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Original Article
Nutrition
Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children
Maria Mexitalia, Yesi Oktavia Dewi, Adriyan Pramono, Mohammad Syarofil Anam
Clin Exp Pediatr. 2017;60(4):118-123.   Published online April 25, 2017
Purpose

Tuberculosis (TB) remains a problem in the community. TB patients usually experience malnutrition, which is characterized by both decreased body weight (BW) and body fat percentage (BFP). Leptin, an important regulator of BW, also plays an important role in cellular immunity, which is integral to defense against Mycobacterium tuberculosis infection. We analyzed the effect of an anti-TB treatment regimen on...

Selenium and leptin levels in febrile seizure: a case-control study in children
Abolfazl Khoshdel, Neda Parvin, Maedeh Abbasi
Clin Exp Pediatr. 2013;56(2):80-85.   Published online February 25, 2013
Purpose

Febrile seizures (FS) are seizures that occur between the age of 6 and 60 months, but its pathophysiology still is not fully understood. There is limited information about the correlation between levels of selenium and leptin with FS. This study aimed to determine the relationship between serum levels of selenium and leptin in children with FS.

Methods

This case-control study was conducted...

Excess of leptin inhibits hypothalamic KiSS-1 expression in pubertal mice
Sung Yeon Ahn, Sei Won Yang, Hee Jae Lee, Jong Seon Byun, Ji Yeon Om, Choong Ho Shin
Clin Exp Pediatr. 2012;55(9):337-343.   Published online September 14, 2012
Purpose

Leptin has been considered a link between metabolic state and reproductive activity. Defective reproductive function can occur in leptin-deficient and leptin-excessive conditions. The aim of this study was to examine the effects of centrally injected leptin on the hypothalamic KiSS-1 system in relation to gonadotropin-releasing hormone (GnRH) action in the initial stage of puberty.

Methods

Leptin (1 µg) was injected directly into...

