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Original Article
Clinical significance of cerebrospinal fluid pleocytosis in pediatric refractory status epilepticus
Jung Mi Kim, Young Mi Kim, Soon Hak Kwon
Clin Exp Pediatr. 2006;49(10):1086-1092.   Published online October 15, 2006
Purpose : Refractory status epilepticus(RSE) is a serious neurological emergency in children. The mortality is high and the neurological outcome is not good. This study aimed to evaluate the clinical significance of cerebrospinal fluid(CSF) pleocytosis in refractory status epilepticus in children. Methods : From January 1999 to January 2006, 25 out of 37 children with refractory status epilepticus had...
The influence of some intrauterine growth variables on neonatal blood pressure
Jungwon Min, Eun Ae Park, Kyoungae Kong, Bohyun Park, Juhee Hong, Young Ju Kim, Hwayoung Lee, EunHee Ha, Hyesook Park
Clin Exp Pediatr. 2006;49(9):966-971.   Published online September 15, 2006
Purpose : ‘Programming’ describes the process that stimulus at a critical period of development has lifelong effects. The fact that low birth weight links to the risk of elevated blood pressures in adult life is well known. This study aims to examine whether this link is evident in the newborn by investigating the relationship of the intrauterine growth indices and...
Case Report
A case of constrictive pericarditis presenting with protein-losing enteropathy
Jeong Mi Hong, Jae Young Lee, Soo Jin Kim, Gi Young Jang, Woo Sup Shim
Clin Exp Pediatr. 2006;49(8):898-901.   Published online August 15, 2006
Constrictive pericarditis represents a rare cause of protein-losing enteropathy in children. Reported is an 11-year-old girl with protein-losing enteropathy (PLE) as the principal manifestations of constrictive pericarditis. After total pericardiectomy, symptoms and signs of PLE disappeared. Doppler echocardiography including tissue Doppler imaging is a useful noninvasive initial diagnostic tool for differential diagnosis of diastolic heart failure.
Original Article
NT-pro BNP : A new diagnostic screening tool for Kawasaki disease
Hyunju Lee, Heejung Kim, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2006;49(5):539-544.   Published online May 15, 2006
Purpose : The purpose of this study was to determine whether N-terminal fragment of B-type natriuretic peptide(NT-proBNP) may be used to differentiate acute Kawasaki disease(KD) from other clinically similar diseases. Methods : Using electrochemiluminescence immunoassay, NT-proBNP concentrations were measured in the acute phase within 10 days after the onset of KD(n=58) and in the convalescent phase, 60 to 81 days after...
Neonatal hearing screening in a neonatal intensive care unit using distortion product otoacoustic emissions
Do Young Kim, Sung Shin Kim, Chang Hwi Kim, Shi Chan Kim
Clin Exp Pediatr. 2006;49(5):507-512.   Published online May 15, 2006
Purpose : Early detection and intervention of hearing impairment is believed to improve speech and language development and behavior of children. The aim of this preliminary study was to determine the prevalence of hearing impairments, and to identify the association of risk factors relating to refer response in high risk neonates who were screened using distortion product otoacoustic emissions (DPOAE). Methods...
Molecular-epidemiologic study on outbreak of colonization by extended spectrum β-lactamase producing Klebsiella pneumoniae in neonatal intensive care unit
Nu-Lee Jun, Mi-Na Kim, Jae-Sim Jeong, Yang-Soo Kim, Ellen Ai-Rhan Kim, Ki-Soo Kim, Soo-Young Pi
Clin Exp Pediatr. 2006;49(2):150-156.   Published online February 15, 2006
Purpose : The aims of this study included assessment of molecular-epidemiologic features during an outbreak of colonization of extended spectrum β-lactamase producing Klebsiella pneumoniae(ESBL- KPN) and re-evaluation of their colonized status one year later. Methods : Rectal swab cultures for ESBL-KPN from all hospitalized infants and newly admitted infants were obtained during the outbreak of colonization from July to December,...
