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Original Article
Influence of Prognostic Factors on Survival Rate of Medulloblastoma Patient with Chemotherapy
Kyung Mi Shin, Sung Yeon Choi, Sung Chul Won, Chang Hyun Yang, Chuhl Joo Lyu, Chang Ok Suh, Joong Uhn Choi, Byung Soo Kim
Clin Exp Pediatr. 2003;46(2):178-182.   Published online February 15, 2003
Purpose : Brain tumors are the second most common tumor in childhood, and medulloblastomas comprise 15-25% of brain tumors. The well known prognostic factors are age at diagnosis, stage of disease, and extent of surgical excision. In this study, we analysed the prognostic factors in patients who received chemotherapy after excision. Methods : We reviewed the medical records of 61...
Case Report
A Case of Subcutaneous Panniculitis-like T Cell Lymphoma in Childhood
Yoon Seok Choi, Kyung Mi Shin, Sung Chul Won, Chuhl Joo Lyu, Chang Hyun Yang, Byung Soo Kim, Moon Kyu Kim
Clin Exp Pediatr. 2002;45(8):1028-1032.   Published online August 15, 2002
Subcutaneous pannicultis-like T cell lymphoma is a rare cutaneous T cell lymphoma. It presents with multiple subcutaneous nodules or plaques involving the extremities or trunk, and with constitutional symptoms that include fever, malaise, fatigue, myalgia, chills and weight loss. Histologically, the lesions of this disease are reminiscent of panniculitis and are composed of a mixture of small and large atypical...
A Case of Wilms Tumor with Thrombi which Invaded the Right Ventricule
Ji Hyun Uhm, Sung Chul Won, Chuhl Joo Lyu, Chang Hyun Yang, Byung Soo Kim, Eui Ho Hwang, Young Hwan Park, Chang Ok Seo
Clin Exp Pediatr. 2002;45(3):390-394.   Published online March 15, 2002
College of Medicine, Yonsei University, Seoul, Korea Wilms tumor is the second most common malignant retroperitoneal tumor. Inferior vena cava and right atrial involvement is found in about 4-10% and 0.5-3% of cases, respectively. But, right ventricular involvement has not been reported. We experienced a case of Wilms tumor with right ventricular invasion in a 2 year-old male who presented intermittent...
Original Article
Effect of GCV on Neuroblastoma Cell Line Expressed by HSV-TK Gene with Retroviral Vector
Hyun Sang Cho, Chuhl Joo Lyu, Yeun Soo Kim, Tae Soo Kim, Byung Soo Kim
Clin Exp Pediatr. 1997;40(12):1719-1724.   Published online December 15, 1997
Background : Gene transfer with vectors derived from murine retroviruses is restricted to cells which are proliferating and synthesizing DNA at the time of infection. Accordingly, selective introduction of genes encoding for susceptibility to otherwise nontoxic drugs(suicide genes) into proliferating tumor may be used to treat cancer. We investigated the efficacy of in vitro transduction of neuroblastoma cell with the herpes simplex-thymidine kinase(HSV-tk) gene followed...
Case Report
Treatment of Vaginal Endodermal Sinus Tumor
Seok Joo Han, Myo Kyung Lee, Chuhl-Joo Lyu, Byung Soo Kim, Eui Ho Hwang
Clin Exp Pediatr. 1995;38(5):707-712.   Published online May 15, 1995
An endodermal sinus tumor of the vagina, a rare pediatric malignancy, was managed with c onservative surgey followed by adjuvant chemotherapy(vincristine, actinomycin D, cyclophosphamide : VAC). Treatment related complications were acceptible, and there is no evidence of d isease twenty months after diagnosis. As a treatment option, primary conservative surgery and adjuvant chemotherapy is viewed as a highly attractive alternative...
