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Original Article
The outcome of short-term low-dose aspirin treatment in Kawasaki disease based on inflammatory markers
Jae Won Yoo, Ji Mok Kim, Hong Ryang Kil
Clin Exp Pediatr. 2017;60(1):24-29.   Published online January 24, 2017

Previously, Kawasaki disease (KD) treatment with low-dose aspirin was administered for 6–8 weeks after the acute phase. However, inflammatory marker levels normalize before 6–8 weeks. In this study, we aimed to investigate the clinical outcome of short-term low-dose aspirin treatment based on inflammatory and thrombotic marker levels.


We performed a retrospective review of the medical records of patients with KD who...

Impact of postoperative duration of Aspirin use on longevity of bioprosthetic pulmonary valve in patients who underwent congenital heart disease repair
Tae-Woong Hwang, Sung-Ook Kim, Sang-Yun Lee, Seong-Ho Kim, Eun-Young Choi, So-Ick Jang, Su-Jin Park, Hye-Won Kwon, Hyo-Bin Lim, Chang-Ha Lee, Eun-Seok Choi
Clin Exp Pediatr. 2016;59(11):446-450.   Published online November 18, 2016

Generally, aspirin is used as a protective agent against thrombogenic phenomenon after pulmonary valve replacement (PVR) using a bioprosthetic valve. However, the appropriate duration of aspirin use is unclear. We analyzed the impact of postoperative duration of aspirin use on the longevity of bioprosthetic pulmonary valves in patients who underwent repair for congenital heart diseases.


We retrospectively reviewed the clinical data...

Sensorineural hearing loss in patients with Kawasaki disease
Sun Young Park, Young Hyun Kim, Yeo Hyang Kim, Myung Chul Hyun, Young Hwan Lee
Clin Exp Pediatr. 2015;58(11):434-439.   Published online November 22, 2015

Kawasaki disease involves acute febrile systemic vasculitis that can cause a variety of symptoms by affecting various organs. Here, we aimed to evaluate the prevalence, causes, and prognosis of sensorineural hearing loss (SNHL) occurring in children with Kawasaki disease.


Patients who were diagnosed with Kawasaki disease and received inpatient treatment in the Pediatrics Department at one of three university hospitals in...

Comparison and analysis of the effectiveness to high dose of aspirin and ibuprofen in acute phase of Kawasaki disease
Seung-woon Keum, Yeon Kyun Oh, Jong Duck Kim, Seung-taek Yu
Clin Exp Pediatr. 2009;52(8):930-937.   Published online August 15, 2009

