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Original Article
The Clinical Types and Characteristics of Diabetes Mellitus in Korean Children
Eun Gyong Yoo, Hye Jung Shin, Duk Hi Kim
Clin Exp Pediatr. 2000;43(12):1591-1598.   Published online December 15, 2000
Purpose : Diabetic children should be classified into type 1 or 2 for adequate diabetic control. However, there is a shortage of information of the appropriate criteria in Korea. This study is desinged to discover the clinical types and characteristics of diabetes mellitus(DM) in Korean children. Methods : We studied the clinical characteristics and laboratory findings of 177 diabetic children. Classification...
Diagnostic Significance of the Urine-Stick Test in Middle and High School Children in Seoul
Mi Jung Park, Yun Ju Kang, Jong Hee Kim, Duk Hi Kim
Clin Exp Pediatr. 2000;43(3):411-416.   Published online March 15, 2000
Purpose : This study was performed to assess the diagnostic significance of the urine-stick test in detecting Diabetes Mellitus(DM) and to assess the clinical characteristics of adolescent diabetes. Methods : A total of 926,208 middle and high school children participated. The urine-stick test was performed and those who showed glycosuria and, further studies such as evaluations of plasma glucose, triglyceride, cholesterol...
Serial Changes of Blood Glucose Levelsin IDDM Patients Using Intermediate-acting Insulin only Therapy
Ye Sik Kim, Mi Jung Park, Duk Hi Kim
Clin Exp Pediatr. 1996;39(4):552-557.   Published online April 15, 1996
Purpose : We investigated the clinical characteristics of IDDM patients, treated with NPH only, and evaluated current problems by measurement of serial blood glucose, insulin, C-peptide for 12 hours after administration of intermediate-acting insulin. Methods : We studied 19 IDDM patients who had been diagnosed and followed up on a regular basis at Severance hospital. They were assigned into 2 groups, one(HbA1c...
Clinical Observations of Transient Idiopathic Hypocalcemia
Jeong Nyun Kim, Mi Jung Park, Duk Hi Kim, Ho Sung Kim
Clin Exp Pediatr. 1995;38(9):1193-1200.   Published online September 15, 1995
Purpose : In concern of diagnosis and treatment of transient idiopathic hypocalcemia, a major cause of infantile, we studied the onset of age, clinical characteristics, laboratory findings, and duration of treatment and recovery of transient idiopathic hypocalcemia. Methods : The author observed 19 infants with transient idiopathic hypocalcemia who had been admitted to Yonsei university hospital due to convulsion for 4...
Characteristics of Childhood Diabetes
Mi Jung Park, Wook Chang, Hyun Chul Lee, Duk Hi Kim, Ho Seoung Kim
Clin Exp Pediatr. 1995;38(8):1116-1123.   Published online August 15, 1995
Purpose : Because of weternized life style, environmental air pollution and infection, the incidence of childhood diabetes is increasing daily. This study was attempted to evaluate charateristics of childhood diabetes. Methods : We evaluated 117 patients diagnosed with Diabetes at Yonsei and Ewha University College of medicine from 1985 to 1994. Results : 1) The majority of patients were diagnosed as IDDM(86%)....
Sex Hormone Binding Globulin Levels in Children with Insulin Dependent Diabetes Mellitus
Duk Hi Kim, Mi Jung Park, Ho Sung Kim
Clin Exp Pediatr. 1995;38(7):963-969.   Published online July 15, 1995
Purpose : Sex hormone binding globulin(SHBG) is produced in liver and binds to testostero-ne and estradiol. Plasma SHBG levels are increased by estrogen and thyrotoxicosis and decreased by testostrone, insulin, growth hormone, prolactin, obesity and noninsulin dependent diabetes mellitus. SHBG levels in patients with NIDDM is known to be higher than normal, but SHBG levels in children with IDDM is controversial....
Comparison Between 24-hour Integrated Growth Hormone Concentrations and Pharmacological Provocation Tests in Children with Short Statue
Mi Jung Park, Duk Hi Kim, Ho Seong Kim
Clin Exp Pediatr. 1995;38(6):835-842.   Published online June 15, 1995
Purpose : The ability to respond to pharmacologial provovation tests may not necessary reflect actuaol secretory patterns of growth hormone. Therefore, the aim of this study in to evaluate the 24-h IC-GH and compare this with their resposnses to standard pharmacological provocation tests for growth hormone comcentrations and to evaluate peak frequency and peak amplitude during 24-h IC-GH in children...
