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Original Article
Changes of Endothelin-1 after Pulmonary Venous Stenosis in Dog Model
Young Mi Hong, Yong Soon Won, Seung Suk Kim
Clin Exp Pediatr. 2000;43(6):769-778.   Published online June 15, 2000
Purpose : Endothelin-1(ET-1) is a potent vasoconstrictor peptide. It has potent contractile and proliferative effects on vascular smooth muscle cells. Congenital heart diseases are often accompanied by pulmonary hypertension, and the severity of pulmonary hypertension is important in the prognosis. The aim of this study was to elucidate changes of ET-1 after pulmonary venous stenosis in a dog model, and...
Oscillometric Blood Pressure of Upper and Lower Extremities and Aortic Blood Flow Velocity in Neonates
Sang Young Bae, Hae Soon Kim, Se Jung Sohn, Young Mi Hong
Clin Exp Pediatr. 2000;43(4):484-488.   Published online April 15, 2000
Purpose : We studied the blood pressure difference between the upper and lower extremities in healthy newborn infants and the effect of isthmic narrowing of the aorta on making a possible difference. Methods : The blood pressure was measured with an oscillometric blood pressure device from four extremities of 62 healthy infants aged 1-15 days. A Doppler echocardiography was performed for...
Comparison Study between Immunohistochemical Staining and Enzyme Linked Immunosorbent Assay in Metalloproteinases and Tissue inhibitor of Metalloproteinases in Virus induced Myocarditis
Young Mi Hong, Seung Sook Kim
Clin Exp Pediatr. 1999;42(11):1524-1534.   Published online November 15, 1999
Purpose : Most tissue disruption of extracellular matrix is mediated by extracellular proteinases. Matrix metalloproteinases(MMP) and tissue inhibitor of matrix metalloproteinases(TIMP) are associated with wound healing and repair. There has been no study done on MMP and TIMP in myocarditis. Methods : Coxsackie B virus(4,000 plaque forming unit) was injected into Balb/c mice by intraperitoneal injection. Histopathological finding was observed...
Effects of Respiration on Right and Left Ventricular Diastolic Function in Normal Children
Hae-Soon Kim, Young Mi Hong
Clin Exp Pediatr. 1999;42(10):1412-1418.   Published online October 15, 1999
Purpose : To evaluate the effects of respiration on diastolic filling pattern in normal children by Doppler echocardiography. Materials and Methods : Doppler echocardiograms of the tricuspid and mitral valves were recorded with electrocardiogram and respirations in 46 normal children aged 3months to 14years(7.6¡¾3.5year). We measured the following variables: heart rate, the peak E and A velocities, the area under the...
Effect of Low-Dose Aspirin Therapy on Platelet Aggregation in Kawasaki Disease
Ju Yeon Yeo, Heon Eui Le, Young Mi Hong, Ki Sook Hong, Wha Soon Chung
Clin Exp Pediatr. 1999;42(4):510-518.   Published online April 15, 1999
Purpose : Aspirin(acetylsalicylic acid) has been used to treat unstable angina and acute myocardial infarction in adults and Kawasaki disease in children. The antithrombotic effect of aspirin was attributed to its ability to inhibit platelet aggregation by inhibiting platelet cyclooxygenase, which leads to decreased thromboxane synthesis. The purpose of this study was to evaluate the effect on the platelet aggregation...
Diagnostic Utility of D-dimer Test in Disseminated Intravascular Coagulation with Sepsis
Jung Eun Kim, Young Mi Hong, Gyung Hee Kim
Clin Exp Pediatr. 1999;42(2):257-263.   Published online February 15, 1999
Purpose : Disseminated intravascular coagulation(DIC) is a confusing disorder from both a diagnostic and therapeutic standpoint. In order to investigate the effectiveness of D-dimer test in disseminated intravascular coagulation associated with sepsis, D-dimer level and other laboratory tests were performed. Methods : Fifty patients with disseminated intravascular coagulation associated with sepsis, who were admitted to the department of pediatrics, were evaluated by...
Estimating Fetal Cardiac Output by Doppler Echocardiography
Young Mi Hong
Clin Exp Pediatr. 1999;42(2):203-210.   Published online February 15, 1999
Purpose : Doppler echocardiography has been used to identify fetal cardiac anatomy and hemodynamics. It can estimate flow velocity, volume, and cardiac output. The purposes of this study were to estimate right and left ventricular stroke volume and cardiac output in fetus, and to see if there were any changes of right and left ventricular parameter with fetal growth. Methods :...
