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Original Article
Pseudomembranous colitis in children: Experience of a university hospital in Korea
Jae Hyun Park, Kyung Ji Kang, Yu Na Kang, Ae Suk Kim, Jin-Bok Hwang
Clin Exp Pediatr. 2010;53(2):184-189.   Published online February 15, 2010
Purpose : Pseudomembranous colitis (PMC) occurs rarely in children, but its incidences are increasing due to frequent antibiotic use. We investigated the incidence and clinical characteristics of PMC accompanied by bacterial enteritis-like symptoms in children. Methods : Between November 2003 and July 2007 at the Department of Pediatrics, Dongsan Medical Center, we analyzed the medical records of consecutive patients who received...
A study on the clinical courses, sigmoidoscopic and histologic findings of allergic proctocolitis
Joo Hee Lee, Sung Shin Kim, Jae Ock Park
Clin Exp Pediatr. 2008;51(3):276-285.   Published online March 15, 2008
Purpose : Allergic proctocolitis is a major cause of bloody stool in early infancy. This study was aimed at ascertaining the clinical courses, sigmoidoscopic and histologic findings of allergic proctocolitis. We also analyzed the relationship between peripheral eosinophilia, the age at symptom onset, and sigmoidoscopic and histologic findings. Methods : We reviewed 25 infants retrospectively who had sigmoidoscopy and biopsy...
Characterization of B Cells of Lymph Nodes and Peripheral Blood in a Patient with Hyper IgM Syndrome
Dong Soo Kim, Kyuong Mi Shin, Woo Ick Yang, Jeon-Soo Shin, Chang Hwa Song, Eun Kyeong Jo
Clin Exp Pediatr. 2003;46(2):128-136.   Published online February 15, 2003
Purpose : Hyper IgM syndrome(HIGM) is characterized by severe recurrent bacterial infections with decreased serum levels of IgG, IgA, and IgE but elevated IgM levels. Recently, it has been classified into three groups; HIGM1, HIGM2 and a rare form of HIGM. HIGM1 is a X-linked form of HIGM and has now been identified as a T-cell deficiency in which mutations...
Case Report
A Case of Incontinentia Pigmenti with Developmental Brain Malformation
Suk Ho Kang, Soon Kim, Seung Hee Jung, Sang Geel Lee
Clin Exp Pediatr. 2002;45(4):535-539.   Published online April 15, 2002
Incontinentia pigmenti is a rare neurocutaneous syndrome characterized by vesiculobullous skin disease in neonates and infants, a noninfectious disease that should be distinguished from infectious diseases with the neonatal seizure or encephalopathy. This disease is X-linked dominant with Xq28 region abnormalities and often associated with developmental defects of the ocular, skeletal, dental, and central nervous system. Central nervous system involvement...
Erratum
Distribution of Anti-Mumps IgM Antibody in Children Presumptively Diagnosed of Mumps
Sung Hee Oh, Do Hack Yum, Jin Han Kang, Young Mo Sohn, Hoan Jong Lee, Bok Yang Pyun, Young Jin Hong, Chang Hwi Kim
Clin Exp Pediatr. 2001;44(1):17-25.   Published online January 15, 2001
Purpose : Outbreaks of mumps continue to occur, even though the number of patients diagnosed of mumps has decreased considerably with the widespread use of vaccine. The accurate diagnosis of mumps is needed to understand the epidemiology of mumps and analyse the safety and effectiveness of vaccine. Therefore, we attempted to appraise the accuracy of provisional diagnosis of mumps in...
Original Article
Congenital Asymptomatic Cytomegalovirus Infection; A Comparison of Specific IgM Antibody Test and pp65 Antigenemia Assay
Jong Hyun Kim, Eun Ah Seo, Ji Hyang Lim, Sang Hee Park, Won Bae Lee, Kyong Su Lee, Sin Ho Jung
Clin Exp Pediatr. 1998;41(2):163-169.   Published online February 15, 1998
Purpose : It is increasingly important to diagnosis asymptomatic infections which make up a majority(90%) of congenital cytomegalovirus(CMV) infections and that they may have sequeles such as sensorineural hearing loss and mental retardation. Recently antigenemia assay has been developed by using monoclonal antibodies against early structural protein pp65 of CMV. This CMV antigenemia assay seems to be more quicker to...
A Study of Serum Cytokines in Nephrotic Syndrome
Mea Young Chang, Jae Ho Lee
Clin Exp Pediatr. 1997;40(12):1701-1706.   Published online December 15, 1997
Purpose : It has been reported that patients with nephrotic syndrome have high serum IgE value and IL-4 involve in IgE synthesis, IL-6 is an autocrine growth factor for the proliferation of mesangial cells. We studied association between serum cytokines and of nephrotic syndrome. Methods : We measured serum IL-6, IL-4, IFN-Υ, CD23 in 14 children with nephrotic syndrome and 3 healthy children by...
