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Original Article
Developmental and Behavioral Medicine
Is meconium exposure associated with autism spectrum disorders in children?
Ensiyeh Jenabi, Erfan Ayubi, Salman Khazaei, Saeid Bashirian, Mojtaba Khazaei
Clin Exp Pediatr. 2021;64(7):341-346.   Published online October 4, 2020
• Meconium exposure is weakly associated with an increased risk of autism spectrum disorder (ASD) development in children.
• More evidence based on large prospective cohort studies is required to conclude whether meconium exposure is associated with an increased risk of ASD.
Case Report
Misdiagnosis of fetus-in-fetu as meconium peritonitis
Yoon Joo Kim, Se Hyung Sohn, Ju Young Lee, Jin A Sohn, Eun Hee Lee, Ee Kyung Kim, Chang Won Choi, Han Suk Kim, Beyong Il Kim, Jung Hwan Choi
Clin Exp Pediatr. 2011;54(3):133-136.   Published online March 31, 2011

Fetus-in-fetu (FIF) is a rare congenital condition in which a fetiform mass is detected in the host abdomen and also in other sites such as the intracranium, thorax, head, and neck. This condition has been rarely reported in the literature. Herein, we report the case of a fetus presenting with abdominal cystic mass and ascites and prenatally diagnosed as meconium...

Original Article
Clinical characteristics of severe meconium aspiration syndrome
Chang Won Choi, Beyong Il Kim, Hyun Ju Lee, Kyoung Eun Joung, Gyu Hong Shim, In Suk Lim, Jin-A Lee, Ee-Kyung Kim, Han-Suk Kim, Jung-Hwan Choi
Clin Exp Pediatr. 2008;51(7):713-721.   Published online July 15, 2008
Purpose : This study aims to describe the clinical characteristics of severe meconium aspiration syndrome (MAS) which required mechanical ventilation over 48 h and to delineate the progress of respiratory failure and radiographic findings in severe MAS. Methods : Twelve infants admitted to the Neonatal Intensive Care Unit (NICU) of the Seoul National University Bundang Hospital diagnosed with severe MAS from...
Effect of surfactant lavage in severe meconium aspiration syndrome
Soon Min Lee, He Min Kim, Ji Hyun Jeon, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee
Clin Exp Pediatr. 2008;51(4):367-371.   Published online April 15, 2008
Purpose : The surfactant dysfunction may play an important role in meconium aspiration syndrome (MAS). We aim to evaluate the effect of surfactant lavage in the treatment of term infants with MAS. Methods : The medical records of 15 neonates with severe MAS admitted at Yongdong Severance Hospital from 2005 to 2007 were reviewed and analyzed. Seven infants with severe...
A case of cystic fibrosis presented with meconium ileus in a female neonate
In-Ok Hwang, Eun-Sil Lee
Clin Exp Pediatr. 2007;50(12):1252-1256.   Published online December 15, 2007
Meconium ileus (MI) is the earliest clinical manifestation of cystic fibrosis (CF) in infants. It arises from the intraluminal accumulation of highly viscid, protein-rich meconium, typically present in the terminal ileum as a neonatal intestinal obstruction. Therefore, the clinical symptoms include abdominal distension, bilious vomiting and delayed passage of meconium. CF is caused by mutations in the transmembrane conductance regulator...
Clinical observation of meconium aspiration syndrome and effect of suctioning through endotracheal intubation on prognosis of meconium aspiration syndrome
Yong Ho Yoon, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin
Clin Exp Pediatr. 2007;50(10):959-964.   Published online October 15, 2007
Purpose : The purpose was to investigate the clinical considerations of patients affected by meconium aspiration syndrome (MAS) and the effect of suctioning through endotracheal intubation immediately after delivery on the prognosis of MAS. Methods : A total of 44 inpatients diagnosed as MAS in the Neonatal Intensive Care Unit (NICU) at Cheil Hospital were selected from January 2004 to...