The Relationship between IL-1β, TNFα, IL-6 and Factors Associated with Febrile Reactions to Transfused Blood
Hae Shin Kyung, Kyung Ha Ryu, Kyung Hyo Kim, Young Mi Hong, Kyung Hi Kim, Keun Lee
Clin Exp Pediatr. 1999;42(1):108-114.   Published online January 15, 1999
Purpose : Aggressive chemotherapy and bone marrow transplantation have a large demand for platelet concentrate and packed RBC transfusion. Febrile nonhemolytic transfusion reactions are an immunologically mediated reaction involving plasma in the recipient and the white blood cells in the donor. This study was performed to understand the role of cytokines and factors associated with febrile nonhemolytic transfusion reaction to...
Microdeletion of Chromosome 7 in Williams Syndrome and Supravalvular Aortic Stenosis
Ho Sung Kim, Yoon Sung Kang, Kyung Hyo Kim, Young Mi Hong, Yong Soo Yun, Kwang Ho Lee
Clin Exp Pediatr. 1999;42(1):47-59.   Published online January 15, 1999
Purpose : Williams syndrome is characterized by supravalvular aortic stenosis, mental retardation and peculiar facial appearance. Its genetic etiology is considered to be a hemizygotic deletion in Chromosome 7q11.23, which includes the elastin gene. We examined the hemizygotic deletion of Chromosome 7q11.23 in 12 Korean Williams syndrome patients and 8 patients with isolated supravalvular aortic stenosis and performed deletion mapping...
A Nationwide Clinical Study of Acute Respiratory Distress Syndrome in Children
Soo Jung Choi, Do Suck Jeong, Jae Won Oh, Ha Baik Lee, Im Ju Kang, Kwang Woo Kim, Kyu Earn Kim, Ki Bok Kim, Young Ho Rah, Kang Seo Park, Byong Kwan Son, Ki Young Lee, Sang Il Lee, Ji Tai Choung, Young Mi Hong
Clin Exp Pediatr. 1999;42(1):23-31.   Published online January 15, 1999
Purpose : Acute respiratory distress syndrome(ARDS) is the final course of acute lung injury. It results from various etiological origins and pathophysiologic mechanisms, and has a mortality rate of approximately 60-70%. Although the confirmative incidence of ARDS in children is yet unknown, the increasing incidence of ARDS has been reported in Korea. In the present study, we report ARDS diagnosed...
Cardiovascular Doppler Flow Waveforms in Human Fetuses
Young Mi Hong
Clin Exp Pediatr. 1998;41(12):1639-1649.   Published online December 15, 1998
Purpose : Doppler echocardiography has been used to identify fetal cardiac anatomy and hemodynamics. It can estimate flow velocity, volume, and cardiac output. The purpose of this study was to look at cardiovascular waveforms in fetus and to see if there were any changes in Doppler parameter with fetal growth. Methods : Blood velocity studies were performed across the mitral, tricuspid,...
Diagnostic Sensitivity in Predicting Hyperlipidemia by Bioelectrical Impedance Analysis in Obese Children
Ji Ah Jung, Hyun Mi Kim,, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1998;41(11):1583-1589.   Published online November 15, 1998
Purpose : Childhood obesity is currently on the rise. The complications of childhood obesity are depression, adult obesity, hypertension, diabetes, hyperlipidemia, coronary artery disease and fatty liver. Therefore, accurate diagnosis of obesity is important. The purpose of this study was to assess diagnostic sensitivity to predict hypelipidemia by bioelectrical impedance analysis(BI) in obese children. Methods : One hundred fifteen healthy...
Volumetric Quantitation of Pulmonary Regurgitation and Right Ventricular Function in Postoperative Tetralogy of Fallot by Echocardiography and Magnetic Resonance Imaging
Eun Young Park, Il Tae Whang, Young Mi Hong, Yong Sun Won, Yun Hyun Choi
Clin Exp Pediatr. 1998;41(11):1530-1537.   Published online November 15, 1998
Purpose : Despite improved surgical techniques, pulmonary regurgitation is a common postoperative sequelae in patients with tetralogy of Fallot. Pulmonary regurgitation may induce deterioration of right ventricular performance, right ventricular dilatation and ventricular arrhythmia. The evaluation of the clinical significance of pulmonary regurgitation in postoperative tetralogy of Fallot has been troublesome since there was no technique that could accurately quantitate...
The Role of Apoptosis in Adriamycin Induced Cardiotoxicity and Preventive Effect of L-carnitine in Rat
Young Mi Hong, Seung Sook Kim
Clin Exp Pediatr. 1998;41(6):760-768.   Published online June 15, 1998
Purpose : Adriamycin is very important in cancer chemotherapy. Unfortunately, the drug shows cumulative dose dependent cardiotoxicity. The precise mechanism of this remains unclear. It has been shown that adriamycin induces programmed cell death or apoptosis in many tissues. But the role of apoptosis in adriamycin induced cardiotoxicity is uncertain. Methods : Sprague-Dawley rats were divided into four groups of ten animals each. All...