A Case of Childhood Adenocarcinoma
Mi Jung Park, Moon Sung Psrk, Seunng Hwang Oh, Chuhl Joo Lyu, Ki Sup Chung, Byung Soo Kim
Clin Exp Pediatr. 1994;37(1):109-114.   Published online January 15, 1994
Gastric adenocarcinoma in childhood is an extremely rare disease with poor prognosis. We experienced a case in which a 14 year old female patient who was admitted with complaints of abdominal pain, indigestion and obstipation. Her physical examination revealed positive Blumer's rectal shelf, positive ascitic fluid cytology and typical radiologic and endoscopic findings suggesting gartric adenocarcinoma. She showed symptomatic improvement...
Original Article
A Clinical Study of Testicular Relapse in Childhood Acute Lymphocytic Leukemia
Hye Ok Roh, Chuhl Joo Lyu, Seung Hwan Oh, Chang Hyun Yang, Kir Young Kim, Byung Soo Kim
Clin Exp Pediatr. 1993;36(5):680-686.   Published online May 15, 1993
From January 1984 to June 1991, we studied testicular relapsed patients among 105 cases of acute lymphocytic leukemia in children who were admitted to the Department of Pediatrics and Yonse Cancer Center, Yonsei University Severance Hospital. The results were as follows: 1) 15 out of 105(14.4%) cases of acute lymphocytic leukemia were diagnosed as testicular relapse. According to the prevalence by the...
Case Report
A Case of Congenital Neuroblastoma: Diagnosed at Antenatal Perio
Hye Young Kang, Chuhl Joo Lyu, Byung Soo Kim, Seung Kang Choi, Woo Hee Jung, Soon Ae Chun
Clin Exp Pediatr. 1992;35(12):1750-1755.   Published online December 15, 1992
Neuroblastoma is one of the most common tumors of childhood. It accounts for about 8% of all pediatric cancers. Because most children who present with this tumor are older than 1 year of age and have advanced disease, they have a poor prognosis in spite of intensive treatment. The patients with less than 1 year of age at the time of...
Original Article
The Treatment Results of Childhood RhaMomyosarcoma
Chuhl-Joo Lyu, Byung Soo Kim, Eui Ho Hwang, Chang Ok Suh, Woo-Hee Cung
Clin Exp Pediatr. 1992;35(11):1520-1527.   Published online November 15, 1992
Rhabdomyosarcoma is a relatively common solid tumor in infants, children and adolescents, according for 4% to 8% of malignant disease in children less than 15 years old. Use of a multimodal approach to treatment has resulted in a dramatic improvement. Yonsei Cancer Center in Korea, since it's establishment in 1975, has been a state of multimodal approach. Thirty-seven cases of childhood...
A Clinical Study of Primay Gastrointestinal Lymphoma in Childhood
Hye Jung Joo, Chuhl-Joo Lyu, Byung Soo Kim, Euy Ho Hwang, Chang Ok Suh, Woo Ick Yang, Woo Hee Chung
Clin Exp Pediatr. 1992;35(9):1210-1219.   Published online September 15, 1992
The 18 cases of primary gastrointestinal lymphoma patients admitted to the Department of Pediatrics and Yonsei Cancer Center, College of Medicine, Yonsei University, during 15 years from January, 1975 to December, 1989 were reviewed on the bases of clinical characteristics, treatment, and survival rates. The results were summarized as follows; 1) The age of patients ranged from 3 years to 14 years,...
Case Report
A Case of Thyroid Papillary Adenocarcinoma.
Duk Hi Kim, Chul Lee, Pyung Kil Kim, Byung Soo Kim, Yi Ho Hwang, Kyung Sik Lee, Woo Hee Chung
Clin Exp Pediatr. 1984;27(3):288-292.   Published online March 31, 1984
We report a case of thyroid papillary adenocarcinoma in a 5 year 1 month old boy. His major problem was palpable thyroid nodule & cervical lymph nodes. Extensive bilateral pulmonary metastasis was noticed. The metastatic thyroid carcinoma was regressed after therapeutic doses of radioiodine without total thyroidectomy.
