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Original Article
Hemodynamic Status of Subpulmonic Ventricular Septal Defect in Relation to Morphologic Changes of Aortic Valve
Myung Hyun Sohn, Jae Young Choi, Jong Kyun Lee, Jun Hee Sul, Sung Kyu Lee, Bum Koo Cho
Clin Exp Pediatr. 1996;39(8):1103-1110.   Published online August 15, 1996
Purpose : Subpulmonic ventricular septal defect is clinically important because the risks of aortic regurgitation and endocarditis are substantially increased. This study was conducted to evaluate the effect of hemodynamic changes induced by structural anomalies of aortic valve on the surgical outcome. Methods : This clinical study was done by reviewing the medical records of 124 patients who were diagnosed and surgically managed at the...
The Usefulness of Clinical Scoring System as Prognostic Predictor in Neonatal Seizure
Hyunmi Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(6):829-838.   Published online June 15, 1996
Purpose : Neonatal seizure is usually the presentation of underlying neurologic dysfunction rather than a disease and have high mortality and morbidity as sequalae. Therefore, the parameter predicting the neurologic prognosis is necessary. This study was performed to identify the usefulness of clinical scoring as predictor in neonatal seizure by analyzing outcomes. Methods : From 1982 to 1994, 101 neonates were admitted to Neonatal Intensive...
Mucormycosis in Leukemic Children
Seung Ghon Nam, Eun Wha Choi, Jin Young Park, Jong Jae Kim, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn
Clin Exp Pediatr. 1996;39(3):379-388.   Published online March 15, 1996
Purpose : Mucormycosis is an opportunistic fungal infection caused by one of the ubiquitous fungi of the order Mucorales, occurring almost exclusively in immunocompromised hosts such as patients with diabetes, leukemia and lymphoma. Recently the incidence of mucormycosis is rising associated with the increasing predisposing factors such as cytotoxic drugs and immunosuppressive agents. Though mucormycosis is frequently fatal, there has...
The Study of Distribution of HI Antibody Titers Aganist Japanese Encephalitis Virus Among Children in Seoul
Jin A Kim, Tae Sung Ko, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Hae Wol Cho
Clin Exp Pediatr. 1996;39(2):230-237.   Published online February 15, 1996
Purpose : Incidence of Japanese encephalitis has been markedly decreased, but this disease is known to be high and lethal in the young age group. This study was designed to find out the HI antibody titers and associated factors of Japanese encephalitis of children in Seoul, and to establish the plan of vaccination. Methods : The survey was conducted from the...
Surfactant Protein SP-A, B, and C: Purification and Biochemical Characterization
Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Kil Lyong Kim, Kyung Soo Hahn
Clin Exp Pediatr. 1996;39(2):218-229.   Published online February 15, 1996
Purpose : Several kinds of exogenous pulmonary surfactants (SF), either synthetic or animalderived, are being used for the replacement therapy in respiratory distress syndrome (RDS) of newborn, especially in premature infants, and improved the neonatal mortality and morbidity. Because synthetic preparations are lack of surfactant protein (SP) and animal-derived preparations cause immunogenecity of heterogenous SP, there have been great necessity for the development of next...
Evaluation of Severity of Childhood Pancreatitis with Multiple Factor Scoring Systems
Young In Choi, Jeong Kee Seo
Clin Exp Pediatr. 1995;38(12):1653-1663.   Published online December 15, 1995
Purpose : Pancreatitis in children is not common but can be associated with severe morbidity rates. Early prognostic evaluation of acute pancreatitis assists in selecting those patients who should be closely monitored. We studied the clinical characteristics and prognostic factors in patients with acute pancreatitis. Methods : Twenty five children with pancreatitis were included ranging in age from 1.8 to 14.9...
