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Review Article
Double-negative T cells in pediatric rheumatic diseases
Dimitri Poddighe, Tilektes Maulenkul, Kuanysh Dossybayeva, Gulsamal Zhubanova, Zaure Mukusheva, Lyudmila Akhmaltdinova
Double-negative (CD4-CD8-) T (DNT) cells have been implicated in Autoimmune Lymphoproliferative Syndrome (ALPS), where their expansion inside the circulating pool of T cells represents a diagnostic criterion. Recent experimental evidence has supported the immunomodulatory roles of DNT cells, and studies in adult patients have suggested that they may be altered in some immune-mediated conditions. This study aimed to retrieve available...
Original Article
Neonatology (Perinatology)
Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis
Rocky Wilar
Clin Exp Pediatr. 2019;62(6):217-223.   Published online October 8, 2018

Purpose: To determine the diagnostic value of eosinopenia and the neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of early onset neonatal sepsis (EONS). Methods: This cross-sectional study was conducted in the Neonatology Ward of R.D. Kandou General Hospital Manado between July and October 2017. Samples were obtained from all neonates meeting the inclusion criteria for EONS. Data were encoded using logistic regression...
Hematology and Oncology
Lymphocyte-monocyte ratio at day 14 of first cisplatin-doxorubicin chemotherapy is associated with treatment outcome of pediatric patients with localized osteosarcoma
Jun Ah Lee, Hea Lin Oh, Dong Ho Kim, Jung Sub Lim
Clin Exp Pediatr. 2019;62(2):62-67.   Published online October 1, 2018

Purpose: We aimed to determine the prognostic significance of lymphocyte counts and the lymphocytemonocyte ratio (LMR) in pediatric patients with osteosarcoma. Methods: We retrospectively reviewed the medical records of 27 pediatric patients with localized extremity osteosarcoma, treated at the Korea Cancer Center Hospital between May 2002 and March 2016. Leukocyte counts and LMR before treatment and on day 14 (LMR14) of...
Nephrology (Genitourinary)
Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection
Song Yi Han, I Re Lee, Se Jin Park, Ji Hong Kim, Jae Il Shin
Clin Exp Pediatr. 2016;59(3):139-144.   Published online March 31, 2016
Purpose

Acute pyelonephritis (APN) is a serious bacterial infection that can cause renal scarring in children. Early identification of APN is critical to improve treatment outcomes. The neutrophil-lymphocyte ratio (NLR) is a prognostic marker of many diseases, but it has not yet been established in urinary tract infection (UTI). The aim of this study was to determine whether NLR is a...

Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients
Hyun O Kim, Hyun Jin Oh, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Bin Cho, Hack-Ki Kim
Clin Exp Pediatr. 2013;56(1):26-31.   Published online January 29, 2013
Purpose

Lymphocyte subset recovery is an important factor that determines the success of hematopoietic stem cell transplantation (HSCT). Temporal differences in the recovery of lymphocyte subsets and the factors influencing this recovery are important variables that affect a patient's post-transplant immune reconstitution, and therefore require investigation.

Methods

The time taken to achieve lymphocyte subset recovery and the factors influencing this recovery were investigated...

CD4+/CD8+ T lymphocytes imbalance in children with severe 2009 pandemic influenza A (H1N1) pneumonia
Ji Eun Kim, Siegfried Bauer, Kyong Suk La, Kee Hyoung Lee, Ji Tae Choung, Kyoung Ho Roh, Chang Kyu Lee, Young Yoo
Clin Exp Pediatr. 2011;54(5):207-211.   Published online May 31, 2011
Purpose

This study was conducted to investigate the immune responses of children with moderate and severe novel influenza A virus (H1N1) pneumonia, and to compare their clinical and immunological findings with those of control subjects.

Methods

Thirty-two admitted patients with H1N1 pneumonia were enrolled in the study. The clinical profiles, humoral and cell-mediated immune responses of the 16 H1N1 pneumonia patients who were...

