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Original Article
Early Postoperative Results of the Large Ventricular Septal Defect in Infants Younger Than 1 Year of Age
Man-Teak Oh, Hyang-Suk Yoon, Jong-Bum Choi
Clin Exp Pediatr. 1996;39(1):72-77.   Published online January 15, 1996
Purpose : We report the results of a policy of primary surgical closure of large ventricular septal defects(VSDs) applied over the past 3 years to all symptomatic infants regardless of patient weight, location or number of VSDs. To analyze the early postoperative mortality and other surgical complications in young infants, comparison of preoperative and outcome variables were made between infants...
Infantile Choledochal Cyst Presenting with Neonatal Cholestasis; Review of Anatomical and Clinical Aspect
Jae Won Jeong, Jeong Kee Seo, Kwi Won Park, In Won Kim
Clin Exp Pediatr. 1995;38(12):1629-1637.   Published online December 15, 1995
Purpose : Extrahepatic biliary atresia, neonatal hepatitis, Allagille syndrome are most common primary causes of the neonatal cholestasis. Infantile choledochal cyst is another primary disease presenting with neonatal cholestasis but its incidence is so low that it has been reported rarely. Choledochal cyst in infancy has been known to have clinically and anatomically different characteristics from ones after infancy. Thus...
Case Report
Two Cases of Systemic Candidiasis in Premature Infants
Dae Kyun Kim, Woo Chul Suh, Eun Gyeoung Jung, Eun Seok Yang, Sang-Kee Park
Clin Exp Pediatr. 1995;38(11):1558-1564.   Published online November 15, 1995
Reports of systemic candidiasis in neonates have been noted recently with its major advances in neonatal care permitting the frequent survival of low birth weight infant. Factors influencing the development of systemic candidiasis include prematurity, very low birth weight, the presence of intravascular catheter, the use of hyperalimentation, prolonged broad spectrum antimicrobial therapy and prolonged endotracheal intubation. We experienced two cases...
Original Article
Effect of Prophylactic Treatment of High Doses Recombinant Human Erythropoietin on Anemia in Premature Infants
Soon Seong Park, Seong Ho Hong, Hye Lime Jung, Dong Hyeok Keum
Clin Exp Pediatr. 1995;38(10):1384-1393.   Published online October 15, 1995
Purpose : This study was conducted to determine whether prophylatic treatment with recombinant human erythropoietin(rHuEPO) could prevent anemia and reduce the need for blood transfusion in premature infants. Methods : This study was conducted from May, 1992 to July 1994. We randomly assigned 24 premature infants with gestational age less than 34 weeks and birth weight less than 2.0kg. After having...
Riboflavin Status of Normal Newborn Infants and the Changes of Riboflavin During Phototherapy in Hyperbilirubinemic Newborn Newborn Infants
Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1995;38(9):1185-1192.   Published online September 15, 1995
Purpose : Riboflavin is the most important water soluble vitamin in infant nutrition. Riboflavin is converts to flavin mononucleotide (FMN), Flavin adenine dinucleotide(FAD) and then, participiates in the metabolism of energy, protein cellular oxidation-reduction reactions as a cofactor of reactions. Also riboflavin, a light sensitive vitamin, has a maximum absorption spectrum at a wave length similar to that at which...
Trend of Maternal Measles Antibody in Korean Infants before 10 Months of Age
Phil-Soo Oh, Sung Hee Oh
Clin Exp Pediatr. 1995;38(5):619-624.   Published online May 15, 1995
Purpose : The measles epidemic occurrence has not well been controlled in Korea. Vaccin- ation schedule for measles in Korea has been modified in several occasions with insufficient da ta base. The most recent recommendation is to immunize at 9 months of age with measles va-ccine(at 6 months of age during epidemics) and reimmunize at 15 months of age with...
Clinical Studies of Metabolic Bone Disease of Prematurity
Seung-Yeon Suh, Eun-Kyung Lee, Ran Namgung, Hae-Jung Joo, Min-Soo Park, Kook-In Park, Chul Lee, Dong-Gwan Han, Meung-Jun Kim, Jin-Suk Suh
Clin Exp Pediatr. 1995;38(2):159-169.   Published online February 15, 1995
Purpose : Preterm formula used in Korea, theoretically does not supply the recommended mineral intake for optimal bone metabolism in very low birth weight infants(Formula 500-700 mg Ca/L, 300~370mg P/L, and 440IU of vitamin D/L). The purpose of this study is to identify th e possible etiologic factors and clinical course of rickets in these infants. Methods : We recently identified...
