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Original Article
Intralipid Infusions Effect on Nutrophil Elastase Level in Newborns
Sue Jeen Min, Yong Woon Baek, Yong Woon Baek, Yong Woon Baek
Clin Exp Pediatr. 1999;42(5):666-671.   Published online May 15, 1999
Purpose : Parenteral nutrition is given to infants who tempararily cannot take oral feeding adequately. A lipid emulsion is added to the parenteral to supply essential fatty acids. In neonatal sepsis, elastase from azuropilic granules of the neutrophils is released and rapidly bound to α1- Proteinase Inhibitor(α1-PI). The lipid emulsion has been noted to markedly inhibit chemotaxis of neutrophils, so...
Retrospective 3-year Clinical Study of Enterobacter Bacteremia in Neonatal Intensive Care Unit
Kwang Ok Chung, Chun Hyuk Chang, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 1998;41(4):466-471.   Published online April 15, 1998
Purpose : Enterobacter is one of the important organisms in neonatal intensive care unit. We reviewed the clinical characteristics, underlying diseases, invasive procedures during admission, mortality and antibiotic sensitivity of Enterobacter infection in NICU. Methods : We retrospectively reviewed 21 neonatal patients whose blood cultures yielded Enterobacter between June 1994 and June 1997 at Dongguk University Hospital. Results : Blood cultures were positive in 62...
Serum G-CSF Level Changes in Neonatal Sepsis
Kyung Ha Ryu, Eun Ae Park, Kyung Hyo Kim, Gyung Hee Kim
Clin Exp Pediatr. 1998;41(1):12-18.   Published online January 15, 1998
Purpose : The neonate is susceptible to severe and overwhelming bacterial infections. One of the most important deficiency in the neonatal host defense system seems to be quantitative and qualitative deficiency of the myeloid and the phagocytic system. Granulocyte colony-stimulating factor(G-CSF) has been shown to induce neutrophilia and enhance mature effector neutrophil function. We examined serum levels of G-CSF in...
The Significance of Increased Circulating Intercellular Adhesion Molecule 1(cICAM-1) in Neonatal Sepsis
Hai Lee Chung, Eun Jung Park, Young Ho An, Jin Bok Hwang, Chang Ho Han, Young Dae Kwon, Sang Gyoung Kim
Clin Exp Pediatr. 1997;40(12):1651-1659.   Published online December 15, 1997
Purpose : The early and efficient diagnosis of neonatal sepsis still remains a difficult task. Reliable laboratory test is not available yet and treatment is mainly based on the physical appearance of infants. And high number of negative blood cultures in cases of clinically diagnosed sepsis further emphasize the need for a more reliable index for early diagnosis. Intercellular adhesion molecule 1(ICAM-1) has been...
Genital Mycoplasmasin the Newborn Infants: Colonization, Prevalence and Clinical Significance
Yun Sil Chang, Sung Gwon Kim, Beyong Il Kim, Won Soon Park, Bo Hyun Yoon, Eui Chong Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1996;39(8):1084-1094.   Published online August 15, 1996
Purpose : The genital mycoplasmas: Ureaplasma urealyticum and Mycoplasma hominis have recently assumed an increasing importance as neonatal pathogens especially in preterm infants. The aim of the present study was to determine the prevalence of infections with these organisms in newborn infants who were admitted in Neonatal Intensive Care Unit(NICU) and who were suspected having infection in newborn nursery Methods : Sixty four inborns who...
Clinical Study of Hickman Catheters in Pediatric Oncologic Patient
Young-Ho Lee
Clin Exp Pediatr. 1996;39(5):682-690.   Published online May 15, 1996
Purpose : We performed a retrospective study to evaluate the complications from Hickman catheters in pediatric oncologic patients. Methods : Between October 1992 and July 1995, 27 Hickman catheters placed in 25 patients who were chemotherapy candidates were evaluated. The frequency and etiologic organisms of catheter infections, mechanical complications, and any problems that might have been related to catheter use were determined. Results : 1) The...
Case Report
A Case of Newborn Sepsis Caused by Streptococcus pneumoniae
Eun Ha Choi, Seong Hee Jang, Eun Sil Dong, Young Min Ann
Clin Exp Pediatr. 1995;38(12):1690-1693.   Published online December 15, 1995
Systemic infection due to Streptococcus pneumoniae is a serious, albeit rare disease in the neonatal period. There is no case of pneumococcal sepsis reported in Korea. The results of epidemiologic studies suggest that the majority of infants with pneumococcal septicemia acquire the microorganisms either by the ascending route or during passage throught the birth canal. The mortality is high in...