Normal Predicted Values of Pulmonary Function Test in Healthy Korean Children
Seung Yeon Nam, Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1998;41(3):338-345.   Published online March 15, 1998
Purpose : We performed a pulmonary function test with simple, computerized spirometry composed of pneumotachometry and evaluated the predicted normal values of air flow rates and lung volumes in healthy Korean children. We calculated each of the simple and complex linear and logarithmic regression equations setting the predicted values. Methods : Four hundred and fifty-two healthy children were enrolled from December, 1994 to August, 1995....
Left Ventricular Mass Estimated by Three Methods of Echocardiography in Normal Children
Yae Jean Kim, Soo Ja Hwang, Dong Hee Shin, Young Mi Hong
Clin Exp Pediatr. 1998;41(2):192-199.   Published online February 15, 1998
Purpose : Left ventricular hypertrophy is an important diagnostic and prognostic finding in children with various cardiovascular diseases. Echocardiographic determination of the left ventricular mass is the most accurate method for assessing left ventricular hypertrophy non-invasively. The purposes of this study are 1) to establish a reproducible, validated method for determining left ventricular mass in children by echocardiography, 2) to...
Urinary Interleukin-1β Levels in Children with Urinary Tract Infection
Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(7):981-990.   Published online July 15, 1997
Purpose : IL-1β and TNF-α are important mediators of the inflammatory response in serious bacterial infections. The mucosal and systemic IL-1β and TNF-α responses to urinary tract infection are analyzed in children with acute urinary tract infection. Methods : We studied the levels of these two cytokines in the urine and sera of 21 children at diagnosis and after treatment with sandwich ELISA method. Results...
Dermatophagoides Pteronyssinus Specific IgG-subclass Antibodies in Allergic Children
Soo Ja Hwang, Kyung Hyo Kim, Young Mi Hong
Clin Exp Pediatr. 1997;40(5):701-707.   Published online May 15, 1997
Purpose : Although immunoglobulin E play a major role in immediate hypersensitivity reactions, some reaginic activity is associated with IgG. Part of the reaginic activity is associated with IgG1, IgG4. In contrast with this reaginic activity of IgG4, allergen-specific IgG4 antibody is allergen neutralizing antibody and contribute to the benificial effect of immunotherapy. The role of specific IgG antibody in allergic...
Dermatophagoides pteronissinus Specific IgG Subclasses according to Severity of Exercise Induced Asthma in Allergic Children
Young Mi Hong
Clin Exp Pediatr. 1997;40(1):110-116.   Published online January 15, 1997
Study of Epstein Barr Virus Antibodies in Patients with Kawasaki Disease
Dong Hee Shin, Kyung Hyo Kim, Young Mi Hong, Gyung Hee Kim
Clin Exp Pediatr. 1996;39(11):1603-1610.   Published online November 15, 1996
Purpose : The etiology of the Kawasaki disease remains unclear, many strong clinical and epidemiologic characteristics suggest an infectious etiology. However, conventional bacterial and viral cultures and extensive serologic studies have not revealed a consistent causative agent. Thus we studied the Epstein Barr virus(EBV), one of the most important pathogens, to access the association between the EBV and Kawasaki disease. Methods : Seventy-two patients with...
Comparison of Left and Right Ventricular Volume and Cardiac Output by MRI and Echocardiography
Young Mi Hong
Clin Exp Pediatr. 1996;39(7):962-969.   Published online July 15, 1996
Purpose : Ventricular volume and cardiac output are very important to evaluate cardiac fuction. Cine MRI has been found to a feasible technique in evaluating cardiac anatomy and cardiovascular function in a variety of cardiac disease. Measurement of left ventricular volume by cine MRI was closely correlated with the result by echocardiography or cine angiography. The purpose of this study is to compare the...
Case Report
A Case of Cystic Pancreatoblastoma Associated with Congenital Hemihypertrophy
Hyun Joo Lee, Kyuong Ha Yoo, Young Mi Hong, Kyung hee Kim, Kum Ja Choi, Joung Hyun Yoo, Sung Sook Kim
Clin Exp Pediatr. 1996;39(6):861-865.   Published online June 15, 1996
We experenced a case of cystic pancreatoblastoma associated with congenital hemihypertrophy in a 4months old male. The mass was located on the anterior side of pancreatic head without any connection to the pancreas. After exision of cystic pancreatoblastoma, chemotherapy(FAM regimen) was performed 15 times due to capsular tumor invasion. Until this time there was no drug side effect and metastasis....