The effectiveness of biochemical indexes for evaluating the nutrition states of children
Jae Kwang Kim, Hyun Seong Jin, Myung Ki Han, Bong Seong Kim, Choong Hwan Cha, Kie Young Park
Clin Exp Pediatr. 2009;52(2):167-175.   Published online February 15, 2009
Purpose : This study has been conducted to analyze whether the biochemical nutrition indexes might be useful and effective for evaluating the nutrition states of children. Methods : We evaluated 269 children, aged 3-9 years old, who had visited Gangneung Asan Hospital for elective surgery from January 2006 to December 2007, and examined their anthropometric and preoperative laboratory data with...
Gastric mucosal immune response of Helicobacter pylori-infected children
Hye Won Yom, Jeong Wan Seo
Clin Exp Pediatr. 2008;51(5):492-499.   Published online May 15, 2008
Purpose : Helicobacter pylori infection is one of the most common gastrointestinal infections worldwide; it almost invariably causes chronic gastritis. Pediatric studies may provide important insights into the mucosal immune response of H. pylori-infection, as children are not submitted to environmental factors such as alcohol, tobacco and anti-inflammatory medication. The aim of the present study was to investigate the mucosal...
Change of Peripheral Blood CD5＋ B Lymphocytes in Early Neonatal Period
Ye Ho Lee, Bin Cho, Department of Pediatrics, College of Medicine, Cat , Kyung Tai Whang
Clin Exp Pediatr. 2000;43(5):674-678.   Published online May 15, 2000
Purpose : This study was aimed to investigate age-related changes of CD5＋ B lymphocytes in healthy Korean neonates. Methods : Sixty healthy neonatal infants were enrolled in this study; at birth(n=10), day 1(n=10), day 2(n=10), day 3(n=10), day 4(n=10) and day 5(n=10). Phenotypic analysis of CD5＋ B lymphocytes was performed on blood samples using standard flow-cytometric techniques. Results : The percentage of...
Case Report
The Lymphocyte Subset Change in a Case of Subacute Necrotizing Lymphadenitis
Ji Hyang Doh, Sung Taek Kim, Kyeong Shin Lee, So Young Jeong
Clin Exp Pediatr. 1998;41(7):994-1000.   Published online July 15, 1998
The subacute necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease, is a benign, self-limited disorder of unknown cause. This rare disease is characterized by fever, lymphadenopathy, leukopenia, and elevated sedimentation rate. This disease preferentially affects young women. The diagnosis of this disease is confirmed by involved lymphnodes biopsy. Evidence for autoimmune dysfunction has been reported, but is usually lacking. According to...
Original Article
Domonstration of in vivo and in vitro Changes of T Helper Lymphocytes by Using Cytokine Flow Cytometry
Yeom Kim, Youn Soo Hahn
Clin Exp Pediatr. 1998;41(7):883-892.   Published online July 15, 1998
Immunomodulation Therapy in Aplastic Anemia : Relapse Rate, Complications and Long-term Survival During Follow-up for More than 1 Year
Jun Ah Lee, Hyoung Jin Kang, Hyo Jeong Han, Hyoung Soo Choi, Eun Sun Yoo, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(6):775-784.   Published online June 15, 1998
Purpose : We evaluated the response to immunomodulation therapy, long-term survival and relapse rate of aplastic anemia during follow-up for more than 1 year. Methods : Twenty-eight children, with moderate to severe aplastic anemia were followed for more than one year and 7 children expired after therapy, were analyzed. Antilymphocyte globulin(ALG) or antithymocyte globulin(ATG) by itself was given to 27 patients, and cyclosporine A(CsA)...
Immunologic Changes of Peripheral Blood Lymphocytes in Kawasaki Disease after Intravenous Gamma Globulin Therapy
Jung Yeon Shim, Kyung Mo Kim, Young Hwue Kim, Soo-Jong Hong
Clin Exp Pediatr. 1996;39(5):712-721.   Published online May 15, 1996
Purpose : Kawasaki disease(KD) is multi-systemic vasculitis and coronary artery abnormalities can develop up to 30 percent in untreated patients. Several observations suggest that immune activation and the secretion of cytokines from immune effector cells contribute to the pathogenesis of this disease. Though high dose intravenous gamma globulin(IVGG,>1 gm/kg) is effective in reducing the prevalence of coronary artery aneurysms in KD,...
Age Related Reference Ranges for Lymphocyte Subsets in Healthy Korean Children
