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Original Article
The Preventive Effect of Dexrazoxane and Pentoxifylline on Adriamycin Induced Cardiomyopathy
Ling Zhu, Eun-Jung Bae, Il-Soo Ha, Jung-Wook Seo, Chung-Il Noh, Jung-Yun Choi, Yong-Soo Yun
Clin Exp Pediatr. 2005;48(12):1378-1384.   Published online December 15, 2005
Purpose : We hypothesized dexrazoxane(DXR) and pentoxifylline(PTX) may prevent myocardial damage in adriamycin(ADR)-induced cardiomyopathic rat model. We also investigated their effects on the myocardial apoptosis and fibrosis in ADR induced cardiomyopathy. Methods : The six-week old female Spregue-Dawley rats were divided into control group(CNT, n= 4), ADR group(n=6), ADR＋DXR group(DXR, n=5), ADR＋PTX group(PTX, n=6), ADR＋DXR＋PTX group(DXPT, n=5). ADR(5 mg/week, twice) was...
Gene Expression of Metalloproteinases, Tissue Inhibitors of Metalloproteinases and Cytokines in Adriamycin-induced Cardiomyopathy
Young Mi Hong
Clin Exp Pediatr. 2005;48(2):197-203.   Published online February 15, 2005
ity has been reported to occur in both clinical and experimental forms of dilated cardiomyopathy. There was no report about MMP in adriamycin(ADR)-induced cardiomyopathy. The purpose of this study was to investigate gene expression of MMP and tissue inhibitor of metalloproteinases(TIMP) in ADR-induced cardiomyopathy and clarify the relationship between MMP and cytokines. Methods : Male Sprague-Dawley rats were divided into two...
Assessment of Left Ventricular Function with Echocardiography in Patients Treated with Adriamycin : A Load-Independent Index of Myocardial Contractility and Comparisons between Rest and Exercise
Pyoung Soo Park, Hye Young Park, Hae Yong Lee
Clin Exp Pediatr. 2002;45(2):214-222.   Published online February 15, 2002
Purpose : The aim of this study was to evaluate myocardial injury in children treated with adriamycin by echocardiography, which is non-invasive and safe measurement for children. Methods : Left ventricular dimensions, wall stress, and contractile function were determined by echocardiographic methods in 17 patient recepients with adriamycin chemotherapy at rest(group 1) and during stress(group 2). Twenty age-matched normal subjects were...
Serum Lipid Levels and Fatty Acid Metabolism in the Rat with Adriamycin Induced Cardiomyopathy
Young Mi Hong, Hye Ran Yoon
Clin Exp Pediatr. 2000;43(11):1480-1487.   Published online November 15, 2000
Purpose : Adriamycin induced cardiomyopathy is irreversible and may procede to clinical congestive heart failure. Recently, it has been suggested that adriamycin may exert cardiomyopathy due to inhibition of transport across mitochondrial membranes mediated by the carnitine palmitoyltransferase system(CPT I). The effect of adriamycin on fatty acid metabolism according to cumulative dose was not clarified. The purpose of this study...
Protective Effect of Probucol against Adriamycin-Induced Apoptosis in Cultured Rat Cardiac Myocytes
Sun-Ju Lee, Dong-Seok Lee, Yong-Wook Jung
Clin Exp Pediatr. 2000;43(6):746-754.   Published online June 15, 2000
Purpose : In adriamycin(ADR)-induced cardiomyopathy, several different mechanisms are suggested. However, little information is available regarding the role of apoptosis. In the present study, we examined the induction of apoptosis on ADR treatment and anti-apoptotic effects of probucol, a lipid-lowering drug, and we also studied the changes of bcl-2 expression in order to see the molecular mechanisms underlying the effect...
The Role of Apoptosis in Adriamycin Induced Cardiotoxicity and Preventive Effect of L-carnitine in Rat
Young Mi Hong, Seung Sook Kim
Clin Exp Pediatr. 1998;41(6):760-768.   Published online June 15, 1998
Purpose : Adriamycin is very important in cancer chemotherapy. Unfortunately, the drug shows cumulative dose dependent cardiotoxicity. The precise mechanism of this remains unclear. It has been shown that adriamycin induces programmed cell death or apoptosis in many tissues. But the role of apoptosis in adriamycin induced cardiotoxicity is uncertain. Methods : Sprague-Dawley rats were divided into four groups of ten animals each. All...