Antibody Response to Capsular Polysaccharide Vaccine of Streptococcal Pneumonia in Patients with Nephrotic Syndrom
Ji Young Choi, Jae Ho Lee
Clin Exp Pediatr. 1995;38(8):1107-1115.   Published online August 15, 1995
Purpose : Although the etiology and pathogenesis of child with nephrotic syndrome remains uncertain, it has been suggested from indirect evidence that this syndrome may represent deficiency in T-cell function and abnormal humoral immune response to antigens or immynoglobulin. Children with nephrotic syndrome are susceptible to pneumococcal infection. Now, we performed this study to evaluate pneumococcal anticapsular antibody concentration and...
Case Report
Angiodysplasia Involving the Sigmoid Colon in Children
Jae Young Kim, Kyung Won Hwang, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hae Lee Chung, Young Dae Kwon, Yong Jin Kim
Clin Exp Pediatr. 1995;38(7):993-999.   Published online July 15, 1995
Angiodysplasia(AD) of the gastrointestinal(GI) tract in children is a very rare cause of bleeding and thought to be a distinct clinicopathologic entity distingishing from the classic adult-type AD by its different clinical settings and diverse histology. We report two cases of AD involving the sigmoid colon in children. The cases, 6-year-old girl and 11-year-old boy, were preoperatively suspected by colonoscopy and...
A Case of Phakomatosis Pigmentovascularis
Seung Mo Park, Kook In Park, Hye Jung Joo, Ran Namgung, Chul Lee, Dong Gwan Han, Soo Il Chun
Clin Exp Pediatr. 1994;37(8):1156-1161.   Published online August 15, 1994
In 1947, Ota et al. First reported a case of phakomatosis pigmentovascularis and defined a subgroup of this disease having a congenital generalized hemangioma and pigmented lesions including anmongolian spot-like lesion, nevus pigmentosus and nevus of Ota. We experienced a case of phakomatosis pigmentovascularis type Iib in a 10-day old male baby, who since birth, had generalized nevus flammeus and...
Original Article
Epstein-Barr Viral Hepatitis in Childhood
Soo Kyung Lee, Ki Sup Chung
Clin Exp Pediatr. 1994;37(8):1124-1135.   Published online August 15, 1994
We analysed 58 patients who were admitted to the Department of Pediatrics, yonsei University College of Medicine due to infectious mononucleosis from January 1986 to August 1992. Of 58 patients who had responses to IgM to EBV viral capsid antigen and/or heterophil antibody, 35 patients had hapatitis. Of 35 hepatitis patients, group I consisted of 22 patients who had only...
Mechanism of Impaired Growth Hormone Response in Children with Simple Obesity
Moon Sung Park, Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1994;37(4):457-463.   Published online April 15, 1994
Obesity is associated with an impairment of the hormone secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown, To determine whether obesity is associated with a chronic state of tonic somatostatin, several tests with growth hormone stimuli such as GHRH (1㎍/kg), clonidine (150㎍/m2) and Resular insulin (0.1U/kg, subcutaneously), to obese subjects and...
Case Report
A Case of Incontinentia Pigmenti
Soo Am Chung, Won Rae Kim, Hyung Kun Nam, Jin Sam No, Jung Hee Park
Clin Exp Pediatr. 1993;36(3):428-433.   Published online March 15, 1993
Incontinentia pigmenti (Bloch-Sulzberger syndrome)is a genetic disease of the skin with generalized ectodermal and mesodermal dysplasia. Skin lesions are uually present at birth or shortly after in the form of eythermatous eruptions with linear vesiculations. The final stage is characterised by irregular macular streaks of brown to slate-grey pigmentation. We experienced five cases of incontinentia pigmenti maternal female relative of a...
Original Article
Cytomegalovirus Infection in Children: The Significance of CMV Specific IgM Antibody Test and Virus Isolation in the Urine
Dong Wook Kim, Hyun Kwack, Seong Hee Jang, I Seok Kang, Hoan Jong Lee, Jung-Hwan Choi, Jeong Kee Seo, Chong Ku Yun
Clin Exp Pediatr. 1992;35(7):890-901.   Published online July 15, 1992
The clinical pictures of 44 children with IgM antibody to CMV (cytomegalovirus) by ELISA(enzyme linked immunosorbent assay) were reviewed retrospectively, and the significance of serum CMV specific IgM antibody and virus isolation in the urine was analyzed. Age of the patients with IgM antibody to CMV ranged from 23 days to 8 years 7 months, and median age was 2 months....