Case Report
A Case of the Renal Artery Aneurysm Associated with the Dysplastic Kidney
Tae Hee Park, Soo Hee Chang, Young Min Han, Soo Chul Cho, Dae Yeol Lee
Clin Exp Pediatr. 1995;38(11):1571-1576.   Published online November 15, 1995
Multicystic dysplastic kidney is the most frequent cause of abdominal mass in the neonate. It is frequently associated with contralateral genitourinary tract abnormalities and the most common abnormality is vesicoureteral reflux. Renal artery aneurysm is very rare in the children. Furthermore the case associated with the renal artery aneurysm has not been reported yet. We experienced a case of the left...
Original Article
Ischemic Hepatitis in Children after Cardiac Operation -Analysis of Clinical Characteristics, Risk Factors and Outcome-
Kyung Mo Kim, Jeong Kee Seo
Clin Exp Pediatr. 1995;38(11):1540-1546.   Published online November 15, 1995
Purpose : We have experienced frequently the ischemic hepatitis after cardiac operations which shows rapid striking rise of transaminase. But the ischemic hepatitis in children after cardiac operation is not defined yet in Korea. We examined the clinical characteristics and analyzed the risk factors and outcome in 20 children who showed typical clinical course of ischemic hepatitis after cardiac operation. Methods...
A Follow-Up Study of Intractable Diarrhea in Early Infancy: Clinical Features of Cow's Milk Allergy and Cow Milk-Sensitive Enteropathy
Young Rak Kwon, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Chung, Young Dae Kwon
Clin Exp Pediatr. 1995;38(11):1515-1524.   Published online November 15, 1995
Purpose : The multiplicity of poorly defined illnesses and the variability of clinical and laboratory features elicited by milk ingestion in sensitized infants has made it difficult to differentiate them from the more common forms of cow milk intolerance. Following up the cases of intractable diarrhea in early infancy(illI), We investigated the clinical features of cow's milk allergy(CMA) and cow...
Use of Fluorescent in Situ Hybridization to Evaluate the Number of Chromosomes in Buccal Smear Cells in Normal Newborn Infants
Byoung Chan Lee, Jee Yeon Song, So Young Kim, Hyun Hee Kim, Seunghoon Han, Jong-In Byun, Wonbae Lee, Kyong Su Lee
Clin Exp Pediatr. 1995;38(11):1470-1475.   Published online November 15, 1995
Purpose : The diagnosis for chromosomal anomality has been made by obtaining cells in metaphase from peripheral blood and fresh tissue culture. But this method is difficult to perform because somewhat invasive and necessary time for cell culture and staining(48-72hr). Recently, the method to find numerical abnormalities in, autosome and sex chromosome of adult buccal mucosal smear by FISH was...
Serum 2-microglobulin and Retinol Binding Protein and Urine 2-microglobulin and 1-microglobulin in Early Neonatal Period
Jong Duck Kim, Jae Kak Choi, Yong Hwoe Moon
Clin Exp Pediatr. 1995;38(9):1176-1184.   Published online September 15, 1995
Purpose : For evaluation of usefulness of the serum .2-microglobulin(B2MG), retinol binding protein(RBP), urine 1-microglobulin(A1MG), and B2MG on neonatal renal function and renal tubular injuries, we detected and compared these values in 20 neonates. Methods : They were grouped into premature neonate, gestational age was 30-50 weeks(group Ⅰ), and full term neonate, gestational age was 38-40 weeks(group Ⅱ), The group Ⅱ...
Intractable Diarrhea in Early Infancy : Clinical Features on Admission and A Nutritional Management
Jong Won Shin, Kyung Won Hwang, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Chung, Young Dae Kwon
Clin Exp Pediatr. 1995;38(7):936-945.   Published online July 15, 1995
Purpose : We studied to assess the value of clinical findings on admission in screening of intractable diarrhea in early infancy(IDI) and the efficiency of early trial of semi-elemental form-ula (protein hydrolysate) as a nutritional management in IDI. Methods : We carried out a retrospective review of medical records of twenty-eight early infants with diarrhea and malnutrition who were diagnosed as...
