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Original Article
Treatment of Acute Myelogenous Leukemia in Children: Remission Induction with Adriamycin and Cytosine Arabinoside, and Postremission Maintenance Chemotherapy with Adriamycin, Cytosine Arabinoside and 6-thioguanine.
Soon Ki Kim, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):850-862.   Published online July 31, 1988
The authers assessed the effectiveness of chemotherapy in 40 children with AML, experienced at Seoul National University Children’s Hospital during 8 years 5 months from April 1979 to August 1987. Remission induction treatment included adriamycin 30 mg/m2/day IV on days 1-3 and cytosine arabinoside 75 mg/m2/day continuous IV infusion on days 1-5. This regimen was repeated, if necessary, for one or two more courses. After...
A Clinical Observation on the Incidence of Childhood Leukemia.
Hyo Seop Ahn, Il Soo Ha, Soon Ki Kim, Hoan Jong Lee, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):841-849.   Published online July 31, 1988
We have analysed the type, age, sex, initial hematologic values and cell markers in 295 children, who had been diagnosed as leukemia at the department of pediatrics, Seoul National University Hospital, from Jan. 1983 to Dec. 1987. The patients were composed of 197 cases (66.8%) of ALL, 82 cases (27.7%) of ANLL and 16 cases (5.5%) of CML. FAB subclassification have been done in...
Study on Diagnostic Methods for Spleen in Complex Heart Disease.
Jung Yun Choi, Yong Soo Yun, Chung Il Noh, Chang Yee Hong, Kyung Mo Yeon, In One Kim
Clin Exp Pediatr. 1988;31(7):833-840.   Published online July 31, 1988
Thirty one cases of congenital heart disease with suspicious splenic anomaly were prospectively studied at Seoul National University Children’s Hopsital from October, 1986 to February, 1988 in order to determine the sensitivity and the specificity of various non-invasive diagnostic methods for splenic status. In most cases, splenic status was confirmed by abdominal aortography. Each case had chest X-ray, abdominal X-ray, bronchus tomography, electrocardiogram, echocardiography,...
Percutaneous Transluminal Balloon Valvuloplasty for Congenital Pulmonary Valve Stenosis.
Heung Jae Lee, Jae Kon Ko, Woong Heum Kim, Nam Su Kim, Chang yee Hong
Clin Exp Pediatr. 1988;31(7):822-832.   Published online July 31, 1988
During the period of 2 years, between January 1986 and December 1987, 36 patients, aged 2 years to 18 years, with congenital pulmonary valve stenosis(PVS) (with peak systolic transvalvar gradient over 30 mmHg) underwent percutaneous transluminal balloon valvuloplasty(TBV) at Sejong General Hospital m Korea. Of a group of 36 patients, 26 were treated successfully by the conventional balloon valve dilatation technique, and 6 were treated...
Percutaneous Balloon Angioplasty in Patients with Congenital Aortic Valvular Stenosis.
Yong Soo Yun, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):817-821.   Published online July 31, 1988
Aortic valve stenosis was relieved by balloon dilatation during cardiac catheterization on 9 children aged 1 month to 15 years. Aortic valve diameter was estimated by two dimensional echocardiography to assist in the choice of balloon size. Before dilatation the transaortic systolic pressure gradients ranged from 60 mmHg to 177 mmHg, (mean: 91 ±38 mmHg). There were signifeant reduction in the transaortic systolic pressure...
Endodermal Sinus Tumor in Children.
Jae Sun Jung, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1988;31(6):772-778.   Published online June 30, 1988
Thirty-three cases of endodermal sinus tumor were reviewed. They were diagnosed at Seoul National University Hospital over the last 9 years. Sixteen were testicular, 12 were sacrococcygeal and the others were mediastinal, vaginal, ovarian, retrovesical and tongue endodermal sinus tumor. Endodermal sinus tumor of the tongue was the first reported case in the world. Serum 公-fetoprotein of 32 cases was elevated at diagnosis and...
Burkitt Lymphoma in Children.
Soo Jong Hong, Dong Kyu Jin, Hee Young Shin, Hyo Seop Ahn, Chang Yee Hong, Je G Chi
Clin Exp Pediatr. 1988;31(4):482-491.   Published online April 30, 1988
Seventeen cases of Burkitt lymphoma under 15 years of age who were admitted to Dept, of Ped., Seoul National University Hospital from Jan. 1979 to Dec. 1986 were reviewed and analysed. One hundred and six cases of non-Hodgkin lymphoma were seen during the same period. 1) Burkitt lymphoma accounted for 16% of non-Hodgkin lymphoma. 2) The age ranged from 10/12 year to 15 5/12 years, with...
Acute Tumor Lysis Syndrome in Burkitt Lymphoma.
