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Original Article
Immunogenicity and Safety of Live Attenuated Vaccine(MAV/06srtain) on Healthy Children and Immunocompromised Children
Young Mo Sohn, Chul Joo Yu, Pyung Kil Kim, Kir Young Kim, Chong Young Park, Mi Ran Kim, Woo Kap Jeung, Kyu Kye Hwang, Gyu Jin Woo, Song Yong Park
Clin Exp Pediatr. 1995;38(6):771-777.   Published online June 15, 1995
Purpose : To study the safety and immunogenicity of new live attenuated varicella vaccine (MAV/06strain) in normal healthy children and immunocompromized children in Korea. Methods : Blood samples for fluorescent antibody to membrane antigen(FAMA) assay were taken before the vaccination among seven hundred forth five healthy children and twenty two nine immunocompromised children. One hundred and seventy seven children and twenty...
Clinical Differences by Karyotype in Patients with Turner Syndrome
Mi Jung Park, Jin Sung Lee, Kir Young Kim, Duk Hi Kim, Ho Seoung Kim
Clin Exp Pediatr. 1995;38(2):143-150.   Published online February 15, 1995
Purpose : The aim of this study was to evaluate clinical differences by karyotype in Turner Syndrome. Methods : We evaluated 66 patients with Turner syndrome diagnosed at Yonsei University College of medicine from Mar.1985 to Feb.1993. We divided subproups as pure 45,X groups, mosaisism groups and structural aberration groups. Clinical features, serum estrogen, LH, FSH, concentrations, gonadotropin release after GnRH...
Risk Factors for Hyperglycemia in Children with Leukemia Receiving L-asparaginase
Min Joong Kwon, Ho Sung Kim, Kir Young Kim, Duk Hi Kim
Clin Exp Pediatr. 1994;37(6):740-745.   Published online June 15, 1994
Hyperglycemia is a well-recognized side effect of L-asparaginase in remission induction therapy of acute lymphocytic leukemia. Since hyperglycemia has preceded fatal diabetic ketoacidosis or hyperosmotic nonketotic coma in some patients, early detection and treatment of this complication are important. We determined retrospectively the risk of hyperglycemia in 117 patients with leukemia who had received L-asparaginase (& prednisolone). The results were as...
Renal size as a Prognostic Factor in Childhood Acute Lymphocytic Leukemia
Soo Kyung Yun, Chang Hyun Yang, Chuhl Joo Lyu, Seung Hwan Oh, Kir Young Kim, Myung Joon Kim
Clin Exp Pediatr. 1994;37(2):174-179.   Published online February 15, 1994
The Kidney size is of special interest during the diagnostic work up of acute lymphocytic leukemia. But is still uncertain whether a finding of kidney enlargement at presentation has long-term prognostic value. We therefore reviewed the kidney size in children with acute lymphocytic leukemia by abdominal ultrasonograms at the time of diagnosis (n=54) and examined if there was any statistical...
A Clinical Study of Testicular Relapse in Childhood Acute Lymphocytic Leukemia
Hye Ok Roh, Chuhl Joo Lyu, Seung Hwan Oh, Chang Hyun Yang, Kir Young Kim, Byung Soo Kim
Clin Exp Pediatr. 1993;36(5):680-686.   Published online May 15, 1993
From January 1984 to June 1991, we studied testicular relapsed patients among 105 cases of acute lymphocytic leukemia in children who were admitted to the Department of Pediatrics and Yonse Cancer Center, Yonsei University Severance Hospital. The results were as follows: 1) 15 out of 105(14.4%) cases of acute lymphocytic leukemia were diagnosed as testicular relapse. According to the prevalence by the...
A case of de Novo trisomy 12p syndrome.