Usefulness of serum procalcitonin test for the diagnosis of upper urinary tract infection in children
Dong Wook Kim, Ju Young Chung, Ja Wook Koo, Sang Woo Kim, Tae Hee Han
Clin Exp Pediatr. 2006;49(1):87-92.   Published online January 15, 2006
Purpose : It is difficult to make a distinction between lower urinary tract infection(UTI) and acute pyelonephritis(APN) during the acute phase of febrile UTI due to nonspecific clinical symptoms and laboratory findings, especially among young children. We measured the serum procalcitonin(PCT) in children with UTI to distinguish between acute pyelonephritis and lower UTI, and to determine the accuracy of PCT...
Changes of Lipid and Lipoprotein Compositions in Kawasaki Disease and its Impact on Cardiac Complications
Sin Weon Yun, Ho Seok Lee, Dong Woon Kim, Kang Won Rhee, Young Soo Jung
Clin Exp Pediatr. 2005;48(12):1370-1377.   Published online December 15, 2005
Purpose : Delineation of serum lipid and lipoprotein values in children after Kawasaki disease(KD) is important because of the predilection of this disease for the coronary arteries. Methods : The KD group was composed of 51 patients who were hospitalized from Jan. 2002 to Dec. 2003. Control was 25 patients with non-KD febrile illness. The levels of total lipid, phospholipid,...
Pneumococcal Surface Protein A of Streptococcus pneumoniae Isolates from Koreans
Kyung Hyo Kim
Clin Exp Pediatr. 2005;48(11):1206-1211.   Published online November 15, 2005
Purpose : Pneumococcal protein vaccine based on pneumococcal surface protein A (PspA) is in development with the potential to offer a broad range of protection against different strains. PspA elicits protection in mice against fatal sepsis as well as carriage and lung infection. This study was performed to investigate the frequency of PspA families among Streptococcus pneumoniae recovered from Korean...
The Study of Clinical Characteristic Changes in Acute Poststreptococcal Glomerulonephtritis - Comparision of Clinical Manifestations between Recent 5 Years and Past 5 Years -
Hye Won Yoon, Kyung Soo Park, Jae Ho Lee
Clin Exp Pediatr. 2005;48(11):1201-1205.   Published online November 15, 2005
Purpose : The purpose of this study is to evaluate the clinical characteristic changes of acute poststeptococcal glomerulonephritis(APSGN) in recent. The cases of APSGN occurred for the last ten years were divided into group I and II by the unit of 5 years and clinical manifestations and laboratory findings of each groups were analyzed. Methods : Total of 74 cases...
A Domestic Outbreak of Bacterial Dysentery Caused by Extended-Spectrum β-Lactamase(ESBL)-producing Shigella sonnei
Hyun Taek Lim, So Hee Lee, Jung Hwa Lee, Jeong Eun Kim, Kyo Sun Kim, Eun Ju Jeong, Seung Hyun Lee, Chang Gyu Kang, Seong Jin Hong
Clin Exp Pediatr. 2005;48(10):1107-1115.   Published online October 15, 2005
Purpose : An outbreak of ESBL-producing Shigella sonnei enteritis was unprecedented not only in Korea but throughout the world in the past. We intended to devise a management guideline for ESBL-producing shigellosis based on analysis of clinical manifestations and response to therapy. Methods : We analyzed 103 patients who were admitted to the hospital with acute GI symptoms and were...
Risk Factors for the Early Recognition of Cow's Milk Protein-induced Enterocolitis
Sung Hyuk Lee, Seon Yun Choi, Byung Cheol Lee, Won Joung Choi, Byung Kyu Choe, Yeo Hyang Kim, Una Kang, Sin Kam, Jin-Bok Hwang
Clin Exp Pediatr. 2005;48(9):991-997.   Published online September 15, 2005
Purpose : Cow's milk protein-induced enterocolitis(CMPIE) is a symptom complex of vomiting and/ or diarrhea caused by delayed hypersensitivity and may result in serious complications. This study was undertaken to identify high risk factors to facilitate the early recognition of CMPIE. Methods : We reviewed the data of 101 patients, aged 15 to 45 days, admitted due to vomiting and/...