Dong Kyu Jin, Soo Jong Hong, Il Soo Ha, Hyo Seop Ahn, Yong Choi, Chang Yee Hong
Clin Exp Pediatr. 1988;31(3):362-369.   Published online March 31, 1988
To assess the tumor lysis syndrome in Burkitt lymphoma, we analyzed the clinical and laboratory findings of 17 patients with Burkitt lymphoma who were admitted to the Department of Pediatrics, Seoul National University Hospital from January 1979 to December 1986. The acute tumor lysis syndrome was diagnosed when two of the five following metabolic abnormal- ities were met: ① hyperuricemia (≥8.0mg/dl), ② hyperphosphatemia (≥5.5 mg/dl),...
Estimation of Pressure Difference Between Right and Left Ventricle in Ventricular Septal Defect with Doppler Echocardiography.
Myung Chul Cho, Byung Kiu Park, Woo Sung Park, Chung Il Noh, Jung Yun Choi, Yong Soo Yoon, Chang Yee Hong
Clin Exp Pediatr. 1988;31(3):315-321.   Published online March 31, 1988
We compared the interventricular pressure gradient with Doppler echocardiography and that measured during cardiac catheterization in 48 children who were admitted for diagnostic cardiac catheterization and angiography to the ward of Pediatrics, Seoul National University Children’s Hospital during the period of 7 months from June to December 1986. Among 48 cases of simple ventricular septal defect, 21 cases were supracristal (type I), and 27...
Percutaneous Balloon Angioplasty in Children with Pulmonary Valvular Stenosis.
Yong Soo Yun, Chang Yee Hong
Clin Exp Pediatr. 1987;30(12):1355-1362.   Published online December 31, 1987
Pulmonary valve stenosis was relieved by balloon dilatation during cardiac catheterization on 58 children aged 8 months to 15 years, mean 6.2 years. Pulmonary valve diameter was estimated by two-dimensional echocardiogrphy to assist in the choice of balloon size. Before dilatation the transpulmonary systolic pressure gradients ranged from 15 mmHg to 250 mmHg. There were significant reduction in the transpulmonary systolic pressure gradients immediately after...
Clinical Observation on Splenectomized Children.
Mi Ryung Um, Jae Won Song, Yong Yull Koh, Jeong Kee Seo, Hyo Seop Ahn, Chang Yee Hong, Kwi Won Park
Clin Exp Pediatr. 1987;30(5):511-517.   Published online May 31, 1987
A clinical study was performed on 26 cases of splenectomized children who had been seen at the Department of Pediatrics, Seoul National University Hospital, during the period of 7 years 7 months from January 1978 to July 1985. The results were as follows: 1) Primary diseases were hereditary spherocytosis (8 cases), Hodgkin disease for staging laparotomy (8 cases), ...
Percutaneous Transluminal Angioplasty in Four Children with Takayasu's Arteritis.
Byung Kiu Park, Sejung Sohn, Chung Il Noh, Young Soo Yun, Chang Yee Hong, Kyung Mo Yeon, In One Kim
Clin Exp Pediatr. 1987;30(4):441-449.   Published online April 30, 1987
Percutaneous transluminal angioplasty (PT A) was done in four children with Takayasu’s arteritis at Seoul National University Children’s Hospital in 1986. Successful results were obtained in all cases. But one child with narrowing of the innominate artery, thoracic aorta and occlusion of the left subclavian artery showed the most dramatic improvement clinically as well as radiologically because the lesions were focal. PT A is...
Clinical Study on the Hypoplastic Right Heart Syndrome.
Sejung Sohn, Soon Ung Kang, Chung Il Noh, Jung Yun Choi, Yong Soo Yun, Chang Yee Hong, Dug Ha Kim, Jong Lin Rhi
Clin Exp Pediatr. 1987;30(3):281-290.   Published online March 31, 1987
A clinical observation was made on 12 cases of the hypoplastic right heart syndrome who were admitted to the department of Pediatrics, Seoul National University Hospital from January 1978 to May 1986. The -results were as follows; 1) The ratio of female to male was 1:1 and, according to the anatomic classification by Khoury, 6 cases were in type 1, 4 cases in type II...
Clinical Observation of Truncus Arteriosus.
Sang Kyu Park, Young Soo Kim, Sejung Sohn, Chung Il Noh, Jung Yun Choi, Yong Soo Yun, Chang Yee Hong
Clin Exp Pediatr. 1987;30(1):45-54.   Published online January 31, 1987
This is the report on 10 cases of truncus arteriosus, experienced at the Seoul National University Hospital, during past 7 years from Jan. 1979 to Dec. 1985. The results of observations were as follows; 1) There were 6 males and 4 females, and according to Collett and Edwards’ classification, 5 cases were in type 1, 4 case were in type II and 1 case...