The Effects of Adriamycin on Ionic Currents in Single Cardiac Myocytes of the Rabbit
Sejung Sohn
Clin Exp Pediatr. 1995;38(8):1093-1106.   Published online August 15, 1995
Purpose : The study objective was to elucidate the possible pathophysiologic mechanism of Ca overload by adriamycin (ADR) which is associated with ADR- induced cardiotoxicity. Methods : The effects of ADR on ionic currents were studied using the whole cell voltage clamp technique in single cardiac myocytes of the rabbit. Results : The magnitude of the inward tail current, recorded at -70mV...
Effect of Different Levels of the Dietary Protein on Long Term Prognosis of Experimental Renal Damage
Choon Haeng Lee, Sang Joo Han, Hong Jin Lee, Won Il Park, Kyung Ja Lee, Young Eui Park, Min Chul Lee, Tae Heon Yoon
Clin Exp Pediatr. 1993;36(6):820-829.   Published online June 15, 1993
We examined the effect of various levels of dietary protein on long term prognosis of Adriamycinephropathy of S-D rat, fed with high protein(30%), intermediately low(10%), and strictly low(5%) protein diet for 15 weeks 1) In rats fed with strictly low protein diets(5%), proteinuria and serum creatinine decreased and creatinine clearance and histological changes were relatively well preserved. But hypoproteinmia and weight...
Effects of Adriamycin on Membrane Potential and Intracellular Sodium Activity in Canine Purkinje fibers
Chan Uhng Joo, Soo Wan Chae
Clin Exp Pediatr. 1992;35(8):1107-1112.   Published online August 15, 1992
Anthracycline antibiotic adriamycin (doxorubicin) is presently considered to be a very effective chemotherapeutic agent in the treatment of many human tumors. Adriamycin induced cardiomyopathy limits its clincal use. A number of hypotheses have been proposed to explain the mechanism of cardiotoxicity with adriamycin, but none has yet been demonstrated. The effects of adriamycin on membrane potential and intracellular sodium ion...
The effects of adriamycin on twitch force and membrane potential in an isolated Guinea-pig papillary muscle.
Chan Uhng Joo, Pyung Han Hwang, Jung Soo Kim, Hee Cheol Yu, Soo Wan Chae
Clin Exp Pediatr. 1991;34(5):677-681.   Published online May 31, 1991
The antiumor antibiotic adriamycin is presently considered to be a very effctive and useful chemotherapeutic agent in the treatment of many human tumors. Cardiotoxicity of adriamycin limits its clinical use. A number of hypotheses have been proposed to explain the mechanism of cardiotox- icity with adriamycin, but none has yet been demonstrated. The effects of adriamycin on twitch force and membrane potential in an...
Morphological Study of Cardiotoxicity in Adriamycin Treated Rats.
H W Shin, J Y Kim, C U Joo, P H Hwang, J S Kim
Clin Exp Pediatr. 1989;32(8):1117-1222.   Published online August 31, 1989
This experiment was carried out to investigate the morphological changes of cardiac tissue in Adriamycin treated rats. Adriamycin was administered (2.5 mg/kg/wk) for 5 weeks, subcutaneously. Cardiac tissue stained by H-E and Trichrom’s method. Clinical findings of congestive heart failure were also observed during experiment. The results were as follows ； 1) Symptoms and signs of congestive heart failure (tachypnea, ascites, hepatomegaly) were appeared in 43% (6 out...
Effect of Adriamycin on Lipid Metabolismin Rats.
Chang Beom Shin, Sun Jun Kim, Chan Unng Joo, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1988;31(9):1133-1138.   Published online September 30, 1988
This experiment was carried out to investigate the disturbance of lipid metabolism after long-term administration of adriamycin in rats (2.5 mg/kg/week for 5 weeks, S.C.). Changes of Serum lipids, GOT, GPT, LDH, albumin, BUN, and creatinine were investigated after administration of adriamycin. Clinical findings of congestive heart failure and changes of body weight were also observed during experiment. The results were as follows; 1) Serum triglyceride, total cholesterol,...
The effect of vincristine and adriamycin on the phagocytic function of reticuloendothelial system of rats.
Hyun Suk Lee, Jong Soo Kim, Jung Soo Kim, Kyu Cha Kim, Ho Yeul Choi
Clin Exp Pediatr. 1982;25(9):880-887.   Published online September 30, 1982
This experiment was carried out to investigate the effects of anticancer drugs on the phagocytic function of reticuloendothelial system. The phagocytic activity was assessed by- means of carbon clearance method, after intravenous injection of vincristine(5 pg or 25 y^g/lOO gm of body weight) and adriamycin (70 pg or 350 ^g/100 gm of body weight) through one， two, and three times at the interval of...