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Original Article
Clinical Study of the Correlation of Tumor Necrosis Factor Alpha and the Proteinuria of Henoch-Schönlein Nephritis and Idiopathic Nephrotic Syndrome
Dong-Ho Jeong, Jeong-Hyun Park, Hye-Cheon Jeong, Hyun-Hoe Koo, Jun-Ho Lee, Tae-Sun Ha
Clin Exp Pediatr. 2002;45(2):240-246.   Published online February 15, 2002
Purpose : It is not clear that the development of glomerular injury and aggravation by tumor necrosis factor alpha(TNF-α) is related to intrarenal or serum concentration of TNF-α. So, we studied the relationship between the concentration of TNF-α and aggravation of glomerular damage in the Henoch-Schönlein nephritis(HSN) and idiopathic nephrotic syndrome(INS). Methods : We collected the sera and urines of...
Risk Factors of Renal Scar After Acute Pyelonephritis in Children
Chur Woo You
Clin Exp Pediatr. 2001;44(1):54-61.   Published online January 15, 2001
Purpose : In this study we re-evaluated the known risk factors of pyelonephritic scarring in children. Methods : A prospective study was performed on 36 acute pyelonephritis(APN) patients who were diagnosed as first acute pyelonephritis on 99mTc-DMSA scan between September 1998 and March 2000 in Masan Samsung Hospital. According to the prescence of remnant lesions on the 99mTc-DMSA scan performed...
Changes in the Findings of 99mTc-dimercaptosuccinic Acid(DMSA) Scan after Acute Pyelonephritis in Childhood and Renal Scar
Sang Hee Ahn, So Young Yoon, Chong Hyun Yoon, Dae Hyuk Moon, Young Seo Park
Clin Exp Pediatr. 2000;43(4):543-549.   Published online April 15, 2000
Purpose : We evaluated the change in the findings of DMSA scan after acute pyelonephritis (APN), and the relationship between renal scar formation and risk factors such as vesicoureteral reflux(VUR), organism and inflammatory reaction. Methods : We examined 200 patients under the age of 5 years with first APN. DMSA scan, voiding cystourethrography(VCUG), erythrocyte sedimentation rate(ESR) and C-reactive protein (CRP) were...
A Clinico-pathologic Study of Childhood Lupus Nephritis
Youn-Sook Rho, Sung-Hoo Cha, Byoung-Soo Cho
Clin Exp Pediatr. 2000;43(2):236-240.   Published online February 15, 2000
Purpose : Systemic lupus erythematosus(SLE) is a disease of immunologic origin, affecting multiple organs including joints, skin, kidneys, nervous system, heart and blood, with rare involvement of gut and liver. The incidence of renal disease in children with SLE was approximately 70 percent and tended to be more severe than in adults. Accordingly we have retrospectively studied on the prognostic...
Comparison between Pathologically and Clinically Diagnosed Group of Acute Postinfectious Glomerulonephritis
Chul Hong Kim, Su Yung Kim
Clin Exp Pediatr. 1999;42(12):1696-1701.   Published online December 15, 1999
Purpose : Postinfectious acute glomerulonephritis usually needs no renal biopsy. But atypical clinical course and laboratory results indicate a need for renal biopsy. Therefore, to investigate clinicopathological characteristics of postinfectious acute glomerulonephritis, we compared clinical manifestations of biopsy group with those of non-biopsy group. Methods : We reviewed the records of clinical and pathological data of 20 cases diagnosed by...
Case Report
A Case of Rheumatic Fever Associated with Acute Poststreptococcal Glomerulonephritis
Jeong Kyung Seo, Un Seok Nho, Eun Jeong Kim, Chur Woo Yoo, Chul Kyu Kim
Clin Exp Pediatr. 1999;42(8):1170-1174.   Published online August 15, 1999
It is well known that both acute glomerulonephritis and rheumatic fever are a common sequelae of group A streptococcal infection. However, their simultaneous occurrence is uncommon. Only a few cases have been reported because they are different in epidemiologic, clinical, serologic and immunopathogenic characteristics. We experienced a 10-year-old boy who presented the manifestation of acute rheumatic fever and acute poststreptococcal...