Case Report
Hodgkin’s Disease in Children
Soo Jong Hong, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1986;29(12):1352-1359.   Published online December 31, 1986
Twenty one cases of Hodgkin’s disease under 15 years of age who were admitted to Dept, of Ped. of Seoul National University Hospital from Jan. 1976 to Dec. 1985 were reviewed and analysed. One hundred and five cases of non-Hodgkin’s lymphoma were seen during the same period. 1) The ratio of non-Hodgkin’s lymphoma to Hodgkin's disease was 5:1. 2) The age ranged from 18/12 years...
A Case of Chronic Myelogenous Leukemia in a Child Treated in a Interferon.
Ill Soo Ha, Jon Lin Rhi, Se Jung Sohn, Dug Ha Kim, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1986;29(11):1232-1238.   Published online November 30, 1986
A child with Ph^positive chronic myelogenous leukemia was treated with human leukocyte interferon (Hu IFN-alpha). Hematologic remission was obtained in 16 weeks of treatment, and white blood cell count was decreased in number from 115,000 to 9,600. Platelet：count, spleen size, LDH and bone marrow M/E ratio were decreased in parallel, but there was no significant change in serum vitamin B12...
Original Article
Heart Diseases in Korean Children: Past and Present.
Chang Yee Hong
Clin Exp Pediatr. 1986;29(11):1161-1167.   Published online November 30, 1986
Clinical Studies on Ventricular Septal Defect with Septal Aneurysm.
Jae Kon Ko, Jung Yun Choi, Yong Soo Yun, Chang Yee Hong, Kyung Mo Yeon
Clin Exp Pediatr. 1986;29(5):504-509.   Published online May 31, 1986
Ninety-nine cases of ventricular septal defect with septal aneurysm which were confirmed by angiocardiography and 2-D echocardiography during the period of 2 years from 1983 to 1984 at SNUH were studied and analyzed. The summary of the findings are as follows: 1) Septal aneurysm was found in 99(26.9%) of 368 cases of total VSD and in 38.2% among membranous VSD....
Renovascular Hypertension in Childhood.
Jae Won Song, Soo Heun Lim, Yong Choi, Kwang Wook Ko, Chang Yee Hong, Kyung Mo Yeon
Clin Exp Pediatr. 1986;29(4):381-386.   Published online April 30, 1986
The following results were obtained from a retrospective analysis of 21 cases of renovascular hypertension who were admitted to Pediatric Department, Seoul National University Hospital, during the period from January 1978 to December 1985. 1) Takayasu arteritis was the most common cause (15 out of 21, 71%), and fibromuscular dysplasia of renal artery was confirmed only in two (9.5%) cases. 2) Male...
Clinical Studies on Congenitally Corrected Transposition of the Great Arteries.
Byong Kwan Son, Chung Il Noh, Jung Yun Choi, Yong Soo Yun, Chang Yee Hong
Clin Exp Pediatr. 1986;29(3):287-295.   Published online March 31, 1986
The clinical studies were performed on 29 congenitally corrected transposition of£the great arteries (C-TGA) confirmed by cardiac catheterization and angiocardiography at the Department of Pediatrics, Seoul National University Hospital, from Oct. 1957 to Dec. 1984. The results are as follows; 1) There were 29 cases of C-TGA, representing 0.7% of a total of 4,096 CHD patients. The male： female ratio was 3.1 :...
Cardiac Malposition.
Sejung Sohn, Jung Yun Choi, Yong Soo Yun, Chang Yee Hong, Je G Chi
Clin Exp Pediatr. 1986;29(2):186-202.   Published online February 28, 1986
Cardiac malposition refers to any position of the heart other than a left-sided heart in a situs solitus individual. Authors analyzed the clinical, radiological, operative and autopsy findings of 69 patients with cardiac malpositions by segmental approach to describe the internal cardiac anatomy and their arterial connections. 1) Male to female sex ratio was 1.23 : 1 and 68% of cases were under...
Bone Marrow Cell Culture(GM-CFU) in Anaplastic Anemia of Children.
Jae Sun Jung, Chang Yee Hong
Clin Exp Pediatr. 1985;28(9):888-898.   Published online September 30, 1985
Bone marrow cell cultures (GM-CFU) were performed in the 15 cases of children with aplastic anemia and the correlation with the clinical course were investigated. They have been treated with androgen with or without low dose prednisone and supportive care. Bone marrow cell cultures from 8 children without any evidence of aplastic anemia were performed as a control. 1)In control...
Left Ventricular Function in Chronic Severe Anemia by Echocardiographic Study.