Case Report
A Case of Meconium Peritonitis Accompanied with Hydrocele
Hoi Kyung Yoon, Ha Young Roh, Jin Hwa Kook, Young Youn Choi, Sang Young Chung
Clin Exp Pediatr. 2004;47(4):448-452.   Published online April 15, 2004
Meconium peritonitis is a rare disease in neonates, characterized by intraperitoneal calcification, numerous fibrosis with or without pseudocyst formation due to antenatal extravasation of meconium. Meconium peritonitis may result in a number of genital manifestations, including inguinal and scrotal or labial hydrocele containing meconium or calcifications. Recently, increased numbers of fetuses with meconium peritonitis have been prenatally diagnosed by ultrasonography....
Original Article
Effect of Meconium Components on Haemophilus influenzae Growth by Surfactan
Min Hee Kim, Sang In Chung
Clin Exp Pediatr. 1997;40(3):327-335.   Published online March 15, 1997
Purpose : Meconium is a complex mixture with a potential variable composition, it is difficulty to determine which components of meconium are responsible for the surfactant inhibition. We previous reported that Surfactant-TA and Exosurf almost completely inhibited the growth of Haemophilus influenzae at the concentration of 100% without apparent difference in the efficiency.In this study, We have determined the effect of...
Clinical Observation of Meconium Aspiration Syndrome : In Relation to Fetal Heart Rate Monitoring
Young Ran Yoon, Jin Sook Kim, Mi Kyung Kim, Sun Young Kho, Seong Ja Lee, Mi Jung Kim, Hye Kyung Han, Kyung Hoon Choi, Mi Na Lee
Clin Exp Pediatr. 1993;36(12):1656-1662.   Published online December 15, 1993
To identify the neonates at the risk of having meconium aspiration syndrome, the perinatal characteristics and finding of fetal heart rate monitorings in 366 neonates who had meconium-stained amniotic fluid were retrospectively reviewed. The results were as follows ; 1) Overall incidence of MAS was 0.7%. 2) Mortality rate of MAS was 5.8%. 3) The mean Apgar scores at 1-and 5-minute were...
Clinical Observation of Meconium Aspiration Syndrome: Prognostic Implication of Early Meconium Suctioning
Dae Hyun Kim, Dong Hoon Ko, Young Jong Woo, Young Youn Choi, Tae Ju Hwang
Clin Exp Pediatr. 1992;35(4):484-491.   Published online April 15, 1992
The authors observed the clinical findings of 36 patients with meconium aspiration syndrome(MAS) to evaluate the effect of early appropriated meconium suctioning on the morbidity and mortality of the syndrome. Patients in the study group, 20 babies born in Chonnam university Hospital, received appropriate meconium suction through endotracheal tube during and rig-ht after the delivery, while the patients in the...
Two cases of meconium peritonitis.
Hye Kyung Nam, Dong Hwan Lee, Sang Jhoo Lee
Clin Exp Pediatr. 1991;34(2):256-260.   Published online February 28, 1991
Meconium peritonitis is a non-bacterial foreign body and chemical peritonitis occurring during intrauterine or early neonatal life as the result of an abnormal communicatiion between the bowel contents and the peritonesal cavity. We experienced two cases of meconium peritonitis, diagnosed in according to the clinical and radiologic features, in two female neonates who had the chief complaint of vomiting and abdominal distention. A brief review...
A clinical study on meconium-stained babies.
Cheol Ki Min, Sung Suk Bang, Chong Young Park, Hae Ran Lee, Choon Myung Ro
Clin Exp Pediatr. 1991;34(1):24-30.   Published online January 31, 1991
Among a total of 667 newborns delivered at Han Gang Sacred Heart Hospital from January 1988 to July 1989, a clinical study was done regarding meconium-stained babies. The results were summarized as follows: 1) The incidence of meconium staining was 25.9% (173 babies) and there was no difference of frequency in sex. 2) The higher the birth weigt and the gestational age, the higher the incidence of...
A case of Meconium Peritonitis.
