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Original Article
A comparison between remission and nonremission groups of hepatitis B virus-associated membranous nephropathy in children.
Kang Yong Park, Hye Won Park, Yon Ho Choe, Tae Sun Ha, Il Soo Ha, Yong Choi, Kwang Wook Ko, Hyun Soon Lee, Yong Il Kim
Clin Exp Pediatr. 1991;34(11):1512-1518.   Published online November 30, 1991
We analyzed medical records of 35 patients with Hepatitis B virus-associated Membranous Nephropathy proven by kidney biopsy at SNUCH from Jan. 1975 to Jun. 1990. Clinical presentation, laboratory and pathologic findings were compared between remission group (who are free of proteinuria and edema in current status) and nonremission group (who have either proteinuria or edema). Age at onset was younger in remission group (4.51 ±2.93...
Prevalence of hepatitis B surface antigen in pediatric in patients.
Kyung Hee Kim, Myung Ik Lee, Young Jin Hong, Keun Chan Sohn
Clin Exp Pediatr. 1991;34(3):355-362.   Published online March 31, 1991
Thirty three from 689 children (4.79%) who were screened among hospitalized patients from July, 1986 to June, 1988, were positive for hepatitis B surface antigen in their serum sample tested by radioimmunoassay. The positive rate of hepatitis B surface antigen was 3.04% when the hepatitis patients were excluded. The incidence of hepatitis B surface antigen was higher (5.18%) in male than in famale (4.17%)...
Transplacental transmission of hepatitis B virus from carrier nothers to neonates.
Soh Yeon Kim, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1991;34(2):190-196.   Published online February 28, 1991
Neonates bom to hepatitis B carrier mothers at Yongdong Severance Hospital, Yonsei University College of Medicine were sampled for hepatitis B viral markers using venous blood drawn from external jugular vein within 3 hours after birth and the following results were obtained. Two thousand nine hundred and seventy two pregnant women who received prenatal care at Yongdong Severance Hospital, Yonsei University College of Medicine...
A Case of Autoimmune Hemolytic Anemia Associated with Chronic Hepatitis in Children.
Kwan Mo Choi, Kyeong Hun Cha, Eun Yeong Kwak, Kyung Rae Moon, Yeong Bong Park
Clin Exp Pediatr. 1990;33(9):1288-1293.   Published online September 30, 1990
Recently, We experienced a case of autoimmune hemolytic anemia in a 13 year old female patient associated with chronic hepatitis. This female child manifested severe pallor, jaundice, abdominal pain and fever. This diagnosis was made on the bases of typical clinical features, C.B.C., blood chemistry, coombs test, warm antibody, immunoelectrophoresis, peripheral blood smear and bone marrow examination. The patient improved with steroid therapy. We report this...
Clinical Study of Fulminant Hepatitis in Childhood.
Se Wook Oh, Chan Yung Kim
Clin Exp Pediatr. 1990;33(7):923-931.   Published online July 31, 1990
Twenty one cases of childhood fulminant hepatitis admitted to Pediatric department of Pusan National University Hospital form Jan. 1979 to Sep. 1989 were analysed. The results were as follows; 1) Age distribution was from 8 months to 13 yerars old and 66.7% of the patients were 2 to 9 year old of age. In sex ratio, male to female was 1,6:1. 2) Presumable etiologic factors were HBV...
The Effect of Low-Dosage Alpha-Interferon Therapy in Children with Chronic Active Hepatitis B.
Hee Kyung Kim, Sung Min Choi, Cheol Woo Ko, Kun Soo Lee, Ja Hoon Koo, Doo Hong Ahn
Clin Exp Pediatr. 1990;33(7):915-922.   Published online July 31, 1990
A clinical trial was conducted to determine the effect of low-dosage recombinant a-interferon therapy in children with HBs Ag and HBe Ag positive chronic active hepatitis. Studied patients consist of 7 biopsy-proven children (aged 6.5-11.5 yr). After 16 weeks of therapy, following results were obtained. Out of 7 HBe Ag positive cases, 5 cases (71.4%) were converted to HBe Ag negative state. One of two...
A Case of Aplastic Anemia Following hepatitis.
Gae Soon Yeo, Doo Kweon Kim, Chul Ho Kim, Soon Yong Lee
Clin Exp Pediatr. 1990;33(6):864-869.   Published online June 30, 1990
We experienced a case of aplastic anemia following hepatitis in a 4-year-old girl. Pancytopenia was developed during the convalescent period of hepatitis, and it was getting worse, while serial data of liver function test showed improvement. We tried a methylprednisolone pulse therapy, and about 7 months after treatment the CBC findings returned completely normal. She has enjoyed her healthy life during follow-up of over 2...