Jae Kon Ko, Chang Yee Hong
Clin Exp Pediatr. 1985;28(9):880-887.   Published online September 30, 1985
It is well known that chronic anemia is associated with hemodynamic alterations like increased cardiac output and stroke volume and decreased peripheral vascular resistance. Left ventricular size and function were studied by echocardiography in 16 chronic anemia patients, mainly aplastic anemia, without evidence of cardiac decompensation. Left ventricular dimension, stroke volume, ejection fraction and fractional shortening were calculated. The LV...
Case Report
Three Cases of Congenital Hypoplastic Anemia.
Heui Jeong Kwon, Myung Hyun Lee, Jung Hwan Choi, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1985;28(8):829-835.   Published online August 31, 1985
Congenital hypoplastic anemia is a rare disease characterized by aplasia or severe hypoplasia of the erythron, with onset usually at birth or during early infancy. This report presented three cases of congenital hypoplastic anemia in 3 infants with pallor and irritability which were noticed since one to three months of age. Three cases were treatsd with prednisolone and the courses of...
Original Article
A Clinical Study on Cardiofacial Syndrome (Asymmetric Cry Syndrome).
Chung Il Noh, Chang Yee Hong
Clin Exp Pediatr. 1985;28(7):637-641.   Published online July 31, 1985
Seven patients with cardiofacial syndrome were observed for twenty months from Oct. 1983 to May. 1985 at the Pediatric Department of Seoul National University. Age ranged from 1 months to 10 years and six patients were male. Right-sided facial palsy occurred in 4 patients and left-sided in 3 patients. Cardiac defects were TOF, VSD(membranous), Criss-Cross heart with large VSD, pulmonary...
Comparative Study on Quantitation of Left to Right Shunts in Ventricular Septal Defect Using Oximetry and Radionuclide Method.
Chang Yee Hong, Jung Yun Choi, Se Won Park, Yong Soo Yun, Chang Soon Koh
Clin Exp Pediatr. 1985;28(4):340-344.   Published online April 30, 1985
In 80 children with isolated ventricular septal defect, quantitation of left to right shunts was performed using oximetry and rdionuclide angiocardiography(RNA). The radionuclide angiocardiograms were acquired and analized by a gamma camera interfaced to a digital computer system. Pulmonary to systemic f!ow(Qp/Qs) ratios were calculated by analysis of pulmonary time-activity histograms using a gamma variate model. A comparison of the...
Heart Disease Screening for Primary School Children.
Chang Yee Hong, In Sil Lee, Hee Ju Kim, Jung Hwan Choi, Hae Il Cheong, Jung Yun Choi, Yong Soo Yun
Clin Exp Pediatr. 1985;28(3):258-262.   Published online March 31, 1985
A heart disease screening program was performed on 15,685 primary school children in Seoul City from the first to sixth grade to estimate the prevalence of heart diseases. Among the 15,685 children examined, 45 were confirmed to have heart disease (2.9/1,000) Out of the 45 children, 38 had congenital heart disease(2.4/1,000) and 7 had rheumatic heart disease(0.4/1,000) and the ratio...
Captopril in Children with Renovacular Hypertension.
Yong Choi, Hoan Jong Lee, Hee Young Shin, Kwang Wook Ko, Chang Yee Hong
Clin Exp Pediatr. 1985;28(1):58-67.   Published online January 31, 1985
Captopril, a kind of converting enzyme inhibitors, is a promising anti-hypertensive drug, which is developed recently, and studied mainly in adult patients. We administered captopril to 4 children with renovascular hypertension, three of them accompanied Takayasu's arteritis and the remainder had isolated lesion. Three to five times of initial trials were performed on each patient with 12.5 mg of captopril....
Case Report
A Case of Isolated Congenital Tricuspid Insufficiency.
Dong Hyun Choo, Dong Kyoon Kim, Jung Yeon Choi, Yong Soo Yoon, Chang Yee Hong
Clin Exp Pediatr. 1984;27(8):814-819.   Published online August 31, 1984
Isolated congenital tricuspid insufficiency is a rare anomaly and may be caused by abnormal chordae tendinae, papillary muscle, or valve leaflets. The cause of these lesions is generally ascribed to incomplete undermining of primitive endocardial cushion by sinusoidal space, which differentiate the cushion into the various valvular structures. Carvallo’s sign, most characteristic clinical sign in tricuspid insufficiency, is augumentation of systolic...
Original Article
Clinical Study of Wilms' Tumor .
Myung Hyun Lee, In Sil Lee, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1984;27(6):603-609.   Published online June 30, 1984
Thirty-five cases of Wilms tumor treated at the Seoul National University Hospital from 1969 to 1983, were analyzed and the results are as follows: 1)Ages at nephrectomy were from 1 monh. to 11 years and 8 months. The mean, age was 3 years and 4 months and the median was 2 years and 9 months. The sex ratio of male...