Clinical and Experimental Pediatrics

Letter to the Editor

Cardiology

Differences over 10 years in epidemiologic and clinical features of Kawasaki disease at a single tertiary center

Hyun Su Kim, Suk Won Shin, Bo Geum Choi, Hee Joung Choi

Clin Exp Pediatr. 2020;63(4):157-158. Published online February 5, 2020

Web of Science 2 Crossref 2

DOI: https://doi.org/10.3345/cep.2019.01109

Original Article

Nephrology (Genitourinary)

Variation in clinical usefulness of biomarkers of acute kidney injury in young children undergoing cardiac surgery

Hee Sun Baek, Youngok Lee, Hea Min Jang, Joonyong Cho, Myung Chul Hyun, Yeo Hyang Kim, Su-Kyeong Hwang, Min Hyun Cho

Clin Exp Pediatr. 2020;63(4):151-156. Published online February 5, 2020

Web of Science 7 Crossref 7

Question: Can clinical usefulness of biomarkers of acute kidney injury vary on the clinical circumstances?
Finding: In young children undergoing cardiac surgery, urine KIM-1/Cr level peaked at 24 hours with significant difference from baseline level and was significantly higher at 6 hours in the AKI group. However, urine NGAL/Cr and IL-18/Cr levels showed no specific trend with time for 48 hours after cardiac surgery.
Meaning: Urine KIM-1/Cr concentration could be considered a good biomarker for early AKI prediction after open cardiac surgery in young children.

DOI: https://doi.org/10.3345/cep.2019.00913

Letter to the Editor

General Pediatrics

Effectiveness of comprehensive hand hygiene module on preschool children in Klang Valley, Malaysia

Mohd Dzulkhairi Mohd Rani, Nurul Azmawati Mohamed, Tengku Zetty Maztura Tengku Jamaluddin, Zarini Ismail, Shalinawati Ramli, Habibah Faroque, Farishah Nur Abd Samad, Abdul Rasyid Ariffien, Aisyah Ar Redha Che Amir Farid, Ilina Isahak

Clin Exp Pediatr. 2020;63(3):115-116. Published online February 5, 2020

Web of Science 7 Crossref 5

DOI: https://doi.org/10.3345/cep.2019.01277

Editorial

Allergy

Is the predictive model for asthma development useful as a tool for diagnosing pediatric asthma?

Bong-Seong Kim

Clin Exp Pediatr. 2020;63(3):102-103. Published online February 5, 2020

DOI: https://doi.org/10.3345/cep.2019.01557

Hematology

When to suspect inherited platelet disorders and how to diagnose them

Eun Sil Park

Clin Exp Pediatr. 2020;63(3):98-99. Published online February 5, 2020

Web of Science 1 Crossref 1

DOI: https://doi.org/10.3345/cep.2019.01207

Original Article

Allergy

Ten-year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017

Jihyun Ha, Seung Won Lee, Dong Keon Yon

Clin Exp Pediatr. 2020;63(7):278-283. Published online January 29, 2020

Web of Science 116 Crossref 113

Background: Major questions remain regarding the agestratified trends of allergic diseases and asthma in Korea.
Purpose: To identify the estimated recent prevalence and 10- year trends in asthma, allergic rhinitis, and atopic dermatitis among the Korean population from 2008 to 2017. Methods: This nationwide cross-sectional survey (Korean National Health and Nutrition Examination Survey) over 10 years (2008–2017) examined representative samples of the...