Young Huuk Lee, Kir Young Kim
Clin Exp Pediatr. 1991;34(11):1581-1586.   Published online November 30, 1991
A case of de novo trisomy 12p syndrome has deen experienced in newborn male child recently. This male child manifested normal birth weight, weak crying, poor sucking, generalized hypotonia, multiple congenital anomalies on face and digits, and progressive psychomotor retardation. The diagnosis was made on the basis of typical morphologic features and chromosomal study. As this is the first case in Korea, it is...
Sodium and calcium transport in spherocytic red blood cells.
Shin Heh Kang, Kir Young Kim, Young Ho Lee, Bok Soon Kang
Clin Exp Pediatr. 1991;34(7):978-991.   Published online July 31, 1991
Hereditary spherocytosis (HS) is an autosomal, dominantly inherited hemolytic disorder which shows characteristic spherocytes on peripheral smear. As spherocytes are rounder, more fragile and susceptible to extravascular hemolysis in the spleen, HS patients suffer from variable degrees of anemia, jaundice, splenomegaly and gall stones. However the pathogenesis is heterogenous in HS, such as spectrin deficiency, decreased spectrin-protein 4.1 binding, increased spectrin binding to the RBC...
The role of exchange transfusion as a therapy for neonatal DIC.
Jung Tak Kim, Kook In Park, Ran Namgung, Dong Gwan Han, Kir Young Kim
Clin Exp Pediatr. 1991;34(1):31-40.   Published online January 31, 1991
A clinical study on the effects of exchange transfusion on disseminated intravascular coagulation was conducted on 32 patients with DIC who were admitted to the pediatric department of YUMC from January 1984 to June 1989. We diagnosed DIC when symptoms were compatible to the diagnosis and there were more than 3 abnormal laboratory findings out of the following 5, which were platelet count, PT,...
A Case of 9p-Syndrome.
Bok Hoi Kim, Shin Heh Kang, Kir Young Kim, Kyung Ja Cho, Kyung Hee Ha, Bum Suk Lee
Clin Exp Pediatr. 1990;33(9):1262-1265.   Published online September 30, 1990
We experienced a case of 9p- syndrome in a 2 year and 5 month old male child who manifested psychomotor retardation and multiple congenital anomalies. His karyotype was 46, XY, del (9) (p22). A brief review of literature was also presented.
Study on Antithyroid Antibody and Thyroid Functional Status in Patients with Turner Syndrome.
Bo Young Lee, Duk Hi Kim, Kir Young Kim
Clin Exp Pediatr. 1989;32(10):1397-1401.   Published online October 31, 1989
This study is a systematic cytogenetic and clinico-hormonal analysis of 26 cases who were diagnosed as Turner syndrome at the Yonsei Medical Center from Jan. 1978 to Jan. 1988. Antithyroid antibody and thyroid function tests were performed in Turner syndrome(3 groups according to karyotypes) and control group. The results were as follows: 1) The incidence of positive antithyroid antibody in the 26 cases was 42.3% and...
A Case of Patient with Common Variable Immunodeficiency.
Keun Cheon Kim, Chang Gee Kang, Chang Hyun Yang, Dong Soo Kim, Kir Young Kim
Clin Exp Pediatr. 1989;32(8):1123-1127.   Published online August 31, 1989
Common variable immunodeficiency, as defined by World Health Organization classification of primary immunodeficiency, is a heterogenous group of disorders with hypogammaglobulinemia, decreased ability to produced antibody following antigenic challenge, and increased incidence of infections. The disorder was often familial, but no mode of inheritance has been discerned. Clinical fingings are recurrent bacterial infections, particularly respiratory infection. Laboratory evaluations in common variable immunodeficiency demonstrate decrease in...
The Direct Coombs Test and Heat Elution Test in ABO Incompatible Hemolytic Disease of the Newborn.
