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Original Article
Pulmonology
Efficacies of different treatment strategies for infants hospitalized with acute bronchiolitis
Hyeri Jeong, Dawon Park, Eun Kyo Ha, Ju Hee Kim, Jeewon Shin, Hey-Sung Baek, Hyunsoo Hwang, Youn Ho Shin, Hye Mi Jee, Man Yong Han
Clin Exp Pediatr. 2024;67(11):608-618.   Published online October 28, 2024
· This study analyzed 45 randomized controlled trials (5,061 participants, 13 interventions) of the comparative efficacies of treatments for acute bronchiolitis in infants.
· Inhalation therapy with epinephrine and hypertonic saline significantly reduced the length of hospital stay compared with normal saline.
· Hypertonic saline had the greatest ability to improve the clinical severity score of bronchiolitis in infants younger than 2 years of age.
Adolescence Medicine
Serum alanine aminotransferase levels are closely associated with metabolic disturbances in apparently healthy young adolescents independent of obesity
Ki Eun Kim, Kyung Suk Baek, Sol Han, Jung Hyun Kim, Youn Ho Shin
Clin Exp Pediatr. 2019;62(2):48-54.   Published online November 23, 2018

Purpose: Liver metabolism plays a pivotal role in the development of metabolic disorders. We aimed to investigate the clinical and laboratory risk factors associated with alanine aminotransferase (ALT) levels in young adolescents from an urban population in Korea. Methods: A population of 120 apparently healthy adolescents aged 12–13 years was included in the cross-sectional design study; 58 were overweight or obese...
Food allergen sensitization in young children with typical signs and symptoms of immediate-type food allergies: a comparison between monosensitized and polysensitized children
Na Yeon Kim, Ga Ram Kim, Joon Hwan Kim, Ji Hyeon Baek, Jung Won Yoon, Hye Mi Jee, Hye Sung Baek, Yong Ho Jung, Sun Hee Choi, Ki Eun Kim, Youn Ho Shin, Hye Yung Yum, Man Yong Han, Kyu-Earn Kim
Clin Exp Pediatr. 2015;58(9):330-335.   Published online September 21, 2015
Purpose

The clinical interpretation of children sensitized to allergens is challenging, particularly in children with food allergies. We aimed to examine clinical differences between children with monosensitization and those with polysensitization to common food allergens and to determine risk factors for polysensitization in young children <10 years of age with immediate-type food allergies.

Methods

The study included children <10 years of age with...

Clinical risk factors associated with the development of wheezing in children less than 2 years of age who required hospitalization for viral lower respiratory tract infections
Joon Hwan Kim, Ji-Yeon Choi, Na Yeon Kim, Jin Woo Kim, Ji Hyeon Baek, Hye Sung Baek, Jung Won Yoon, Hye Mi Jee, Sun Hee Choi, Hyeung Yoon Kim, Ki Eun Kim, Youn Ho Shin, Man Yong Han
Clin Exp Pediatr. 2015;58(7):245-250.   Published online July 22, 2015
Purpose

Wheezing following viral lower respiratory tract infections (LRTIs) in children <2 years of age is an important risk factor for the development of asthma later in life; however, not all children with viral LRTIs develop wheezing. This study investigated risk factors for the development of wheezing during viral LRTIs requiring hospitalization.

Methods

The study included 142 children <2 years of age hospitalized...

Associations of matrix metalloproteinase (MMP)-8, MMP-9, and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys
Youn Ho Shin, Ki Eun Kim, Yong-Jae Lee, Jae-Hwan Nam, Young Mi Hong, Hye-Jung Shin
Clin Exp Pediatr. 2014;57(12):526-532.   Published online December 31, 2014
Purpose

Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults. However, there is little data on circulating levels of MMPs and tissue inhibitors of MMPs (TIMPs) with regard to obesity-related biomarkers in the general adolescent population. In the present study, we determined the associations of MMP-8, MMP-9, and TIMP-1 levels and...

Review Article
Determinants of sensitization to allergen in infants and young children
Hyeong Yun Kim, Youn Ho Shin, Man Yong Han
Clin Exp Pediatr. 2014;57(5):205-210.   Published online May 31, 2014

Atopic sensitization is a complex phenomenon that changes dynamically with age throughout childhood; its prevalence increases with age in young children. Additionally, with increasing age, the prevalence of sensitization to inhalant allergens and the prevalence of polysensitization to allergens increase. It is also well established that the development of atopic sensitization is the result of a complex interplay of genetic...

Original Article
Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
Youn Ho Shin, Jinho Yu, Kyung Won Kim, Kangmo Ahn, Seo-Ah Hong, Eun Lee, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Ji-Won Kwon, Byoung-Ju Kim, Hyo-Bin Kim, Jung Yeon Shim, Woo Kyung Kim, Dae Jin Song, So-Yeon Lee, Soo Young Lee, Gwang Cheon Jang, Dong In Suh, Hyeon-Jong Yang, Bong Sung Kim, Suk-Joo Choi, Soo-Young Oh, Ja-Young Kwon, Kyung-Ju Lee, Hee Jin Park, Pil Ryang Lee, Hye-Sung Won, Soo-Jong Hong
Clin Exp Pediatr. 2013;56(10):439-445.   Published online October 31, 2013
Purpose

Previous studies suggest that the concentration of 25-hydroxyvitamin D [25(OH)D] in cord blood may show an inverse association with respiratory tract infections (RTI) during childhood. The aim of the present study was to examine the influence of 25(OH)D concentrations in cord blood on infant RTI in a Korean birth cohort.

