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Original Article
C3 glomerulopathy in children: experience at a resource-limited center
Soumya Reddy, Abhishek Ghante, Mahesha Vankalakunti, Anil Vasudevan
Background: In children, C3 glomerulopathy (C3G) is a heterogeneous disease characterized by diverse clinicopathological profiles and kidney outcomes. However, diagnostic work-up in resource-limited settings is challenging because of the unavailability of complement assays and limited access to electron microscopy or genetic testing.
Purpose: This study aimed to describe the clinicopathological features and response to immunosuppression and evaluate renal outcomes among...
Allergy
Influence of age at complementary food introduction on the development of asthma and atopic dermatitis in Korean children aged 1–3 years
Jihyun Lee, Meeyong Shin, Bora Lee
Clin Exp Pediatr. 2021;64(8):408-414.   Published online November 1, 2020
Question: Is age at the time of complementary food introduction associated with asthma and atopic dermatitis (AD) in early childhood?
Finding: We found no significant association between age at the time of complementary food introduction and the incidence of AD and asthma in Koreans aged 1–3 years.
Meaning: Our findings suggest that the influence of individual allergenic foods on the development of AD and asthma should be clarified.
Nutrition
Local-food-based complementary feeding for the nutritional status of children ages 6–36 months in rural areas of Indonesia
Tantut Susanto, Syahrul, Lantin Sulistyorini, Rondhianto, Alfi Yudisianto
Clin Exp Pediatr. 2017;60(10):320-326.   Published online October 20, 2017
Purpose

This study aimed to evaluate a pilot project of the Nursing Feeding Center “Posyandu Plus” (NFCPP) through local food-based complementary feeding (LFCF) program designed to improve the nutritional status of children aged 6–36 months at community health centers in Indonesia.

Methods

A quasi-experimental design was used to obtain data regarding the nutritional status of 109 children who participated in the project from...

Review Article
Neurology
The use of complementary and alternative medicine in children with common neurologic diseases
Gyu-Min Yeon, Sang Ook Nam
Clin Exp Pediatr. 2016;59(8):313-318.   Published online August 24, 2016

Complementary and alternative medicine (CAM) is a phrase used to describe additional health care methods such as mind/body practices and natural products not regarded as treatments by conventional medicine. The use of CAM in children with common neurologic diseases is more frequent than its use in healthy children (24%–78% vs. 12%). However, less than half of patients report such use...

Complement regulation: physiology and disease relevance
Heeyeon Cho
Clin Exp Pediatr. 2015;58(7):239-244.   Published online July 22, 2015

The complement system is part of the innate immune response and as such defends against invading pathogens, removes immune complexes and damaged self-cells, aids organ regeneration, confers neuroprotection, and engages with the adaptive immune response via T and B cells. Complement activation can either benefit or harm the host organism; thus, the complement system must maintain a balance between activation...

Nutritional management of breastfeeding infants for the prevention of common nutrient deficiencies and excesses
Jin Soo Moon
Clin Exp Pediatr. 2011;54(7):282-286.   Published online July 31, 2011

Breastfeeding is the best source of nutrition for every infant, and exclusive breastfeeding for 6 months is usually optimal in the common clinical situation. However, inappropriate complementary feeding could lead to a nutrient-deficient status, such as iron deficiency anemia, vitamin D deficiency, and growth faltering. The recent epidemic outbreak of obesity in Korean children emphasizes the need for us to...