Dong Un Kim, Joon Sung Lee
Clin Exp Pediatr. 1996;39(2):264-272.   Published online February 15, 1996
Purpose : This study was aimed to investigate the age related changes of lymphocyte subset values in healthy Korean children. Methods : Eighty healthy children were divided into four groups: group A(less than 1yr, n=20), group B(from 1 to 211/12 yr, n=20), group C(from 3 to 511/12 yr, n=20), group D(more than 6 yr, n=20). Their blood were examined for the...
Case Report
A Case of Disseminated Pagetoid Reticulodsis
Hyang Mi Kwon, Sun Seong Park, Hye Lim Jung, Dong Hyuck Keum, Kye Yong Song
Clin Exp Pediatr. 1995;38(7):988-992.   Published online July 15, 1995
Pagetoid reficulosis is a rare skin disorder consisting of localized(WoringerKolopp type) or disseminated (Ketron-Goodman type), asymptomatic hyperkeratotic, cutaneous plaque. The disseminated form has clinical similarities with mycosis fungoides and histologically characteri-sed by prominent infiltration of cytologically atypical mononuclear cells within a hyperplastic epidermis. It is suggested that the infiltrating cells orginate from T-lymphocytes. A 6yr old male patient visited with...
Original Article
Stem Cell Transplantation in Umbilical Cord Blood(II) Characteristics of T-Lymphocyte Subpopulation in Umbilical Cord Blood
Kyung Ha Ryu, So Young Ahn
Clin Exp Pediatr. 1995;38(6):819-826.   Published online June 15, 1995
Purpose : Homatopoietic stem cells, which have the ability to undergo self-renewal as well as to develop into multipotential differentiations, have been consistantly demonsteraten in human umbilical cord blood. Recently, there have been a few studies using the umbilical cord blood as a source of stem cell transplantation. However it remains unclear whether umbilical cord blood in safe with regards to...
Case Report
A Case of Congenital Agammaglobulinemia
Sang Yong Kim, Jong Hyun Kim, Jin Han Kang, Joon Sung Lee, Sang In Shim
Clin Exp Pediatr. 1995;38(1):99-103.   Published online January 15, 1995
Congenital agammaglobulinemia was described first among all human immunodeficiencies, and characterized by defect of B lymphocyte maturation and severe panhypogammaglobulinemia. These patients frequently acquire infections with high-grade extracellular pyogenic pyogenic organisms since infancy. We experienced a case of congenital agammaglobulinemia in a 10 years old male. He had history of recurrent pneumonia and purulent otitis media since late infancy. Also he...
Original Article
Antilymphocyte Globulin Therapy for Aplastic Anemia in Children
Soo Jong Hong, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1994;37(11):1526-1539.   Published online November 15, 1994
Immunosuppressive therapy based on the use of antilymphocyte globulin (ALG) has become standard therapy for patients with aplastic anemia who are not eligible for bone marrow transplantation. In this study, T cell subsets before and after ALG therapy, hematologic responses, complications and prognostic factors were analysed. Eleven (42%) out of twenty-six patients treated with ALG showed response, but...
Case Report
Characterization of the Novel Late T Cell Activation Proteins, 519 and 520
Dae-Yeol Lee, Alan M Krensky
Clin Exp Pediatr. 1993;36(3):409-416.   Published online March 15, 1993
The late T cell activation gene, 519, is expressed in antigen specific, growth factor dependent T cell lines and clones but not in T or B cell tumors, other hematopoietic cells, tonsil, muscle, lung, or liver. Resting peripheral blood ymphocytes(PBLs)express little or no 519mRNA, but levels increase dramatically 5~7 days after activation with alloantigen or mitoen. Four alternatively spliced transcripts...
Original Article
Identification of Human Mononuclear Cell Population by Acid alpha-Naphthyl Acetate Esterase Staining.
S G Lee, B H Choi, K Ch Han, T H Chung
Clin Exp Pediatr. 1982;25(6):547-553.   Published online June 30, 1982
This study was carried out to determine the clinical usage of acid alpha-naphthyl acetate esterase staining technic to define subpopulation of human peripheral blood lymphocytes and monocytes. 18 samples of peripheral blood smear of normal subjects were fixed in the formalin-aceton buffer fixative an stained by alpha-naphthyl acetate esterase techinc to be differentiated into 3 types of mononuclear cells; granular,...