Erratum
Three Cases of Necrotizing Lymphadenitis in Childhood
Seong Hoon Hah, Dong Woon Shin, Kyung Hee Lee, Tae Sun Ha, Beom Soo Park, Heon Seok Han, Sang-Hoon Cha, Geon Kook Lee
Accepted January 1, 1970  
Necrotizing lymphadenitis(named as "Kikuchi disease"), initially described by a Japanese pathologist as "a histiocytic necrotizing lymphadenitis with paracortical necrosis, plasmacytoid monocytes infiltration and prominent phagocytic appearance" has been found worldwide. Be-cause of its self-limited course, it has been well known that what should be considered as more important issues are its deatiled pathologic criteria for confirmation and thorough concern about...
Original Article
Comparison Between 24-hour Integrated Growth Hormone Concentrations and Pharmacological Provocation Tests in Children with Short Statue
Mi Jung Park, Duk Hi Kim, Ho Seong Kim
Clin Exp Pediatr. 1995;38(6):835-842.   Published online June 15, 1995
Purpose : The ability to respond to pharmacologial provovation tests may not necessary reflect actuaol secretory patterns of growth hormone. Therefore, the aim of this study in to evaluate the 24-h IC-GH and compare this with their resposnses to standard pharmacological provocation tests for growth hormone comcentrations and to evaluate peak frequency and peak amplitude during 24-h IC-GH in children...
Immunogenicity and Safety of Live Attenuated Vaccine(MAV/06srtain) on Healthy Children and Immunocompromised Children
Young Mo Sohn, Chul Joo Yu, Pyung Kil Kim, Kir Young Kim, Chong Young Park, Mi Ran Kim, Woo Kap Jeung, Kyu Kye Hwang, Gyu Jin Woo, Song Yong Park
Clin Exp Pediatr. 1995;38(6):771-777.   Published online June 15, 1995
Purpose : To study the safety and immunogenicity of new live attenuated varicella vaccine (MAV/06strain) in normal healthy children and immunocompromized children in Korea. Methods : Blood samples for fluorescent antibody to membrane antigen(FAMA) assay were taken before the vaccination among seven hundred forth five healthy children and twenty two nine immunocompromised children. One hundred and seventy seven children and twenty...
Plasma Lipid Alteration in Leukemia and Solid Tumor
Eun Sik Kang, Myoung Soon Song, Hea Jin Cheoh, Kyu Chul Choeh
Clin Exp Pediatr. 1995;38(4):529-536.   Published online April 15, 1995
Purpose : A sensitive, specific blood test to detect cancer would be of great value but the search for such a test has been fruitless so far. In actual practice, there is often a considerable interval between the point at which a tumor could have been detected and the point at which it produces symptoms as a result of tumor...
Clinical Study of Subarterial Ventricular Septal Defect
Yon Sook Rho, Yong Won Park, Sang Woo Kim, Bon Il Ku, Sang Joon Oh, Hong Sup Lee, Chang Ho Kim
Clin Exp Pediatr. 1995;38(4):493-500.   Published online April 15, 1995
Purpose : The incidence of subarterial ventricular septal defect(SA VSD) ranges 25-30% among oriental patients with VSDs, which is greater than 5% reported in western. Natural history of the disease is characterized by progressive aortic valve prolapse(AVP), frequently subarterial VSD, we evaluated clinical characteristics emphasizing on the incidence of AVP and the degree of AI as aging. Methods : Study subjects...
Clinical Characteristics of Childhood Cerebrovascular Disease and Analysis on the Prognostic Factors
Yong Seung Hwang, Moon Sun Yang
Clin Exp Pediatr. 1995;38(3):353-365.   Published online March 15, 1995
Purpose : Cerebrovascular disease in children is more common than was once recognized and the etiology and prognosis of the disease in children are quite different from those of adults. Recently according to medical reports and clinical experiences, the incidence of childhood cerebrovascular disease is increasing in Korea. To clarify the clinical features of childhood cerebrovascular disease and to analyze its...