Purpose:We evaluated the effectiveness of treatment and cardiac complications of replacing a high dose of aspirin with a high dose of ibuprofen for children in acute phase of Kawasaki disease. We also analyzed the possibility of replacing a high dose of aspirin with a high dose of ibuprofen to prevent complications such as Reye s syndrome caused by aspirin. Methods:One hundred eight children...
Comparative study of therapeutic effects according to duration of medium-dose aspirin therapy at the acute stage of Kawasaki disease
Jung Hwa Lee, So Hee Lee, Sang Taek Lee, Yong Hyun Park, Seong Jin Hong
Clin Exp Pediatr. 2006;49(7):790-795.   Published online July 15, 2006
Purpose : This study was performed to compare the therapeutic effects according to duration of medium-dose aspirin(50-60 mg/kg/day) therapy at the acute stage of Kawasaki disease(KD). Methods : Total 87 patients with KD were enrolled in this study. We performed retrospective analysis of clinical characteristics and echocardiographic findings based on medical records. Patient were randomly divided into 2 groups according to...
Reye syndrome after acute enteritis during the neonatal period
Jun Suck Bang, Sang Jung Nam, Kyung Hwa Lee, Eun Joo Bae, Won Il Park, Hyun Sook Lee, Bae Young Son, Hwan Suck Choi, Hong Jin Lee
Clin Exp Pediatr. 2006;49(3):273-277.   Published online March 15, 2006
Purpose : The reinfection rate of H. pylori reported before 13C-urea breath test(13C-UBT) era was higher than that of the post 13C-UBT era. Children are usually reluctant to receive invasive endoscopic evaluation for the reinfection of H. pylori, particularly when they are asymptomatic. The aim of the study is to discover the reinfection rate by different diagnostic tests, and to...
Changes of c-Fos Immunoreactivity in Midbrain by Deep Pain and Effects of Aspirin
Jin A Jung, Ki Soo Yoo, Kyu Keun Hwang
Clin Exp Pediatr. 2003;46(7):695-701.   Published online July 15, 2003
Purpose : It had been suggested that pain arising from deep somatic body regions influences neural activity within periaqueductal gray(PAG) of midbrain via distinct spinal pathways. Aspirin is one of the popular non-steroidal anti-inflammatory drugs used in the management of pain. Fos expression was used as a marker for neuronal activity throughout central neurons following painful peripheral stimulation. This study...
Effect of Low-Dose Aspirin Therapy on Platelet Aggregation in Kawasaki Disease
Ju Yeon Yeo, Heon Eui Le, Young Mi Hong, Ki Sook Hong, Wha Soon Chung
Clin Exp Pediatr. 1999;42(4):510-518.   Published online April 15, 1999
Purpose : Aspirin(acetylsalicylic acid) has been used to treat unstable angina and acute myocardial infarction in adults and Kawasaki disease in children. The antithrombotic effect of aspirin was attributed to its ability to inhibit platelet aggregation by inhibiting platelet cyclooxygenase, which leads to decreased thromboxane synthesis. The purpose of this study was to evaluate the effect on the platelet aggregation...
The Optimal Dosages of Gammaglobulin and Aspirin in Treating Kawasaki Disease
Seung Baik Han, Jong Woon Choi, Soon Ki Kim, Sei Woo Chung, Jeung Gyu Kim, Byong Kwan Son
Clin Exp Pediatr. 1996;39(5):703-711.   Published online May 15, 1996
Purpose : There are some disagreements about the optimal dosages of intravenous gammaglobulin(IVGG) and oral aspirin(ASA) in the treatment of Kawasaki disease. So authors performed a prospective clinical study to evaluate the efficacy of IVGG 1g/kg plus ASA 50mg/kg/day. Methods : We treated 29 patients who were admitted to Inha University Hospital from June 1993 through May 1994 with IVGG 1g/kg plus ASA 50mg/kg/d. We...
A Study about Optimal Dose of Aspirin in Treating Kawasaki Disease
Yun-Jeong Chang, Seung-Kyoo Han, Soon-Ki Kim, Byong-Kwan Son, Jong-Woon Choi
Clin Exp Pediatr. 1995;38(3):378-385.   Published online March 15, 1995
Purpose : A prospective study was performed to evaluate the efficacies of two different dosages of aspirin(ASA) in treating Kawasaki disease(KD). Methods : Thirty-nine children with KD were admitted to this hospital from July, 1992 to May, 1993, and were assigned randomly into 2 groups. Group A(medium-dose group, 20 patients) was given 50mg/kg/d(# 4), and group B(high-dose gorup, 19 patients) was...
Case Report
A Case of Remission of Systemic Juvenile Rheumatoid Arthritis (Still's Disease) Treated with High-dose Intravenous Gammaglobulin
Yon Sook Rho, Yun Woo Lee, Sang woo Kim
Clin Exp Pediatr. 1994;37(12):1767-1772.   Published online December 15, 1994
High dose intravenous gammaglobuline (IVIG) therapy is effective in some of the autoimmune diseases. Although the exact mechamism of action of IVIG is uncertain, the action as a neutralizing antibody against unknown etiologic agents, the action of blocking of Fc receptors of effector cells, or the action as a antiidiotypic antibody are suggested. We report a case of 12 year old...
Original Article
Clinical Observation of 44 Cases of Kawasaki Disease.
K H Chang, B H Lim, H J Suh, I J Kang
Clin Exp Pediatr. 1985;28(11):1097-1103.   Published online November 30, 1985
44 Cases of Kawasaki Disease in children who were admitted to department of pediatrics of Fatima Hospital, Daegu, Kore, from January 1980 to June 1984 were analysed and following results were obtained. 1)Most cases (79.5%) were under the 2 years of age. 2)The sex ratio of male to female was 2.5:1. 3)The main clinical symptoms observed were fever over 5...
Electron Microscopic Study of the Renal Proximal and Distal Convuluted Tubular Epithelial and Distal Convoluted Tubular Epithelial Cells after Administration of Aspirin.
Sung Gum Hong, Cheul Woon Back, Im Ju Kang, Byung Heon Kim, Dong Koo Lee
Clin Exp Pediatr. 1983;26(6):564-572.   Published online June 30, 1983
The author has investigated ultrastructural changes of the renal proximal and distal convoluted tubular epithelial cells of rats with oral administration of aspirin, COmg per kg of body weight for 15 and 30 days consecutively. The experimental animals have divided into two group. The group I was received aspirin for 15 consecutive days and group H for 30 days. The...
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