Original Article
Predictor of Fatty Liver in Obese Children
Hyunmi Kim, Young Mi Hong, Gyoung-Hee Kim, Jung Hyun Yu
Clin Exp Pediatr. 1996;39(6):803-810.   Published online June 15, 1996
Purpose : The childhood obesity is currently increasing. The childhood obesity is difficult to treat and the response of treatment is transitory because it is caused by the hyperplasia of fatcells. The complications of obesity are hyperlipidemia, hypertension, diabetes, artherosclerotic coronary arterial disease and fatty liver. Therefore the early diagnosis and prevention of obesity from childhood is very important. This study...
Serum Secretory CD4 and CD8 Levelsin Kawasaki Disease
Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(4):543-551.   Published online April 15, 1996
Purpose : Kawasaki disease (KD) is an acute febrile illness of infancy and early childhood characterized by diffuse vasculitis. Although the disease is generally self-limited, up to 25% of untreated patients with KD may develop coronary artery abnormalities. The acute phase of KD is characterized by marked activation of the immune system leading to increased cytokine production by immune effector...
Evaluation of Abnormal Coronary Artery Flow in Anomalous Coronary Artery Connections by Pulsed and Color Doppler Echocardiography
Young Mi Hong
Clin Exp Pediatr. 1996;39(1):78-87.   Published online January 15, 1996
Purpose : Anomalous connection of coronary artery can result in damage of myocardial perfusion, myocardial infarction, or congestive heart failure. Echocardiography has been used to demonstrate coronary artery anomalies such as coronary artery fistula, anomalous origin of the left coronary artery from the pulmonary artery, and aneurysm of the coronary arteries in Kawasaki disease. Definitive diagnosis relies on cardiac catheterization The...
3 Cases of Kawasaki Disease Associated Thrombocytopenia
Hye Soon Kim, Young Mi Hong, Seung Joo Lee
Clin Exp Pediatr. 1995;38(12):1686-1690.   Published online December 15, 1995
Kawasaki disease may be associatde with a variety of hematologic abnormalities, the most characteristic being thrombocytosis. Thrombocytopenia, in contrast, appears to occur rarely in children with this disease. Hera et al observed the 2% manifested thrombocytopenia early in their illness. To our knowledge, early thrombocytopenia has not been reported in other populations, We report the case of a children with...
CorreJation between High Blood Pressure and Lipid Profile in School Children
Young Mi Hong, Yun Ju Kang, Sung Jae Suh
Clin Exp Pediatr. 1995;38(12):1645-1652.   Published online December 15, 1995
Purpose : Adult essential hypertension begins in early childhood. Blood pressure patterns in children differ from those in adults, and the design of hypertension programs need to modified for young people. Hypertension in children is associated with several factors, but correlation with lipid profiles is not unknown. The purpose of this study is to analyze the affecting factors in child hypertension...
Changes of Cerebral Blood Flow Velocity before and after Closure of Ductus Arteriosus using Doppler Ultrasound in Normal Full-term Newborns
Myung Su Lee, Young Mi Hong, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(12):1620-1628.   Published online December 15, 1995
Purpose : With PDA, major fluctuations of blood flow are noted between opening and closure of ductus arteriosus and there is an increase in the amplitude of each pulse of blood flow. The purpose of this study was to evaluate the changes of cerebral blood flow before and after closure of ductus arteriosus in healthy term newborns. Methods : Forty-two normal term...
Comparative Study on the Allergy Skin Test and RAST in Allergic Patients
Il Tae Whang, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1994;37(12):1693-1700.   Published online December 15, 1994
The allegic skin test and RAST are used commonly to demonstrate the presence of skin sensitizing IgE antibody in the diagnosis of allergic disease. To evaluate the agreement rate and correlation between results of skin test and RAST (radioallergosorbent test) in allergic subject, 83 allergic childgood with positive skin test (bronchial asthma: 26, allergic rhinitis: 27, atopic dermatitis and urticaria: 6...
Airway Resistance after Exercise Loading Test in Asthmatic Children
Ji Eun Lee, Young Mi Hong, Kyung Hee Kim
Clin Exp Pediatr. 1994;37(10):1333-1339.   Published online October 15, 1994
Exercise induced asthma(EIA) is defined as acute, reversible, usually self-immiting airway obstruction which develop after strenous exercise in patients with asthma. EIA is a bigger problem in children than adults due to more active and smaller airways which obstruct more easily when bronchospasm develops. The exercise elicited amny change in pulmonary function of asthmatic children. These change could be measured...