Relationship between Bronchial Hyperresponsiveness by Methacholine Provocation and the Severity of Asthma Symptoms, Pulmonary Function and Atopy
Sang Hyug Ma, Jung Mi Lee, Byung Hag Lim, Im Ju Kang
Clin Exp Pediatr. 1995;38(2):223-231.   Published online February 15, 1995
Purpose : Bronchial asthma is a disorder that is characteized by symptoms of reversible airway obstruction and increased responsiveness of the bronchus and to quantify the degree of br onchial hyperresponsivenes can be very helpful in determing the severity of disease and the prognosis. But the Methacholine provocation test is not always easy to be performed in all patients. Thus...
Clinical and Histologic Study of Progressive Muscular Dystrophy Which was Considered as Chronic Hepatitis
Jae Kwang Kim, Ki Sup Chung, Tae Seung Kim
Clin Exp Pediatr. 1995;38(2):216-222.   Published online February 15, 1995
Purpose : The authors have experienced thirty three children of progressive muscular dystrophy. 10 children of these(30.3%) were considered as chronic hepatitis because of persistent, u nexplained elevated serum aminotransferase values. We performed this study in order to evaluate the characteristics of age distribution, clinical and histologic features in children considered as chronic hepatitis. Methods : This study was performed on...
Case Report
Recurrent Hematuria due to Renal Hypouricemia
Kyu Young Kim, Il Soo Ha, Hae Il Cheong, Yong Choi
Clin Exp Pediatr. 1995;38(1):129-132.   Published online January 15, 1995
A marked low concentration of serum uric acid(0.7-1.2mg/dl) was detected in a 14-year-old boy with recurrent episodes of gross hematuria. The hypouricemia accompanied with a markedly increased urinary clearance of uric acid (32.6-56.0ml/min), which was only minimally changed after both the administration of pyrazinamide, and inhibitor of the renal tubular secretion of uric acid, and the administration of probenecid, and...
A Case of Type V Hyperlipoproteinemia
Yo Ahn Rho, Jong Kwang Lee, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(12):1752-1756.   Published online December 15, 1994
The hyperlipoproteinemias are the disturbance of lipid transport resulted from accelerated synthesis or retarded degradation of lipoproteins that transport cholesterol and trigycerides through plasma. These diseases are classified as type I, type IIa, type IIb, type III, type IV, type V, and hyper-α-triglyceride levels due to increases in both VLDL and chylomicrons and lipoprotein electrophoresis shows increases pre-β, β, and...
Original Article
A Study on Prognostic Factors in Children with Encephalopathy
Jin Nyoung Park, In Joon Seol
Clin Exp Pediatr. 1994;37(12):1738-1745.   Published online December 15, 1994
To elucidate the clinical characteristics-especially its clinical pattern and outcome of chidren with encephalopathy, we carried out a retrospective review on medical records of 45 patients who were intially diagnosed as encephalopathy except mumps meningitis, Reye's syndome and neonatal hypoxic ischemic encephalopathy at the Department of pediatrics, Hanyang University children's hospital from January 1986 to February 1994. The results were summerized...
Characteristics of Insulin-Like Growth Factor I in Serum; Pattern of Insulin-Like Growth Factor Binding Protein (Large Complex) in Short Stature Patients with Complete Growth Hormone Deficiency
Jin Nyoung Park, Byung Deok Seo, Jeh Hoon Shin, Soo Ji Moon, Sung Yeoul Chang
Clin Exp Pediatr. 1994;37(11):1548-1559.   Published online November 15, 1994
To elucidate the complex of insulin-like growth factor binding proteins (IGF-BPs) in short stature patients, we carried out a prospective study on three patients who were diagnosed as complete GH deficiency at the department of pediatrics form July 1992 to June 1993. The results were summarized as follows: 1) Two circulating IGFs complexed to specific binding protein existed in normal serum. Binding...