DOI: https://doi.org/10.3345/cep.2019.01291

Editorial

Allergy

Hereditary angioedema in childhood

Young Min Ahn

Clin Exp Pediatr. 2020;63(1):18-19. Published online January 15, 2020

Web of Science 1 Crossref 1

DOI: https://doi.org/10.3345/kjp.2019.01165

Neonatology (Perinatology)

Prevention and management of pain in the neonatal intensive care unit

Sung Shin Kim

Clin Exp Pediatr. 2020;63(1):16-17. Published online January 15, 2020

Web of Science 6 Crossref 5

DOI: https://doi.org/10.3345/kjp.2019.01200

Perspective

Other

The long journey toward improving children’s health: from ‘Korean Journal of Pediatrics’ to ‘Clinical and Experimental Pediatrics’

Man Yong Han, Yeong Ho Rha, Chong-Woo Bae, Baik-Lin Eun; Clinical and Experimental Pediatrics Editorial Team

Clin Exp Pediatr. 2020;63(1):1-2. Published online January 15, 2020

Web of Science 1 Crossref 1

DOI: https://doi.org/10.3345/kjp.2019.01564

Review Article

Pulmonology

The past, present, and future of humidifier disinfectant-associated interstitial lung diseases in children

Eun Lee, So-Yeon Lee, Soo-Jong Hong

Clin Exp Pediatr. 2020;63(7):251-258. Published online December 9, 2019

Web of Science 13 Crossref 15

Exposure to environmental factors can cause interstitial lung diseases (ILDs); however, such types of ILDs are rare. From 2007 to 2011, an ILD epidemic occurred in South Korea owing to inhalational exposure to toxic chemicals in humidifier disinfectants (HDs). HD-associated ILDs (HD-ILDs) are characterized by rapidly progressing respiratory failure with pulmonary fibrosis and a high mortality rate of 43.8%−58.0%. Although...

DOI: https://doi.org/10.3345/cep.2019.01326

Gastroenterology

Increasing incidence of inflammatory bowel disease in children and adolescents: significance of environmental factors

Sowon Park, Yunkoo Kang, Hong Koh, Seung Kim

Clin Exp Pediatr. 2020;63(9):337-344. Published online December 6, 2019

Web of Science 15 Crossref 18

Inflammatory bowel disease (IBD) is a chronic relapsing immune-mediated disease of the intestinal tract. Although its prevalence is reportedly lower in Asia than in Western countries, the rapid increase in the incidence of IBD has drawn attention to its etiology, including genetic susceptibility and environmental factors. Specifically, recent studies concerning dietary treatments and intestinal microbiota suggest that these factors may...

DOI: https://doi.org/10.3345/cep.2019.00500

Original Article

Immunology

Immunogenicity and safety of a 12-valent pneumococcal conjugate vaccine in infants aged 6–10 weeks: a randomized double-blind active-controlled trial

Jonghoon Shin, Jamaree Teeratakulpisarn, Thanyawee Puthanakit, Tuangtip Theerawit, Ji Hwa Ryu, Jinhwan Shin, Seulgi Lee, Hayoung Lee, Kyungjun An, Hun Kim

Clin Exp Pediatr. 2020;63(7):265-271. Published online December 6, 2019

Web of Science 3 Crossref 2

Question: The immunogenicity and safety of GBP411 when administered to healthy infants are not understood.
Finding: The intergroup differences were not significant for all 12 serotypes after the booster dose. The overall incidence of solicited local adverse events between the groups did not differ significantly.
Meaning: GBP411 with a 2p+1 dosing schedule induced a substantial immune response, and may be safe for administration to healthy infants.

DOI: https://doi.org/10.3345/cep.2019.01067

Endocrinology

Effect of agricultural pesticide on precocious puberty in urban children: an exploratory study

Junghwan Suh, Han Saem Choi, Ahreum Kwon, Hyun Wook Chae, Ho-Seong Kim

Clin Exp Pediatr. 2020;63(4):146-150. Published online December 6, 2019

Web of Science 6 Crossref 5

Question: Does agricultural pesticide effect precocious puberty in girls?
Finding: Dinotefuran, an insecticide of neonicotinoid class, was detected in one of 30 patients with precocious puberty, and in 2 girls of the normal control group, which was not statistically significant.
Meaning: There was no close relationship between agricultural pesticides and development of precocious puberty.