Original Article
The Risk Factors of Renal Scar in Childhood Acute Pyelonephritis
Soo Ja Hwang, Seung Joo Lee
Clin Exp Pediatr. 1999;42(4):545-552.   Published online April 15, 1999
Purpose : To observe the risk factors of renal scar in children with first acute pyelonephritis (APN) who had photopenic defects on initial 99mTc-DMSA spect renal scan. Methods : Forty-seven children with first APN(M : F=33 : 14) who were admitted to Ewha Womans University Hospital from September, 1993 to Febrary, 1998, were divided into renal scar group(N=17, Kidney unit(KU)=18) and...
Case Report
A Case of Microscopic Polyangitis Presented as Pulmonary Hemorrhage and Rapidly Progressive Glomerulonephritis
Jae Eun Lee, Young Sook Chae, Oh Keyng Lee, Dae Youl Lee
Clin Exp Pediatr. 1999;42(2):274-278.   Published online February 15, 1999
Microscopic polyangitis(MPA) is defined as a systemic necrotizing vasculitis that affects small- sized vessels without granulomata. MPA is associated with focal segmental necrotizing glomerulonephritis. Clinical manifestations are similar to those of polyarteritis nodosa, but are characterized by the presence of rapidly progressive glomerulonephritis and pulmonary involvement, including pulmonary hemorrhage. We reported a case of microscopic polyangitis presenting pulmonary hemorrhage and...
Three Cases of Acute Focal Bacterial Nephritis
Yeon Soo Lim, Jae Kook Cha, Kon Hee Lee, Kwan Seop Le
Clin Exp Pediatr. 1999;42(1):138-142.   Published online January 15, 1999
Acute focal bacterial nephritis(AFBN) is an unusual form of localized renal infection, which has various imaging findings and should be distinguished from abscess or other renal masses. Clinical symptoms are similar to other urinary tract infections but the diagnosis needs a CT or sonographic confirmation. Treatment, which is nonoperative, consists of intensive antibiotic therapy. We report three cases of AFBN...
Original Article
Diagnostic Value of 99mTc-DMSA Renal Scan for Early Diagnosis of Acute Pyelonephritis in Children with Febrile Urinary Tract Infection
Soo Ja Hwang, Eun Ae Park, Jeong Wan Seo, Seung Joo Lee, Sun Whan Lee
Clin Exp Pediatr. 1996;39(11):1586-1593.   Published online November 15, 1996
Purpose : For prevention of renal scar, early diagnosis and treatement of acute pyelonephritis are important in children with febrile urinary tract infection. But it has been difficult to differentiate acute pyelonephritis from lower urinary tract infection. We have performed this study to evaluate the diagnostic value of 99mTc-DMSA renal scan and to clarify the relationship among acute pyelonephritis, vesico-ureteral reflux and renal scar. Methods...
Case Report
A Case of Idiopathic Crescentic Glomerulonephritis
Jung Keum Park, Sang Il Goo, Woo Yeong Chung, Chul Ho Kim
Clin Exp Pediatr. 1996;39(1):131-135.   Published online January 15, 1996
We experienced a case of idiopathic crescentic glomerulonephritis in a 10-year-old girl who was admitted to our hospital due to gross hematuria and oliguria for 2 months. The diagnosis was based on the rapidly progressive clinical course to chronic renal failure, positive p-ANCA test and light microscopic findings of diffuse crescents formation in about 80% glomeruli of renal tissue obtained...
A Case of Xanthogranulonatous Pyelinephritis with Idiopathic Hypercalciruia in a Child
Young Jun Kim, Hyun Joo Kwak, Keun Haeng Cho, Kee Hwan Yoo, Young Sook Hong, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(12):1778-1783.   Published online December 15, 1994
Xanthogranulomatous pyelonephritis in childhood is a rare chronic pyelonephritis often assodiated with calculi of urinary tract obstruction, with a clinical presentation of renal mass. A 3-year old boy was admitted to Korea University Hospital complaining of intermittent fever and palpable mass at right upper quadrant of the abdomen. The CBC revealed increased ESR and the finding of iron deficientcy anemia....