Methods

The levels of 25(OH)D in cord blood obtained from 525 Korean...

Review Article
Vitamin D status and childhood health
Youn Ho Shin, Hye Jung Shin, Yong-Jae Lee
Clin Exp Pediatr. 2013;56(10):417-423.   Published online October 31, 2013

Vitamin D is an essential component of bone and mineral metabolism; its deficiency causes growth retardation and skeletal deformities in children and osteomalacia and osteoporosis in adults. Hypovitaminosis D (vitamin D insufficiency or deficiency) is observed not only in adults but also in infants, children, and adolescents. Previous studies suggest that sufficient serum vitamin D levels should be maintained in...

Original Article
Prevalence and comorbidity of allergic diseases in preschool children
Hyeong Yun Kim, Eun Byul Kwon, Ji Hyeon Baek, Youn Ho Shin, Hye Yung Yum, Hye Mi Jee, Jung Won Yoon, Man Yong Han
Clin Exp Pediatr. 2013;56(8):338-342.   Published online August 27, 2013
Purpose

Allergic disease and its comorbidities significantly influence the quality of life. Although the comorbidities of allergic diseases are well described in adult populations, little is known about them in preschool children. In the present study, we aimed to assess the prevalence and comorbidity of allergic diseases in Korean preschool children.

Methods

We conducted a cross-sectional study comprising 615 Korean children (age, 3...

Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis
Ji Hyeon Baek, Hyun Kyong Seo, Hye Mi Jee, Youn Ho Shin, Man Yong Han, Eun Sang Oh, Hyun Ju Lee, Kyung Hyo Kim
Clin Exp Pediatr. 2013;56(7):286-290.   Published online July 19, 2013
Purpose

Although chronic and recurrent rhinosinusitis is prevalent in children, little is known about its causes. Here, we investigated the humoral immunity in children with chronic or recurrent rhinosinusitis.

Methods

We examined 16 children attending the outpatient clinic at the CHA Bundang Medical Center including 11 boys and 5 girls, aged 3.11 years (mean age, 5.6 years), who had rhinosinusitis for >3 months...

Reference values for respiratory system impedance using impulse oscillometry in healthy preschool children
Jye Hae Park, Jung Won Yoon, Youn Ho Shin, Hye Mi Jee, Young Sun Wee, Sun Jung Chang, Jung Hwa Sim, Hye Yung Yum, Man Yong Han
Clin Exp Pediatr. 2011;54(2):64-68.   Published online February 28, 2011
Purpose

The normal values for lung resistance and lung capacity of children, as determined by impulse oscillometry (IOS), are different for children of different ethnicities. However, reference values there is no available reference value for Korean preschool children have yet to be determined. The aim of the present study was to determine the normal ranges of IOS parameters in Korean preschool...

Case Report
A case of newly developed pulmonary lesion during the antitubercular agents in tuberculous pleurisy : A paradoxical response
Jee Min Park, Youn Ho Shin, Gyu Rak Chon, Hyun Joon Shin, Young Chil Choi
Clin Exp Pediatr. 2009;52(6):717-720.   Published online June 15, 2009
Paradoxical response refers to the enlargement of old lesions or unexpected appearance of new lesions after initial improvement following treatment with antitubercular agents. Various types of paradoxical responses have been reported in the world, but they are rarely reported in Korean children. We report the case of a 17-year-old boy who was diagnosed with tuberculous pleurisy and was treated appropriately....
Original Article
Safety and efficacy of the ultra-rush immunotherapy with extracts of Dermatophagoides pteronyssinus in children
Sei Eun Hyun, Hyoung Yun Kim, Ji Hee Kwak, Youn Ho Shin, Ji Yeong Seo, Man Yong Han
Clin Exp Pediatr. 2008;51(8):868-873.   Published online August 15, 2008
Purpose : Immunotherapy is accepted as the only treatment of allergic disease that can modify the natural course of the disease and ameliorate symptoms. This study aimed to evaluate the safety and efficacy of ultra-rush therapy using Dermatophagoides extracts in children. Methods : Of children older than four years who had visited Bundang CHA Pediatric Allergy Clinic, those showing positive...
Case Report
Stent implantation to relieve secondary pulmonary venous stenosis in total anomalous pulmonary venous connection: case report
Youn Ho Shin, Ki Eun Kim, Hae Sik Kwon, Byung Won Yoo, Jae Young Choi
Clin Exp Pediatr. 2007;50(9):919-924.   Published online September 15, 2007
Pulmonary venous stenosis may be congenital or acquired. Regardless of its origin, the prognosis for patients affected with PVS remains poor. There have been many attempts to palliate PVS with little success. This report describes two patients with PVS which became evident after repair of total anomalous pulmonary venous connection. Intravascular stents were successfully implanted, but progressive restenoses in the...