Serum leptin, adiponectin and resistin levels in obese children and their correlations with insulin resistance
Min Young Park, Sun A Ahn, Won Kyoung Cho, Kyoung Soon Cho, So Hyun Park, Seung Hoon Hahn, Min Ho Jung, Byung-Kyu Suh
Clin Exp Pediatr. 2009;52(7):766-771.   Published online July 15, 2009
Purpose : The objective of this study was to compare the levels of adipocytokines in obesity group with those in control group and examine their correlation with insulin resistance. Methods : We enrolled 36 obese children (male:female [M:F]=17:19; age, 9.3±1.9 yrs) with ≥95th percentile body mass indexes (BMIs) (obesity group) and 35 healthy children (M:F=16:19; age, 9.1±2.1 yrs) with 25th-75th percentile...
The relationship between adiponectin, leptin, insulin, insulin-like growth factor and IGF binding protein-3 in cord blood and neonatal anthropometric parameters
Hai Jung Cho, Ji Young Kim, Me Jin Kim, Il Tae Hwang, Hae Ran Lee
Clin Exp Pediatr. 2008;51(7):722-728.   Published online July 15, 2008
Purpose : This study was designed to examine the effects of adiponectin, leptin, insulin, insulin-like growth factor (IGF)-I and IGF binding protein (BP)-3 levels in cord blood on weight, length, and adiposity at birth in healthy term infants. In addition, we evaluated the mechanism to change the hormone levels in appropriate for gestational age (AGA) during the first month. Methods :...
Leptin, adiponectin, interleukin-6 and tumor necrosis factor- in obese adolescents
Joo Hyun Gil, Jung Ah Lee, Ji Young Kim, Young Mi Hong
Clin Exp Pediatr. 2008;51(6):597-603.   Published online June 15, 2008
Purpose : Obesity is associated with insulin resistance. Insulin resistance and the presence of pro-inflammatory mediators are thought to cause a state of vascular endothelial dysfunction, an abnormal lipid profile, hypertension, and vascular inflammation. These chronic inflammatory responses, which are characterized by abnormal cytokine production, lead to activation of a pro-inflammatory signaling pathway. Leptin is an important mediator of inflammatory...
The relationship between leptin adiponectin ratio and insulin resistance in healthy children
Gae-Hyun Ahn, Shin-Hye Kim, Eun-Gyong Yoo
Clin Exp Pediatr. 2008;51(3):256-261.   Published online March 15, 2008
Purpose : Leptin and adiponectin are two representative adipocytokines. Leptin increases, but adiponectin decreases, with obesity and insulin resistance. We aimed to study the relationship between the leptin/adiponectin ratio and insulin resistance in healthy children. Methods : Seventy-seven healthy children (36 boys and 41 girls) were enrolled in this study. Anthropometric measurements were performed, and the percentage of weight for...
Serum ghrelin and leptin concentrations in children with cancer : comparisons with normal children
So Hyun Park, Min Ho Jung, Nac Gyun Chung, Byung-Kyu Suh, Byung Churl Lee
Clin Exp Pediatr. 2007;50(9):905-911.   Published online September 15, 2007
Purpose : Ghrelin, being secreted from the stomach, stimulates growth hormone secretion and controls energy homeostasis by increasing appetite. Leptin, being secreted from the adipocytes, controls weight and energy homeostasis by decreasing appetite. Leptin concentration is reported to increase after childhood cancer therapy. This study was aimed to compare ghrelin and leptin concentrations in normal children and children who received...
Correlations of cord blood Ghrelin and leptin concentrations with anthropometry of appropriate for gestational age newborns
Jin Lee, Se Na Moon, So Hyun Park, Min-Ho Jung, Byung Kyu Suh, Byung Churl Lee
Clin Exp Pediatr. 2006;49(1):93-98.   Published online January 15, 2006
Purpose : Ghrelin stimulates the secretion of growth hormone and other pituitary hormones, and has orexigenic effects. It may have a physiologic role in fetal and neonatal growth. Leptin secreted by the adipocytes reflects fat mass in infants as well as adults. The aim of this study was to evaluate the relation of cord blood ghrelin and leptin levels to...
The Separate and Combined Effects of Insulin, Dexamethasone and Growth Hormone on the OB Gene Expression and Leptin Secretion from Cultured Human Visceral Adipose Tissue
Il Tae Hwang, Kyung Hee Kim, Jin Soon Hwang, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2003;46(8):795-802.   Published online August 15, 2003
Purpose : We investigated the hormonal control of OB gene expression and leptin secretion in cultured human visceral adipose tissue. Methods : Visceral adipose tissues were cultured for up to 48 hrs in modified Eagle's medium with varying concentration of hormones : Control(no hormone), bovine insulin(100 nM), Dexamethasone(DEX, 100 nM), growth hormone(GH, 40 ng/mL), insulin＋DEX(100 nM each), insulin＋DEX＋GH(100 nM insulin...
The Relationship of Maternal Disorder with Neonatal Cord Blood Leptin - Preeclampsia, Diabetes Mellitus, Antenatal Steroid Treatment -
Seon Mi Park, Eun Young Kim, Yeong Bong Park, Sang Kee Park
Clin Exp Pediatr. 2001;44(10):1119-1126.   Published online October 15, 2001
