Clinical and Experimental Pediatrics

Original Article

Allergy

Ten-year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017

Jihyun Ha, Seung Won Lee, Dong Keon Yon

Clin Exp Pediatr. 2020;63(7):278-283. Published online January 29, 2020

Web of Science 116 Crossref 113

Background: Major questions remain regarding the agestratified trends of allergic diseases and asthma in Korea.
Purpose: To identify the estimated recent prevalence and 10- year trends in asthma, allergic rhinitis, and atopic dermatitis among the Korean population from 2008 to 2017. Methods: This nationwide cross-sectional survey (Korean National Health and Nutrition Examination Survey) over 10 years (2008–2017) examined representative samples of the...

DOI: https://doi.org/10.3345/cep.2019.01291

General Pediatrics

Efficacy of conservative treatment of perianal abscesses in children and predictors for therapeutic failure

Lars Boenicke, Johannes Doerner, Stefan Wirth, Hubert Zirngibl, Mike Ralf Langenbach

Clin Exp Pediatr. 2020;63(7):272-277. Published online May 15, 2020

Web of Science 10 Crossref 10

Background: The optimal management of perianal abscess in children is controversial.
Purpose: To evaluate the efficiency of conservative treatment of perianal abscess in children and identify parameters that predict therapy failure. Methods: All cases of children younger than 14 years of age with perianal abscesses between 2001–2016 were evaluated. Results: Of the 113 enrolled patients, 64 underwent subsequent surgery for advanced disease (primary...

DOI: https://doi.org/10.3345/cep.2019.00969

Immunology

Immunogenicity and safety of a 12-valent pneumococcal conjugate vaccine in infants aged 6–10 weeks: a randomized double-blind active-controlled trial

Jonghoon Shin, Jamaree Teeratakulpisarn, Thanyawee Puthanakit, Tuangtip Theerawit, Ji Hwa Ryu, Jinhwan Shin, Seulgi Lee, Hayoung Lee, Kyungjun An, Hun Kim

Clin Exp Pediatr. 2020;63(7):265-271. Published online December 6, 2019

Web of Science 3 Crossref 2

Question: The immunogenicity and safety of GBP411 when administered to healthy infants are not understood.
Finding: The intergroup differences were not significant for all 12 serotypes after the booster dose. The overall incidence of solicited local adverse events between the groups did not differ significantly.
Meaning: GBP411 with a 2p+1 dosing schedule induced a substantial immune response, and may be safe for administration to healthy infants.

DOI: https://doi.org/10.3345/cep.2019.01067

Editorial

Allergy

Trends in prevalence of allergic diseases in Korean children: how and why?

Kyung Suk Lee

Clin Exp Pediatr. 2020;63(7):263-264. Published online April 13, 2020

Web of Science 2 Crossref 2

DOI: https://doi.org/10.3345/cep.2020.00213

Gastroenterology

Management of perianal abscess and fistula-in-ano in infants and children

Jinyoung Park

Clin Exp Pediatr. 2020;63(7):261-262. Published online March 23, 2020

Web of Science 8 Crossref 10

DOI: https://doi.org/10.3345/cep.2020.00150

Infection

Pneumococcal conjugate vaccines: choice of schedule and product development

Jin Lee

Clin Exp Pediatr. 2020;63(7):259-260. Published online April 27, 2020

Web of Science 2 Crossref 2

DOI: https://doi.org/10.3345/cep.2019.01739

Review Article

Pulmonology

The past, present, and future of humidifier disinfectant-associated interstitial lung diseases in children

Eun Lee, So-Yeon Lee, Soo-Jong Hong

Clin Exp Pediatr. 2020;63(7):251-258. Published online December 9, 2019

Web of Science 13 Crossref 15

Exposure to environmental factors can cause interstitial lung diseases (ILDs); however, such types of ILDs are rare. From 2007 to 2011, an ILD epidemic occurred in South Korea owing to inhalational exposure to toxic chemicals in humidifier disinfectants (HDs). HD-associated ILDs (HD-ILDs) are characterized by rapidly progressing respiratory failure with pulmonary fibrosis and a high mortality rate of 43.8%−58.0%. Although...

DOI: https://doi.org/10.3345/cep.2019.01326

Immunology

Immunopathogenesis of COVID-19 and early immunomodulators

Kyung-Yil Lee, Jung-Woo Rhim, Jin-Han Kang

Clin Exp Pediatr. 2020;63(7):239-250. Published online June 18, 2020

Crossref 33

The novel coronavirus disease 2019 (COVID-19) is spreading globally. Although its etiologic agent is discovered as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there are many unsolved issues in COVID-19 and other infectious diseases. The causes of different clinical phenotypes and incubation periods among individuals, species specificity, and cytokine storm with lymphopenia as well as the mechanism of damage to organ...