Kook In PArk, Chul Lee, Ran Namgung, Dong Gwan Han, Kir Young Kim
Clin Exp Pediatr. 1988;31(12):1633-1640.   Published online December 31, 1988
The clinical study on 28 cases of ABO HDN who were diagnosed at Pediatric Department of Severance hospital and Yong Dong Severance hospital, Yonsei University for last 5 months was. And in these cases, heat elution test in combined with direct Coombs test using standard techniques were performed to evaluate the clinical significance of serological diagnosis. The following results were obtained. 1) Of 28 ABO HDN...
A Case of Thrombotic Thrombocytopenic Purpura in Childhood.
Dong Kun Hyun, Jung Bae Lee, Chang Hyun Yang, Kir Young Kim
Clin Exp Pediatr. 1988;31(4):511-518.   Published online April 30, 1988
Thrombotic thrombocytopenic purpura is clinically characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, renal disorder and transient bizarre neurological symptoms. Its essential histological lesion consists of numerous complete or, more often, incomplete occlusions of the arterioles and capillaries by hyaline material. We have experienced a case of thrombotic thrombocytopenic purpura in infancy. The patient was a one year and 4 month-old who complains petechiae on the...
A Case of Multiple Congenital Abnormalities Associated with Ring Chromosome 13.
Yung Hyuk Lee, Dong Won Choi, Chang Jun Coe, Kir Young Kim
Clin Exp Pediatr. 1988;31(4):506-510.   Published online April 30, 1988
A case of ring chromosome 13 has been experienced in 1 year and 9 month old female child recently. This female child manifested psychomotor retardation and multiple congenital anomalies. The diagnosis was made on the basis of typical morphologic features and chromosome study. As this is the first case in Korea, it is worthwhile to report with reviewing literature.
A Clinical Study and Comprehensive Total Care in Hemophilia.
Shin Heh Kang, Chang Hyun Yang, Kir Young Kim
Clin Exp Pediatr. 1988;31(2):202-211.   Published online February 28, 1988
Hemophilia is one of the hereditary coagulation disorders characterized by deficiency in plasma clotting facotrs such as factor VIII and IX. As life long bleeding occurs in hemophiliacs, continous comprehensive total care is required for the patients. After the self therapy, home care program was introduced in the 1970s’ in the United States, there was significant reduction in absentism, hospitalized days, outpatient visits, decrease...
A Clinical Studies in Patients with Turner's Syndrome.
Chang Hyun Yang, Duk Hi Kim, Kir Young KIm, Young Ho Yang
Clin Exp Pediatr. 1987;30(10):1143-1151.   Published online October 31, 1987
This study is systematical cytogenetic and clinico-hormonal analysis of 42 cases who were diagnosed as Turner’s syndrome at the Yonsei Medical Center from Jan. 1971 to Dec. 1985. The careful history taking, physical examination, cytogenetic studies, radiologic and hormonal evalua- tion, and GnRH stimulation test were performed. The results were as follows. 1) The patients ranged in age from 14 months to 30 years at the...
Registry System and Medical Control Program in Congenital Diseases.
Kir Young Kim
Clin Exp Pediatr. 1987;30(7):712-715.   Published online July 31, 1987
The Response of Leukocytes in the Peripheral Blood Following Exchange Transfusion in the Newborn.
Young Mo Sohn, Yu Young Chang, Young Ho Kim, Kir Young Kim
Clin Exp Pediatr. 1983;26(11):1049-1054.   Published online November 30, 1983
We have studied the hemoglobin level and. leukocyte count of 23 fullterm and 1 premature jaundiced babies soon after exchange transfusion and daily thereafter until 7 days. The resixlts are: 1) One exchange transfusion was enough in 16 patients but 8 were required more than 2times of exchange transfusion. The maximum is 6 times. 2) The postnatal age was...
Etiological & Clinical Study for Neonatal Hepatitis & Biliary Atresia.