Incidence and Complications of Obesity in Pubescent School Children
Boo Hyun Han, Duk Hi Kim, Yoo Kyung Park, Jong Ho Lee, Ho Seong Kim
Clin Exp Pediatr. 1995;38(4):520-528.   Published online April 15, 1995
Purpose : In recent years, obesity in children has become one of the major nutritional problems, and the trend is that number of obese children is increasing. The purpose of this research is to examine the incidence of obesity in pubescent school children in Seoul and Cheju, and to analyze body fat component, complications and eating habits of those obese...
Clinical Differences by Karyotype in Patients with Turner Syndrome
Mi Jung Park, Jin Sung Lee, Kir Young Kim, Duk Hi Kim, Ho Seoung Kim
Clin Exp Pediatr. 1995;38(2):143-150.   Published online February 15, 1995
Purpose : The aim of this study was to evaluate clinical differences by karyotype in Turner Syndrome. Methods : We evaluated 66 patients with Turner syndrome diagnosed at Yonsei University College of medicine from Mar.1985 to Feb.1993. We divided subproups as pure 45,X groups, mosaisism groups and structural aberration groups. Clinical features, serum estrogen, LH, FSH, concentrations, gonadotropin release after GnRH...
Body Composition of Children and Adolescents with Insulin-dependetn Diabetes Mellitus
Hye Young Kang, Mi Jung Park, Duk Hi Kim, You Kyung Park, Jong Ho Lee, Ho Seong Kim
Clin Exp Pediatr. 1994;37(12):1709-1716.   Published online December 15, 1994
Bodycomposition measurement is useful in the diagnosis of pathoogy, assessment of disease process and response to treatment in many endoclonologic and metabolic diseases. The Techniques used currently are mostly indirect, often expensive, difficult and time-consuming. A new method for estimation of body composition, infrared interactance, is rapid, safe, noninvasive, and may be useful in research ad clinical studies. Body composition was...
Case Report
One Case of Maffucco's Syndrome with Testicular Teratoma
Seung Mo Park, Duk Hi Kim, Ho Seong Kim
Clin Exp Pediatr. 1994;37(8):1162-1168.   Published online August 15, 1994
Maffucci's syndrome is a very rare, congenital and non-hereditary mesodermal dysplasia manifested by multiple enchondromas and soft tissue hemangiomas. Since Maffucci had reported this syndrome in 1881, there have been more than 100 cases reported, and also there has been reported that Maffuddi's syndrome has various interstitial tumor. However there hasn't been any report about Maffucci's syndrome with testicular teratoma....
Original Article
Risk Factors for Hyperglycemia in Children with Leukemia Receiving L-asparaginase
Min Joong Kwon, Ho Sung Kim, Kir Young Kim, Duk Hi Kim
Clin Exp Pediatr. 1994;37(6):740-745.   Published online June 15, 1994
Hyperglycemia is a well-recognized side effect of L-asparaginase in remission induction therapy of acute lymphocytic leukemia. Since hyperglycemia has preceded fatal diabetic ketoacidosis or hyperosmotic nonketotic coma in some patients, early detection and treatment of this complication are important. We determined retrospectively the risk of hyperglycemia in 117 patients with leukemia who had received L-asparaginase (& prednisolone). The results were as...
Mechanism of Impaired Growth Hormone Response in Children with Simple Obesity
Moon Sung Park, Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1994;37(4):457-463.   Published online April 15, 1994
Obesity is associated with an impairment of the hormone secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown, To determine whether obesity is associated with a chronic state of tonic somatostatin, several tests with growth hormone stimuli such as GHRH (1㎍/kg), clonidine (150㎍/m2) and Resular insulin (0.1U/kg, subcutaneously), to obese subjects and...
The Effect of Testosterone on the Response of Grow Hormone Secretion in Cultured Rat Pituitary Cells
Ho Seong Kim, Duk Hi Kim, Deok Bae Park
Clin Exp Pediatr. 1993;36(11):1578-1582.   Published online November 15, 1993
The effects of testosterone on the pituitary growth hormone(GH) response directly and to hypothalamic growth hormone-releasing hormone(GHRH) were evaluated in vitro using a male pituitary cell monolayer culture system. Wistar male rats were gonadectomized at 22 days of age, and 21 days later their anterior pituitaries were removed and trypsinized for cell dispersion. Testosterone 0.01, 1.0, 10.0nM was added to...
Growth Pattern and Final Height in Congeital Adrenal Hyperplasia
Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1993;36(10):1359-1365.   Published online October 15, 1993
Clinical characteristics and growth pattern were evaluated in 42 patients with classical congenital adrenal hyperplasia treated since diagnosis. And final height was evaluated in 16 patients who had reached final adult height with regard to clinical form, degree of hormonal control, and age of initial treatment. The results were as follows; 1) Among 42 patients with classical congenital adrenal hyperplasia, the male...