Original Article
Changes of Serum Tumor Necrosis Factor-α and Interleukin-1β in the Sepsis of Neonates
Mi Yeon Lee, Yeon Kyun Oh, Ji Hyun Cho
Clin Exp Pediatr. 1995;38(10):1307-1314.   Published online October 15, 1995
Purpose : Cytokines have recently been identified as important endogenous mediators of the host immune response to bacterial infection. But little is clarify about serum levels of cytokines in neonatal sepsis. The aim of this study was to know the changes of the level of cytokines during neonatal sepsis, to compare the level of cytokines in gram negative and gram...
Clinical Observation of Neonatal Sepsis according to Onset of Disease
Young Chul Han, Soon Kyung Baik, Chang Sung Lim, Dong Jin Lee
Clin Exp Pediatr. 1994;37(12):1676-1686.   Published online December 15, 1994
Comparison between Preterm and Fullterm infants in Neonatal Sepsis
Sung Hee Kim, Kum Hee Hur, Hee Sup Kim, Myoung Jae Chey, Kil Hyoun Kim, Hak Soo Lee
Clin Exp Pediatr. 1993;36(11):1542-1554.   Published online November 15, 1993
We retrospectively evaluated datas on 61 cases of neonatal sepsis confirmed by clinical symptoms and blood cultures at the NICU of Gil General Hospital From Mar. 1989, to Reb. 1992. The result obtained were as follows : 1) The mean gestational age was 32.7±2.6 weeks in preterm infants, and 39±1.5weeks on term infants. The mean birth weight was 1,701.4±422.4g in preterm infants,...
Intravenous Immunoglobulin for Prophylaxis of Neoneatal Sepsis in the Premature Infants
K.H. Hur, S.H. Kim, H.S. Kim, M.J. Chey, K.H. Kim, H.S. Lee
Clin Exp Pediatr. 1993;36(11):1534-1541.   Published online November 15, 1993
Newborn premature babies have low levels of transplacentally acquired maternal immunoglobulin which is mostly transferred after 32∼34weeks gestation, therefore they may have IgG deficiencies that incerase their susceptibillity to bacterial infection. We preformed this study to determine whether intravenous immunoglobulin (IVIG) therapy improves mortality or infection occurrence rate. From 1 october 1991 to 31 july 1992, 73premature newborn iffants with gestational age≤34weeks...
A Clinical Study of Neonatal Sepsis
Hyoung Shim Chang, Jung Sook Park, Young Ho Lee, Ahn Hong Choi
Clin Exp Pediatr. 1993;36(6):771-777.   Published online June 15, 1993
The 35 newborns with neonatal sepsis admitted to the Neonatal Intensive Care Unit of Dong-A Univesity Hospital during 2 years and 6months from April 1990 to October 1992, and were reivewed on the bases of incidence, clinical manifestations, underlying conditions, etiologic organisms, results of antibiotics sensitivity test and mortality rate. The result were summarized as follows; 1) The incidence of neonatal sepsis...
Clinical Observation of Neonatal Sepsis
Jin A Son, Soon Wha Kim, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1993;36(5):671-679.   Published online May 15, 1993
Ninety two cases of culture proved neonatal sepsis who had been admitted to pediatric department, National medical Center, during 7 years from Jan, 1984 to Dec, 1990 were reviewed clinically and the following results were obtained. 1) The frepuency of neonatal sepsis was 3.1% and male to female sex ratio was 1.9:1, Sepsis was more prevalent in prenature infants (9.9%) than...
A Clinical Study on Early Diagnosis in Neonatal Sepsis
Jong Kwang Lee, Hae Won Cheon, Jee Hee Park, Jung Hwa Lee, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1993;36(1):49-56.   Published online January 15, 1993
Neonatal sepsis is a major contributing factor for increased mortality and morbidity in the newborn and its successful outcome depends on early detection and prompt institution of an effective antimicrobial therapy. Accurate diagnosis of the neonatal septicemia, however, is quite difficult because its early signs and symptoms are rather subtle. This study was conducted in an attempt to search for useful...
Case Report
Three Cases of Listeria Infection in the Immunocompromised Children
Mee Ran Kim, Bo Young Yun, Hye Young Kang, Sung Hee Jang, Hoan Jong Lee, Yong Seung Hwang, Eui Chong Kim
Clin Exp Pediatr. 1992;35(10):1419-1426.   Published online October 15, 1992
Infection by Listeria monocytogenes, an uncommon pathogen in immunocompromised host, has been reported in neonates, pregnant women and adults with defective cell mediated immunity but not in children in Korea. It can cause sepsis, meningitis, abortion, premature labor, intrauterine fetal infection. etc. We have experienced L. monocytogenes sepsis and/or meningitis in three children under immunosuppresive therapy for lymphoma-leukemia, cytophagic histiocytic...
