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Original Article
Effect of Oxygen Radicals on Cultured Cerebral Neurons of Neonatal Mouse
Yeon-kyun Oh, Seung-taek Park
Clin Exp Pediatr. 1997;40(6):786-793.   Published online June 15, 1997
Purpose : In order to elucidate the neurotoxic mechanism of oxygen radicals which are pathological factor of ischemia, we evaluated the oxidant-induced neurotoxicity and the neuroprotective effect of antioxidant on cultured cerebral neurons derived from neonatal mouse. Methods : Neurotoxic effect was investigated after cultured mouse neuronal cells were exposed to oxygen radicals which were generated enzymatically by reaction of xanthine oxidase(XO) and hypoxanthine(HX). And also...
Periventricular Leukomalacia: Electroencephalographic Features and Neurodevelopmental Outcome
Hee Jung Chung, Young Rae Kim, Mun Chul Kim
Clin Exp Pediatr. 1996;39(4):530-542.   Published online April 15, 1996
Purpose : Periventricular leukomalacia(PVL) is associated with the characteristic neurologic sequale of spastic diplegia or quadriplegia, and cortical blindness. So early diagnosis of PVL in the neonatal period is of importance because of the prognostic implications of this lesion. Novotny et al reported that Positive Rolandic Sharp waves(PRS) on the EEGs was a marker of PVL because most infants who...
Case Report
A Case of Cerebral Infarction Associated with Mycoplasma pneumoniae Infection
Young Jae Koh, Dong Jun Kim, In Joon Seol, Ha Baik Lee, Ki Woong Hong
Clin Exp Pediatr. 1996;39(1):115-119.   Published online January 15, 1996
Mycoplasma pneumoniae has been shown to be of etiologic importance in cases of upper-and lower-respiratory tract infections, especially in children and young adults. It may cause a variety of extrapulmonary manifestations in multiple organ systems, most commonly the central nervous system. The extrapulmonary syndromes include meningitis, cerebral infarction, acute transverse myelitis, psychosis, cerebellar ataxia, Guillain-Barré syndrome and Reye syndrome. Cerebral...
Original Article
Changes of Cerebral Blood Flow Velocity before and after Closure of Ductus Arteriosus using Doppler Ultrasound in Normal Full-term Newborns
Myung Su Lee, Young Mi Hong, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(12):1620-1628.   Published online December 15, 1995
Purpose : With PDA, major fluctuations of blood flow are noted between opening and closure of ductus arteriosus and there is an increase in the amplitude of each pulse of blood flow. The purpose of this study was to evaluate the changes of cerebral blood flow before and after closure of ductus arteriosus in healthy term newborns. Methods : Forty-two normal term...
Neonatal Neurosonographic Findings, Cerebral Doppler and Electrophysiological Findings in Infants with Motor Idsturbance
Jae Kwang Kim, Kook In Park, Chang Il Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Kwan Han
Clin Exp Pediatr. 1995;38(4):445-460.   Published online April 15, 1995
Purpose : Neurosonography, cerebral doppler and electrophysiological study are valuable in predicting neurodevelopmental outcome. The purpose of this study was to analyze characteristics of neonatal neurosonographic findigs, cerebral doppler and electrophysiological findings in infants withmotor disturbance. Methods : The subjects were 33 infants hospitalized at Yonsei Severance Medical Center NICU from January, 1990 to December, 1992. 19 of these patients underwent...
Case Report
A Case of Cerebral Infarcion due to Thrombosis Associated with Focal Segmental Glomerulosclerosis and Steroid Resistant Nephrotic Syndrome
Dae Woo Kim, Heon Lang Park, Sang Man Shin, Eun Mi Kim
Clin Exp Pediatr. 1994;37(9):1317-1324.   Published online September 15, 1994
Focal segmental glomerulosclerosis is the renal histopathologic lesion observed in 10% of children with idopathic nephrotic syndrome. Complications include infection, thrombosis, hypocalcemia and adverse effect of steroid use. The incidnce of thrombosis reported ranges from 10~40%. The pathogenesis are changes in coagulation system, decrease of Antithrombin III, increase platelet aggregability and steroid or diuretics use. These changes take place passively...
Original Article
Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with Perinatal Asphyxia and Hypoxic-Ischemic Encephalopathy with Doppler Technique
Kook In Park, Dong Kwan Han, Joon Soo Lee, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(9):1196-1204.   Published online September 15, 1994
Fifty-three full-term, preterm, term-SGA newborn infants with perinatal asphyxia and 16 full-term infants with hypoxic-ischemic encephalopathy were studied with color Doppler songraphy to assess the postnatal change of the cerebral blood flow velocity(CBFV) longitudinally. A control group of 81 healthy infants also had CBFV recordings during the 1st week of life. Pourcelot Resistance index(PI) and area under the velocity curve(AUVC)...
Changes in Somatostatin Immunoreactive Neurons in Rat Corebral Cortes after Systemic Kainic acid Administration
Myung Yeun Lee, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1993;36(9):1279-1290.   Published online September 15, 1993
This study was aimed to clarify the effects of systemic kainic acid(KA) administration(10mg/kg i.p.) on somatostatin containing neurons, and to examine the distribution of somatostain immunoreactive neurons in the cerebral cortex of the rats. Animals were sacrificed at three time points at the two, six, and ten days after the injection of KA. Thirty-six rats were observed by using the free-floating immunohistochemical...