Clinical and Ultrasonographic Study on Prenatal Brain Damage in Newborn Infants
Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(10):1364-1375.   Published online October 15, 1994
To determine the incidence of prenatal brain damage, and evaluate the clinical and neurosonographical characteristics, we prospectively examined 508 newborn infants with intracranial ultrasound within the first day of life who admitted to the NICU of Severance Hospital from June 1990 to January 1992 and reviewed maternal or neonatal medical records. We found 12 cases(2.4%) of fetal brain...
Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with Perinatal Asphyxia and Hypoxic-Ischemic Encephalopathy with Doppler Technique
Kook In Park, Dong Kwan Han, Joon Soo Lee, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(9):1196-1204.   Published online September 15, 1994
Fifty-three full-term, preterm, term-SGA newborn infants with perinatal asphyxia and 16 full-term infants with hypoxic-ischemic encephalopathy were studied with color Doppler songraphy to assess the postnatal change of the cerebral blood flow velocity(CBFV) longitudinally. A control group of 81 healthy infants also had CBFV recordings during the 1st week of life. Pourcelot Resistance index(PI) and area under the velocity curve(AUVC)...
Meta-analysis of Impact of Neonatal Intensive Care on Neurodevelomental Outcome of Very Low Birth Weight Infants
Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1994;37(7):937-945.   Published online July 15, 1994
We analyzed neurodevelopmental outcome data of 36 selected studies. Data of individual studies were pooled by birth weight group: <800g, <1,000g, <1,500g and by time period of birth year: Period I(pre-intensive care era), 1960-67:Period II(beginning period of intensive care), 1968-76:and Period III(established period of intensive care), 1977-87. In all weight groups, survival and intact outcome rates based on live birth have...
Case Report
Two Cases of Toxic Shock Syndrome (TSS) in Infants
Jin Kil Park, Hong Ju Choi, Hee Tag Im, Jae Sam Kim, Hyo Kyung Shin, Chul Ho Koo
Clin Exp Pediatr. 1994;37(6):861-871.   Published online June 15, 1994
Much has been learned of the pathogenesis and pathophysiology of the toxic shock syndrome (TSS) sinde the initial description in 1978 by Dr. James K, Todd. The clinical illness in defined by the criteria listed in the case definition formulated for epidemiologic studies. With the advent of widespread recognition of TSS, there have been numerous published reports describing the clinical...
Original Article
Clinical Study on Very Low Birth Weight Infants
Sha Young Choi, Dae Young Jang, Oh Kyung Lee, Wan Seob Kim
Clin Exp Pediatr. 1994;37(5):628-635.   Published online May 15, 1994
Medical records of very low birth weight infants weighing less than 1500 grams at birth were reviewed and analyzed. One hundred and forty three infants who were admitted to neonatal intensive care unit of Presbyterian Medical Center, including those who were born and transferred from other hospitals, from January 1987 to December 1991 were examined and the following results were obtained; 1)...
Case Report
Furosemide-Induced Nephrocalcinosis in Very Low Birth Weight Infants
Clin Exp Pediatr. 1994;37(4):553-559.   Published online April 15, 1994
Renal calcifications are a recognized complication of furosemide therapy in premature infants. Particularly in infants with chronic lung disease, the use of this potent diuretic is associated with hypercalciuria, which may predispose the infant to medullary nephrocalcinosis and renal calculi. We experienced two cases of nephrocalcinosis in very low birth weight infants. One had bronchopulmonary dysplasia, pneumonia, patent ductus arteriosus,...
Original Article
The Metabolic Acidosis and Clinical Outcome in Acute Infantile Diarrhea
Ae Yeon Lim, Yo Ahn Rho, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(3):332-338.   Published online March 15, 1994
To determine the types of metabolic acidosis using anion gap in acute infantile diarrhea and to correlate it with clinical outcome, we examined 103 infants admitted with acute diarrhea. The serum electrolytes (sodium, potassium, chloride, phosphorus), creatinine, CO2 content and anion gap were measured on first admission day. They were classified group A with normal anion gap (8~16 mEq/L) and...
Case Report
A Case of Transfusion-Associated Gragt-Verus-Host Disease in a Preterm Infant
Hye Jung Joo, Seung Mo Park, Ran Namgung, Kook In Park, Jin Sung Lee, Chul Lee, Dong Kwan Han, Kir-Young Kim, Kwang-Hoon Lee, Kwang-Gil Lee
Clin Exp Pediatr. 1993;36(11):1613-1620.   Published online November 15, 1993
Graft-versus-host disease is commonly observed after allogeneic bone marrow transplantation but rarely recognized transfusion or solid-organ transplantation. Transfusion-associated graft-versus-host disease can occur in immunosuppressed recipients and immunocompetent transplant recipients. The clinical manifestations of gastrointestinal or hepatic dysfunction, rash and pancytopenia should heighten the physician's index of suspicion for GVHD. Among premature infants, only four cases have been reported to develop...