Case Report
Three Cases of Acute Suppurative Thyroiditis in children
Min Joong Kwon, Ho Seong Kim, Duk Hi Kim, Duk Hi Kim
Clin Exp Pediatr. 1993;36(9):1320-1324.   Published online September 15, 1993
Acute suppurative thyroiditis is uncommon in children. The relative rarity of thyroid infection is thought to reflect its complete fibrous encapsulation, generous vascular and lymphatic supply and high local iodine level. the bacterial involvement include the normal oropharyngeal microflora, and broad spectrum antibiotic therapy including anaerobic coverage should be utilized initially. We have experienced three cases of acute suppurative throiditis. All...
Pancreatic Islet-cell Adenoma
Ji Hong Kim, Ho Seong Kim, Duk Hi Kim, Hyun Yee Im, Chan Il Park
Clin Exp Pediatr. 1993;36(6):870-876.   Published online June 15, 1993
Pancreatic islet cell adenoma is a benign tumor of pancreatic β-cell and a rare cause of hyperinsulinemic hypoglycemia in chidren. The autors experienced a case of pancreatic islet cell adenoma(Insulinoam) in a 11 year and 8 month old male who had frequent loss of consciousness and seizuere. Enucleation was done after localiztion of tumor by selective celiac artery angiography and abdominal...
Original Article
Growth Outcome in Congenital Hypothyroidism
Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1993;36(5):713-720.   Published online May 15, 1993
Congenital hypothyroidism is one of the most common endocrine disease in childhood and it causes not only mental retardation but also growth retardation. There were many papers about evaluation of developmental outcome in congenital hypothyroidism, The aim of this study was to evaluate growth outcome in congenital hypothyroidism. We evaluated 65 patients with congenital hypothyroidism diagnosed at yonsei University College...
Clinical Significance of Urinary Growth Hormone Measurement in patients with Growth Hormone Deficien
Ho Seong Kim, Duk Hi Kim, Min-Seok Cheon
Clin Exp Pediatr. 1993;36(4):478-484.   Published online April 15, 1993
Urinary growth hormone (GH) excretion was quantitated in 12-hr overniaght urine collections obtained from 13 children with complete growth hormone deficiency(CGHD), 6 children with partial growth hormone deficiency(PGHD), 5 children with short stature and normal GH provocation tests(NSC), and 5 normal control children (NC) to investigate whether the measurement of urinary GH can clearly separate the PGHD and CGHD groups...
Measurement of Bone Mineral Density in Korean Newborns by Dual Photon Absorptiometry
Kook In Park, Chul Lee, Ran Namgung, Duk Hi Kim, Dong Gwan Han
Accepted January 1, 1970  
Bone mineral density (BMD), bone mineral content (BMC) and bone width (BW) of lumbar spine was measured in 37 term and 38 preterm appropriate-for-gestational-age (AGA) infants and 22 term small-for-gestational-age (SGA) infants who were delivered at Yonsei University Severance Hospital from January to September 1991 using dual photon absorptiometry (DPA). All of the infants were studied once within three days...
Case Report
A Case of Primary Hyperparathyroidism in Infancy
Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1992;35(7):1008-1013.   Published online July 15, 1992
Primary hyperparathyroidism is very rare and often fatal disease in childhood. We experienced a case in which a 4 months old male patient complaning of lethargy, hypotonia, respiratory difficulty showed typical laboratory and radiological findings compatible to primary hyperparathyroidism. He was successfully treated with total parathyroidectoimy with partial parathyroid autotrans-plantation. Thus the case of primary hyperparathyroidism in infancy is presented with...
A Case of Congenital Hypopituitarism Presenting Ectopic Pituitary Gland and Pituitary Stalk Transection Identified by Magnetic Resonance Imaging
Do Seong Kim, Kyung Eun Oh, Duk Hi Kim, Myung Joon Kim
Clin Exp Pediatr. 1992;35(6):809-815.   Published online June 15, 1992
The syndrome of congenital hypopitutarism is a rare but well recognized entity. The typical clinical picture consists of presentation in infanncy with hypoglycemia, microgenitalia, and evidence of multiple anterior pituitary hormone deficiencies, but not diabetes inspidus. Recently, magnetic resonance imaging has disclosed a consistent abnormality in many patients with congenital hypopituitarism as well as idiopathic hypopituitarism characterized by an adenohypophysis...
