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Original Article
A Study of Milk β-Glucuronidase Activity in Breast Milk Associating with Neonatal Jaundice.
Soo Chun Kim, Chong Woo Bae, Yong Mook Choi, Chang Il Ahn
Clin Exp Pediatr. 1989;32(9):1202-1209.   Published online September 30, 1989
Since the 1960s, several reports have been presented to explain how the ingestion of human milk is related to neonatal jaundice. Recently, the jaundiced neonates whose mother’s milk contain sub- stances (eg, pregnane 3a, 20β-diol, lipoprotein lipase, free fatty acid, β-glucuronidase etc) facilitating the reabsorption of unconjugated bilirubin in the neonatal intestine through the enhancement of the enterohepatic circulation, were called the breast milk...
Acid-Base and Electrolyte Change Before and After Exchange Transfusion with ACD-B Blood in Hyperbilirubinemia of Newborn.
Ki Hong Park, Chong Woo Bae, Yong Mook Choi, Chang Ill Ahn, Jung Kook Lee
Clin Exp Pediatr. 1989;32(3):311-320.   Published online March 31, 1989
Exchange transfusion is being used widely to correct anemia and control existing hyperbilirubinemia for the prevention of kernicterus in newborn. But the blood used for exchange transfusion is stored blood containing anticoagulants and other substances. So many metabolic changes can be developed after exchange transfusion. This study was undertaken to evaluate the acid-base and electrolyte change after exchange transfusion using the ACD-B blood. In...
Bilirubin-Binding Capacity of Albumin in Korean Neonates.
Jung Bae Lee, Chul Lee, Ran Namgung, Dong Gwan Han, Kyung Son Song
Clin Exp Pediatr. 1988;31(10):1259-1266.   Published online October 31, 1988
The binding of bilirubin by albumin is thought to play an important role in the pathogenesis of kemictems. Free bilirubin hypothesis has led to develop methods to evaluate the binding capacity and affinity of bilirubin to albumin in the plasma. Horseradish peroxidase oxidation of free bilirubin can estimate the level of free bilirubin, bilirubin binding capacity and bilirubin binding affinity. Twenty four term infants...
A Case of Hemolytic Disease of Newborn due to Anti-E.
Sang Keun Oh, Youn O Park, hyun Sook Seo, Mi Sook Park, Young Chul Lee, Hee Dae Park, Hee Joo Lee
Clin Exp Pediatr. 1988;31(8):1059-1063.   Published online August 31, 1988
A 2-day-old male infant was admitted to the Incheon Christian Hospital due to severe jaundice. He was a third baby and his Rh phenotype was CcDEe. The direct antiglobulin test of the infant was strong positive. Eluates that were made from the infanfs elder brother and sister were both CDe. Her two previous infants showed no evidence of erythroblastosis. She had a past...
Changes in Auditory Brainstem Resposes in Hyperbilirubinemic Neonates Before and after Exchange Transfussion and Phototherapy.
Chong Woo Bae, Young Ho Ra, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1988;31(5):547-554.   Published online May 31, 1988
More recently, several studies of newborns involving ABR testing have demonstrated abnormalities following an exposure to moderate or severe hyperbilirubinemia. Jaundice in the early neonatal period is associated with significant transient aberrations of ABR, which suggested transient brain- stem encephalopathy. So, many authors mentioned that ABR may be a useful tool for the monitoring of early biliubin toxicity in infants who were at risk...
Auditory Brainstem Evoked Responses in Hyperbilirubinemic Neonates.
Eun Yong Lee, Pyung Hwa Chee, Sei Joo Kim
Clin Exp Pediatr. 1987;30(8):846-851.   Published online August 31, 1987
An association between neonatal hyperbilirubinemia and hearing loss has been found in several studies. Because auditory brainstem evoked responses (ABR) may be useful tool for the monitoring of early bilirubin txicity in hyperbilirubinemic neonates, ABR in 16 fullterm neonates with serum total bilirubin values 15 mg/dl were compared with the responses in 17 control neonates. The results were as follows: 1) The statistically significant absence of...
Clinico-Hematologic Observation of Neonatal Hemolytic Disease due to Minor Blood Group Isoimmunization.