Original Article
A Clinical Study of Histiocytosis in Childhood.
Hee Jung Chung, Byung Soo Kim, Chan Il Park
Clin Exp Pediatr. 1984;27(3):253-264.   Published online March 31, 1984
A clinical study with particular emphasis on the result of chemotherapy has been made on. 34 cases of histiocytosis diagnosed at the Department of the Severance Hospital and Yonsei Cancer Center from January 1975 to December 1981. The results may be summarized as follows: 1) Among histiocytosis, HSC and LSD were each present in elevent cases, E-G in seven and HMR...
Case Report
A Case of Hypereosinophilic Syndrome.
Chul Young Lee, Ki Sup Chung, Byung Soo Kim, Chang Jin Kim, Chan Il Park
Clin Exp Pediatr. 1982;25(4):388-392.   Published online April 30, 1982
Marked eosinophilia is a common finding in many disease, occurring most frequently in allergic and parasitic conditions. A Separate syndrome characterized by peripheral eosinophilia and multisystem eosinophilic infiltration has been reported by many authors with a variety of diagnoses. In 1968, Hardy and Anderson proposed the term hypereosinophilic syndrome to encompass the entire group and in 1975, Chusid reported 14...
Original Article
Results of Treatment in 33 Patients with Neuroblastoma.
Hak Yong Kim, Choong Kil Chung, Duk Jin Yun, Byung Soo Kim
Clin Exp Pediatr. 1981;24(10):942-949.   Published online October 31, 1981
Neuroblastoma is a malignant neoplasm which arises from primitive sympathetic neuroblasts. It is the second most common solid tumor in young children, exceeded in incidence only by brain tumors. This tumor shows immunological features and spontaneous regression. But, in spite of recent advances in multimodality therapy survival rate has not been improved much. We reviewed 33 patients with neuroblastoma who...
Case Report
A Case of Acute(infantile) Gaucher's Disease.
Baek Keun Lim, Kwan Sub Chung, Jae Seung Lee, Kir Young Kim, Byung Soo Kim, Duk Jin Yun, Chang Jin Kim, Chan Il Park
Clin Exp Pediatr. 1981;24(10):982-990.   Published online October 15, 1981
A case of Acute infantile form of Gaucher's disease in Korean infant is described. The large cells characteristically found in the bone marrow and liver in Gaucher's disease have been investigated with electron microscope, as well as light microscope. The pertinent literature has reviewed briefly concerning the clinical and laboratory fingings, roentgenographic picture, pathogenesis, pathology, diagnosis and treatment of this...
A Case of Acute Lymphocytic Leukemia with Both Renal Enlargement.
Choong Kil Chung, Jae Seung Lee, Byung Soo Kim
Clin Exp Pediatr. 1981;24(5):502-504.   Published online May 15, 1981
A case of acute lymphocytic leukemia with both renal enlargement found in a 2 3/12-year-old female has been presented. A brief review of the literatures was made on this subject.
A Case of Chronic Myelocytic Leukemia associated with Neurofibromatosis.
Byung Zoo Choi, Jung Ho Lee, In Ho Kim, Seoc Koo Bae, Churl Young Chung, Byung Soo Kim
Clin Exp Pediatr. 1980;23(10):849-854.   Published online October 15, 1980
There have been few cases of Neurofibromatosis associated with Chronic Myelocytic Leukemia in literature and we found only one report in Korea which described the association of Chronic Myelocytic Leukemia with Neurofibromatosis. We report a case of patient whose clinical and hematological findings were compatible with Chronic Myelocytic Leukemia and Neurofibromatosis. Busulfan was used in the treatment of this patient...
Histiocytic Medullary Reticulosis in childhood Report of Three Cases.