DOI: https://doi.org/10.3345/cep.2020.00759

Perspective

Infection

COVID-19 in children: reasons for uneventful clinical course

Sweni Shah, Ramachandran Meenakshisundaram, Subramanian Senthilkumaran, Ponniah Thirumalaikolundusubramanian

Clin Exp Pediatr. 2020;63(7):237-238. Published online June 18, 2020

Crossref 4

DOI: https://doi.org/10.3345/cep.2020.00801

Original Article

General Pediatrics

Ability of children to perform touchscreen gestures and follow prompting techniques when using mobile apps

Savita Yadav, Pinaki Chakraborty, Arshia Kaul, Pooja, Bhavya Gupta, Anchal Garg

Clin Exp Pediatr. 2020;63(6):232-236. Published online February 5, 2020

Web of Science 6 Crossref 6

Background: Children today get access to smartphones at an early age. However, their ability to use mobile apps has not yet been studied in detail.
Purpose: This study aimed to assess the ability of children aged 2–8 years to perform touchscreen gestures and follow prompting techniques, i.e., ways apps provide instructions on how to use them. Methods: We developed one mobile app...

DOI: https://doi.org/10.3345/cep.2019.00997

Neonatology (Perinatology)

Synbiotics use for preventing sepsis and necrotizing enterocolitis in very low birth weight neonates: a randomized controlled trial

Ozge Serce Pehlevan, Derya Benzer, Tugba Gursoy, Guner Karatekin, Fahri Ovali

Clin Exp Pediatr. 2020;63(6):226-231. Published online February 5, 2020

Web of Science 21 Crossref 22

Background: Probiotics and prebiotics have strain-specific effects on the host. Synbiotics, a mixture of probiotics and prebiotics, are proposed to have more beneficial effects on the host than either agent has alone.
Purpose: We performed a randomized controlled trial to investigate the effect of Lactobacillus and Bifidobacterium together with oligosaccharides and lactoferrin on the development of necrotizing enterocolitis (NEC) or sepsis...

DOI: https://doi.org/10.3345/cep.2019.00381

Long-term cognitive, executive, and behavioral outcomes of moderate and late preterm at school age

Ju Hyun Jin, Shin Won Yoon, Jungeun Song, Seong Woo Kim, Hee Jung Chung

Clin Exp Pediatr. 2020;63(6):219-225. Published online September 25, 2019

Web of Science 19 Crossref 28

Question: Infants born at moderate to late preterm gestations are known to have little problem later on, but is that really true?
Finding: At school age, cognitive problem was observed in about a quarter of the children. In addition, more than half of the children was suspected of having attention problems.
Meaning: Moderate to late preterm infants are at risk of developing abnormal intelligence and attention problems at early school age, therefore they should not be neglected on longterm follow-up evaluation.

DOI: https://doi.org/10.3345/kjp.2019.00647

Editorial

Neonatology (Perinatology)

Should we regularly evaluate the neurodevelopmental status of moderate and late preterm infants?

Son Moon Shin

Clin Exp Pediatr. 2020;63(6):217-218. Published online June 11, 2020

Crossref 3

DOI: https://doi.org/10.3345/cep.2020.00472

What do we know about the long-term cognitive and behavioral outcomes of school-aged children who were born moderate to late preterm?

Eun Sun Kim

Clin Exp Pediatr. 2020;63(6):215-216. Published online February 5, 2020

Crossref 1

DOI: https://doi.org/10.3345/cep.2019.01340

Allergy

Are you sure that it is a drug allergy?

Eun Hee Chung

Clin Exp Pediatr. 2020;63(6):213-214. Published online June 1, 2020

DOI: https://doi.org/10.3345/cep.2019.01487

Neurology

Next-generation sequencing is a powerful method to enhance diagnostic yield in global developmental delay/intellectual disability

Jon Soo Kim

Clin Exp Pediatr. 2020;63(6):211-212. Published online June 11, 2020

Crossref 1

DOI: https://doi.org/10.3345/cep.2019.01683

Review Article

Allergy

Drug Allergy in Children: What Should We Know?

Ji Soo Park, Dong In Suh

Clin Exp Pediatr. 2020;63(6):203-210. Published online November 12, 2019

Web of Science 15 Crossref 15

The drug allergy “label” may have a lifetime of consequences for a child. Many children with alleged drug allergies are proven to be tolerant to the culprit medication when challenged. The field of drug hypersensitivity is a recently evolving field of research, but studies on its epidemiology and diagnostic tools are lacking in children. Clinical history is significant in the...