Chong Woo Bae, Yong Mook Choi, Chang Il Ahn, Hyun sok Chi
Clin Exp Pediatr. 1987;30(5):504-510.   Published online May 31, 1987
The isoimmune hemolytic diseases of the newborn due to minor blood group are characterized by the abnormal titer of minor group antibody in mother’s serum and neonatal progressive jaundice caused by isoimmune hemolytic anemia. This report present the clinico-hematologic features of six cases of hemolytic diseases of newborn due to minor blood group isoimmunization who were admitted to the Kyung Hee university Hospital and presented...
Cord Plasma Alpha-Fetoprotein Values and Neonatal Jaundice.
Mee Kyung Namgoong, Sei Hee Choi, Ae Sook Kim, Baek Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 1986;29(8):836-839.   Published online August 31, 1986
Alpha-fetoprotein(aFP) levels were studied in 20 neonatally hyperbilirubinemic children and 20 controls matched for gestational age. The mean aFP value of cord blood (119+58.2산g/ml) with hyperbilirubinemic children was significantly greater than that(79.6±40.8/zg/ml) for the control infants(P<0.001). At the age of 3 and 5 days the mean serum aFP in hyperbilirubinemic children were higher compared with the control group, the difference...
Change of Bilirubin in Newborn with Trancecutaneous Bilirubinometer.
Mee Yeon Park, Jong Woo Sin
Clin Exp Pediatr. 1986;29(6):626-632.   Published online June 30, 1986
The Transcutaneous Bilirubinometer is a accurate and noninvasive instrument for either screening or monitoring of serum Eilirubin concentrations in newborn. The present study evaluates the efficacy of Transcutaneous Bilirubinometer using a sample of 100 full term infants and 50 preterm infant at II Sin Christian Hospital from Jan- uary 1984 to June 1984. The result was as follows: 1) The neonatal...
Clinical Observation of Acute Viral Hepatitis in Childhood.
Byung Hak Lim, Ki Ho Jang, Sang Geel Lee, Im Ju Kang
Clin Exp Pediatr. 1985;28(11):1057-1065.   Published online November 30, 1985
A clinical observation has been made on 127 cases who were admitted to the department of pediatrics, Fatima Hospital, Taegu, from January 1983 to June 1984 and following results was obtained. 1)Ratio of male to female cases was 3 : 1. 2)On admission, anorexia, nausea, fever and jaundice were significantly more common in HBsAg negative group but skin rash was more...
Transcutaneous Bilirubin Measurements in Newborn Infants.
Cook Huh, Soon Bock park, Baek Keun Lim, Jong Soo Kim, Duk Jin Yun
Clin Exp Pediatr. 1985;28(4):314-324.   Published online April 30, 1985
Neonatal jaundice is probably the most frequently encountered diagnostic and therapeutic problem in the newborn, but its accurate assessment still requires a measurement of the serum bilirubin concentration. To date, repetitive and continuing blood sampling has been the only acceptable methodology available for monitoring the jaundiced newborn infant. This technique serves as a source of discomfort and of serious infection(Lilien...
Evaluation of transcutaneous minolta bilirubinometer in neonatal hyperbilirubinemia.
Yeo Joong Kim, Moon Tae Jeong, Young Youn Choi, Chull Sohn
Clin Exp Pediatr. 1985;28(2):116-122.   Published online February 28, 1985
To evaluate the efficacy of the Transcutaneous Minolta Bilirubinometer in neonatal hyperbilirubinemia, the value of serum bilirubin measured by alkali azo bilirubin method and American optical biliribinometry were compared with the reading of transcutaneous bilirubinometer in 86 fullterm newborns. The following results were obtained: 1)The Transcutaneous Minolta Bilirubinometer was assessed to have the objective value in determining the severity of hyperbilirubinemia...
Determination of Bilirubin Concentration in the Jaundiced Korean Newborn Infants with Transcutaneous Bilirubinometer.
Man Jin Chung, Young Joo Suh, Jong Doo Kim, Myung Hi Shin, Ji Sub Oh
Clin Exp Pediatr. 1983;26(12):1179-1187.   Published online December 31, 1983
The efficacy of transcutaneous Minolta Bilirubinometer was evaluated in 169 jaundiced. Korean newborn infants, regardless the causes of jaundice, who were admitted to the pedia- tric ward and nursery of wallace Memorial Baptist Hospital, Busan, since Nov. 1981. The results were obtained as follows: 1) The transcutaneous bilirubinometer is sufficiently precise to provide a reliable indication of total serum bilirubin concentration level with the resulting...
The Response of Leukocytes in the Peripheral Blood Following Exchange Transfusion in the Newborn.