Purpose : Leptin, the product of the ob gene is primarily by adipose tissue but also by the human placenta. Leptin may also have a role as a regulator of fetal growth and development during normal pregnancy as well as in pregnancies associated with anomalous fetal growth. Our study aimed to discover whether or not leptin concentration in neonatal cord...
Relationship between Serum Leptin Levels and Other Predictors in Obese Children
Se Jin Park, Ki Won Park, Young Mi Hong
Clin Exp Pediatr. 2001;44(10):1103-1111.   Published online October 15, 2001
Purpose : The product of the ob gene, leptin is an adipocyte specific hormone that might be involved in the regulation of food intake by the central neuroendocrine system. Recent studies reported that serum leptin concentrations were correlated with Body mass index(BMI) and other obesity measurements. The aims of this study were to evaluate leptin concentrations according to degree of...
Effect of Growth Hormone Secretion on Serum Concentration of Leptin
Se-Eun Kim, Jeong-Nyeo Lee, Sang-Ook Nam, Woo-Yeong Chung
Clin Exp Pediatr. 2000;43(7):959-966.   Published online July 15, 2000
Purpose : To investigate the effect of growth hormone(GH) secretion on serum concentration of leptin, we evaluated the differences in serum concentration of leptin between patients with growth hormone deficiency(GHD) and GH normal short stature in prepubertal male children, and the relationship between GH and serum leptin level. Also, we analyzed the correlation between serum concentrations of leptin and insulin-like growth factor-I(IGF-I), insulin-like growth...
Serum Leptin Levels in Children with Type I Diabetes Mellitus
Eun Sil Lee, Han Ku Moon, Yong Hoon Park, Yong Woon Kim
Clin Exp Pediatr. 2000;43(4):550-555.   Published online April 15, 2000
Purpose : Leptin is a highly hydrophobic 16-kDa protein encoded by the ob gene which is expre- ssed in adipocytes and participates in the regulation of food intake and energy expenditure. The aims of the present study were to examine the comparison of leptin levels between type I diabetes mellitus(DM) patients who received exogenous insulin therapy and healthy children, and...
Serum Leptin Concentrations in Extremely Obese Childen
Yon Ho Choe, In Young Hyun
Clin Exp Pediatr. 1999;42(8):1136-1140.   Published online August 15, 1999
Purpose : The purpose of this study is to investigate whether there is a difference in leptin concentrations between those of children of normal weight and extremely obese children. Methods : We measured serum concentrations of leptin in 70 extremely obese subjects(7 to 12 years, 20 girls and 50 boys), whose serums had been frozen at -70℃. Height, weight, obesity index,...
Neonatal Cord Blood Leptin : Its Relationship to Birth Weight
Byung Churl Lee, In Kyung Sung, Byung Kyu Suh, Moon Young Song
Clin Exp Pediatr. 1999;42(5):637-643.   Published online May 15, 1999
Purpose : The purpose of this study was to correlate birth weight, skinfold thickness, gestational age, BMI and ponderal index of neonates and maternal status with cord serum leptin concentration. Methods : Sixty newborns were enrolled in this study. Standard growth curves were used to categorize infants as appropriate(AGA), large(LGA), or small for gestational age(SGA). Gestational age, birth weight, length, skinfold...
Serum Leptin Concentrations in Korean Children
Yon Ho Choe, Soon Ki Kim, Young Hyun
Clin Exp Pediatr. 1998;41(7):960-965.   Published online July 15, 1998
Purpose : Leptin is the product of the ob gene secreted by adipocyte. This study investigated whether leptin concentrations were elevated in obese children and the relationship between leptin concentrations and gender, and age in Korean children. Methods : We measured serum concentrations of leptin in 124 subjects(10 to 18 years, 62 girls and 62 boys). Height, weight, obesity index, and...
Serum Leptin Levels in Obese Children
Kyoung Ah Ha, Il Ran Kim, Mi Jung Park, Jae Heon Kang, Churl Young Chung
Clin Exp Pediatr. 1998;41(7):953-959.   Published online July 15, 1998
Purpose : Leptin is a protein encoded by the ob gene that is expressed in adipocytes. It regulates eating behavior by the action to the satiety centers in the hypothalamus. In ob/ob mouse, adipocytes can not produce leptin because of a mutation in the ob gene which results in obesity. Whereas, leptin concentrations were elevated in obese adults, and leptin...
Serum Leptin Levels in Children with Obesity
Byung Churl Lee, Moon Young Song, Byung Kyu Suh
Clin Exp Pediatr. 1998;41(6):785-790.   Published online June 15, 1998
Purpose : The identification of the ob gene and its adipocyte-specific protein leptin has provided the first physiologic links to the regulatory system controlling body weight. In adults, elevations of serum leptin concentrations correlated closely with the percentage of body fat. This study investigated whether leptin concentrations were elevated in obese children, and the relationship between leptin concentrations and gender and pubertal stage. Methods :...