A Case of Anti-Neutrophil Cytoplasmic Antibodies (ANCA) Positive Wegener's Granulomatosis
Won Tae Kim, Woo Jeong Kim, Joon Sik Kim, Chin Moon Kang, Kwan Kyu Park
Clin Exp Pediatr. 1994;37(8):1175-1181.   Published online August 15, 1994
Wegener's granulomatosis is a disease of unknown etiology that is characterized by the clinicopathologic complex of necrotizing granulomatous vasculitis of the upper and lower respiratory tract, glomerulonephritis, and variable degrees of small vessel vasculitis. Recently Antineutrophil Cytoplasmic Antibody (ANCA) has been reported to be a highly specific test for the diagnosis of Wegener's granulomatosis. We have experienced a patient of Wegener's...
Original Article
Significance of Urinary Interleukin 6 Level in Mesangial Proliferative Glomerulonephritis in Children
Byeong Ho Kang, No Hyun Kim, Woo Yeong Chung, Chul Ho Kim, Soon Yong Lee
Clin Exp Pediatr. 1994;37(7):900-905.   Published online July 15, 1994
By animal experiments in rat, it has been known that Interleukin-6(IL-6) is secreted from renal mesangial cells and is an autocrine growth factor for the proliferation of mesangial cells. According to these facts, several studies have been tried for its clinical usefulness by measuring their serum or urinary IL-6 in glomerulonephritis patients with mesangial proliferation. The authors measured urinary IL-6...
A Clinical Observation on Lupus Nephritis in Children
Kang Mo Ahn, Jae Sung Ko, Hye Won Park, Il Soo Ha, Hae Il Cheong, Yong Choi, Hee Joo Kim
Clin Exp Pediatr. 1994;37(6):842-849.   Published online June 15, 1994
We reviewed the clinical features, histrologic patterns and clinical courses of 30 children with lupus nephritis retrospectively, and the results were summerized as follows; 1) The male to female ratio was 1:2.8, and the mean age at the onset was 108/12 years. 2) The clinical symptoms were diverse, and malaise, weight loss, anorexia, fever and malar rash were the most frequent findings. 3)...
Atypical Presentation of Acute Glomerulonephritis
Hyun Ho Shin, Thy Hyung Park, Sung Ho Cha, Byoung Soo Cho, Chang Il Ahn, Young Tae Ko, Moon Ho Yang
Clin Exp Pediatr. 1993;36(7):987-993.   Published online July 15, 1993
Form March 1982 to December 1991, 110 cases of typical post-streptococcal glomerulonephritis and 25 cases of Atypical acute glomerulonephritis were clinically investigated at Department of pediatrics, Kyung Hee University Hospital, and follwing Data were obtained. 1) Male to Femal ratio was 1.8:1 (Atypical AGN). Peak incidence was from 7 to 12 years. 2) The most common preceding infections were upper respiratory infection,...
Case Report
A Case of Xanthogranulomatous Pyelonephritis in Child
Sa-Young Kim, Byung-Mun Lee, Soo-Young Kim, Hee-Joo Jeon, Chan-Yung Kim
Clin Exp Pediatr. 1993;36(2):273-279.   Published online February 15, 1993
Xanthogranulomatous pyelonephritis, and uncommon chronic inflammatory renal disorder of middle-aged women, is rarely seen in childhood. A 10 year-old boy with focal type of this disease in upper and lower pole was experienced. Patient had a intermittent fever and right flank pain without palpable mass. The blood analysis only revealed ESR increase but no anemia, no leukocytosis. There nothing abnormal....
Original Article
A case of xanthogranulomatous pyelonephritis misdiagnosed as Wilms' tumor.