Young Mo Sohn, Yu Young Chang, Young Ho Kim, Kir Young Kim
Clin Exp Pediatr. 1983;26(11):1049-1054.   Published online November 30, 1983
We have studied the hemoglobin level and. leukocyte count of 23 fullterm and 1 premature jaundiced babies soon after exchange transfusion and daily thereafter until 7 days. The resixlts are: 1) One exchange transfusion was enough in 16 patients but 8 were required more than 2times of exchange transfusion. The maximum is 6 times. 2) The postnatal age was...
Clinical and Follow up Study of 52 cases of Blood Exchange Transfusion for Neonatal Hyperbilirubinemia.
Hong In Eum, Jae Gae Rheu, Sang Cheol Lee, Jung Hee Lee
Clin Exp Pediatr. 1983;26(10):996-1003.   Published online October 31, 1983
The study was made of 52 cases of neonatal hyperbilirubinemia receiving blood exchange transfusion at St. Benedict Hospital from January 1977 to June 1981 with the following results; 1) 34.6% of total exchanged patients were born at St. Benedict hospital. Remains were born at outside. 2) 27 patients(51.9%) returned for follow up, 21 patients(40.4%) not returned for follow up 4 patients (7.7%) had died. 3) The...
Case Report
Two Cases of Rotor Syndrome in Brothers.
Sonn Il Kwon, Kum Le Ko, Jong Hun Park, Young Soo Lim, Dong Heuck Kum
Clin Exp Pediatr. 1983;26(9):934-938.   Published online September 30, 1983
Two cases of Rotor syndrome were observed clinically. Both cases were observed as follows; 1. Both cases were observed in a same family; They were brothers. 2. Jaundice was appsirel fro.n aboat sscoai year of life without any clinical disturbance. 3. Oral cholangiography and Ultra sonogram on abdomsn showed normal Findings and functions except slight enlargement of liver. 4. Direct...
Original Article
Study of Bilirubin Concentration on The Neonatal Jaundice.
Seung Kwon Kim, Woo Sik Chung, Byung Do Nam, Kew Taek Kim
Clin Exp Pediatr. 1982;25(11):1089-1096.   Published online November 30, 1982
W« studied the guidelines on the serum bilirubin concentration of 15 mg% for the management of neonatal jaundice and compared the group of serum bilirubin concentration below 15 mg% ■and the group of serum bilirubin concentration above 15 mg%. 83 cased of icteric infants without any risk factors for kernicterus, ahove 12 m.g% in serum bilirubin concentration, were born at the St. Benedict hospital...
A Study of Correlation between Bilirubin Leel of Cord Blood and Neonatal Hyperbilirubinemia.
Hwan Sup Kang, Chang Il Ahn
Clin Exp Pediatr. 1982;25(10):1039-1045.   Published online October 31, 1982
For adequate management and prevention of severe sequellae of neonatal hyperbilirubinemia^ such as kernicterus, early detection of its presence is very important in fields of neonatology. The author studied the correlation between bilirubin level of the cord blood and neonatal hyperbilirubinemia in random sampled 169 neonates of 729 deliveries during a period of five months since December 1981 at the Kyung Hee University Hospital....
A Case-Control Study on the Factors Influencing Neonatal Hyperbilirubinemia.
Kwang Ho Meng, Won Chul Lee, Kyung Tai Whang
Clin Exp Pediatr. 1982;25(2):136-140.   Published online February 28, 1982
Neonatal Hyperbilirubinemia is increasing in frequency and there have been suggestions that this may be due to some change in factors involved in delivery. In this study, among numerous hypothesized factors, maternal age, gestational age, birth weight, birth order, and methods of delivery were tested if there were statistical associations between these factors and occurance of neonatal hyperbilirubinemia. For the...
A Follow-up Study of Newborns who had Exchange Blood Transfusion for Hyperbilirubinemia.
Young Soo Yoon, Seung Joon Park, Ki Bok Kim
Clin Exp Pediatr. 1981;24(9):826-836.   Published online September 15, 1981
A follow up study was made of 59 cases of neonatal hyperbilirubinemia receving blood exchange transfusion at Kwangju Christian Hospital from early 1976 to early 1979, with the following results. 1. 42patients(71.2%) returned for followup: 12 patients(20.3%) did not return; and 5 patients(8.5%) had died. 2. Of those returning, developmental status was studied by D.D.S.T. 38 patients(90.5%) had normal development...
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