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Original Article
Subclinical left ventricular dysfunction in children after hematopoietic stem cell transplantation for severe aplastic anemia: a case control study using speckle tracking echocardiography
Beom Joon Kim, Kyung Pil Moon, Ji-Hong Yoon, Eun-Jung Lee, Jae Young Lee, Seong Koo Kim, Jae Wook Lee, Nack Gyun Chung, Bin Cho, Hack Ki Kim
Clin Exp Pediatr. 2016;59(4):190-195.   Published online April 30, 2016

Severe aplastic anemia (SAA), a fatal disease, requires multiple transfusion, immunosuppressive therapy, and finally, hematopoietic stem cell transplantation (HSCT) as the definitive treatment. We hypothesized that iron overloading associated with multiple transfusions and HSCTrelated complications may adversely affect cardiac function. Left ventricular (LV) function was assessed in children after HSCT for SAA.


Forty-six consecutive patients with a median age of 9.8...

Case Report
Graves disease following rabbit antithymocyte globulin treatment of severe aplastic anemia in a Korean child
In Su Choi, Han Kyul Kim, Dong Kyun Han, Hee Jo Baek, Hae In Jang, Chan Jong Kim, Hoon Kook
Clin Exp Pediatr. 2015;58(7):267-269.   Published online July 22, 2015

Antithymocyte globulin (ATG) is used as an immunosuppressive treatment (IST) to deplete clonal suppressor T cells in patients with severe aplastic anemia (SAA). The depletion of suppressor T cells by ATG may affect the activation of B cells, which results in an increased risk for autoimmune conditions. A 12-year-old boy was diagnosed with idiopathic SAA. As he did not have...

Review Article
Haploidentical hematopoietic stem cell transplantation in children and adolescents with acquired severe aplastic anemia
Ho Joon Im, Kyung-Nam Koh, Jong Jin Seo
Clin Exp Pediatr. 2015;58(6):199-205.   Published online June 22, 2015

Severe aplastic anemia (SAA) is a life-threatening disorder for which allogeneic hematopoietic stem cell transplantation (HSCT) is the current available curative treatment. HSCT from matched sibling donors (MSDs) is the preferred therapy for children with acquired SAA. For patients who lack MSDs, immunosuppressive therapy (IST) is widely accepted as a first-line treatment before considering HCT from an unrelated donor (URD)....