DOI: https://doi.org/10.3345/cep.2019.00416

Editorial

Nephrology (Genitourinary)

Is there a simple and less invasive way to accurately diagnose acute pyelonephritis?

Seong Heon Kim

Clin Exp Pediatr. 2019;62(12):442-443. Published online November 19, 2019

DOI: https://doi.org/10.3345/kjp.2019.01186

Original Article

Other

Korean parents’ perceptions of the challenges and needs on school re-entry during or after childhood and adolescent cancer: a multi-institutional survey by Korean Society of Pediatric Hematology and Oncology

Jun Ah Lee, Jae Min Lee, Hyeon Jin Park, Meerim Park, Byung Kiu Park, Hee Young Ju, Ji Yoon Kim, Sang Kyu Park, Young Ho Lee, Ye Jee Shim, Heung Sik Kim, Kyung Duk Park, Yeon-Jung Lim, Hee Won Chueh, Ji Kyoung Park, Soon Ki Kim, Hyoung Soo Choi, Hyo Seop Ahn, Jeong Ok Hah, Hyoung Jin Kang, Hee Young Shin, Mee Jeong Lee

Clin Exp Pediatr. 2020;63(4):141-145. Published online November 14, 2019

Web of Science 8 Crossref 9

Question: What are the parental needs and challenges when their children return to school after cancer?
Finding: In addition to scholastic aptitude-oriented programs, emotional and psychosocial support is necessary for a successful return to school.
Meaning: Pediatric oncologists should actively engage in improving oncology practices to better integrate individualized school plans and educate peers and teachers to improve health literacy to make them understand the needs of children with cancer.

DOI: https://doi.org/10.3345/kjp.2019.00696

Perspective

General Pediatrics

Integrative care for children with medical complexity

Jung Lee, Min Sun Kim, Hee Young Shin

Clin Exp Pediatr. 2020;63(2):32-33. Published online November 14, 2019

Web of Science 1 Crossref 1

DOI: https://doi.org/10.3345/kjp.2019.00717

Review Article

Neurology

Factors associated with seizure and cognitive outcomes after epilepsy surgery for low-grade epilepsy-associated neuroepithelial tumors in children

Ara Ko, Joon Soo Lee

Clin Exp Pediatr. 2020;63(5):171-177. Published online November 13, 2019

Web of Science 8 Crossref 9

Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are responsible for drug-resistant chronic focal epilepsy, and are the second-most common reason for epilepsy surgery in children. LEATs are extremely responsive to surgical treatment, and therefore epilepsy surgery should be considered as a treatment option for LEATs. However, the optimal time for surgery remains controversial, and surgeries are often delayed. In this review, we...

DOI: https://doi.org/10.3345/kjp.2019.01151

Allergy

Drug Allergy in Children: What Should We Know?

Ji Soo Park, Dong In Suh

Clin Exp Pediatr. 2020;63(6):203-210. Published online November 12, 2019

Web of Science 16 Crossref 15

The drug allergy “label” may have a lifetime of consequences for a child. Many children with alleged drug allergies are proven to be tolerant to the culprit medication when challenged. The field of drug hypersensitivity is a recently evolving field of research, but studies on its epidemiology and diagnostic tools are lacking in children. Clinical history is significant in the...

DOI: https://doi.org/10.3345/kjp.2019.00675

Original Article

Nutrition

Positive association of breastfeeding on respiratory syncytial virus infection in hospitalized infants: a multicenter retrospective study

Min Jeong Jang, Yong Joo Kim, Shinhye Hong, Jaeyoon Na, Jong Hee Hwang, Son Moon Shin, Young Min Ahn

Clin Exp Pediatr. 2020;63(4):135-140. Published online November 12, 2019

Web of Science 28 Crossref 28

Question: Human milk has stronger antiviral, antibacterial, and anti-inflammatory properties compared with formula milk. How dose breastfeeding affect respiratory syncytial virus infection in Korea?
Finding: Breastfed infants required less oxygen therapy and possible intensive care unit admission than artificial formulafed infants during respiratory syncytial virus infection.
Meaning: This protective role of breast milk on RSV severity can be a supporting evidence for promoting breastfeeding in Korea.