DOI: https://doi.org/10.3345/kjp.2019.00675

Neurology

Genetic tests by next-generation sequencing in children with developmental delay and/or intellectual disability

Ji Yoon Han, In Goo Lee

Clin Exp Pediatr. 2020;63(6):195-202. Published online November 4, 2019

Crossref 32

Developments in next-generation sequencing (NGS) techogies have assisted in clarifying the diagnosis and treatment of developmental delay/intellectual disability (DD/ID) via molecular genetic testing. Advances in DNA sequencing technology have not only allowed the evolution of targeted panels but also, and more currently enabled genome-wide analyses to progress from research era to clinical practice. Broad acceptance of accuracy- guided targeted gene...

DOI: https://doi.org/10.3345/kjp.2019.00808

Original Article

Cardiology

Importance of pulmonary valve morphology for pulmonary valve preservation in tetralogy of Fallot surgery: comparison of the echocardiographic parameters

Su Jin Choi, Jung Eun Kwon, Da Eun Roh, Myung Chul Hyun, Hanna Jung, Young Ok Lee, Joon Yong Cho, Yeo Hyang Kim

Clin Exp Pediatr. 2020;63(5):189-194. Published online November 8, 2019

Web of Science 7 Crossref 7

Question: Is echocardiographic examination is useful for surgical method decision in patients with tetralogy of Fallot (TOF)?
Finding: Various echocardiographic parameters serve as predictors for determining surgical methods for TOF patients. However, the PV morphology and tissue characteristics should also be considered.
Meaning: A full dependence on the size of the pulmonary valve annulus (PVA), the z score, and the ratio of the size of PVA to aortic valve annulus or descending aorta surgery may result in inadequate surgical results during TOF total correction.

DOI: https://doi.org/10.3345/kjp.2019.01060

Critical Care Medicine

Assessment of interhospital transport care for pediatric patients

Krittiya Chaichotjinda, Marut Chantra, Uthen Pandee

Clin Exp Pediatr. 2020;63(5):184-188. Published online August 29, 2019

Web of Science 8 Crossref 17

Background: Many critically ill patients require transfer to a higher-level hospital for complex medical care. Despite the publication of the American Academy of Pediatrics guidelines for pediatric interhospital transportation services and the establishment of many pediatric transport programs, adverse events during pediatric transport still occur.
Purpose: To determine the incidence of adverse events occurring during pediatric transport and explore their complications...

DOI: https://doi.org/10.3345/kjp.2019.00024

Editorial

Emergency Medicine

Pediatric transport medicine: a yet unknown territory in Korea

Jeong-Min Ryu

Clin Exp Pediatr. 2020;63(5):182-183. Published online May 15, 2020

DOI: https://doi.org/10.3345/cep.2019.01270

Neurology

Targeted temperature management and neuroprotective outcomes of pediatric patients after cardiac arrest

Yun-Jin Lee

Clin Exp Pediatr. 2020;63(5):180-181. Published online April 14, 2020

DOI: https://doi.org/10.3345/cep.2019.01396

Nephrology (Genitourinary)

Dapsone: a steroid-sparing drug for refractory immunoglobulin A vasculitis?

Jin-Soon Suh

Clin Exp Pediatr. 2020;63(5):178-179. Published online April 14, 2020

DOI: https://doi.org/10.3345/cep.2019.01634

Review Article

Neurology

Factors associated with seizure and cognitive outcomes after epilepsy surgery for low-grade epilepsy-associated neuroepithelial tumors in children

Ara Ko, Joon Soo Lee

Clin Exp Pediatr. 2020;63(5):171-177. Published online November 13, 2019

Web of Science 8 Crossref 9

Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are responsible for drug-resistant chronic focal epilepsy, and are the second-most common reason for epilepsy surgery in children. LEATs are extremely responsive to surgical treatment, and therefore epilepsy surgery should be considered as a treatment option for LEATs. However, the optimal time for surgery remains controversial, and surgeries are often delayed. In this review, we...

DOI: https://doi.org/10.3345/kjp.2019.01151

How can neurological outcomes be predicted in comatose pediatric patients after out-of-hospital cardiac arrest?

Hyo Jeong Kim

Clin Exp Pediatr. 2020;63(5):164-170. Published online October 10, 2019

Web of Science 2 Crossref 2

The prognosis of patients who are comatose after resuscitation remains uncertain. The accurate prediction of neurological outcome is important for management decisions and counseling. A neurological examination is an important factor for prognostication, but widely used sedatives alter the neurological examination and delay the response recovery. Additional studies including electroencephalography, somatosensory-evoked potentials, brain imaging, and blood biomarkers are useful for...