Youn Young Yu, Hyun Soon Lee, Eui Bon Koo, Sung Won Kim, Gil Hyun Kim
Clin Exp Pediatr. 1990;33(9):1266-1270.   Published online September 30, 1990
Meconium peritonitis is an aseptic peritonitis caused by spill of meconium in the abdominal cavity through discontinuation of the intestine by any cause, which have taken place during intrauterine or perinatal life. We experienced a case of meconium peritonitis in an 1-day-old male neonate who had the chief complaint of dyspnea and abdominal distension. The review of the literature was made briefly.
A clinical and Statistical study of Meconium Stained Baby: A Two Year Prospective Study.
Joo Hyun Ham, Sang Yoon Ahn, In Joon Seol, Soo Jee Moon, Hahng Lee
Clin Exp Pediatr. 1990;33(9):1173-1179.   Published online September 30, 1990
Among the total of 2,483 Newborns delivered at Hanyang University Hospital from January 1987 to December 1988, a clinical study was performed of meconium stained baby. The results are summerized as follows: 1) The incidence of meconium staining was 13.4% (333 cases) in total 2,483 newborns. 2) In the groups that the birth weight is 2501 ~ 4000 gm and up to 4001 gm, the incidence...
A Clinical Study of Meconium Stained Baby and Culture of the Tracheal and Gastric Meconium.
Dong Ryong Lee, Sung Ho Bae, Yeon Kyun Oh, San Ho Kim
Clin Exp Pediatr. 1988;31(12):1580-1587.   Published online December 31, 1988
Among the total of 3,102 newborns delivered at Won Kwang University Hospital from September 1984 to December 1986, a clinical study was performed of meconium stained baby and culture of the tracheal and gastric meconium. The results were as follows: 1) The incidence of meconium staining was 8.8% (272 cases) and the positive rate of meconium culture was 22.8% (62 cases). 2) The cultures of tracheal and gastric...
A Study of Meconium Aspiration Syndrome.
Chae Sup Yoo, Mee Kyung Kim, Keun Lee, Jae Sun Jung
Clin Exp Pediatr. 1988;31(11):1425-1431.   Published online November 30, 1988
The authors observed 51 cases of meconium aspiration syndrome in newborns who were bom at Ewha Womans University Hospital during the period of January 1986 through May, 1987. The results are summarized as follows: 1) The incidence of meconium aspiration syndrome was 1.6% (51 cases). 2) There was a significantly greater incidence of developing meconium aspiration syndrome in meconium stained babies who had toxemia mothers and low...
Diagnosis of Meconium Aspiration by Spectrophotometric Analysis of Urine.
Chang Yul Kim, Hye Kyung Bae, Mee Kyung Namgoong, Baek Keun Lim, Joong Soo Kim
Clin Exp Pediatr. 1988;31(10):1275-1280.   Published online October 31, 1988
We measured optical density of aqueous extracts of meconium and meconium stained amniotic fluid at 390 nm, 405 nm, 420 nm, 435 nm, 450 nm by spectrophotometry. We also applied the spectrophotometric method to the urine from 25 infants with clinical sign of meconium aspiration and from normal infants. The absorption band at 450 nm observed on the spectra of urine was estimated as...
A Study on Prognostic Factors of Meconium Aspiraion Syndrome.
Oh Kyung Lee, Hong Chul Lee, Wan Seoub Kim, Myung Ho Lee
Clin Exp Pediatr. 1988;31(9):1114-1119.   Published online September 30, 1988
We observed 42 cases of neonates, who were diagnosed as having Meconium aspiration syndrome in neonatal intensive care unit of Presbyterian Medical Center from July 1984 to May 1987. The followings were obtained: 1) The incidence of Meconium aspiration syndrome was 0.6% of all deliveries and 7.4% of meconium stained babies. 2) The geatational age was over 37 weeks in all cases and the body weight was...
A Prospective Study of Urinary beta2 -Microglobulin in Infants with Meconium-Stained Amniotic Fluid.