Original Article
Inciedence of Sepsis Associated with Total Parenteral Nutrition Solutions Made in the Nursery and Pharmacy
Moon Chan Kim, Jin Won Park, Yun Joo Chung
Clin Exp Pediatr. 1992;35(5):646-651.   Published online May 15, 1992
From 1985 to 1987, when Total Parenteral Nutrition (TPN) solutions was made in the nursery without laminar flow hood and other usual aseptic techniques (method 1), there was sepsis in 27% out of 33. From 1988 to 1990, to prevent high incidence of sepsis, TPN was made in the pharmacy under laminar flow hood and by pharmacist who wore scrub...
Case Report
Four Case of Neonatal Group B Streptococcal Sepsis/Meningitis
Jae Geon Sim, Soon Wha Kim, Young Jin Hong, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1992;35(2):275-281.   Published online February 15, 1992
Authors have experienced four cases of neonatal sepsis and meningitis whose organisms were group B streptococci which are thought to be rare causative agent for neonatal sepsis in Korea. Two of four cases were early onset type. Three of them were recovered with antibiotic therapy. One of three alives was found to have mild neurologic sequelae when we examined him...
Original Article
Predictive factors and initial selection of antibiotics in neonatal sepsis.
Dong Chul Park, Chul Lee, Kook In Park, Ran Namgung, Dong Gwan Han
Clin Exp Pediatr. 1991;34(6):755-762.   Published online June 30, 1991
For simplifying and standardizing the interpretation of usual findings for neonatal sepsis, prenatal and perinatal factors, clinical symptoms and signs, method of management and hematologic findings were evaluated as a screening test. From the data obtained, a scoring system was formulated that assigns a score of 3 for diarrhea, 1. 5 for tachypnea, 1.5 for cyanosis, 1 for umbilical vessel catheterization, 1 for intravenous...
A clinical study on influences of premature rupture of membranes in the newborn infant.
Ji Sun Cho, Young Sun Ko, Soon Ok Byun, Ji Sub Oh
Clin Exp Pediatr. 1991;34(2):180-189.   Published online February 28, 1991
A clinical study was made on 607 newborns of mothers with premature rupture of membrane (PROM group) and 5,775 newborns of mothers without ruptured membrane Baptist Hospital from January 1987 to December 1989. The results are summarized as follows: 1) The overall incidence of PROM was 9.5% with little yearly variations. 2) 11.9% of all babies with PROM were bom prematurely, significantly higher than the incidence of control...
Clinical Obervation in 40 Cases with Neonatal Sepsis.
Jung Hee Lee, Jae Jin Park, In Kyung Sung, Byung Churl Lee
Clin Exp Pediatr. 1990;33(11):1489-1494.   Published online November 30, 1990
Sepsis is still one of major causes of mortality and morbidity in neonatal period and early diagnosis and appropriate treatment for neonatal sepsis is difficult due to its vague clinical manifestation and rapid progress. An analysis of 40 cases of neonatal sepsis confirmed by clinical manifestation and blood cultures from Jan. 1986 to Dec. 1989 at nursery of St. Mary’s Hospital of Catholic University...
A Study of Clinical Observations in Neonatal Sepsis.
E S Kim, K H Kim
Clin Exp Pediatr. 1990;33(9):1180-1187.   Published online September 30, 1990
We have experienced 67 cases of neonatal sepsis confirmed by clinical symptoms and blood culture between July 1983 and June 1988 at Ewha university hospital. The results obtained were as follows: 1) The incidence of septicemia was 0.6%. The sex ratio of patients was 0.97:1 with 33 males and 34 females. 2) The incidence was higher in preterm babies than in full term babies and higher in...
Sepsis Associated with Total Parenteral Nutrition in the Neonates.
Jae Won Huh, Jo Sam Koo, Yun Joo Cheung
Clin Exp Pediatr. 1989;32(4):495-499.   Published online April 30, 1989
The retrospective study was performed on the 33 neonates with TPN admitted to the nursery of Gospel Hospital of Kosin medical college between January 1985 and Jun 1987. 1) The incidence of sepsis during TPN was 27% and it was related only to the duration of TPN received for more than 7 days. 2) Major organisms were S. epidermids (30%), Enterobacter cloacae (20%). 3) Major...