Original Article
Quantification of Human Urinary Growth Hormone and Its Clinical Significance in the Diagnosis of Growth Hormone Deficiency
Seung Ryul Lee, Ho Seong Kim, Duk Hi Kim, Chang Mi Kim
Clin Exp Pediatr. 1992;35(5):595-601.   Published online May 15, 1992
Twelve-hour nocturnal urine was collecte in 5 patients diagnosed of having complete GH deficiency, 6 of having partial GH deficiency and 7 persons as normal control group. The GH levels in urine collections were evaluated, and the results are as follows. 1) The GH level of normal control group was 16.76¡¾1.91ng/12hr, 59.00¡¾6.92ng/gCr, 16.24¡¾2.52ng/m2, 0.58¡¾0.12ng/kg. 2) The GH level of complete GH deficiency...
The Effects of Testosterone on the Pituitary Growth Hormone Secretion
Ho Seong Kim, Duk Hi Kim, Kyung Za Ryu, Chang Mee Kim, Deok Bae Park
Clin Exp Pediatr. 1992;35(2):174-181.   Published online February 15, 1992
The effects of testosterone on growth hormone secretion and somatic growth have been reported in several previous studies. In order to investigate the role of testosterone in growth hormone secretion, we have studied the effect of testosterone on somatic growth, basal growth hormone concentration, and growth hormone response to growth hormone-releasing hormone (GHRH) in orchiectomized rats. In experiment 1, four groups...
Effects of sex hormone on secretion of growth hormone.
Bo Young Lee, Duk Hi Kim
Clin Exp Pediatr. 1991;34(12):1621-1628.   Published online December 31, 1991
Sex honnone had been thought to influence in the serum level of growth honnone (GH) since 1944 year. After it became known that the exogenous administration of sex honnone to growth-retarded children increase serum GH level, sex honnone-especially testosterone-was thought to induce GH release. Testosterone is thought to act on the hypothalamo-pituitary axis to stimulate GH secretion and estradi이 is also thought...
Study on the antibody formation in patinets treated with recombinant human growth hormone(rhGH).
Hye Jung Joo, Duk Hi Kim, Dong Soo Kim
Clin Exp Pediatr. 1991;34(9):1261-1268.   Published online September 30, 1991
Patients with short stature admitted to the Pediatrics Endocrinology Clinic, Yonsei University College of Medicine during a six-year period from August, 1983 to August, 1989 were divided into three groups. The group 1 received rhGH, group 2 received Oxandrolone and group 3 did not receive any treatment. These patients were tested for presence of antibodies to rhGH with ELISA and effect of rhGH was evaluated. 1) Among 53...
Physical Growth According to Sexual Maturation of Korean Adolescents
Hwan Gyu Park, Chang Ho Hong, Duk Hi Kim
Clin Exp Pediatr. 1994;37(9):1187-1195.   Published online September 15, 1991
Adolescence is the period in which physical, mental and social maturation occurs and it is an important transit stage, changing from childhood to adulthood. This is a period in which important changes occur physically such as rapid growth in height and weight gain but significant differences in growth may occur for the same age. Therfore, the degree of sexual maturation...
Clinical effects of recombinant Korean growth hormone (LBD-003).
Duk Hi Kim
Clin Exp Pediatr. 1991;34(8):1110-1115.   Published online August 31, 1991
LBD-003, methionyl GH, has been produced recently in the yeast by the use of recombinant method. The clinical efficacy and immunogenecity of LBD-003 were studied in 20 patients with naive GH deficiency. The subjects of this study were aged 5.1—13.9 years and received GH 1.5IU/kg thrice weekly for 1 year. During treatment, height, body weight & bone age were checked. Blood count, chemistry amd thyroid...
The effects of human growth hormone on short stature.
Sang Mi Ha, Duk Hi Kim
Clin Exp Pediatr. 1991;34(7):999-1008.   Published online July 31, 1991
Since Raben’s original report that human growth hormone promoted growth in a boy with pituitary dwarfism, the hormone’s efficacy in children with growth hormone deficiency has been amply confirmed. However the scarcity of growth hormone prepared human pituitaries has limited studies of its usefulness in short stature. The availability of a biologically active human growth hormone produced by recombinant-DNA technology has dramatically changed the...
The mechanism of Arginine-stimulated growth hormone secretion.
Wan Kyu Lee, Dong Goo Lee, Duk Hi Kim
Clin Exp Pediatr. 1991;34(4):544-552.   Published online April 30, 1991
Although Arginine is widely used in the evaluation of growth hormone (GH) secretion in short stature patient, the mechanism of action is unclear, yet. To elucidate how Arginine stimulate GH secretion, we studied the interaction of Arginine with growth homrone releasing hormone (GHRH) on GH secretion in GH deficient short stature patient and constitutional growth delay. The results of the studies were as follows: 1) Peak...
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