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Original Article
Neonatology (Perinatology)
Mortality of very low birth weight infants by neonatal intensive care unit workload and regional group status
Sung-Hoon Chung, Chae Young Kim, Yong-Sung Choi, Myung Hee Lee, Jae Woo Lim, Byong Sop Lee, Ki-Soo Kim; the Korean Neonatal Network
Clin Exp Pediatr. 2024;67(11):619-627.   Published online September 12, 2024
Question: How do structural and staffing characteristics of neonatal intensive care units (NICUs) influence the mortality rates of very low birth weight infants (VLBWIs)?
Findings: NICUs with higher staffing levels, particularly with more neonatologists, and those offering advanced care levels were associated with lower mortality rates. Additionally, regional disparities were observed, with some areas demon-strating significantly higher survival rates.
Meaning: Adequate staffing and equitable regional distribution of medical resources are crucial for improving survival outcomes in VLBWIs. Efforts to enhance NICU staffing and address regional healthcare disparities are essential for optimizing care quality and reducing mortality in this vulnerable population.
Editorial
Neonatology (Perinatology)
Impacts of maternal COVID-19 during pregnancy on neonatal health and epidemiology
Jae Woo Lim
Clin Exp Pediatr. 2024;67(3):149-151.   Published online December 28, 2023
Newborns born to mothers infected with coronavirus disease 2019 (COVID-19) should be closely monitored for respiratory disorders, such as transient tachypnea of the newborn, regardless of their COVID-19 test results. Further research is required of the development of infants born to mothers with COVID-19. The trends in Korea's birth rate and infant mortality rates have not been significantly affected by COVID-19.
Original Article
Cardiology
The improvement of right ventricular function after adenotonsillectomy in children with obstructive sleep apnea
Dong Yeop Kim, Kyung Ok Ko, Jae Woo Lim, Jung Min Yoon, Young Hwa Song, Eun Jeong Cheon
Clin Exp Pediatr. 2018;61(12):392-396.   Published online October 26, 2018

Purpose: Adenotonsillar hypertrophy (ATH) that causes upper airway obstruction might lead to chronic hypoxemic pulmonary vasoconstriction and right ventricular (RV) dysfunction. We aimed to evaluate whether adenotonsillectomy (T&A) in children suffering from obstructive sleep apnea (OSA) due to severe ATH could improve RV function. Methods: Thirty-seven children (boy:girl=21:16; mean age, 9.52±2.20 years), who underwent T&A forsleep apnea due to ATH, were...
Gastroenterology
Clinical manifestation of Campylobacter enteritis in children
Joon Yeol Bae, Dong Hyuk Lee, Kyung Ok Ko, Jae Woo Lim, Eun Jeong Cheon, Young Hwa Song, Jung Min Yoon
Clin Exp Pediatr. 2018;61(3):84-89.   Published online February 28, 2018
Purpose

Timely antibiotic therapy in selected cases of diarrhea associated with bacterial infections can reduce the duration and severity of illness and prevent complications. The availability of a predictive index before identification of causative bacteria would aid in the choice of a therapeutic agent.

Methods

The study included patients admitted to the pediatrics unit at Konyang University Hospital for acute inflammatory diarrhea from...

Case Report
Gastroenterology
Granular cell tumor of the esophagus in an adolescent
Ji Sun Lee, Kyung Ok Ko, Jae Woo Lim, Eun Jeong Cheon, Young Jin Kim, Jang Sin Son, Jung Min Yoon
Clin Exp Pediatr. 2016;59(Suppl 1):S88-S91.   Published online November 30, 2016

Esophageal granular cell tumor (GCT) is a rare neoplasm originating from the Schwann cells of the submucosal neuronal plexus. Histology is the gold standard for its diagnosis. Endoscopic resection or surgical excision should be considered, depending on the potential for malignancy. Here, we report a case of an esophageal GCT in an adolescent. A 12-year-old boy presented with a 1-year...