Ki Sub Chung, Kir Young Kim, Hyo Kyu Kim
Clin Exp Pediatr. 1983;26(5):440-448.   Published online May 31, 1983
The following result WBS obtained through the clinical observation of 67 cases with neonatal hepatitis, 7 cases with extrahepaticbiliary atresia, 1 case with intrahepatic biliary atresia admitted at Department of Pediatrics, Yonsei University Hospital during the period of January, 1979 through October, 1982. The clinical & etiological study was performed by the Hepatitis B marker, Liver function test, Liver scan, pathologic findings by percutaneous liver...
Clinical Observation of Dds Induced Methemoglobinemia.
Hee Seon Auh, Kwan Hwooy Cho, Kir Young Kim, Duk Jin Yun, Sook Pyo Kwon
Clin Exp Pediatr. 1983;26(3):257-264.   Published online March 31, 1983
Various compounds activate the oxidation of hemoglobin. These include nitrites, sulfonamides, aniline derivatives, chlorates, quinones, acetanilid and phenacetin. The striking offender has been DDS in infancy and childhood who live in Kangwon Do, Korea. The common untoward effects of DDS are hemolytic anemia and methemoglobinemia. This clinical study was carried out for analysis on 57 cases which were diagnosed as DDS induced methemoglobinemia at...
A study in The Changes of Platelet Count in iron Deficiency Anemia among Children.
Nam Ae Kim, Kir Young Kim
Clin Exp Pediatr. 1982;25(10):1015-1021.   Published online October 31, 1982
Iron deficiency anemia (IDA) is the most common nutritional anemia among chidren. A study on the changes of platelet count in IDA was conducted with 83 children who were diagnosed at the Severance Hospital in a 5 J/2-year pericd from Jan. 1975 to Jun. 1981. The results are summarized as follows. 1. IDA was most common among chidren younger than 2-years(61%) due to nutritional deficiency. It...
Allogenic bone marrow transplantation in rabbit.
Kir Young Kim, Duk Hee Kim, Young Mo Shon, Kwan Sub Chung, Hong Jin Kim, Duk Jin Yun
Clin Exp Pediatr. 1982;25(9):867-879.   Published online September 30, 1982
Allogenic bone marrow transplantation was done with Korean unspecified rabbits. Fresh bone marrow cell of different sex was infused to the recipient. The study group was divid- edfive groups according to immunosuppresive drugs. Each group was consited of 20 rebbits, was exposed to 1200 Rad. Group A, which were not have bone marrow transplantation, showed 100% mortality rate after 8 weeks. Group 8, which did not...
Clinical Observation of Hemolytic Anemia in Children Except Isoimmunization.
Hak Yong Kim, Young Mo Sohn, Kwan Sub Chung, Kir Young Kim, Duk Jin Yun
Clin Exp Pediatr. 1981;24(12):1149-1156.   Published online December 15, 1981
Hemolytic anemia is caused by early destruction of red cells and there are many etiologies,ecently, prosthetic devices are used frequently to correct cardiac diseases and they also cause hemolytic anemia. We performed clinical analysis of 74 patients with hemolytie anemia who had been diagnosed at Severance hospital in recent 10 years. Results were as follows: 1)In 74 cases, male were 46...
Case Report
A Case of Acute(infantile) Gaucher's Disease.
Baek Keun Lim, Kwan Sub Chung, Jae Seung Lee, Kir Young Kim, Byung Soo Kim, Duk Jin Yun, Chang Jin Kim, Chan Il Park
Clin Exp Pediatr. 1981;24(10):982-990.   Published online October 15, 1981
A case of Acute infantile form of Gaucher's disease in Korean infant is described. The large cells characteristically found in the bone marrow and liver in Gaucher's disease have been investigated with electron microscope, as well as light microscope. The pertinent literature has reviewed briefly concerning the clinical and laboratory fingings, roentgenographic picture, pathogenesis, pathology, diagnosis and treatment of this...
Original Article
Cluster of Guillain-Barre Syndrome.