Sung Oh Kim, Jeh Hoon Shin, Woo Gill Lee, Soo Jee Moon, Keun Soo Lee
Clin Exp Pediatr. 1988;31(8):968-976.   Published online August 31, 1988
We studied prospectively whether events that result in meconium staining may be associated with additional abnormalities that are not clinically apparent associated by measurements of urinary concentrations of β₂-microglobulin indicating renal proximal tubular functions. Among 61 fullterm, healthy neonates delivered at Hanyang University Hospital during the period of September 1986 through April 1987, urinary concentration of β₂-microglobulin and creatinine were measured during the immediate perinatal...
Meconium Staining; A Five Year Retrospective Review.
Kei Hag Son, Kyun Woo Lee, Hong Bae Kim, Soom Ok Byun, Ji Sub Oh
Clin Exp Pediatr. 1987;30(1):26-34.   Published online January 31, 1987
Among a total of 15,250 newborns delivered at wallace memorial Baptist Hospital in a 5 year period from January 1980 to December 1984, a clinical study was done regarding meconium stained babies. The results were summarized as follows; 1) The incidence of meconium staining was 10.94% (1,669 babies). 2) Most of the meconium group (95.08%) had a birth weight exceeding 2,500 grams. The incidence of meconium staining...
Case Report
Two Cases of Meconium Peritonitis.
Yeong Ho Ra, Soon Don hong, Sang Ho Park, Kyu Chul Choi, Chong Woo Bae, Chang Il Ahn
Clin Exp Pediatr. 1986;29(11):1239-1244.   Published online November 30, 1986
We experienced two cases of meconium peritonitis with sigmoidal perforation in three-day-old male neonate and ileal perforation in one-day-old male neonate, respectively which were treated by primary closure. Literatures are reviewed briefly.
Original Article
Two Cases of Meconium Peritonitis.
Hye Jin Lim, Hae Young Kim, Yang Suk Choi, Jung Woo Yang
Clin Exp Pediatr. 1986;29(6):674-678.   Published online June 30, 1986
Meconium peritonitis is an aseptic peritonitis caused by spill of meconium in the abdominal cavity through one or several intestinal perforations which have taken place during intrauterine life or early neonatal life. We experienced two cases of Meconium Peritonitis in a 1 day-old male baby and a 2day-old male baby who had the chief complaint of vomiting and abdominal...
Spontaneous Pneumothorax in the Newborn.
Dong Gwan Han
Clin Exp Pediatr. 1985;28(1):16-24.   Published online January 31, 1985
A retrospective 13 medical records of symptomatic and spontaneous pneumothorax of newborn has been reviewed, which occurred during last 13 years from Jan. 1971 through Dec. 1983 at Pediatric Department of Yonsei Medical School. Spontaneous pneumothorax was defined one with pneumothorax which was not given positive pressure or intubation. And following results W6re obtained; 1)The incidence of spontaneous pneumothorax in...
A Clinical Observation of Meconium Aspiration Syndrome.
Chul Lee, Kook In Park, Jean Young Lee, Dong Gwan Han
Clin Exp Pediatr. 1984;27(10):958-964.   Published online October 31, 1984
The Authors observed 51 cases of meconium aspiration syndrome in newborns who were born at Severance Hospital during the period of Jan. 1980 through Jun. 1983. The following results were obtained: 1) The incidencs of meconium aspiration syndrome was 0.6%(51 cases). 2)88.2% of newborn with meconium aspiration syndrome was weighing more than 2,500 gm and 93.1% of that was with a...
A Clinical Statistics of Meconium-Stained Baby.
Choong Hee Kim, Soon Hee Choi, Seung Joo Lee, Keun Lee
Clin Exp Pediatr. 1981;24(10):950-956.   Published online October 15, 1981
Clinical study on meconium-stained babies among 6190 newborn's delivered at EWHA Womans University Hospital in 5-year period from January 1973 to December 1977 was. The results are summarized as follows: 1) The incidence of meconium staining was 10.87% in total 6190 newborns. 2) There was a tendency of increasing incidence of meconium staining in babies with higher birth weights and...