Genetics and Metabolism
Interstitial deletion of 5q33.3q35.1 in a boy with severe mental retardation
Jin Hwan Lee, Hyo Jeong Kim, Jung Min Yoon, Eun Jung Cheon, Jae Woo Lim, Kyong Og Ko, Gyung Min Lee
Clin Exp Pediatr. 2016;59(Suppl 1):S19-S24.   Published online November 30, 2016

Constitutional interstitial deletions of the long arm of chromosome 5 (5q) are quite rare, and the corresponding phenotype is not yet clearly delineated. Severe mental retardation has been described in most patients who present 5q deletions. Specifically, the interstitial deletion of chromosome 5q33.3q35.1, an extremely rare chromosomal aberration, is characterized by mental retardation, developmental delay, and facial dysmorphism. Although the...

Original Article
Cardiology
Age-adjusted plasma N-terminal pro-brain natriuretic peptide level in Kawasaki disease
Heul Jun, Kyung Ok Ko, Jae Woo Lim, Jung Min Yoon, Gyung Min Lee, Eun Jung Cheon
Clin Exp Pediatr. 2016;59(7):298-302.   Published online July 31, 2016
Purpose

Recent reports showed that plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) could be a useful biomarker of intravenous immunoglobulin (IVIG) unresponsiveness and coronary artery lesion (CAL) development in Kawasaki disease (KD). The levels of these peptides are critically influenced by age; hence, the normal range and upper limits for infants and children are different. We performed an age-adjusted analysis of plasma...

Case Report
A pediatric case of Bickerstaff's brainstem encephalitis
Ju Yi Park, Kyong Og Ko, Jae Woo Lim, Eun Jung Cheon, Jung Min Yoon, Hyo Jeong Kim
Clin Exp Pediatr. 2014;57(12):542-545.   Published online December 31, 2014

Bickerstaff's brainstem encephalitis is characterized by ophthalmoplegia, ataxia, and disturbance of consciousness. It is similar to Miller Fisher syndrome, a variant of Guillain-Barre syndrome, in that they share features such as ophthalmoplegia and ataxia. The difference is that patients with Bickerstaff's brainstem encephalitis have impaired consciousness, whereas patients with Miller Fisher syndrome have alert consciousness and areflexia. Here, we report...

Original Article
Effect of adenotonsillar hypertrophy on right ventricle function in children
Jin Hwan Lee, Jung Min Yoon, Jae Woo Lim, Kyung Og Ko, Seong Jun Choi, Jong-Yeup Kim, Eun Jung Cheon
Clin Exp Pediatr. 2014;57(11):484-488.   Published online November 30, 2014
Purpose

Chronic upper airway obstruction causes hypoxemic pulmonary vasoconstriction, which may lead to right ventricle (RV) dysfunction. Adenotonsillar hypertrophy (ATH) is the most common cause of upper airway obstruction in children. Therefore, we aimed to evaluate RV function in children with ATH.

Methods

Twenty-one children (male/female, 15/6; mean age, 92.3¡¾39.0 months; age range, 4-15 years) with ATH and 21 healthy age- and gender-matched...

Fecal calprotectin concentration in neonatal necrotizing enterocolitis
Jung Min Yoon, Ju Yi Park, Kyung Ok Ko, Jae Woo Lim, Eun Jeong Cheon, Hyo Jeong Kim
Clin Exp Pediatr. 2014;57(8):351-356.   Published online August 25, 2014
Purpose

Among the many factors associated with acute intestinal mucosal infection, numerous studies have proposed the usefulness of fecal calprotectin. The aim of this study was to evaluate the usefulness of fecal calprotectin in the diagnosis of necrotizing enterocolitis (NEC).

Methods

We collected 154 stool samples from 16 very low birth weight and premature newborns at the Konyang University Hospital neonatal intensive care...