The Change of Anti-HBs Titer after Hepatitis B Vaccination in Newborn.
Ji Hye Kang, Young Mi Hong, Seung Joo Lee
Clin Exp Pediatr. 1990;33(5):598-605.   Published online May 31, 1990
Hepatitis B vaccination is an accepted preventive measure for all newborn as well as the risk group. However, there is some uncertainty about the persistence of anti-HBs and the timing of booster vaccination. We studied anti-HBs titer, positive rate and minimum protective rate in relation to time interval after the third vaccination in 102 infants bom to HBsAg negative mother (Group I) and 52...
A Study on Periphral T Cell Subsets in Asymptomatic HBsAg Carriers and Children with Chronic Hepatitis B and Hepatitis B vaccine Inoculated Infants.
Hee Joo Jeon, Chan Yung Kim
Clin Exp Pediatr. 1989;32(9):1248-1258.   Published online September 30, 1989
To elucidate the characteristics of immunoregulatory system of children with chronic active hepatitis B and hepatitis B vaccine inoculated infant, the authors examined T cell subsets of the peripheral blood in 16 children with asymptomatic HBsAg carriers, 19 children with chronic hepatitis B (11 chronic persistent hepatitis (CPH) and 8 chronic active hepatitis (CAH) and 21 hepatitis B vaccine inoculated infants as well as...
A Case of Wilson Disease.
Cheol Soo Dan, Sang Hoon Lee, Woo Yeong Chung, Soon Yong Lee, Jong Eun Joo, Hye Jae Cho
Clin Exp Pediatr. 1988;31(11):1502-1508.   Published online November 30, 1988
We have experienced a case of Wilson disease manifesting chronic hepatitis. The patient, 10-year-old boy, has shown elevated SGOT and SGPT levels since 5 years ago, but no other specific symptoms of Wilson disease. His younger sister died of fulminant hepatitis (absence of hepatitis A or B markers) at the age of eight. The diagnosis was based on the characteristic laboratory data and the...
Hepatitis with Positive HBsAg in 3 Generations in 3 Families.
Dong Hak Shin
Clin Exp Pediatr. 1987;30(11):1265-1273.   Published online November 30, 1987
Since Jolly reported multiple occurences of cryptogenic cirrhosis in children in a family members in 1892, there had been sporadic cases reported and this familial liver cirrhosis was called as familial juvenile cirrhosis by Gunn. In 1960, numer of family pedigree of chronic liver diseases (such as chronic hepatitis, liver cirrhosis and liver cell carcinoma) in adult was more numerous than that of in...
The Effect of Hepatitis B Vaccination on Newborns of Hepatitis B Carrier Mothers.
Ho Taek Kom, Pyung Kil Kim, Chang Ho Hong, Chul Lee
Clin Exp Pediatr. 1987;30(11):1228-1235.   Published online November 30, 1987
The transmission of hepatitis B virus (HBV) from carrier mothers to their infants is a serious problem in many countries and the transmission rate is reported to be as high as 60%. The best preventive method of perinatal transmission is hepatitis B immune globulin (HBIG) which confers a passive immunity and HB vaccine which confers an active immunity. However, the exact dosage and the...
Immunogenecity of Low-Dose Administration of Hepatitis B Virus Vaccine in School Aged Group.
Young Mo Sohn, Pyung Kin Kim, Kyung Soon Song
Clin Exp Pediatr. 1987;30(11):1221-1227.   Published online November 30, 1987
For evaluation of immunogenecity of low-dose of hepatitis vaccine-prepared by Korea Green Cross Corporation 74 school aged children were given routine schedule (0, 1, 6 months). A dose of 5 microgram was administered intramuscullary in the cases of age under 10 yrs of age and 10 microgram was administered in the cases over 11 yrs of age. An adequate follow-up observation of antibody titer...
Chronic Hepatitis B in Children.
Don Gyu Yang, Jong Kyun Lee, Pyung Kil Kim, Chang Ho Hong, Chul Lee
Clin Exp Pediatr. 1987;30(10):1115-1123.   Published online October 31, 1987
We reviewed 19 cases of chronic hepatitis B confirmed by liver biopsy during the 3 years and 5months from March 1983 to July 1986 at Young Dong Severance Hospital. The following results were obtained: 1) There were 16 boys and 3 girls with ages ranging from 7 months to 14 years old (mean+S.D.; 6.5 ±0.9 years). 2) There were 2 cases (10.5%) of chronic persistent...
A Clinical Observation on Fulminant Hepatitis in Children.