DOI: https://doi.org/10.3345/kjp.2019.00402

Perspective

Allergy

Food allergy and food-induced anaphylaxis in children: an increasing critical public health issue

Sooyoung Lee

Clin Exp Pediatr. 2019;62(12):431-432. Published online November 12, 2019

Crossref 3

DOI: https://doi.org/10.3345/kjp.2019.00493

Original Article

Cardiology

Importance of pulmonary valve morphology for pulmonary valve preservation in tetralogy of Fallot surgery: comparison of the echocardiographic parameters

Su Jin Choi, Jung Eun Kwon, Da Eun Roh, Myung Chul Hyun, Hanna Jung, Young Ok Lee, Joon Yong Cho, Yeo Hyang Kim

Clin Exp Pediatr. 2020;63(5):189-194. Published online November 8, 2019

Web of Science 8 Crossref 8

Question: Is echocardiographic examination is useful for surgical method decision in patients with tetralogy of Fallot (TOF)?
Finding: Various echocardiographic parameters serve as predictors for determining surgical methods for TOF patients. However, the PV morphology and tissue characteristics should also be considered.
Meaning: A full dependence on the size of the pulmonary valve annulus (PVA), the z score, and the ratio of the size of PVA to aortic valve annulus or descending aorta surgery may result in inadequate surgical results during TOF total correction.

DOI: https://doi.org/10.3345/kjp.2019.01060

Allergy

Asthma predictive index as a useful diagnostic tool in preschool children: a cross-sectional study in Korea

Dong Hyeon Lee, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Hyo-Bin Kim, So-Yeon Lee, Gwang-Cheon Jang, Dae-Jin Song, Woo Kyung Kim, Young-Ho Jung, Soo-Jong Hong, Jung Yeon Shim

Clin Exp Pediatr. 2020;63(3):104-109. Published online November 8, 2019

Web of Science 9 Crossref 8

Question: Is physician-diagnosed current asthma in preschool children associated with the asthma predictive index, atopic sensitization, or pulmonary function test?
Finding: Physician-diagnosed current asthma in preschool children was associated with the asthma predictive index, but not with spirometry, methacholine provocation test, fractional expiratory nitric oxide level, and atopic sensitization.
Meaning: Physician-diagnosed asthma in preschool children may be different from classic atopic asthma in school children or adolescents.

DOI: https://doi.org/10.3345/kjp.2019.00640

Clinical Note

Allergy

Complement 4 levels of a 4-year-old girl with angioedema

Soyoung Shin, Yoon Tae Lee, Kyung Yil Lee, Joonhong Park, Jae Ho Lee, Eun Ae Yang

Clin Exp Pediatr. 2020;63(1):30-31. Published online November 8, 2019

Web of Science 1

DOI: https://doi.org/10.3345/kjp.2019.00241

Systematic review and meta-analysis

Neurobehavior

Association between neonatal jaundice and autism spectrum disorders among children: a meta-analysis

Ensiyeh Jenabi, Saeid Bashirian, Salman Khazaei

Clin Exp Pediatr. 2020;63(1):8-13. Published online November 7, 2019

Web of Science 22 Crossref 25

Autism spectrum disorder is a common neurodevelopmental disorder with an unknown etiology. The correlation between neonatal jaundice and the risk of developing autism spectrum disorder was investigated previously. Some studies showed significant associations, whereas others demonstrated no association. In this meta-analysis, we pooled the results of observational studies to examine the association between neonatal jaundice and the risk of autism...