Effect of early postnatal neutropenia in very low birth weight infants born to mothers with pregnancy-induced hypertension
Yang Hee Park, Gyung Min Lee, Jung Min Yoon, Enn Jung Cheon, Kyung Ok Ko, Yung Hyuk Lee, Jae Woo Lim
Clin Exp Pediatr. 2012;55(12):462-469.   Published online December 20, 2012
Purpose

In this study, we aimed to investigate the perinatal clinical conditions of very low birth weight (VLBW) infants born to mothers with pregnancy-induced hypertension (PIH) focusing on the effects of early postnatal neutropenia.

Methods

We reviewed the medical records of 191 VLBW infants who were born at Konyang University Hospital, between March 2003 and May 2011. We retrospectively analyzed the clinical characteristics...

Review Article
The changing trends in live birth statistics in Korea, 1970 to 2010
Jae Woo Lim
Clin Exp Pediatr. 2011;54(11):429-435.   Published online November 30, 2011

Although Korean population has been growing steadily during the past four decades, the nation is rapidly becoming an aging society because of its declining birth rate combined with an increasing life expectancy. In addition, Korea has one of the lowest fertility rates in the world due to fewer married couples, advanced maternal age, and falling birth rate. The prevalence of...

Original Article
A study on the measurement of the nucleated red blood cell (nRBC) count based on birth weight and its correlation with perinatal prognosis in infants with very low birth weights
Tae Hwan Kil, Ji Yeon Han, Jun Bum Kim, Gyeong Ok Ko, Young Hyeok Lee, Kil Young Kim, Jae Woo Lim
Clin Exp Pediatr. 2011;54(2):69-78.   Published online February 28, 2011
Purpose

The aim of this study was conducted to investigate the mean nRBC count in very low births weight infants (VLBWIs) and to determine the usefulness of the nRBC as an independent prognostic factors of perinatal complications in VLBWIs.

Methods

This study was conducted on 112 VLBWIs who were hospitalized in the neonatal intensive care unit (NICU) of the author's hospital within the...