Hoan Jong Lee, Jeong Kee Seo, Hyung Ro Moon
Clin Exp Pediatr. 1987;30(4):406-415.   Published online April 30, 1987
Twenty-seven cases of fulminant hepatitis in children were retrospectively analyzed. The overall survival rate was 11%. The interval between onset of encephalopathy and death, and that between jaundice and death were 2-26 days (median 4 days), 4-61 days (median 14 days), respectively. HBs antigenemia was detected in 24%, HAV IgM was negative in 5 patients tested, and 4 cases were suspected as non-A, non-B...
A Clinical and Pathologic Study on Chronic Hepatitis in Infancy and Childhood.
Ki Sub Jung, Chan Ill Park
Clin Exp Pediatr. 1987;30(1):35-44.   Published online January 31, 1987
A clinical and pathologic study was undertaken on 46 cases of chronic hepatitis who had been admitted to Department of Pediatrics, Yonsei University College of Medicine during the period of 6 years from August, 1979 to July, 1985. The results were as follows: 1) Of 46 patients with chronic hepatitis, 40 cases were caused by hepatitis B virus, 3 cases by autoimmunity, and in 3 cases...
The relationship between Dose of Hepatitis B Vaccine and Seroconversion Rate in Infants.
Jung Hye Choi, Ki Sup Chung, Dong Gwan Han
Clin Exp Pediatr. 1986;29(10):1080-1086.   Published online October 31, 1986
After the discovery of Australia antigen by Blumberg et al in 1965, subsequent studies revealed that Australia antigen is identical with surface antigen of hepatitis B virus. The infants born to HBsAg positive mother can be protected from perinatal hepatitis B virus infection with hepatitis B vaccine and hepatitis B immunoglobulin. If the dose of vaccine can be reduced from...
Evaluation of Antibody Formation After Hepatitis B Vaccination in Children.
Pyung Kil Kim, Ho Taek Kim, Kyu Earn Kim, Kyung Soon Song
Clin Exp Pediatr. 1986;29(10):1072-1079.   Published online October 31, 1986
Hepatitis B virus infection is a serious problem in many countries, especially Africa, Southeast Asia and Korea. As we know, vaccination against hepatitis B virus is the most effective method to prevent hepatitis B and the rate of anti-HBs formation after hepatitis B vaccination is known to be 91 〜99%. We studied the titer of anti-HBs after 3 times of...
Studies on Type A and Type B Acute Hepatitis in Children.
Moo Young Oh, Soon Ho Kim
Clin Exp Pediatr. 1986;29(7):740-747.   Published online July 31, 1986
The author investigated incidence, age and sex distribution and some liver function tests in 128 cases of type A acute hepatitis and in 62 cases of type B acute hepatitis of children who were admitted to the pediatric ward of Busan In Je Medical college Hospital from January, 1982 to August, 1984. Diagnosis was established clinically and serologically in all patients....
Epidemiologic Study on Hepatitis B Virus Infection in Childhood.
Byoung Tae Kim
Clin Exp Pediatr. 1986;29(6):613-625.   Published online June 30, 1986
We conducted HBsAg, HBsAb and HBcAb determinations by the method of radioimmunoassay on 329 healthy children who visited for the purpose of immunization with HB vaccine, or had been admitted because of miscellaneous diseases except for liver disease from July 1984 to December 1984. The following results were obtained; 1) Among the 329 children, 16(4.9%) were positive for HBsAg. There was...
Clinical Observation of Acute Viral Hepatitis in Childhood.
Byung Hak Lim, Ki Ho Jang, Sang Geel Lee, Im Ju Kang
Clin Exp Pediatr. 1985;28(11):1057-1065.   Published online November 30, 1985
A clinical observation has been made on 127 cases who were admitted to the department of pediatrics, Fatima Hospital, Taegu, from January 1983 to June 1984 and following results was obtained. 1)Ratio of male to female cases was 3 : 1. 2)On admission, anorexia, nausea, fever and jaundice were significantly more common in HBsAg negative group but skin rash was more...
A Study on Serum Lipids and Lipoproteins in Acute Viral Hepatitis in Children.
Kyu Hyoung Han, Chang Soo Ra
Clin Exp Pediatr. 1985;28(7):642-652.   Published online July 31, 1985
Most of the lipids in serum are transported in the from of lipoproteins. A major portion of these lipoproteins is formed in the liver. The determination of serum lipoprotein patterns is a better index of liver abnormalities than determination of lipids alone. The authors determined serum lipid concentration and the patterns of serum lipoproteins in 40 cases of acute viral...
Intrafamilial Spread of Hepatitis B virus Ifection.