Influences of Premature Rupture of Membranes on the Newborn Infant.
Kyoung Sim Kim, Young Ok Park, In Sung Lee, Ki Bok Kim
Clin Exp Pediatr. 1989;32(2):149-157.   Published online February 28, 1989
A comparative study on the frequencies of premature birth, neonatal sepsis, asphyxia, perinatal death and respiratory distress syndrome was carried out between 1309 newborns with premature rupture of membranes (PROM) and the normal group of 4636 newborns without PROM among all 5945 babies delivered at Kwangju Christian Hospital for the 2-year period starting from March 1985. The results are sumrnarized as follows: 1) The overall...
7 Cases of Group B Streptococcal Meningitis and Sepsis.
Young Wan Kim, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1988;31(7):873-880.   Published online July 31, 1988
We report 7 cases of Group B streptococcal meningitis and sepsis. Six of the patients were admitted to the Department of Pediatrics, Severance Hospital and Youngdong Severance Hospital in 1986 and one was admitted in 1979. The age of onset ranged from 10 to 34 days of age and all were cases of late onset. The Clinical findings were fever, seizure, poor feeding,...
Analysis for Causative Agents in Neonatal Sepsis.
Jung Sook Hong, Ki Ji Lee, Shul Hoe Koo, Yun Joo Cheung
Clin Exp Pediatr. 1988;31(1):22-28.   Published online January 31, 1988
To determine causative organisms and their antibitotics sensitivities in neonatal sepsis, we made a review on the 26 cases of neonatal sepsis. Patients were admitted to the special care nursery of Gospel hospital of Kosin Medical College during the period of 2 years from January 1985 to December 1986 and the results were: 1) The most frequently growing organism was Staphylococcus epidermidis (34.6%) and drugs...
Clinical Observations on Neonatal Sepsis.
Beyong Il Kim, Hae Lim Chung, Yoon Deok Kim, Weon Soon Park, Son Moon Shin, Hoan Jong Lee, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1987;30(2):130-138.   Published online February 28, 1987
We studied the 73 cases of proven neonatal sepsis among 11,102 newborn infant under 1 month of age, admitted to the pediatric ward, the nursery and the NICU of Seoul National University Hospital from Jan. 1, 1980, to Dec. 31, 1985. The results were as follows: 1) The incidence was 6.6/1000 live births. Incidence of male babies was 8.3/1000 live births. The morbidity rate of...
Clinical observation in 72 Cases with Neonatal Sepsis.
Jae Seung Yang, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1986;29(12):1309-1313.   Published online December 31, 1986
Since the clinical features of neonatal sepsis were first reported by Dunham in 1933, there have been many studies. But because of the uncertain early symptoms and it’s rapid progression, the mortality rate of neonatal sepsis runs still high. We are reporting 72 cases of neonatal sepsis confirmed by clinical symptoms and blood culture studies over 3 years and 5 months between...
Associated Ventilation with Mechanical Aids in Newborn Infants.
Eue Cho Yang, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1985;28(5):435-447.   Published online May 31, 1985
Clinical features of 85 neonates who treated with assisted ventilation in Neonatal Intensive Care Unit at Seoul National University Hospital from April ’80 to Dec. 5 84 were analyzed with special respect to mechanical aids. The results were as follows; 1)According to diagnostic categories, 56 cases (66%) were hyaline membrane disease (HMD), 14 cases (16%) were postasphyxia syndrome (PAS), 9 cases...
Premature Rupture of Membranes and Its Effect on Neonatal Sepsis.
Weon Soon Park, Chong Ku Yun
Clin Exp Pediatr. 1984;27(12):1162-1167.   Published online December 31, 1984
A clinical study was carried out to evaluate the effect of PROM on neonatal sepsis on 626 newborns with PROM, who had been born at SNUH during the two-year period from January 1982 to December 1983. The results were as follows; 1) The incidence of PROM was 16.5% and the frequency of prematurity and neonatal sepsis was increased in newborns with PROM. 2) The...
A Clinical Study on Morbidity and Mortality in Newborns of Mothers wieh Premature Rupture of Membrane.
Myung Shik Lee, Dong Gwan Han
Clin Exp Pediatr. 1984;27(11):1045-1054.   Published online November 30, 1984
A clinical study was made on 997 newborns of mothers with premature rupture of membrane (study group) and 5,552 newborns of mothers without ruptured membrane (control group) at YUMC from January 1981 to December 1983. The following results were obtained: 1) The incidence of the study group was 15.2% and morbidity incidences were 5.4% due to sepsis, 9.5% due to asphyxia and...