Woo Yeong Chung, Chul Ho Kim, Jeong Nyeo Lee
Clin Exp Pediatr. 1995;38(7):970-975.   Published online July 15, 1995
The presence of IgG, IgA and IgM antineutrophil cytoplasmic antibodies(ANCA) were inves-tigated in 32 children with Henoch-Schölein Purpura(HS purpura), in 14 children with HS pur-pura nephritis who were confirrned by renal biopsy and in 12 control children using flow cytom-etry(FASCan, Beckton-Dickinson, Co, USA) and indirect immunofluorescence technique(Sigma Diagnostics, USA). There were no evidence of IgG, IgA or IgM cytoplasmic ANCA(p-ANCA),...
A Comparative Study o fIntavenous Methylprednisolone Dosage for Treatment of Children with Acute Idiopathic Thrombocytopenic Purpura
Eun Ju Shin, Yeong Jae Song, Woo Yeong Chung, Tae Gyu Hwang, Soon Yong Lee
Clin Exp Pediatr. 1995;38(4):513-519.   Published online April 15, 1995
Purpose : It is well known that use of intranenous methylprednisolone(IVMP)for the patients with idiopathic thrombocytopenic purpura(ITP) is not only as effective as use of intravenous gammaglobulin to mincrease platelets quickly, but also the former is less expensive than the latter. As the adequate dosage of IVMP has not been fully elucidated, we have tried to determine it. Methods : The...
Significance of Urinary Interleukin 6 Level in Mesangial Proliferative Glomerulonephritis in Children
Byeong Ho Kang, No Hyun Kim, Woo Yeong Chung, Chul Ho Kim, Soon Yong Lee
Clin Exp Pediatr. 1994;37(7):900-905.   Published online July 15, 1994
By animal experiments in rat, it has been known that Interleukin-6(IL-6) is secreted from renal mesangial cells and is an autocrine growth factor for the proliferation of mesangial cells. According to these facts, several studies have been tried for its clinical usefulness by measuring their serum or urinary IL-6 in glomerulonephritis patients with mesangial proliferation. The authors measured urinary IL-6...
Urinary Vitamin C Loading Test and Therapeutic Effect of Vitamin C in Children with Idiopathic Recurrent Epistaxis
In Soon Park, Woo Yeong Chung, Soon Yong Lee
Clin Exp Pediatr. 1993;36(2):266-272.   Published online February 15, 1993
Recurrent epistaxis is not one of rare symptoms in children, the well-known causes of which are anatomical abnormalities of nasal cavity and systemic bleeding tendency. But, in the majority of cases of recurrent epistasix, it is usually very difficult to find out their underlying causes, so that the treatment is only symptomatic control of nasal bleeding whenever epistaxis occurs, but...
Case Report
A Case of Prune Belly Syndrome in Female
Zu Heo, Eun Joo Shin, Woo Yeong Chung, Soon Yong Lee
Clin Exp Pediatr. 1992;35(10):1454-1458.   Published online October 15, 1992
We experienced a case of prune belly syndrome in a 2 days old female with deficient abdominal wall musculature and urinary tract anomalies which composed of bilateral multicystic kidney, left vesicoureteral reflux and megaureter with kinking in appearance and marked distended bladder. On ultrasonographic examination, there were no abnormalities in uterus, vagina and overies. A review of literatures was also presented briefly.
Original Article
Immunohistochemical Studies on Neuroendocrine Markers in Malignant Neuronal Tumors (Neuroblastoma and Ganglioneuroblastoma) in Children
Woo Yeong Chung, Sun Kyung Lee
Clin Exp Pediatr. 1992;35(10):1377-1388.   Published online October 15, 1992
The authors studied 24 cases of malignant neuronal tumors, 14 neuroblastomas and 10 ganglioneuroblastomas, immunohistochemically, using antibodies to neuroendocrine markers including neuron specific enolase (NSE), somatostatin, chromogranin, β-endorphin, and adrenocorticotrophic hormone (ACTH). The tissue specimens were obtained by biopsy or autopsy at Pusan National University Hopital and Pusan Paik Hospital from 1980 to 1989. The positive reactivity of markers in...
A Case of Congenital Anterior Urethral Valve.
Chang Ok Soh, Min Seop Song, Woo Yeong Chung, Soon Young Lee
Clin Exp Pediatr. 1989;32(12):1749-1751.   Published online December 31, 1989
We experienced a case of congenital anterior urethral valve in a 13-month old male child. He had recurrent fever and urinary dribbling. The diagnosis was based on radiologic and cystoscopic findings, and excision of the valve with suprapubic cystostomy was performed. A review of literatures was also presented briefly.
A Case of Wilson Disease.
Cheol Soo Dan, Sang Hoon Lee, Woo Yeong Chung, Soon Yong Lee, Jong Eun Joo, Hye Jae Cho
Clin Exp Pediatr. 1988;31(11):1502-1508.   Published online November 30, 1988
We have experienced a case of Wilson disease manifesting chronic hepatitis. The patient, 10-year-old boy, has shown elevated SGOT and SGPT levels since 5 years ago, but no other specific symptoms of Wilson disease. His younger sister died of fulminant hepatitis (absence of hepatitis A or B markers) at the age of eight. The diagnosis was based on the characteristic laboratory data and the...
An Analysis of Incidence Requiring Resuscitation in Full-Term Cesarean Delivered Infants.
Ewi Seong Seo, Cheol Soo Dan, Woo Yeong Chung, Soon Yong Lee, Goo Hwa Je
Clin Exp Pediatr. 1987;30(7):722-726.   Published online July 31, 1987
An analysis of incidence requiring resuscitation in relation to the indication of cesarean section in full-term deliveries were carried out retrospectively during 24 months from January 1984 to December 1985. The results obtained were as follows. 1) The overall incidence of cesarean delivery was 17.2% (397 cases out of 2,308 total deliveries) and the rate of full-term was 77.6% of total cesarean deliveries. 2) Among full-term cesarean delivered...
A Case of Congenital Anterior Urethral Diverticulum.
Young Ho Lee, Gyu Jeon Song, Woo Yeong Chung, Moo Young Oh, Soon Yong Lee
Clin Exp Pediatr. 1987;30(4):431-434.   Published online April 30, 1987
Recently, we experienced a case of congenital anterior urethral diverticulum in 8-month-old male infant. He had recurrent fever and urinary dribbling for 3 months. The diagnosis was based on radiologic and cystoscopic findings, and anterior urethral diverticulectomy was performed. A review of literatures was also presented briefly.
Case Report
A Case of Combined Esophageal Atresia and Duodenal Atresia.
Ju Yeong Seo, Cheol Lee, Woo Yeong Chung, Soon Yong Lee, Yeon Soon Kim
Clin Exp Pediatr. 1985;28(9):912-915.   Published online September 30, 1985
We experienced a case of combined esophageal atresia without tracheoesophageal fistula and duodenal atresia. Choanal Atresia was also associated. The diagnosis was confirmed by prenatal ultrasonography, abdominal radiography and autopsy. A review of literatures was also presented briefly.
A Case of Werdnig Hoffmann Disease.
Woo Yeong Chung, Cheol Lee, Tai Gyu Hwang, In Soon Park, Soon Young Lee, Jong Eun Joo
Clin Exp Pediatr. 1985;28(7):726-730.   Published online July 31, 1985
We experienced a case of Werdnig Hoffmann disease in a 1 year 5 month old female child with the complaint of progressive muscular weakness on both lower extremities. Her development had been almost normal since birth and she could stand alone briefly at 12 months of age, but progressive muscular weakness had been apparent since then. Diagnosis was based on...