Kew Keun Hwang
Clin Exp Pediatr. 1985;28(3):242-250.   Published online March 31, 1985
The authors evaluated serologic markers of Hepatitis B on 205 cases in families of HB marker positive 67 patients who were admitted to pediatric ward of St. Benedict Hospital from April, 1983 to April, 1984, to determine the intrafamilial spread of hepatitis B virus infection. The results were as follows; 1)Intrafamilial positive rate of HB marker was 52.7%. HB marker...
Hepatitis B Serologic Markers at Birth in Babies of HBsAg-Positive Mothers.
Jeoung Wan Seo, Hye Seung Kim, Keun Lee
Clin Exp Pediatr. 1985;28(3):236-241.   Published online March 31, 1985
It has been established that hepatitis B virus may be transmitted from mothers to infants in the perinatal period. A study was undertaken to identify HBsAg in neonates born to mothers who were asymptomatic carriers of HBsAg. From Jan. 1 ’83 to June 30 ’84, total 4,044 cases of pregnant women and 131 babies were studied for serologic markers of hepatitis...
Case Report
Acute hepatitis in a 10 month old girl with Rubeola.
Youn Ha Kang, Young Min Ahn, Kyo Sun Kim
Clin Exp Pediatr. 1985;28(2):174-176.   Published online February 28, 1985
Hepatitis has rarely been recognized as a complication of acute measles infection. Recently, a 10 month old girl is reported in whom abnormal liver function was a prominent clinical feature during acute measles infection. Hepatitis may be a clinical manifestation of acute measles infection of infant.
Two cases of Aplastic Anemia Following Hepatitis.
Chang Yeol Jeon, Beyung Sang Choi, Hyeon Sook Lee, Jung Soo Kim
Clin Exp Pediatr. 1985;28(1):73-77.   Published online January 31, 1985
Recently, we experienced two cases of aplastic anemia following hepatitis in 6 and 12year old boys. A 6 year old boy was admitted to Jeonbug National University Hospital in Dec. ’82, because of frequent expistaxis and petechiae on entire body. He had a history of hepatitis 2 months ago. On admission liver function was normal and pancytopenia was revealed. Bone...
Original Article
A Clinical Study of Viral Hepatitis in Childhood.
Ju Kyeong Lee, Chan Yong Kim
Clin Exp Pediatr. 1984;27(11):1078-1087.   Published online November 30, 1984
A clinical study has been made on 158 children with viral hepatitis who had been admitted to the pediatric department of Busan Maryknoll Hospital during a 472 year period from January 1979 to June 1983. The following results were obtained. 1) Viral hepatitis was 1.61% of all the pediatric inpatients. Positive rate of HBsAg was 25.9% of viral hepatitis. 2) Age incidence showed even distribution after...
Case Report
Two Case of Aplastic Anemia Following Hepatitis.
Mi Sook Park, Seung Ha Rheu, Young Gun Kim, Baek Keaun Lim, Jong Soo Kim
Clin Exp Pediatr. 1984;27(8):808-813.   Published online August 31, 1984
Aplastic Anemia following Hepatitis is an uncommon disease and it has a poor prognosis. Recently the authors experienced two cases of aplastic anemia following hepatitis in a 13 year old girl and a 14 year old boy. The thirteen year old girl was admitted following 2 months of Jaundice and 1 day df epistaxis. . At admission, pancytopenia developed and her...
Original Article
A Clinical Study of Type A Hepatitis Confirmed by IgM Anti-HAV.
Oh Kyung Lee, Sung Seek Lee, Keun Chul Choi, Myung Ho Lee, Sook Ja Park
Clin Exp Pediatr. 1984;27(8):778-785.   Published online August 31, 1984
79 children with Type A Hepatitis who were admitted to the pediatric department of the Presbyterian Medical Center from April 1, 1983 to October 31, 1983 were clinically analized and we report the following result. 1) Type A Hepatitis occupied 8% of total in patients and 88% of total Hepatitis patients. 2)The peak age incidence was between 7 and 9 years...
Hepatobiliary Scintigraphy with 99mTc-DISIDA in the Evaluation of Neonatal Jaundice.
Kwang Soo Hwang, Sae Jin Lee, Kyung Sook Cho, Chong Dae Cho, Bok Hwan Park
Clin Exp Pediatr. 1984;27(7):664-672.   Published online July 31, 1984
Hepatobiliary scintigraphy with 99mTc-DISIDA was used to evaluate neonates with direct hyperbilirubinemia who were admitted to the department of Pediatrics, Maryknoll hospital, between May 1981 and Jun. 1983. 1)Total number of patients were 10, boys to girls ratio was 4:1, and age distribution ranging from 9 to 200 days of age. 2)Initial studies of the seven patients intrahepatic cholestasis showed definite...