Original Article
A study on the utilization of complementary and alternative medicine for elementary children
Young Joon Ahn, Eun Young Kim, Kyung Rye Moon
Clin Exp Pediatr. 2009;52(10):1103-1108.   Published online October 15, 2009
Purpose : Recently, complementary and alternative medicine (CAM) has been increasingly used in children. Studies have shown that 34% of adults and 11% of children use CAM in the USA and Canada. The purpose of this study was to investigate the prevalence and patterns of CAM use in elementary children in Korea. Methods : From July to August 2007, parents...
Current feeding practices and maternal nutritional knowledge on complementary feeding in Korea
Hye Won Yom, Jeong Wan Seo, Hyesook Park, Kwang Hae Choi, Ju Young Chang, Eell Ryoo, Hye Ran Yang, Jae Young Kim, Ji Hyun Seo, Yong Joo Kim, Kyung Rye Moon, Ki Soo Kang, Kie Young Park, Seong Soo Lee, Jeong Ok Shim
Clin Exp Pediatr. 2009;52(10):1090-1102.   Published online October 15, 2009
Purpose : To evaluate current feeding practices and maternal nutritional knowledge on complementary feeding. Methods:Mothers of babies aged 9-15 months who visited pediatric clinics of 14 general hospitals between September and December 2008 were asked to fill questionnaires. Data from 1,078 questionnaires were analyzed. Results : Complementary food was introduced at 4-7 months in 89% of babies. Home-made rice gruel was the...
Case Report
A Korean familial case of hereditary complement 7 deficiency
Moon Kyu Ki, Kyung Yul Lee, Jun Hwa Lee
Clin Exp Pediatr. 2009;52(6):721-724.   Published online June 15, 2009
Meningococcal infections can be associated with abnormalities of the complement system, which contains 5 terminal complement proteins. Furthermore, deficiencies in 1 of these 5, complement component 7 (C7), leads to the loss of complement lytic function, and affected patients show increased susceptibility to recurrent meningococcal meningitis and systemic Neisseria gonorrhoeae infection. In September 2003, an 11-year-old female patient presented at...
Review Article
Hemolytic uremic syndrome
Hye Won Park
Clin Exp Pediatr. 2007;50(10):931-937.   Published online October 15, 2007
The hemolytic uremic syndrome (HUS) is a rare disease of microangiopathic hemolytic anemia, low platelet count and renal impairment. HUS usually occurs in young children after hemorrhagic colitis by shigatoxin-producing enterohemorrhagic E. coli (D+HUS). HUS is the most common cause of acute renal failure in infants and young children, and is a substantial cause of acute mortality and morbidity; however,...
Clinical Lecture
Infection and Innate Immunity
Moo-Young Oh
Clin Exp Pediatr. 2005;48(11):1153-1161.   Published online November 15, 2005
As known by other name(natural immunity), the innate immune system comprises all those mechanisms for dealing with infection that are constitutive or built in, changing little with age or with experience of infection. Though in some ways less sophisticated than adaptive immunity, innate immunity should not belittled, since it has evidently protected thousands of species of invertebrates sufficiently to survive...
Original Article
Complementary and Alternative Medical Therapies in Children and Adolescent with Chronic Disease : Utilizations and Patterns
Young Bin Kim, Jun Ho Song, Myoung Wan Jang, Hwang Jae Yoo, Cheol Hong Kim, Hyun Hee Lee
Clin Exp Pediatr. 2005;48(9):929-934.   Published online September 15, 2005
Purpose : This study describes how often complementary and alternative medical(CAM) therapies, what patterns of CAM therapies utilization, what types of CAM therapies and why CAM therapies are used in children and adolescent with chronic disease. Methods : We interviewed and filled out questionnaires with parents of patients suffering from asthma, atopic dermatitis, congenital myopathy, epilepsy and so on from Mar...
Case Report
A Case of Meningococcal Meningitis with Complement 9 Deficiency
Sun-Mee Choi, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Byung-Churl Lee
Clin Exp Pediatr. 2005;48(1):101-103.   Published online January 15, 2005
Meningococcal disease is not rarely associated with abnormalities of the complement system. We experienced a case of C9 deficiency with meningococcal meningitis from a 12-year-old girl. Identification of complement deficiency has implications for management, including family studies, prophylaxis, vaccination, and altered threshold for infection screening and treatment.
A Case of Hypocomplementemic Henoch-Schönlein Purpura Presenting Features of Membranoproliferative Glomerulonephritis
Kyong-A Lee, Tae-Sun Ha