Hyung Shim Chang, Hyung Doo Lee, Young Ho Lee, Woo Taek Kim, An Hong Choi, Jin Han Yoon, Jin Sook Jeong
Clin Exp Pediatr. 1991;34(11):1612-1617.   Published online November 30, 1991
Xanthogranulomatous pyelonephritis is an uncommon form of pyelonephritis that is usually seen in middle-aged women and is much rarer in children. We report a case of focal xanthogranulomatous pyelonephritis in a 3-month-old boy, which misdiagnosed as Wilms’ tumor and successfully treated with total nephrectomy and long-term antibiotic therapy.
A case of xanthogranulomatous pyelonephritis.
Jin Oh Kim, Soo Young Cho, Joo Hyung Kim, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1991;34(3):413-418.   Published online March 31, 1991
Xanthogranulomatous pyelonephritis is an atypical form of severe chronic renal parenchymal infection, which can be mistaken for tumor or other inflammatory renal disease due to similar clinical manifestations. This disease was classified into three stages based on the extent of involvement of renal and adjacent tissue by the xanthogranulomatous process. In stage I (nephric), the characteristic xantho- granulomatous inflammatory process is confined to the kidney. The...
Changes of immune indices in children with recurrent gross hematuria (IgA nephropathy and non-IgA nephropathy) and Henoch-Schonlein purpura nephritis.
Seong Mi Kim, Myung Chul Hyun, Cheol Woo Ko, Ja Hoon Koo, Doo Hong Ahn, Jung Sik Kwack
Clin Exp Pediatr. 1991;34(3):317-322.   Published online March 31, 1991
A Prospective study was conducted to see the changes of immune system in recurrent gross hematuria (IgA nephropathy and non-IgA nephropathy) and HSP nephritis in children. Study patients consisted of 60 children with recurrent gross hematuria and Henoch-schdnlein purpura nephritis (8 IgA nephropathy, 24 non-IgA nephropathy and 28 HSP nephritis). The cellular immune indices (total T, T4, T8 cells and T4/T8 ratio) and humoral...
A Case of Acute Interstitial Nephritis Associated with Yersinia Pseudotuberculosis Infection.
Keun Hee Chung, Yoo Mee Kim, Mee Won Kim, Soon Gi Kim, Moon Soo Park, Jin Keun Chang
Clin Exp Pediatr. 1990;33(8):1123-1128.   Published online August 31, 1990
Authors recently experienced a case of acute interstitial nephritis associated with Yersinia pseudotuberculosis infection in 10-8/12 year old boy, who was admitted to prolonged high fever. On 3rd hospital day, puffy face and oliguria were noted. BUN and serum creatinine rose to peak level, 94.1 mg/dl and 10.1 mg/dl, respectively on 7th hospital day. After then renal functions were normal- ized gradually without specific...
A Case of Acute Rhenmatic Fever Associated with Acute Poststreptococcal Glomerulonepheitis.
Ho Kyung Choi, Dong Seok Choi, Jae Ho Lee, Young Hun Chung, Hyon Soon Lee
Clin Exp Pediatr. 1989;32(12):1744-1748.   Published online December 31, 1989
A case of acute glomerulonephritis in association with acute rheumatic fever was presented. The patient rheumatic arthritis and carditis with mitral insufficiency, who had been diagnosed as acute poststreptococcal glomeruoonephritis with non-oliguric renal failure with renal biopsy and laboratory findings. The patient was treated, and symptom and sign were improved.
A case of Idiopathic Crescentic Glomerulonephritis.
Mi Kyung Kim, Hyun Joo Choi, Seung Joo Lee, Ok Kyung Kim
Clin Exp Pediatr. 1989;32(10):1435-1441.   Published online October 31, 1989
Idiopathic crescentic glomerulonephritis is a very rare disease especially in children with poor prognosis. We experienced a case of idiopathic crescentic glomerulonephritis in a 4-year-old male patient who presented initially with a nephrotic syndrome and progressed to a rapidly progressive glomerulonephritis. We review literatures briefly.
A Trend of Serum C3 and C4 levels in Acute Poststreptococcal Glomerulonephirtis.