Case Report
A Case of Congenital Giant Pigmented Nevus
Seung Wan Lee, Wu Ha You, Chang Bin Im, Chang Woo Lee, Chan Kum Park
Clin Exp Pediatr. 1992;35(5):723-728.   Published online May 15, 1992
The congenital giant pigmented nevus, also known as bathing trunk nevus, is a severely disfiguring lesion covering large areas of the body surface. Although the occurrence of giant nevi in childhood is uncommon, it is frequent enough to represent a source of guilt for parents, and psychic trauma, and is advised. For those patients who do not choose to undergo...
Original Article
A Study of Serologically Confirmed Measles
Sang Mook Choi, Chang Soo Oh, Sang Chul Park, Chang Hwi Kim, Sang Jhoo Lee
Clin Exp Pediatr. 1992;35(4):508-514.   Published online April 15, 1992
Forty one cases of serologically confirmed measles(positive measles specific IgM antibody) were evaluated among 55 cases of clinically diagnosed measles admitted to Soon Chun Hyang University Hospital from May to August 1990. The results were as follows: 1) Sex ratio was 1.6 : 1 with male predominance in 41 cases, 13 cases(31.7%) were vaccinated and 28 cases(68.3%) were unvaccinated. Primary vaccine failure...
Case Report
A Case of Incontinentia Pigmenti
Soo Young Kweon, Hyun Joo Choi, Gyung Hee Kim
Clin Exp Pediatr. 1992;35(3):417-421.   Published online March 15, 1992
Incontinentia Pigmenti is an uncommon genodermatosis that usually affects female infants. The dermatosis may be only a part of more generalized disorder which may affect with great variability the teeth, the eyes, the bones or central nervous system, or may be associated with other malformations or developmental disturbances. We experienced a case of Incontinentia Pigmenti associated with defect of a eye...
Original Article
A case of incontinentia pigmenti.
Kwang Ik Song, Hyo Jeong Kim, Jin Bok Hwang, Chang Ho Han, Hye Li Chung, Young Dae Kwon
Clin Exp Pediatr. 1991;34(10):1446-1451.   Published online October 31, 1991
A case of incontinentia pigmenti, Bloch-Sulzberger type, without any developmental defect has been presented with the review of related literatures. The patient was a 4 day-old female infant with irregular, grouped vesicobullous lesions on the whole body, especially on the trunk and extremities since birth. No familial traits was noted. Diagnosis was made by the charateristic clinical, labaratory and histopathologic findings.
Malignant Schwannomas in children.
Joon Jai Kim, Dong Joo Shin, Dong Won Son, Hong Hoe Koo, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(4):525-531.   Published online April 30, 1991
Six pediatric patients who were diagnosed as malignant Schwannoma and treated at Seoul National University Children’s Hospital from Aug. 1981 to Jun. 1990 were reviewed. Mean age was 11 years and 1 month and all cases except one were over 10 years old. Of six cases, three (50%) were associated with von Recklinghausen’s disease. Overall male to female ratio was 1 : 2. In...
Transplacental transmission of hepatitis B virus from carrier nothers to neonates.
Soh Yeon Kim, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1991;34(2):190-196.   Published online February 28, 1991
Neonates bom to hepatitis B carrier mothers at Yongdong Severance Hospital, Yonsei University College of Medicine were sampled for hepatitis B viral markers using venous blood drawn from external jugular vein within 3 hours after birth and the following results were obtained. Two thousand nine hundred and seventy two pregnant women who received prenatal care at Yongdong Severance Hospital, Yonsei University College of Medicine...
Measles in Previously Vaccinated Children during Measles Epidemics.
Hwan Gyu Park, Jeong Wan Yoo, Soh Yeon Kim, Young Mo Shon, Sung Kyu Lee, Kyung Soon Song
Clin Exp Pediatr. 1990;33(11):1510-1515.   Published online November 30, 1990
A clinical study was made on 98 cases of measles patients admitted to YoungDong Severance Hospital during the period of 7 months from June to December 1989. The patients with measles were evaluated for presence of measles specific IgM antibody in serum, clinical symptom and vaccination history. We obtained the following results: 1) Out of 98 patients, 62 patients (63.3%) were vaccinated children and 36 patients...
A Case of Peutz-Jeghers Syndrome.
Ick berm Park, Sung guen Oh, Jung suk Ko, Sang hyun Byun, Kyu chul Choeh
Clin Exp Pediatr. 1989;32(7):990-994.   Published online July 31, 1989
This is a report of our experience of Peutz-Jeghers syndrome in a 14 year old girl having family history. She was admitted with complaints of crampy abdominal pain and vomiting, and showed melanotic pigmentation on the lips, face around nose, oral mucosa around molar areas, fingers and toes. Colon study revealed multiple polyposis in colon and small bowel. In family, her father has melanotic...
A Case of Incontinetia Pigmenti Associated with Convulsions.