Aplastic anemia
Hack Ki Kim
Clin Exp Pediatr. 2007;50(6):519-523.   Published online June 15, 2007
Aplastic anemia is a rare disease, which is characterized by pancytopenia and hypocellular bone marrow without infiltration of abnormal cells or fibrosis. The incidence in Asia is higher than in the West and new cases are diagnosed at a rate of 5.1 per million pediatric populations per year in Korea. The pathophysiology is understood roughly by defective hematopoiesis, impaired bone...
Case Report
A Case of Aplastic Anemia following Hepatic Failure by Acute Hepatitis
Hye Jin Ku, Young Tak Lim, Jae Hong Park
Clin Exp Pediatr. 2004;47(12):1356-1359.   Published online December 15, 2004
Aplastic anemia following acute hepatitis or acute hepatic failure is an uncommon disease and has a poor prognosis. We experienced a case of aplastic anemia following acute hepatic failure in a 10- year-old girl. She was admitted because of jaundice and lethargy for 8 days. Laboratory findings revealed marked elevated serum transaminases and bilirubin levels, prolonged prothrombin time and partial...
Original Article
Immunomodulation Therapy in Aplastic Anemia : Relapse Rate, Complications and Long-term Survival During Follow-up for More than 1 Year
Jun Ah Lee, Hyoung Jin Kang, Hyo Jeong Han, Hyoung Soo Choi, Eun Sun Yoo, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(6):775-784.   Published online June 15, 1998
Purpose : We evaluated the response to immunomodulation therapy, long-term survival and relapse rate of aplastic anemia during follow-up for more than 1 year. Methods : Twenty-eight children, with moderate to severe aplastic anemia were followed for more than one year and 7 children expired after therapy, were analyzed. Antilymphocyte globulin(ALG) or antithymocyte globulin(ATG) by itself was given to 27 patients, and cyclosporine A(CsA)...
Antilymphocyte Globulin Therapy for Aplastic Anemia in Children
Soo Jong Hong, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1994;37(11):1526-1539.   Published online November 15, 1994
Immunosuppressive therapy based on the use of antilymphocyte globulin (ALG) has become standard therapy for patients with aplastic anemia who are not eligible for bone marrow transplantation. In this study, T cell subsets before and after ALG therapy, hematologic responses, complications and prognostic factors were analysed. Eleven (42%) out of twenty-six patients treated with ALG showed response, but...
Treatment of severe aplastic anemia: comparison between bone marrow transplantation and immunomodulation.
Dae Chul Jeong, Sung Dong Choi, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Du Bong Lee
Clin Exp Pediatr. 1991;34(2):172-179.   Published online February 28, 1991
Twenty, six children younger than 15 years with severe aplastic anemia underwent either bone marrow transplantation or immunomodulation therapy (antilymphocyte globulin with cyclosporin A therapy). Six patients who had an HLA-identical sibling donor underwent bone marrow transplantation after conditioning with cyclophosphamide, procarbazine and antilymphocyte globulin. Twenty children who did not have an HLA-identical donor recieved antilymphocyte globulin and cyclosporin A. The results were as follows; 1) Hematologic responses:...
A Case of Aplastic Anemia Following hepatitis.
Gae Soon Yeo, Doo Kweon Kim, Chul Ho Kim, Soon Yong Lee
Clin Exp Pediatr. 1990;33(6):864-869.   Published online June 30, 1990
We experienced a case of aplastic anemia following hepatitis in a 4-year-old girl. Pancytopenia was developed during the convalescent period of hepatitis, and it was getting worse, while serial data of liver function test showed improvement. We tried a methylprednisolone pulse therapy, and about 7 months after treatment the CBC findings returned completely normal. She has enjoyed her healthy life during follow-up of over 2...
Immunomodulation Therapy in Children with Aplastic Anemia.
Won Suk Suh, Ki Sik Min, Woo Gun Choi, Hack Ki Kim, Kyoung Sn Lee, Soon Yong Lee
Clin Exp Pediatr. 1990;33(2):170-177.   Published online February 28, 1990
Thirty patients with aplastic anemia(fifteen severe aplastic anemia and fifteen moderate aplastic anemia) treated with antilymphocyte globulin and cyclosporin A as a kind of immunomodulation therapy were studied by analysing hematologic reseponses and complications. The results were as follows; 1) Nineteen out of thirty patients (63.3%) treated with anti lymphocyte globulin plus cyclosporin A showed responses (complete response of 33.3%, partial response of 30.0%). 2) Hematologic responses according...
Bone Marrow Cell Culture(GM-CFU) in Anaplastic Anemia of Children.
Jae Sun Jung, Chang Yee Hong
Clin Exp Pediatr. 1985;28(9):888-898.   Published online September 30, 1985