Medicolegal Problems in Pediatric Area
Soo Jeong Kwon, Ji Young Jang, Nam Su Kim, Myung Kul Yum, In Joon Seol, Ku Won Jung
Clin Exp Pediatr. 2005;48(8):813-819.   Published online August 15, 2005
Purpose : Medicolegal problems start when the patient asserts the mistake of doctor and doctor does not accept it. The purpose of this study is to assess the actual condition of medicolegal problems and to provide solutions of medicolegal problems in the pediatric field. Methods : There is not official statistical data about medicolegal problems in our country. We gathered...
Airway Compression or Airway Anomaly Causing Respiratory Symptoms in Infants and Children with Cardiovascular Diseases
Ja-Hyeong Kim, So-Yeon Lee, Hyo-Bin Kim, So-Eun Koo, Sung-Jong Park, Young-Hui Kim, In-Suk Park, Jae-Kon Ko, Dong-Man Seo, Soo-Jong Hong
Clin Exp Pediatr. 2005;48(7):737-744.   Published online July 15, 2005
Purpose : Infants and children with cardiovascular diseases often present with respiratory symptoms. However, missed or delayed evaluation for potential airway problem may complicate overall prognosis. The aim of this study is to determine the clinical characteristics of these patients and explore the cause of airway problem. Methods : We reviewed the medical records of 64 patients(M : F=33:31, mean...
Medical Lecture Course
Mechanisms of Action of Probiotics
Jae Sung Ko
Clin Exp Pediatr. 2005;48(7):691-695.   Published online July 15, 2005
There is scientific evidence that administration of probiotics is effective in the treatment of acute infectious diarrhea in children and the prevention of antibiotic associated diarrhea and nosocomial/ community acquired diarrhea. Probiotics prevent relapse of recurrent pouchitis and decrease the initial onset of pouchitis in ulcerative colitis. Probiotic organisms suppress growth of pathogens as well as their epithelial attachment and/or...
Original Article
Clinical Outcome and Prognostic Factors of Acute Respiratory Distress Syndrome in Children
Jung-Min Ko, Eun-Ju Ha, Eun-Hee Lee, So-Youn Lee, Hyo-Bin Kim, Soo-Jong Hong, Seong-Jong Park
Clin Exp Pediatr. 2005;48(6):599-605.   Published online June 15, 2005
Purpose : The purpose of this study was to examine the causes, clinical courses and outcomes in children with acute respiratory distress syndrome(ARDS), and evaluate the physiologic variables as prognostic factors in the patients. Methods : Retrograde medical chart review was carried out in 24 patients who were diagnosed with ARDS at the pediatric intensive care unit(PICU) during 20-month period. Results...
Medical Lecture Course
Proliferative and Synthetic Responses of Airway Smooth Muscle in Asthma
Jung Yeon Shim
Clin Exp Pediatr. 2005;48(6):580-587.   Published online June 15, 2005
New evidence is emerging that airway smooth muscle(ASM) may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, polypeptide growth factors, extracellular matrix proteins, cell adhesion receptors and co-stimulatory molecules. ASM can promote the formation of the interstitial extracellular matrix, and potentially contribute to the alterations within the extracellular matrix in asthma. In addition, extracellular matrix components can...
Original Article
Difference of Clinical Features according to Hypoalbuminemia in the Children with Pleural Effusion
Min-Jung Sung, Hee-ju Park
Clin Exp Pediatr. 2005;48(5):523-526.   Published online May 15, 2005
Purpose : Hypoalbuminemia is a rare cause of pleural effusion. The relationship between the severity of hypoalbuminemia and the clinical course of pleural effusion is unclear. The aim of this study was to evaluate the change of clinical course according to the severity of hypoalbuminemia due to pleural effusion in children. Methods : A total of 96 patients admitted to Pusan...