Young Mo Sohn, Sung Sik Lee, Kwan Sub Chung, Ki Sub Chung, Seung Kyu Lee, Pyung Kil Kim, Kir Young Kim, Duk Jin Yun, Kyoung Ja Cho
Clin Exp Pediatr. 1981;24(9):820-825.   Published online September 15, 1981
Of 7 cases of Guillain-Barre syndrome reviewed, which was admitted to the Department of Pediatrics Yonsei University, College of Medicine during 3 months period from July through September 1980, serologic surveys for an infectious agent were found to be without demonstrable causes such as cytomegalovirus and measles virus. We reviewed 87 acses of Guillain-Barre syndrome, which was admitted to our...
Clinical Study on Neonatal Meningitis.
Kyo Sun Kim, Kee Young Lee, Kir Young Kim, Duk Jin Yun
Clin Exp Pediatr. 1981;24(8):709-722.   Published online August 15, 1981
A clinical study was made on 58 cases of neonatal meningitis occuring under the age of 1 month in the department of Pediatrics at Severance Hospital, yonsei University College of Medicine, from Jan. 1, 1965 to Dec. 31, 1978. 1. The sex ratio of male and female was approximately 1.8:1. 2. Neonatal predisposing factors significantly associated with meningitis were omphalitis(14...
Case Report
Two Cases of Cri Du Chat(5p-) Syndrome.
Han Soo Choi, Sung Seek Lee, Chul Lee, Kwan Sub Chung, Pyung Kil Kim, Kir Young Kim, Sa Suk Han
Clin Exp Pediatr. 1981;24(6):597-602.   Published online June 15, 1981
We have experienced two cases of the Cri Du Chat Syndrome. The first case, 1 and 11/12 year old female, was admitted to evaluated profound mental retardation and failure to thrive. The other, 3 month old female, visit this dept for cat-like cry. They had the typical clinical characteristics of the Cri Du Chat Syndrome and showed showed the classical...
Original Article
The Study of Fetomaternal Transfusion in Korea.
Chul Lee, Jun Hee Sul, Kir Young Kim, Duk Jin Yun
Clin Exp Pediatr. 1980;23(12):983-990.   Published online December 31, 1980
Blood samples from mothers during labor and after delivery were tested for the occurrence of fetomaternal transfusing using Nierhaus acid elution technique. Fetomaternal transfusion had occured 1/2 of the mothers after delivery, 2/3 of the mothers during labor. The fetomateonal transfusions after delivery were most often less than 4.0?? and only few percent had fetomaternal transfusions more than 4.0??. Complicated...
Case Report
Histiocytic Medullary Reticulosis in childhood Report of Three Cases.
Kwan Sub Chung, Kyo Sun Kim, Do Kwang Yun, Pyung Kil Kim, Kir Young Kim, Byung Soo Kim, Tae Jung Kwon, In Jun Chor
Clin Exp Pediatr. 1980;23(10):833-842.   Published online October 15, 1980
Three cases of hisiocytic medullary reticulosis occurring in children aged 6 years, 9 years and 14 years, are described. In all children the diagnosis was based on anemia, granulocytopenia, thrombocytopenia and marked erythrophagocytosis by bone marrow and lymph node atypical histiocytes. They all showed immediate remission with combined chemotherapy of vinblastine and prednisolone, but Case 1 eventually died at 6...
Emergencies in Hemophilia.
Dong Soo Kim, Kwan Sub Chung, Kir Young Kim, Duk Jin Yun
Clin Exp Pediatr. 1980;23(10):809-814.   Published online October 15, 1980
9 classic hemophilacs in Severance Hospital, Yonsei University from Dec. '77 to Aug. '79 were reviewed and analysed and the following results were obtained. 1. Intracranial hemorrhage is required the most immediate emergent therapy in hemophiliacs and computerized transverse axial tomogarhy may be essential for the accurate and noninvasive diagnosis and for the effective emergency treatment. 2. To conserve supplies...