Original Article
Intractranial Hemorrhage in Full-Term Neonates by Ultrasonography
Chang Gyu Lim, Joon Soo Park, Woo Ryong Lee, Jae Ock Park, Sang Mann Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1993;36(11):1570-1577.   Published online November 15, 1993
Intracranial hemorrhage is the most common neuropathologic finding in premature infants. But in full-term infants, It is less common and rarely causes death. We found out intracranial hemorrhages in 21 full-term neonates by real-time neurosonography and concluded as followings. 1) Among 21 neonates, 17 infants were male and 4 infants were female. 2) In 11(52.3%) infants the hemorrhage was detected within 7...
Comparison between Preterm and Fullterm infants in Neonatal Sepsis
Sung Hee Kim, Kum Hee Hur, Hee Sup Kim, Myoung Jae Chey, Kil Hyoun Kim, Hak Soo Lee
Clin Exp Pediatr. 1993;36(11):1542-1554.   Published online November 15, 1993
We retrospectively evaluated datas on 61 cases of neonatal sepsis confirmed by clinical symptoms and blood cultures at the NICU of Gil General Hospital From Mar. 1989, to Reb. 1992. The result obtained were as follows : 1) The mean gestational age was 32.7±2.6 weeks in preterm infants, and 39±1.5weeks on term infants. The mean birth weight was 1,701.4±422.4g in preterm infants,...
A Clinical Study on Infants of Diabetic Mothers
Gyeong Choe, Young Kwon Choi, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 1993;36(10):1407-1416.   Published online October 15, 1993
Thirty one infants of diabetic mothers(IDM) who had been admitted in Neonatal Intensive Care Unit at Chonnam University Hospital from January 1987 to July 1991 were studied for evaluation of their perinatal outcome and prognosis. The results were as follws; 1) The distribution of diabetic mothers according to modified White뭩 classification was GD & class A in 12 cases (38.7%), B in...
Comparison of Tuberculin Skin Test Results and Adberse Reactions Following BCG Vaccination In Various Infant Groups of Different Ages
In Seung Park, Dong Ki Han, Ho Joon Lim, Sung Hee Oh, Hahng Lee
Clin Exp Pediatr. 1993;36(9):1300-1307.   Published online September 15, 1993
Most authorities including WHO recommended immununizing infants with BCG as early as possible in areas prevalent with tuberculosis, however the optimal time for immunization has not well been characterized. Therefore the investigation was undertaken by vaccinating various infant groups of different ages with BCG and subsequently evaluating for adverse effects and tuberculin reactions, in order to contribute to undestanding the...
Clinical Observation for Low Birth Weight Infants
Hye Jin Lee, Soon Wan Kwon, Soon Ok Byun, Ji Sub Oh
Clin Exp Pediatr. 1993;36(7):928-935.   Published online July 15, 1993
Clinical observations were made on 338 low birth weight infants, who were delivered at Pusan Wallace Memorial Baptist Hospital, during the 3 year periods from 1989 to 1991. The results were as follows; 1) The incidence of LBWI was 5.6% and sex ratio was 1:1.09. Among them AGA was 62.7%. 2) Of all infants, 47.3% were in the birth weight range of 2251-2500...
Clinical Study on Infants of Diabetic Mothers
Eun Eui Kim, Min Jeong Kim, Yang Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1993;36(3):347-355.   Published online March 15, 1993
A clinical observation was performed on the 80 cases of neonates born from diabetic mothers among the total of 34,936 neonates delivered at Il Sin Christian Hospital from January 1985 to December 1989. The results were as follows : 1) The incidence of infants of diabetic mothers was 0.23%, among whom gestational diabetic mothers were 63 cases(78.7%) and overt diabetic mothers...
Neurosonographic Diagnosis of Periventricular-Intaventricular Hemorrhage in Low Birth Weiht Infants
Hee Seok Koh, Dong Kyun Ryu, Young Tack Jang, Oh Kyung Lee, Jin Ok Choi
Clin Exp Pediatr. 1993;36(1):57-66.   Published online January 15, 1993
Periventricular-intraventricular hemorrhage (PV-IVH) is one of the most important neurologic lesion of the low birth weight infants. Serial neurosonographic examinations were performed in 113 low birth weight infants who were admitted to the neonatal internsive care unit of Presbyterian Medical Center from November 1, 1990 to July 31, 1991. The results were summarized as follows: 1) The incidence of PV-IVH in he study...
Evaluation of the Development of High Risk Low Birth Weight Infants Using Bayley Developmental Test
Chul Lee, Yil Seob Lee, Hyung Rae Cho, Dong Kwan Han
Clin Exp Pediatr. 1993;36(1):38-48.   Published online January 15, 1993
Forty two high risk low birth weight infants who had been admitted in neonatal intensive care unit at Yongdong Severance Hospital from August 1987 to July 1990 and followed up in the high risk infants follow-up clinic were studied for evaluation of their development using the Bayley developmental test at the age of 9 month (corrected age). The results obtained were...