Dong Seok Choi, Young Hun Chung
Clin Exp Pediatr. 1989;32(7):965-971.   Published online July 31, 1989
Acute poststreptococcal glomerulonephritis is generally stated to be the most common cause of acute nephritis in childhood and secondary to an immunologic mechanism. In acute poststreptococcal glomerulonephritis, there have been several reports on the change of serum complement levels in the course of disease. This paper reports on observation of change of serum C3 & C4 levels and its clinical significance in 41 cases of...
A Clinical Study on Children with Acute Glomerulonephritis.
Jeong Ok Kim, Son Moon Shin, Yong Hoon Park
Clin Exp Pediatr. 1989;32(6):779-788.   Published online June 30, 1989
A clinical observation has been made on 111 children with acute glomerulonephritis who were admitted to Pediatric Department of Yeungnam University Hospital during 5 years period from June 1, 1983 to May 31, 1988. The incidence of acute glomerulonephritis among hospitalized patients was 1.59% and the annual incidence was decreased markedly after June 1986. Peak incidence was noticed in the wintertime from November to January...
A Clinical Study of Acute Glomerulonephritis in Children.
Sung Ho Bae, Jin Hong Park, Jong Duck Kim
Clin Exp Pediatr. 1989;32(4):525-532.   Published online April 30, 1989
A Clinical study has been made on 33 cases of acute glomerulonephritis who were admitted to pediatric department of Won Kwang University Hospital, during 2 year period from Jan. 1985 to Dec. 1986 The results were as follows: 1) Male to female ratio was 1.4:1 and the age incidence was highest among children from 4 -12 years of age group(78.8%). 2) The most common season was...
A Case of Systemic Lupus Erythematosus Accompanied with Nephritis and Arteritis.
Oh Kyun Kwon, Hong Yang Khil, Jae Ho Lee, Young Hun Chung
Clin Exp Pediatr. 1987;30(11):1311-1317.   Published online November 30, 1987
The systemic lupus erythematosus (SLE) is a chronic inflammatory disease involving skin, kidney, serous membrane, nervous system and other organs. We experienced a case of SLE accompanied with nephritis and arteritis on the region of the left thigh, diagnosed by clinical, serologic, immunologic, radiologic and pathologic evaluations. A 15 years old female patient was admitted to pediatric ward due to sustained pain on left...
Immunologic Function in Early Phase of Various Glomerulonephritis.
Soon Don Hong, Hyoung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1987;30(7):735-741.   Published online July 31, 1987
Abnormal lymphocyte function has been postulated to have a pathogenetic role in nephrotic syndrome. To assess immunologic parameters in the pathogenesis of various glomerulonephritis in early phase, in prdiatric department of Kyung Hee University Hospital from September 1985 to June 1986, serum immunoglobulin concentration and T cell subsets were measured in 32 children and compared with normal control group (n=30). Further studies are needed to...
A Clinicopathological Study on the Biopsy-proven Henoch-Schonlein Purpura Nephritis in Children.
Jong Yoon Kim, Yong Choi, Kwang Wook Ko, Young il Kim
Clin Exp Pediatr. 1986;29(3):265-276.   Published online March 31, 1986
40 patients with Henoch-Schonlein nephritis in whom a per cutaneous renal biopsy was performed at department of pediatrics, Seoul National University Hospital during the periods Jan. 1978-Jan. 1985 inclusive were analyzed in view of clinicopathological correlation. The results were as follows: 1) Of the 40 patients reviewed, 24 cases were male and 16 female. The mean age of onset was 9 years...
Clinical Study of Acute Glomerulonephritis in Children.
Kyeong Rae Moon, Choon Ho Park, Sang Kie Kim, Jin Heon Kim, Chang Soo Ra
Clin Exp Pediatr. 1986;29(2):178-185.   Published online February 28, 1986
From January 1979 to June 1984, 96 cases of acute glomerulonephritis were clinically investigated at the Department of Pediatrics, Chosun University Hospital, and following results were obtained: 1) Male to female ratio was 1.7 : 1, and the age incidence was highest in children from 7 to 9 years (35.4%), with a seasonal peak in Autumn and Winter (66.8%). 2) The most common...
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