Human Surfactant Protein-A(SP-A) Gene Locus Associated with Mycoplasma pneumoniae Pneumonia in Korean Children
Seung Soo Kim, In Kyu Lee, Jung Ho Ko, Myung Ho Oh, Chong Woo Bae
Clin Exp Pediatr. 2005;48(4):376-379.   Published online April 15, 2005
Purpose : Mycoplasama pneumoniae is a leading cause of pneumonia and exacerbates other respiratory conditions such as asthma. Surfactant protein A(SP-A) is involved in surfactant physiology and surfactant structure, and plays a major role in innate host defense and inflammatory processes in the lung. In this study, SP-A mediated mycoplasma cidal activity. The candidate-gene approach was used to study the...
Evaluation of Serum Insulin-Like Growth Factor(IGF)-I, Insulin-Like Growth Factor Binding Protein(IGFBP)-2 and IGFBP-3 Levels in Healthy Korean Children
Gi Hoon Yang, Hye Lim Jung, Deok Soo Kim, Jae Won Shim, Jung Yeon Shim, Moon Soo Park
Clin Exp Pediatr. 2005;48(3):298-305.   Published online March 15, 2005
Purpose : We performed this study to evaluate the mean serum levels of insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 in healthy Korean children according to age and sex. Methods : Ninety two healthy children, consisting of 42 boys and 50 girls, were classified into five groups according to age : neonate; infancy; early childhood; late childhood;...
Case Report
A Case of Protein Losing Enteropathy Associated with Henoch-Sch nlein Purpura
Kee Dae Kim, Chang Whan Oh, Eun Young Lee, Jae Young Kim
Clin Exp Pediatr. 2005;48(2):224-227.   Published online February 15, 2005
Henoch-Sch nlein purpura(HSP) is an IgA mediated immune complex vasculitic disease characterized by non-thrombocytic purpura, arthritis, gastrointestinal manifestations, and glomerulonephritis. HSP related glomerulonephritis induces hypoproteinemia and edema in some cases. Protein-losing enteropathy is another rare but known manifestation of HSP leading to hypoproteinemia and edema. We report a 6-year-old girl with HSP who showed edema caused by intestinal protein loss,...
Original Article
Gene Expression of Metalloproteinases, Tissue Inhibitors of Metalloproteinases and Cytokines in Adriamycin-induced Cardiomyopathy
Young Mi Hong
Clin Exp Pediatr. 2005;48(2):197-203.   Published online February 15, 2005
ity has been reported to occur in both clinical and experimental forms of dilated cardiomyopathy. There was no report about MMP in adriamycin(ADR)-induced cardiomyopathy. The purpose of this study was to investigate gene expression of MMP and tissue inhibitor of metalloproteinases(TIMP) in ADR-induced cardiomyopathy and clarify the relationship between MMP and cytokines. Methods : Male Sprague-Dawley rats were divided into two...
Case Report
A Case of Hypocomplementemic Henoch-Schönlein Purpura Presenting Features of Membranoproliferative Glomerulonephritis
Kyong-A Lee, Tae-Sun Ha
Clin Exp Pediatr. 2005;48(1):81-84.   Published online January 15, 2005
Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis that can affect multiple organs predominantly the skin, joints, gastrointestinal tract and kidney. Although the specific pathogenesis of HSP is not known, there are several hypotheses. Although the importance of the complement activation in glomerular injury in HSP has been suggested, the complement levels and the blood pressure in...
Original Article
Serum and Cerebrospinal Fluid(CSF) Nitric Oxide, Macrophage Inflammatory Protein-1α and Lactoferrin Levels in Aseptic Meningitis
Young Seo, Jung Yeon Shim, Jae Won Shim, Deok Su Kim, Hye Lim Jung, Moon Soo Park
Clin Exp Pediatr. 2005;48(1):48-54.   Published online January 15, 2005
Purpose : The pathologic mechanisms of central nervous system(CNS) injuries in human meningitis are not yet completely understood. Recent studies indicate that the host inflammatory responses are as important in brain damage as the infecting organisms and toxins. There have been some reports on the relationship of nitric oxide(NO), macrophage inflammatory protein-1α(MIP-1α), and lactoferrin in bacterial meningitis, but few reports...