Clin Exp Pediatr. 2005;48(1):81-84.   Published online January 15, 2005
Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis that can affect multiple organs predominantly the skin, joints, gastrointestinal tract and kidney. Although the specific pathogenesis of HSP is not known, there are several hypotheses. Although the importance of the complement activation in glomerular injury in HSP has been suggested, the complement levels and the blood pressure in...
A Case of Hereditary C7 Deficiency Associated with Meningococcal Meningitis
Hyun Woo We, Won Duck Kim, Sun Ju Lee, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Gyoung Yim Ha
Clin Exp Pediatr. 2004;47(7):799-802.   Published online July 15, 2004
The complement system is composed of more than 25 different proteins and is usually divided into classical and alternative pathways. Complement component 7(C7) is one of the five terminal complement proteins that, upon activation of either the classical or the alternative pathway, interacts sequentially to form a large protein-protein complex, called membrane attack complex(MAC). Assembly of the MAC on target...
Original Article
A Study on Serum Immunoglobulins and Complements in Newborn Infants by Gestational Weeks
Ji Eun Lee, Kyung Hyo Kim, Kyung Hee Kim
Clin Exp Pediatr. 1993;36(11):1555-1561.   Published online November 15, 1993
The author investigated serum immunoglobulin (IgG, IgA, and IgM) and complements (C3) of cord blood in 74 cases of normal fulterm infants and 50 cases of premature infants. Serum immunolglobulin and complement levels were measured by the single radial immunodiffusion method. The following results were obtained ; 1) The mean serum IgG levels of cord blood in 74 cases of the normal...
Comparison of C3 and C4 in Umbilical Blood and with those in Maternal Sera.
Bong Joon Chung, Jong Woo Shin
Clin Exp Pediatr. 1987;30(3):253-258.   Published online March 31, 1987
To assess the fetal development of the complement system, C3 and C4 in umbilical arterial and venous blood were measured, and compared with those in maternal sera. Moreover, C3 and C4 in maternal sera were compared with those in normal adult women’s sera. The results were as following: 1) The difference of mean C3 and C4 between neonatal umbilical arterial and venous blood was not...
A Study on Serum Immuoglobulins and Complements in Newborn Infants.
Song Soo Moon, Chang Soo Ra
Clin Exp Pediatr. 1986;29(1):58-71.   Published online January 31, 1986
The author investigated serum immunoglobulins (IgG, IgA, and IgM) and complements (C3and C4) of cord blood in 29 cases of normal fullterm infants, 14 cases of low birth weight infants (8 cases of premature infants) and 43 cases of their mothers at delivery. Serum immunoglobulin and complement levels were measured by the single radial immuno diffusion method (NISSUI, Japan). The...
Primary Peritonitis in Children with Nephrotic Syndrome.
Hae Il Cheong, Whan Jong Lee, Jeong Kee Seo, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1985;28(7):695-704.   Published online July 31, 1985
Thirty episodes of primary peritonitis in 22 children with nephrotic syndrome who had admitted in the Department of Pediatrics, Seoul National University Hospital from Jan. *81 to Sept. ’84 were studied, and the results were as follows; 1)Among 22 children, male to female ratio was 16 : 6 and the mean age at the onset of peritonitis was 7.80 years (average...
Case Report
A Case Of Systemic Lupus Erythematosus.
Kong Youb Han, Jung Sue Suh, Jung Woo Shin
Clin Exp Pediatr. 1982;25(10):1063-1067.   Published online October 31, 1982
A case of S.L.E. in a 11-years old boy was presented with a brief review of the literature. He was admitted with the chief complaints of generalized edema, dyspnea and skin lesion. He showed a butterfly rash on the face and nasal bridges, alopecia, infected scaly crusted skin lesions on scalp and face. Generalized edema, Hepatomegaly and photosensitivity were showed. Laboratory findings revealed anemia,...
Original Article
Changes in Serum Complement and Immunglonulins following Cardiopulmonary Bypass.
Hong Jin Kim, Jun Hee Sul, Sung Kyn Lee, Dong Shik Chin, Kwang Ho Kim, Pill Whoon Hong
Clin Exp Pediatr. 1982;25(8):781-786.   Published online August 31, 1982
Clinical problem occuring in the early post operative period after cardiopulmonary bypass may ne related to the altered function of capillary bed which was affected by activation of complement system. This is so called post perfusion syndrome. We selected 20 patients with confirmed congenital heart disease by cariac catheterization. We studied the changes in the C3 , immunolglobulins, total protein,...