• Search
  • Advanced Search

Search

  • HOME
  • Search
Original Article
Physical and Biological Activity of Domestic Product of Modified Bovine Lung Surfactant
Chul Lee, Min Soo Park, Moon Sung Park, Jung Nyeon Kim, Jong Wook Lee, Kwang Hyun You, Won Jae Kwag, Kook In Park, Ran Nam gung, Dong Gwan Han
Clin Exp Pediatr. 1997;40(6):771-785.   Published online June 15, 1997
Purpose : Neonatal respiratory distress syndrome is caused by the deficiency of lung surfactant in premature babies. For the treatment of RDS at present surfactants such as Surfacten․ (Tokyo-Tanabe Co., Japan) and Exosurf․ (Wellcome Co., USA) are used. As awarded the grant from the Ministry of Science and Technology for a model research project of Medium-Technology program, we have modified (supplemented) the bovine lung...
Effect of Meconium Components on Haemophilus influenzae Growth by Surfactan
Min Hee Kim, Sang In Chung
Clin Exp Pediatr. 1997;40(3):327-335.   Published online March 15, 1997
Purpose : Meconium is a complex mixture with a potential variable composition, it is difficulty to determine which components of meconium are responsible for the surfactant inhibition. We previous reported that Surfactant-TA and Exosurf almost completely inhibited the growth of Haemophilus influenzae at the concentration of 100% without apparent difference in the efficiency.In this study, We have determined the effect of...
Surfactant Protein SP-A, B, and C: Purification and Biochemical Characterization
Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Kil Lyong Kim, Kyung Soo Hahn
Clin Exp Pediatr. 1996;39(2):218-229.   Published online February 15, 1996
Purpose : Several kinds of exogenous pulmonary surfactants (SF), either synthetic or animalderived, are being used for the replacement therapy in respiratory distress syndrome (RDS) of newborn, especially in premature infants, and improved the neonatal mortality and morbidity. Because synthetic preparations are lack of surfactant protein (SP) and animal-derived preparations cause immunogenecity of heterogenous SP, there have been great necessity for the development of next...
Diagnostic Value of Stable Microbubble Rating test and Efficacy of Surfactant Replacement Therapy in Neonates with Respiratory Distres syndroems
Jeong Hee Kim, Eun Ae Park, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(6):760-770.   Published online June 15, 1995
Purpose : Stable microbubble rating test(SMR) plays an important role in the clinical course and the prognosis of respiratory distress syndrome(RDS) patients, because SMR can be easily performed and it can predict quickly the neonatal RDS. After the success of the pulmonary surfactant replacement therapy in RDS infants by Fujiwara and co-workers in 1980, many supporting studies were presented and...
Comparison of Oxygenation and Lung Damage of High Frequency Flow Interruption to Conventional Ventilation in Surfactant Deficient Rabbits
Chang Keun Kim, Churl Young Chung, Hye Jae Cho
Clin Exp Pediatr. 1995;38(5):591-601.   Published online May 15, 1995
Purpose : This study was performed kto evaluate the High frequency flow interruption(HFF I) can prevent the lung injury and achieve a bettre oxygenation than conventional ventilation(C V) in surfactant deficient lungs when associated with lung volume recruitment and maintenance, and the need of background intermittent mandatory ventilation(IMV) to prevent the progressive atelectasis during HFFI. Methods : Surfactant deficiency was produced...
Sequential Changes of Chest Radiographic Finding after Exogenous Surfactant Replacement Therapy in Neonates with RDS
Hyeok Choi, Chong-Woo Bae, Sa-Jun Chung, Yong-Mook Choi
Clin Exp Pediatr. 1995;38(2):151-158.   Published online February 15, 1995
Purpose : The chest radiograph is useful and reliable in assessing the severity and progres-sion of neonatal respiratory distress syndrome. To evaluate the effect of exogenous surfactant r eplacement therapy, we performed sequential observation of chest radiogratphic findings in ne-onates with respiratory distress syndrome. Methods : Two groups of infant with RDS in mechanical ventilation therapy were studied. S-urfactant(S-Tx) group(n=36) was...
A Study of Relation between Stable Microbubble Rating and Pulmonary Surfactant Concentration in vitro