Statistical Study on the Incidence and Mortality Rate of Low Birth Weight Infant
Sun-ae Kang, Jae-Kag Choi, Yeon-Kyun Oh
Clin Exp Pediatr. 1992;35(12):1690-1695.   Published online December 15, 1992
A statistical study on the icidence and mortality rate of low birth weight infant (LBW) was done on 11,406 newborns delivered at Wonkwang University Hospital during 9 years from Jan. 1,983 to Dec. 1,991. The results were as follows, 1) The incidence of LBW was 10.2%. 2) The incidence of LBW was higher than that of other hospital delivery (p<0.005). 3) Mortality rate of...
The Relationship Between Neonatal Hypoglycemia and Newborn Iron Status in Hypoglycemic Large-for-Gestational Age Infants
Myung Ja Yun, In Ho Song, Hye Lim Jung, Dong Hyuck Kum
Clin Exp Pediatr. 1992;35(12):1667-1673.   Published online December 15, 1992
We assessed the relationship between neonatal hypoglycemia and newborn iron status in hypoglycemic large-for-gestational age, euglycemic large for gestational age and euglycemic appropriate for gestational age infants that were admitted to the department of Pediatrics, Koryo General Hospital from July 1989 to June 1990. The results are as follows; 1) The incidence of large for gestational age infants was 3.3% (32...
Case Report
A Case of Early Infantile Epileptic Encephalopathy
Sang Mi Ha, Hee Jung Jung
Clin Exp Pediatr. 1992;35(11):1590-1596.   Published online November 15, 1992
Early infantile epileptic encephalopathy is characterized by its early onset (less than 3 months of age), frequent tonic spasms, suppression-burst on EEG, extremely poor response to treatment and grave outcome. The authors experienced a case of early infantile epileptic encephalopathy. The patient was a 1-month-old girl with a complaint of generalized tonic convulsion since 2 days of age, and her EEG...
Original Article
Children with Delayed Speech Development
Sang Kee Park, Ho Sung Yoo, Yeong Bong Park
Clin Exp Pediatr. 1992;35(9):1236-1242.   Published online September 15, 1992
The antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase and the lipid peroxidation were assayed in erythroctyes from the cord blood of 25 fullterm newborn infants and their maternal blood abtained immediatedly after normal delivery. Superoxide dismutase and catalase activites in cor blood erythroctytes were significantly lower when compared with their mothers, but glutathione peroxidase activities were not significantly lower....
Infantile Asthma and Egg Allergy
Sung Hee Lim, Hye Sun Lee, Young Min Ahn
Clin Exp Pediatr. 1992;35(9):1226-1235.   Published online September 15, 1992
Egg is known to be the most common food allergen, which induces various symptoms such as atopic dermatitis, bronchial asthma, urticaria, angioedema, gastrointestinal symproms & anaphylaxis, especially during infancy. To evaluate the clinical course & significance of egg allergy in infantile asthma, we performed diagnostic study on 44 patients who were diagnosed as infantile asthma in our hospital from 1988 to...
Case Report
Transfusion-Acquired Cytomegalovirus Infections in Two Premature Infants
Dong Wook Kim, Kyung Un No, Mi Jung Kim, Soon Mee Park, Hee Sup Kim, Young Pyo Chang, Hoan Jong Lee, Jung-Hwan Choi, Chong Ku Yun, Je Geun Chi
Clin Exp Pediatr. 1992;35(8):1141-1147.   Published online August 15, 1992
Transfusion-acquired perinatal cytomegalovirus (CMV) infection can cause significant morbidity and mortality, particularly in premature infants with a birth wight of less than 1,500 gm. This recognizable syndrome consisted of deterioration of respiratory function, hepatosplenogaly, unusual gray pallor with disturbing septic appearance, lymphocytosis, thrombocytopenia and hemolytic anemia. We experienced transfusion-acquired CMV infections in 2 premature infants with a birth weight of...
A Case of Necrotizing Enterocolitis Associated with Cow and Soy Milk Intolerance
Sang Soo Roh, Young Il Park, Sang Il Lee
Clin Exp Pediatr. 1992;35(6):862-866.   Published online June 15, 1992
A case of necrotizing enterocolitis was associated with cow and soy milk intolerance in a term infant. The infant developed symptoms and radiologic findings-pneumatosis intestinalis and portal vein gas-after ingestion of cow and soy milk. Vomiting and diarrhea recurred with reintroduction of either cow or soy milk several times. The infant remained asymptomatic with a good growth rate on breast...
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