Bone marrow cell cultures (GM-CFU) were performed in the 15 cases of children with aplastic anemia and the correlation with the clinical course were investigated. They have been treated with androgen with or without low dose prednisone and supportive care. Bone marrow cell cultures from 8 children without any evidence of aplastic anemia were performed as a control. 1)In control...
Case Report
Two cases of Aplastic Anemia Following Hepatitis.
Chang Yeol Jeon, Beyung Sang Choi, Hyeon Sook Lee, Jung Soo Kim
Clin Exp Pediatr. 1985;28(1):73-77.   Published online January 31, 1985
Recently, we experienced two cases of aplastic anemia following hepatitis in 6 and 12year old boys. A 6 year old boy was admitted to Jeonbug National University Hospital in Dec. ’82, because of frequent expistaxis and petechiae on entire body. He had a history of hepatitis 2 months ago. On admission liver function was normal and pancytopenia was revealed. Bone...
Original Article
Clinical Study of Childhood Aplastic Anemia.
Sung Won Kim
Clin Exp Pediatr. 1984;27(12):1192-1201.   Published online December 31, 1984
The author reviewed the clinical findings of the 53 children diagnosed as aplastic anemia at the pediatric department of St. Benedict Hospital and W.M. Baptist Hospital, Busan, during a period of 12 years from January 1971 to December 1982. The results were summarized as follows: 1) Among the 53 children with aplastic anemia, the ratio between male and female was1.4 : 1. The male was...
Case Report
Two Case of Aplastic Anemia Following Hepatitis.
Mi Sook Park, Seung Ha Rheu, Young Gun Kim, Baek Keaun Lim, Jong Soo Kim
Clin Exp Pediatr. 1984;27(8):808-813.   Published online August 31, 1984
Aplastic Anemia following Hepatitis is an uncommon disease and it has a poor prognosis. Recently the authors experienced two cases of aplastic anemia following hepatitis in a 13 year old girl and a 14 year old boy. The thirteen year old girl was admitted following 2 months of Jaundice and 1 day df epistaxis. . At admission, pancytopenia developed and her...
A Case of Aplastic Anemia Following Hepatitis.
Woo Yeong Chung, Seung Won Park, In Soon Park, Chul Ho Kim, Soo Yong Lee
Clin Exp Pediatr. 1983;26(8):812-815.   Published online August 31, 1983
We experienced a case of aplastic anemia following hepatitis in a 11-year old male child. He was admitted because of pallor and gum bleedings with an episode of hepatitis 2 months prior to this admission. On admission CBC showed pancytopenia and there was marked hypocellularity of all hematopoietic elements in bone marrow aspiration. Transfusion and treatment with prednisolone and oxymetholone were tried but...
Original Article
A Study on Purpura in Children.
Jong Sub Lee, Kyung Ho Kim, Ki bok Kim
Clin Exp Pediatr. 1983;26(2):151-157.   Published online February 28, 1983
We have seen 96patients who were admitted with purpura to the Pediatric Department of Kwangju Christian Hospital during the period of 10 years from Jan., 1971 to Dec., 1980. The following observations were made; 1) Leukemia(26 cases, 27.0%) was the most common underlying disease, followed by allergic purpura (25 cases, 26.0%), idiopathic thrombocytopenic purpura (22 cases, 22.9%), Aplastic Anemia (13 cases, 13.5%), sepsis (5 cases,...
Case Report
A Case of Aplastic Anemia Following Hepatitis.
Chul Ho Lee, Hyo Jyung Kim, Hye Kyung Lee, Soon Jae Lee
Clin Exp Pediatr. 1983;26(1):81-85.   Published online January 31, 1983
A case of aplastic anemia following hepatitis is presented. A 13-year-old boy was admitted due to unexpected bleeding manifestations after recovery from hepatitis. There was marked pancytpenia and examiation of bone marrow revealed remarkable hypoplasia. His clinical course became worsened despite antibiotics, multiple transfusions and therapy with corticosteroid, oxymetholone. Related literatures are also briefly reviewed.
Original Article
Clinical Obseervation for Hematologic Disorders in Children.
Eung Sang Choi, Soon Ung Kang, Jeong Kee Seo, Hyo Seop Ahn, Chang Yoo Hong
Clin Exp Pediatr. 1981;24(3):235-244.   Published online March 15, 1981
Nine hundred and twenty-three cases of hematologic disorders in children who were admi-tted to department of pediatrics, SNUH, from 1955 to Oct. 1980 were analysed. The patients consisted of 624 males and 299 females. The results were as follows; 1.Mean annual percentage of hematologic patients among total admitted patients was 6.8%. 2.The peak age incidence of various hematologic disorders was...
Clinical Studies on Purpura in Children.
Change Soo Han, Seong Won Park, Yong Seob Kang, Cheol Ho Lee, Youn Ki Kim
Clin Exp Pediatr. 1981;24(1):56-62.   Published online January 15, 1981
This is a clinical study on 72 cases of purpura hospitalized at Han Il Hospital during the period from Jan., 1970 to Dec, 1979. The authors obtained the following results : 1) Allergic purpura (25 cases, 34.7%) was the most common disease, followed by I.T.P. (20 cases, 27.8%), Ieukemia (10 cases, 13.9%), meningoccemia (7 cases, 9.7%), and aplastic anemia (5...
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