DOI: https://doi.org/10.3345/kjp.2019.00815

Review Article

Neurology

Genetic tests by next-generation sequencing in children with developmental delay and/or intellectual disability

Ji Yoon Han, In Goo Lee

Clin Exp Pediatr. 2020;63(6):195-202. Published online November 4, 2019

Crossref 32

Developments in next-generation sequencing (NGS) techogies have assisted in clarifying the diagnosis and treatment of developmental delay/intellectual disability (DD/ID) via molecular genetic testing. Advances in DNA sequencing technology have not only allowed the evolution of targeted panels but also, and more currently enabled genome-wide analyses to progress from research era to clinical practice. Broad acceptance of accuracy- guided targeted gene...

DOI: https://doi.org/10.3345/kjp.2019.00808

Pulmonology

High-flow nasal cannula oxygen therapy in children: a clinical review

Ji-Won Kwon

Clin Exp Pediatr. 2020;63(1):3-7. Published online October 28, 2019

Web of Science 51 Crossref 60

High-flow nasal cannula (HFNC) is a relatively safe and effective noninvasive ventilation method that was recently accepted as a treatment option for acute respiratory support before endotracheal intubation or invasive ventilation. The action mechanism of HFNC includes a decrease in nasopharyngeal resistance, washout of dead space, reduction in inflow of ambient air, and an increase in airway pressure. In preterm...

DOI: https://doi.org/10.3345/kjp.2019.00626

Original Article

Endocrinology

Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity

Bahar Özcabı, Salih Demirhan, Mesut Akyol, Hatice Öztürkmen Akay, Ayla Güven

Clin Exp Pediatr. 2019;62(12):450-455. Published online October 28, 2019

Crossref 15

Background: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults.
Purpose: Here we evaluated the ability of LAP to predict NAFLD in obese children. Methods: Eighty obese children (38 girls; age 6–18 years) were included. Anthropometric measurements and biochemical values were obtained from the patients’ medical records. LAP was calculated as [waist...

DOI: https://doi.org/10.3345/kjp.2019.00248

Neonatology (Perinatology)

Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia

Ga Won Jeon, R. Ann Sheldon, Donna M Ferriero

Clin Exp Pediatr. 2019;62(12):444-449. Published online October 18, 2019

Crossref 9

Background: Sixty percent of infants with severe neonatal hypoxic-ischemic encephalopathy die, while most survivors have permanent disabilities. Treatment for neonatal hypoxic-ischemic encephalopathy is limited to therapeutic hypothermia, but it does not offer complete protection. Here, we investigated whether hypoxia-inducible factor (HIF) promotes cell survival and suggested neuroprotective strategies.
Purpose: HIF-1α-deficient mice have increased brain injury after neonatal hypoxia-ischemia (HI), and the...

DOI: https://doi.org/10.3345/kjp.2019.00850

Review Article

Nephrology (Genitourinary)

Reconsideration of urine culture for the diagnosis of acute pyelonephritis in children: a new challenging method for diagnosing acute pyelonephritis

Jun Ho Lee, Seonkyeong Rhie

Clin Exp Pediatr. 2019;62(12):433-437. Published online October 18, 2019

Crossref 5

Acute pyelonephritis (APN) should be detected and treated as soon as possible to reduce the risk of the development of acquired renal scarring. However, in the medical field, urine culture results are not available or considered when the prompt discrimination of APN is necessary and empirical treatment is started. Furthermore, urine culture cannot discriminate APN among children with febrile urinary...

DOI: https://doi.org/10.3345/kjp.2019.00710

Editorial

Nephrology (Genitourinary)

Monitoring BK virus infection in pediatric kidney transplant recipients

Min Hyun Cho

Clin Exp Pediatr. 2019;62(11):414-415. Published online October 18, 2019

Crossref 2

DOI: https://doi.org/10.3345/kjp.2019.01123

Cited By 23	Neurodevelopmental outcomes of preterm infants
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