Antilymphocyte Globulin Therapy for Aplastic Anemia in Children
Soo Jong Hong, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1994;37(11):1526-1539.   Published online November 15, 1994
Immunosuppressive therapy based on the use of antilymphocyte globulin (ALG) has become standard therapy for patients with aplastic anemia who are not eligible for bone marrow transplantation. In this study, T cell subsets before and after ALG therapy, hematologic responses, complications and prognostic factors were analysed. Eleven (42%) out of twenty-six patients treated with ALG showed response, but...
The Growth Hormone-Binding Proteins in Human Serum: Partial characterization and Regulation
Ji Young Suh, Bu Hun Lee, Jeh Hoon Shin, Hang Lee, Seong Ryul Jang
Clin Exp Pediatr. 1994;37(10):1427-1436.   Published online October 15, 1994
We assessed abotu growth homone binding proteins(GHP|BP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus(IDDM), short stature due to growth hormone deficiency(GHD), chronic renal failure, short stature due to nutritional deficiency. Hypothyroidism, and noraml control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1)...
Studies on the B Cell Proliferation and Differentiation Factors in Human B Cell System
Kwang-Ju Lee, Young-Hun Chung, Jae-Ho Lee
Clin Exp Pediatr. 1994;37(10):1386-1396.   Published online October 15, 1994
We have studied the function of lymphokines on human tonsillar B cell proliferation and differentiation. B cells were stimulated with Staphylococcus aureus Cowan1(SAC) or anti-μ bead. The followings showed the results of this study. 1) In B cell activation, SAC induced B cell DNA synthesis but anti-μ bead did not. SAC could activate and proliferate B cells. Minimal number of B cells...
Case Report
A Case of Anti-Neutrophil Cytoplasmic Antibodies (ANCA) Positive Wegener's Granulomatosis
Won Tae Kim, Woo Jeong Kim, Joon Sik Kim, Chin Moon Kang, Kwan Kyu Park
Clin Exp Pediatr. 1994;37(8):1175-1181.   Published online August 15, 1994
Wegener's granulomatosis is a disease of unknown etiology that is characterized by the clinicopathologic complex of necrotizing granulomatous vasculitis of the upper and lower respiratory tract, glomerulonephritis, and variable degrees of small vessel vasculitis. Recently Antineutrophil Cytoplasmic Antibody (ANCA) has been reported to be a highly specific test for the diagnosis of Wegener's granulomatosis. We have experienced a patient of Wegener's...
Original Article
A Study on Evolution of Lipoportein(a) in Newborns
Keun Haeng Cho, Young Sook Hong, Soo Won Lee, Soon Kyum Kim, Young Chang Tockgo, Han Kyeom Kim
Clin Exp Pediatr. 1994;37(8):1078-1091.   Published online August 15, 1994
Lipoprotein(a) [Lp(a)] is considered an additional, independent and largely genetically determined risk factor for the development of premature coronary heart disease. Furthermore abnormal plasma lipoprotein patterns have been associated with increased risk for developing coronary heart disease. Among these lipoproteins, an increased concentration of serum Apo B and decreased level of Apo A are considered as major risk factors, together...
Significance of Urinary Interleukin 6 Level in Mesangial Proliferative Glomerulonephritis in Children
Byeong Ho Kang, No Hyun Kim, Woo Yeong Chung, Chul Ho Kim, Soon Yong Lee
Clin Exp Pediatr. 1994;37(7):900-905.   Published online July 15, 1994
By animal experiments in rat, it has been known that Interleukin-6(IL-6) is secreted from renal mesangial cells and is an autocrine growth factor for the proliferation of mesangial cells. According to these facts, several studies have been tried for its clinical usefulness by measuring their serum or urinary IL-6 in glomerulonephritis patients with mesangial proliferation. The authors measured urinary IL-6...
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