DOI: https://doi.org/10.3345/kjp.2019.00941

Nephrology (Genitourinary)

Treatment of refractory IgA vasculitis with dapsone: a systematic review

Keum Hwa Lee, Sung Hwi Hong, Jinhae Jun, Youngheun Jo, Woogyeong Jo, Dayeon Choi, Jeongho Joo, Guhyun Jung, Sunghee Ahn, Andreas Kronbichler, Michael Eisenhut, Jae Il Shin

Clin Exp Pediatr. 2020;63(5):158-163. Published online September 24, 2019

Web of Science 12 Crossref 15

IgA vasculitis, formerly known as Henoch-Schönlein purpura, is a systemic IgA-mediated vasculitis of the small vessels commonly seen in children. The natural history of IgA vasculitis is generally self-limiting; however, one-third of patients experience symptom recurrence and a refractory course. This systematic review examined the use of dapsone in refractory IgA vasculitis cases. A literature search of PubMed databases retrieved...

DOI: https://doi.org/10.3345/kjp.2019.00514

Letter to the Editor

Cardiology

Differences over 10 years in epidemiologic and clinical features of Kawasaki disease at a single tertiary center

Hyun Su Kim, Suk Won Shin, Bo Geum Choi, Hee Joung Choi

Clin Exp Pediatr. 2020;63(4):157-158. Published online February 5, 2020

Web of Science 2 Crossref 2

DOI: https://doi.org/10.3345/cep.2019.01109

Original Article

Nephrology (Genitourinary)

Variation in clinical usefulness of biomarkers of acute kidney injury in young children undergoing cardiac surgery

Hee Sun Baek, Youngok Lee, Hea Min Jang, Joonyong Cho, Myung Chul Hyun, Yeo Hyang Kim, Su-Kyeong Hwang, Min Hyun Cho

Clin Exp Pediatr. 2020;63(4):151-156. Published online February 5, 2020

Web of Science 7 Crossref 7

Question: Can clinical usefulness of biomarkers of acute kidney injury vary on the clinical circumstances?
Finding: In young children undergoing cardiac surgery, urine KIM-1/Cr level peaked at 24 hours with significant difference from baseline level and was significantly higher at 6 hours in the AKI group. However, urine NGAL/Cr and IL-18/Cr levels showed no specific trend with time for 48 hours after cardiac surgery.
Meaning: Urine KIM-1/Cr concentration could be considered a good biomarker for early AKI prediction after open cardiac surgery in young children.

DOI: https://doi.org/10.3345/cep.2019.00913

Endocrinology

Effect of agricultural pesticide on precocious puberty in urban children: an exploratory study

Junghwan Suh, Han Saem Choi, Ahreum Kwon, Hyun Wook Chae, Ho-Seong Kim

Clin Exp Pediatr. 2020;63(4):146-150. Published online December 6, 2019

Web of Science 6 Crossref 5

Question: Does agricultural pesticide effect precocious puberty in girls?
Finding: Dinotefuran, an insecticide of neonicotinoid class, was detected in one of 30 patients with precocious puberty, and in 2 girls of the normal control group, which was not statistically significant.
Meaning: There was no close relationship between agricultural pesticides and development of precocious puberty.

DOI: https://doi.org/10.3345/cep.2019.00416

Other

Korean parents’ perceptions of the challenges and needs on school re-entry during or after childhood and adolescent cancer: a multi-institutional survey by Korean Society of Pediatric Hematology and Oncology

Jun Ah Lee, Jae Min Lee, Hyeon Jin Park, Meerim Park, Byung Kiu Park, Hee Young Ju, Ji Yoon Kim, Sang Kyu Park, Young Ho Lee, Ye Jee Shim, Heung Sik Kim, Kyung Duk Park, Yeon-Jung Lim, Hee Won Chueh, Ji Kyoung Park, Soon Ki Kim, Hyoung Soo Choi, Hyo Seop Ahn, Jeong Ok Hah, Hyoung Jin Kang, Hee Young Shin, Mee Jeong Lee

Clin Exp Pediatr. 2020;63(4):141-145. Published online November 14, 2019

Web of Science 8 Crossref 9

Question: What are the parental needs and challenges when their children return to school after cancer?
Finding: In addition to scholastic aptitude-oriented programs, emotional and psychosocial support is necessary for a successful return to school.
Meaning: Pediatric oncologists should actively engage in improving oncology practices to better integrate individualized school plans and educate peers and teachers to improve health literacy to make them understand the needs of children with cancer.

DOI: https://doi.org/10.3345/kjp.2019.00696

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Cited By 16	Prevalence of anxiety, depression, and stress among parents of neonates admitted to neonatal intensive care unit: a systematic review and meta-analysis

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