Clinical Utilities of Serum Ferritin as a Marker of Disease Activity and Prognostic Factor in Childhood Tumors
Eun Seok Roh, Jung Hyun Lee, Yu Ra Hong, Jae Sun Park, Jong Shin Kim
Clin Exp Pediatr. 2004;47(12):1319-1324.   Published online December 15, 2004
Purpose : In order to assess the usefulness of serum ferritin as a marker of disease activity and prognostic factor in pediatric malignancy, serum ferritin levels were measured. Methods : Peripheral blood samplings for ferritin level were made at presentation, in remission following therapy, and in relapse in 95 children with malignancy admitted to the Department of Pediatrics, Kosin University Gospel...
Thermogenic Response to Fasting and Exercise in Different Aged Rats
Ae Jung Kwak, Kwang Hae Choi, Yong Hun Park, Yong Woon Kim
Clin Exp Pediatr. 2004;47(10):1100-1105.   Published online October 15, 2004
Purpose : Recently, there has been a marked increase in childhood obesity, and that has aroused social concern. Obesity increases several metabolic disease such as hypertension, diabetes, fatty liver, heart disease and the mortality rate. Complications of obesity are more closely related with the accumulation of visceral fat. Therefore, fundamental treatment of obesity Should be the reduction of body fat....
The Tumor Suppressor Function of PTEN/MMAC1 through the Regulation of IGFs and IGFBPs
Ho Keun Yi, Dong Jin Hwang, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2004;47(8):884-891.   Published online August 15, 2004
Purpose : PTEN/MMAC1, a novel tumor suppressor gene, is mutated in a variety of advanced and metastatic cancers. It acts as a phosphatase, and thereby, regulates the PI-3 kinase/Akt pathway. In this study, we examined to evaluate the new function of anti-tumor effects of PTEN/MMAC1 through the regulation of the IGFs-IGFBPs in gastric cancer cells. Methods : PTEN/MMAC1 was expressed in...
Protein C as a Differential Marker for Bacterial Infection among Pediatric Patients with Fever
Eun Ha Mo, In Hae Nam, Kyung Duk Park
Clin Exp Pediatr. 2004;47(8):839-843.   Published online August 15, 2004
Purpose : This study was performed to find the clinical significance in protein C as a differential marker in the beginning stage of infection and prognosis factor in severe infection among pediatric patients who were admitted due to fever. Methods : A total of 40 pediatric patients who had temperatures higher than 37.5℃ on admission at the Department of Pediatrics,...
The Change in Intestinal Lactobacillus Count among Healthy Neonates
Hyun Joo Lee, Hyun Ji Lee, Su Jin Cho, Jung Wan Seo, Seung Joo Lee, Eun Ae Park
Clin Exp Pediatr. 2004;47(8):833-838.   Published online August 15, 2004
Purpose : Enhancing overall health by preventive and therapeutic use of probiotics has shown great promise on inflammatory, infectious, neoplastic disorders, allergies, et al. To attain preliminary data for the use of probiotics, we have studied the change in intestinal flora, Lactobacillus count among healthy, full term neonates. Methods : Fresh stool samples were collected on the 2nd or 5th day...
Association between the Human Surfactant Protein-A(SP-A) Gene Locus and Respiratory Distress Syndrome in Korean Neonates
Jae Hoon Choe, Myung Ho Oh, Jung Ho Ko, Sun Young Kim, In Kyu Lee, Chong Woo Bae
Clin Exp Pediatr. 2004;47(7):735-739.   Published online July 15, 2004
Purpose : Respiratory distress syndrome(RDS) is caused by a deficiency of pulmonary surfactant, which is a lipoprotein complex. Both low levels of surfactant protein A(SP-A) and SP-A alleles have been associated with RDS. However, the genes underlying susceptibility to RDS are insufficiently known. The candidate-gene approach was used to study the association between the SP-A gene locus and RDS in...