Case Report
Two Case of Dyke-Davidoff-Masson Syndrome
Dong Gun Park, Ji Hee Park, Kee Hwan Yoo, Ji Tae Choung, Chang Sung Son, Young Chang Tockgo
Clin Exp Pediatr. 1993;36(6):865-869.   Published online June 15, 1993
Dyke-Davidoff Masson syndrome is a rare disorder which developed hemiatrophy of brain, enlargement of ventricles and prominet pneumatrization of pertous pyramid of the temporal bone. It manifests hemiparesis, varying type seizure, and mental retardation. We experienced two cases of Dyke-Davidoff-Masson Syndrome, in a 6/12 year-old boy and a 1,10/12 year-old girl who were admitted to our department of pediatrics, because of...
Recurrent Rhinocerebral Mucormycosis - A Case Report
Ho Sung Kim, Jin Young Park, Bo Young Yun, Eun Sil Dong, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn, Je Geun Chi, Myung Whun Sung
Clin Exp Pediatr. 1993;36(4):589-595.   Published online April 15, 1993
A case of recurrent rhinocerebral mucormycosis that has occurred during an induction chemotherapy for acute megakaryocytic leukemia in a 10 year-old boy is reported. He had suffered from high fever, proptosis, right eye ball pain and necrotic inflammation of hard palate during the chemotherapy of leukemia. CT scan of the paranasal sinus showed inflammatory change of right ethmoid and maxillary...
Rhinocerebral Mucormycosis : A case Report
Kyuchul Choeh, Hae Jin Choeh, Jung Hae Park, Chong Sung Chung, Won Sil Huh, Hyun Sook Chi
Clin Exp Pediatr. 1992;35(9):1267-1271.   Published online September 15, 1992
We experienced a case of rhinocerebral form of mucormycosis in a 9-year-old male suffered from acute lymphocytic leukemia(FAB L2). On 15th day of induction chemotherapy(Hospital day 23) pain, tenderness and swelling on left maxillary sinus. He expired on Hospital day 47.
Original Article
Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with the Doppler Technique
Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee, Jin Suk Suh, Myung Joon Kim
Clin Exp Pediatr. 1992;35(1):60-68.   Published online January 15, 1992
Eighty-one asymptomatic preterm, term-SGA, and full term infants who were delivered at Yonsei University Severance Hospital from January to July 1990 were studied with color duplex imaging doppler sonography to assess the postnatal changes of the cerebral blood flow velocity longitudinally. Pulsatility index (PI) and area under the velocity curve (AUVC) were calculated to quantitate changes in anterior cerbral artery blood...
Changein Regional Cerebral Blood Flow Velocity in Premature Infant.
Young Kyoo Shin, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1990;33(10):1333-1340.   Published online October 31, 1990
In order to estimate the influence of systemic hemodynamic change in cerebral blood flow before and after closure of ductus arteriosus in premature mewborn infants, blood flow velocities of internal carotid artery (ICA), anterior cerebral artery (ACA) and middle cerebral artery (MCA) were measured in 17 premature newborn infants by pulsed Doppler ultrasonography. The data was compared with those of normal full-term infants by...
Two Cases of Cerebral Gigantism (Sotos Syndrome).
Hee Jeung Ahn, Young Tae Kim, In Hoon Seol, Jeh Hoon Shin
Clin Exp Pediatr. 1990;33(8):1155-1158.   Published online August 31, 1990
Cerebral gigantism, the condition described by Sotos et al in 1964, consists of excessively rapid growth rating from infancy followed by a normal growth rate, acromegalic features, and a non- progressive neurological disorder manifested by clumsiness. The etiology of cerebral gigantism is not clear. Increased growth hormone levels have not been documented and somatomedin activity was found to be within normal range as yet...
Case Report
A Case of Cerebral Paragonimiasis.
Jin Young Lee, Byung Chun Suh, In Joon Seol, Heung Jae Lee, Keun Soo Lee
Clin Exp Pediatr. 1985;28(10):1037-1041.   Published online October 31, 1985
The authors experienced a case of cerebral paragonimiasis with severe eosinophilia in a 13 year old female patient. Since several years ago, she frequently drank spring water with her family, especially, with her father. She came to the hospital because of speech disturbance, weakness of right upper extremity and maculopapular skin rashes of lower half of body. In her family history,...
A Case of Congenital Ateriovenous Malformation.
Sook Kyeung Jung, Dong Hwan Cho, Jeong Bok Lee, Won Jae Park, Kyeung Soo Park
Clin Exp Pediatr. 1983;26(10):1029-1032.   Published online October 31, 1983
We experienced a case of Congenital Cerebral arteriovenous malformation which produced hematomas in a 9 years old girl. We confirmed the AVM and hematomas in the right frontal area, feeding from the right frontopollar artery, a branch of the right anterior carotid artery, and draining to superior sagittal sinus by carotid angiography & brain C-T. She was treated with, total surgical excision of AVM and...
A Case of Cerebral Paragonimiasis with Focal Epilepsy.
Sang Kee Park, Kwang Rhun Koo, Shin Chung Jee, Song Soo Moon, Chang Soo Ra
Clin Exp Pediatr. 1983;26(2):198-202.   Published online February 28, 1983
Cerebral pa ragonimiasis is widely distributed in the Far East, particularly in Korea, Japan, Formosa, and the Philippines. It is characterized by seizure, headache, visual disturbance, mental deterioration, and motor and sensory disorders. We experienced a case of cerebral paragonimiasis in a 13 year-old female patient who was admitted because of Jacksonian-type epileptic fits and headache for 15 days and was diagnosed by P.W. skin...
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