Review Article
Development and language problems in children of immigrant marriages
Jae Woo Lim
Clin Exp Pediatr. 2009;52(4):417-421.   Published online April 15, 2009
The number of international marriages in South Korea has drastically increased since the year 2000, and among these, the proportion of couples with a Korean husband and foreign wife accounts for more than 70%. At the same time, the number of children resulting from an international marriage has also risen dramatically; this tendency is especially evident in preschool children below...
Case Report
A case of Kawasaki disease preceding a retropharyngeal abscess
Hee Ok Park, Jae Woo Lim, Eun Jung Cheon, Kyung Ok Ko
Clin Exp Pediatr. 2008;51(5):542-545.   Published online May 15, 2008
Epidural hematoma (EDH) is relatively rare in newborn infants and frequently associated with instrumental deliveries or other complications during labor and delivery. Although surgical evacuation has been the most common therapy, many other procedures have been suggested. Although many epidural hematomas require surgical evacuation rather than non-surgical management, the conservatiob or aspiration of hematoma have been attempted. In the case...
Original Article
Association of apolipoprotein E polymorphisms with serum lipid profiles in obese adolescent
Jung Min Yoon, Jae Woo Lim, Eun Jung Cheon, Kyoung Og Ko
Clin Exp Pediatr. 2008;51(1):42-46.   Published online January 15, 2008
Purpose : Apolipoprotein E (Apo E) plays a major role in lipoprotein metabolism and lipid transport. Many investigators have described that Apo E polymorphisms is one of the most important genetic determinants for cardiovascular disease. The purpose of this study was to evaluate the association between Apo E polymorphisms and serum lipid profiles in obese adolescent. Methods : We measured...
Correlation of inhalant MAST on chronically coughing children
Jung Min Yun, Eui Jung Roh, Jae Woo Lim, Eun Jung Choen, Kyoung Og Ko, Young Hyuk Lee
Clin Exp Pediatr. 2006;49(6):643-647.   Published online June 15, 2006
Purpose : Recently, incidences of chronic cough with allergic disease have been increased. The identification of specific allergens for chronically coughing children is significant for diagnosis, proper treatment and prevention. The aim of this study was to identify significant contributors for sensitization in chronically coughing children. Methods : A total of 106 children, aged 1-6 years, visiting for chronic cough(>3 weeks),...
Change of early atherosclerotic markers in obese children
Eui Jung Roh, Jung Min Yoon, Jae Woo Lim, Eun Jung Cheon, Kyoung Og Ko
Clin Exp Pediatr. 2006;49(4):368-374.   Published online April 15, 2006
Purpose : The prevalence of obesity in children is increasing rapidly. Epidemiologic studies suggest that obesity induced atherosclerosis may start in childhood. We investigated whether obese children show early abnormalities of the arterial wall and endothelial dysfunction. Methods : Thirty-eight obese children(14-16 years old of age, male, body mass index 29.40¡¾3.18 kg/m2) and forty-five age and sex-matched healthy control children(body...
Case Report
MR Imaging of Disseminated Tuberculosis of the Brain in a Patient with Miliary Tuberculosis : Initial Findings and Changes Six Months after Antituberculous Therapy
Jae Ho Jang, Jae Woo Lim, Soon Lee Jung, Kyuchul Choeh, Taeil Han
Clin Exp Pediatr. 2002;45(12):1596-1600.   Published online December 15, 2002
A 23-month-old girl visited with chronic cough and her chest radiograph showed miliary tuberculosis. There was no neurological abnormality. But CSF findings showed WBC 22/mm3(lymphocyte 20%, neutrophil 80%) and positive result of polymease chain reaction(PCR) for M. tuberculosis. MR imaging showed multiple ring enhanced nodules and ovoid nonenhancing bright signal lesion on the cerebrum, cerebellar parenchyme, and left basal ganglia....
Original Article
The Effect of Massage on Premature Infants
Hee Sook Son, Jae Woo Lim, Kyuchul Choeh, Chang Soo Ra, Hark Hee Kim
Clin Exp Pediatr. 2000;43(8):1046-1051.   Published online August 15, 2000
Purpose : To determine the effects of massage therapy on growth, development, hormones, immune function, hepatic function, hematopoietic function and sleep pattern of preterm infants. Methods : Thirty-one preterm infants of less than 35 weeks gestational age, who were admitted to Eulji Medical College Hospital Neonatal Intensive Care Unit between August 1998 and May 1999, and were in the state without mechanical ventilation or...
Infantile Hypertrophic Pyloric Stenosis Treated with Intravenous Atropine Sulfate
Jae Woo Lim, Hee Sook Son, Kye Shik Shim, Kyu Chul Choeh, Tae Il Han
Clin Exp Pediatr. 2000;43(6):763-768.   Published online June 15, 2000
Purpose : The pharmacologic effect of atropine on HPS can be considered to control pyloric muscle spasm. Therefore, we studied the effects of intravenous atropine sulfate on the clinical course of HPS, and periodically observed the ultrasonographic appearance of the pyloric muscles after atropine treatment. Methods : From April 1998 to May 1999, 14 infants who were diagnosed with HPS were...
Case Report
A Case of Megacystis Microcolon Intestinal Hypoperistalsis Syndrome
Jae Woo Lim, Jong Su Shin, Kyuchul Choeh, Chang Su Na, Tae Il Han
Clin Exp Pediatr. 2000;43(2):278-282.   Published online February 15, 2000
Megacystis Microcolon Intestinal Hypoperistalsis(MMIH) Syndrome is a rare cause of functional neonatal bowel obstruction, characterized by hypoperistalsis, narrow distal ileum and colon, and bladder distension. We report a case of MMIH syndrome and review the literature. The patient was born after 34 weeks of gestation with marked abdominal distension. Her birth weight was 2,830g with 276ml of urine drained by...