Young Ok Suh, Gyun Woo Lee, Un Ki Yoon, Ji Sub Oh, Kee Suck Suh, Sang Tae Kim
Clin Exp Pediatr. 1988;31(5):641-647.   Published online May 31, 1988
Incontinentia pigmenti is a complex hereditary syndrome in which vesicular, verrucous and pigmented cutaneous lesions are associated with developmental defects of the eye, skeletal system and central nervous system. A case of incontinentia pigmenti associated with convulsions, Block-Sulzberger type, is presented with a review of related literatures. The patient was a 40 day-old female infant with convulsions and verrucous, dark brown pigmented lesions on the trunk...
Clinical Analysis of Mesangial IgM Nephropathy in Childhood.
Joo Hong Cha, Byoung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1986;29(8):862-867.   Published online August 31, 1986
In order to clarify mesangial IgM nephropathy in childhood the author performed this study, for which 12 cases of mesangial IgM nephropathy demonstrated by Immunofluorescent technique were analyzed. The immunoglobulin deposited predominantly in mesangium was IgM, but also C3 deposited on most occasions. It was demonstrated that this groups of the patients with mesangial IgM nephropathy showed very similar picture...
Case Report
Three Cases of Familial Glucocorticoid Deficiency.
Soo Heum Lim, Young Wun Kim, Byoung Hai Ahn, Hyung Ro Moon
Clin Exp Pediatr. 1986;29(5):549-552.   Published online May 31, 1986
Familial glucocorticoid defiency is a form of chronic adrenal insufficiency which is characterized by isolated deficiency of glucocorticoid and elevated levels of corticotropin in association with normal aldosterone production. It is thought to be degenerative process of adrenal cortex, with autosomal recessive or X-linked recessive pattern of inheritance. Skin hyperpigmentation and hypoglycemic symptom are characteristic and salt-losing symptom doesn’t develop....
Original Article
Clinical Observation of Acute Viral Hepatitis in Childhood.
Byung Hak Lim, Ki Ho Jang, Sang Geel Lee, Im Ju Kang
Clin Exp Pediatr. 1985;28(11):1057-1065.   Published online November 30, 1985
A clinical observation has been made on 127 cases who were admitted to the department of pediatrics, Fatima Hospital, Taegu, from January 1983 to June 1984 and following results was obtained. 1)Ratio of male to female cases was 3 : 1. 2)On admission, anorexia, nausea, fever and jaundice were significantly more common in HBsAg negative group but skin rash was more...
Case Report
A case of Incontinentia Pigmenti.
Wan Seob kim, Yong Woo Choi, Myung Ho Lee, Chul Wan Lim
Clin Exp Pediatr. 1985;28(9):940-944.   Published online September 30, 1985
A case of incontinentia pigmenti with CNS involvement was presented. And literatures have been reviewed. The patient was a 7 month-old female had been affected with numerous dark brownishinear streaks, irregular macules, and splashes of brown to slate gray pigmentation on the entire body, especially both trunk, axillary, and extremity. The chief complaint was severe vomiting and comatous mental state for...
A case of Incontinentia Pigmenti.
Hyun Mo Koo, Chun Dong Kim, Byung Ryul Choi, Han Gu Moon, Yong Hoon Park, Jin Gon Jun, Jeong Ok Hah
Clin Exp Pediatr. 1985;28(4):396-399.   Published online April 30, 1985
A case of Incontinentia pigmenti, Bloch-Sulzberger type, is presented with the review of related literatures. One month old female infant was admitted with irregular, grouped vesicobullous lesion on the whole body especially on the trunk and extremities which have been persistent since birth. No familial traits were noted. Diagnosis was made by the characteristic clinical and laboratory and histopathologic：findings
Original Article
A Clinical Study of Type A Hepatitis Confirmed by IgM Anti-HAV.
Oh Kyung Lee, Sung Seek Lee, Keun Chul Choi, Myung Ho Lee, Sook Ja Park
Clin Exp Pediatr. 1984;27(8):778-785.   Published online August 31, 1984
79 children with Type A Hepatitis who were admitted to the pediatric department of the Presbyterian Medical Center from April 1, 1983 to October 31, 1983 were clinically analized and we report the following result. 1) Type A Hepatitis occupied 8% of total in patients and 88% of total Hepatitis patients. 2)The peak age incidence was between 7 and 9 years...
Case Report
Fanconi's Anemia.
J H Yoo, E M Kim, S J Lee, W B Kim, D W Lee, D Y Kang, K Y choi
Clin Exp Pediatr. 1983;26(11):1139-1144.   Published online November 30, 1983
We report 1 case of Fanconi’s anemia which has severe pancytopenia, increased fetal Hb, hyperpigmented skin, absence of right thumb and metacarpal bone, retardation of bone age and chromosomal abnormalities with a brief review of related literature and references.