Kwan Sub Chung, Kyo Sun Kim, Do Kwang Yun, Pyung Kil Kim, Kir Young Kim, Byung Soo Kim, Tae Jung Kwon, In Jun Chor
Clin Exp Pediatr. 1980;23(10):833-842.   Published online October 15, 1980
Three cases of hisiocytic medullary reticulosis occurring in children aged 6 years, 9 years and 14 years, are described. In all children the diagnosis was based on anemia, granulocytopenia, thrombocytopenia and marked erythrophagocytosis by bone marrow and lymph node atypical histiocytes. They all showed immediate remission with combined chemotherapy of vinblastine and prednisolone, but Case 1 eventually died at 6...
Original Article
A Clinical Study of Wilms' Tumor with Special Reference to the Cure Rate by Multimodality Treatment.
Kwan Sub Chung, Duk Jin Yun, Byung Soo Kim, Dong Sik Kim
Clin Exp Pediatr. 1980;23(7):557-566.   Published online July 15, 1980
Wilms' tumor is the most common intra-abdominal malignant tumor of childhood. There has been a progressive improvement in the over all survival rate of children with Wilms' tumor since the introduction of radiotherapy and nephrectomy. Survival has continued to improve with the addition of chemotherapy, initially actinomycin D, and later vincristine. This paper reviewed 34 patients with Wilms' tumor seen...
Case Report
A Case of Renal Cell Carcinoma(Adenocarcinoma) in Nine Years Old Girl.
Chee Ok Ahn, Sang Hak Park, Chang Jun Coe, Pyung Kil Kim, Byung Soo Kim, Jae Yun Rho, In Jun Choi, Sung Jin Kim, Jin Moo Lee
Clin Exp Pediatr. 1979;22(8):737-743.   Published online August 15, 1979
A 9 years old girl has been admitted to hospital because of 5 days history of gross hem aturia. Physical examination on admission, She was eassentially normal except enlarged tonsils. Hb, Hct, WBC and Platelets were also nornal, ESR was 5mm/Hr. ASO titer was less than 1:60, C3 was 58mg%(normal:43-200mg%), BUN 11mg%, Creatinine 0.8mg% Serum cholesterol 160mg%, Total Protein 7.1mg%...
Two Cases of Peutz-Jeghers Syndrome.
Jun Hee Sul, Kee Choon Kim, Byung Soo Kim, No author name is english No author name is english
Clin Exp Pediatr. 1978;21(7):557-562.   Published online July 31, 1978
Familial association of gastrointestinal polyposis with mucocutaneous pigmentation was first reportde by Peutz in 1921. Following reemphsis by Jeghers in 1949, it became a definite clinical disease entity known as Peutz-Jeghers syndrome, which is rare disease with about 12cases reported in Korea. This was a report of our experience with two cases of Peutz-Jeghers syndrome, which were diagnosed in a...
Original Article
I131 Rose Bengal Liver Scanning.
Chang Jun Coe, Jae Song Kim, Jae Seung Lee, Byung Soo Kim, Duk Jin Yun
Clin Exp Pediatr. 1977;20(8):613-620.   Published online August 31, 1977
This is a clinical study of I131 Rose Bengal liver scanning on 17 in-patients with jaundice hospitalized at Severance hospital from October 1969 to March 1976. And we observed following results. 1) In 13 patients, the liver scanning showed complete biliary obstructive pattern, in 2 patients partial obstruction and two had space occupying lesions. Of the 13 patients with complete...
Clinicostatistical Study of Malignant Tumors in Infants and Children.
Ki Young Lee, Byung Soo Kim, Suk Kyou Cha, Soo Hyung Kim
Clin Exp Pediatr. 1977;20(4):265-270.   Published online April 30, 1977
Clinicostatistical study was carried out on 130 cases of children with malignant tumors admitted in pediatric ward of Severance Hospital from 1965 to 1974 and the following results were obtained: 1) The incidence of malignancies on all admitted cases was 1.0% and males were more affected(68.5%) than females. 2) The annual increase of incidence on childhood malignancies couldn't be observed....