Seong Yong Jung, Thi Hyung Park, Chong Woo Bae, Chang Il Ahn
Clin Exp Pediatr. 1994;37(8):1048-1054.   Published online August 15, 1994
Respiratory distress syndrome (RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventilatory techniques. After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement produced exellent...
Improvement of Thoracic Pressure-Volume, Complincace and Histological Characteristics in Premature Newborn Rabbit after Treatment of Bovine Purified Natural Surfactant-Phospholipid
Chong-Woo Bae, Chang Il Ahn, Haruo Maeta, Tetsuro Fujiwara
Clin Exp Pediatr. 1994;37(2):157-166.   Published online February 15, 1994
We had previously reported the purification of bovine lung natural surfactant-phospholoipd (PNS-L) and the assessment of it's surface physical properties in vitro. To observe the clinical effectiveness of PNS-L in vivo, the degree of improvement of thoracic pressure-volume, compliance and histological changes following PNS-L instillation in premature rabbits with respiratory distress syndrome (RDS) were investigated. Rabbits, delivered prematurely by cesarean section...
Surfactant Replacement Therapy in Neonates with Respiratory Distress Syndrome: A Collective Evaluation of Trials from 16 Hospitals
CW Bae, YD Kwon, SJ Ko, KS Kim, HM Kim, WS Park, SH Byun, CS Son, HS Ahn, SG Lee, YP Chang, YJ Chung, KS Cho, KH Cho, KC Choeh, MJ Chey, JH Choi, JK Yoon, CI Ahn, S Chida, T Fujiwara
Clin Exp Pediatr. 1993;36(2):244-265.   Published online February 15, 1993
Surfactant replacement therapy in neonates with respiratory distress syndrome (RDS) has been introduced in our country since May 1990. The purpose of this study was to assess the effect and short-term outcome of surfactant replacement for neonatal RDS using collective data of uncontrolled trials from different hospitals in Korea. For the period May 1990 to Dec. 1991, a total of 68...
Surfactant replacement therapy in neonatal respiratory distress syndrome.
Chan Ok Park, Boung Yul Lim, Byeong Gie Yeo, Ji Ho Song, Eun Kyung Sohn, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1991;34(9):1211-1222.   Published online September 30, 1991
Respiratory distress syndrome (RDS) in tiny infants remains a major medical challenge as they are less tolerant of supportive care. In 1959, after identification of the pulmonary surfactant (S), S replacement therapy were used to treat RDS. This idea was first successfully tested on RDS infants by Fujiwara, et. al” in 1980. Now the trial and use of S for the treatment in RDS...
Exogenous Surfactant Replacement Therapy of Hyaline Membrane Disease: A controlled clinical trial.
Ran Namgung, Chul Lee, Kook In Park, Dong Gwan Han
Clin Exp Pediatr. 1990;33(1):22-34.   Published online January 31, 1990
We conducted a clinical controlled trial of exogenous surfactant replacement therapy in premature infants with hyaline membrane disease at the neonatal intensive care unit of Yonsei University Medical Center form Nov. 1987 to May 1988. Sixteen premature infants with severe HMD were randomly assigned to control group or surfactant-treated group. Eight infants (mean gestational age 29.9±2.8 week, mean birth weight 1, 425±308.9 gm) were given...
Clinicao-Pathologic Study on Hyaline Membrane Disease.
Jung Woo Suk, Je G Chi
Clin Exp Pediatr. 1983;26(6):534-544.   Published online June 30, 1983
A total of 27 cases of hyaline membrane disease (idiopathic respiratory distress syndrome was studied clinically, and postmortem findings were reviewed on 14 cases that were available：for autopsy. These 27 cases were obtained during a period of 19 years from January, 1961 to December,1979, at National Medical Center, Seoul. Following results were obtained. 1. The overall incidence of hyaline membrane disease (HMD) among...
TOPICS

Browse all articles >

ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
FOR CONTRIBUTORS
ABOUT
Editorial Office
Korean Pediatric Society
#1606 Seocho World Officetel, 19 Seoun-ro, Seocho-ku, Seoul 06732, Korea
Tel: +82-2-3473-7306    Fax: +82-2-3473-7307    E-mail: office@e-cep.org                

Clinical and Experimental Pediatrics is an open access journal. All articles are distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/)

Copyright © 2025 by Korean Pediatric Society.      Developed in M2PI