Clinical and Experimental Pediatrics

Original Article

Nutrition

Positive association of breastfeeding on respiratory syncytial virus infection in hospitalized infants: a multicenter retrospective study

Min Jeong Jang, Yong Joo Kim, Shinhye Hong, Jaeyoon Na, Jong Hee Hwang, Son Moon Shin, Young Min Ahn

Clin Exp Pediatr. 2020;63(4):135-140. Published online November 12, 2019

Web of Science 28 Crossref 28

Question: Human milk has stronger antiviral, antibacterial, and anti-inflammatory properties compared with formula milk. How dose breastfeeding affect respiratory syncytial virus infection in Korea?
Finding: Breastfed infants required less oxygen therapy and possible intensive care unit admission than artificial formulafed infants during respiratory syncytial virus infection.
Meaning: This protective role of breast milk on RSV severity can be a supporting evidence for promoting breastfeeding in Korea.

DOI: https://doi.org/10.3345/kjp.2019.00402

Editorial

Neonatology (Perinatology)

Epidermal growth factor as a reliable marker of necrotizing enterocolitis in preterm neonates

Na Mi Lee

Clin Exp Pediatr. 2020;63(4):133-134. Published online September 18, 2019

DOI: https://doi.org/10.3345/kjp.2019.00409

Review Article

Infection

Epidemiology and clinical features of coronavirus disease 2019 in children

Soo-Han Choi, Han Wool Kim, Ji-Man Kang, Dong Hyun Kim, Eun Young Cho

Clin Exp Pediatr. 2020;63(4):125-132. Published online April 6, 2020

Web of Science 131 Crossref 134

Coronavirus disease-2019 (COVID-19), which started in Wuhan, China, in December 2019 and declared a worldwide pandemic on March 11, 2020, is a novel infectious disease that causes respiratory illness and death. Pediatric COVID-19 accounts for a small percentage of patients and is often milder than that in adults; however, it can progress to severe disease in some cases. Even neonates...

DOI: https://doi.org/10.3345/cep.2020.00535

Epidemiology, virology, and clinical features of severe acute respiratory syndrome -coronavirus-2 (SARS-CoV-2; Coronavirus Disease-19)

Su Eun Park

Clin Exp Pediatr. 2020;63(4):119-124. Published online April 2, 2020

Web of Science 313 Crossref 333

A cluster of severe pneumonia of unknown etiology in Wuhan City, Hubei province in China emerged in December 2019. A novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was isolated from lower respiratory tract sample as the causative agent. The current outbreak of infections with SARS-CoV-2 is termed Coronavirus Disease 2019 (COVID-19) by the World Health Organization (WHO). COVID-19...

DOI: https://doi.org/10.3345/cep.2020.00493

Perspective

Pulmonology

Early preemptive immunomodulators (corticosteroids) for severe pneumonia patients infected with SARS-CoV-2

Kyung-Yil Lee, Jung-Woo Rhim, Jin-Han Kang

Clin Exp Pediatr. 2020;63(4):117-118. Published online April 8, 2020

Web of Science 14 Crossref 14

DOI: https://doi.org/10.3345/cep.2020.00290

Letter to the Editor

General Pediatrics

Effectiveness of comprehensive hand hygiene module on preschool children in Klang Valley, Malaysia

Mohd Dzulkhairi Mohd Rani, Nurul Azmawati Mohamed, Tengku Zetty Maztura Tengku Jamaluddin, Zarini Ismail, Shalinawati Ramli, Habibah Faroque, Farishah Nur Abd Samad, Abdul Rasyid Ariffien, Aisyah Ar Redha Che Amir Farid, Ilina Isahak

Clin Exp Pediatr. 2020;63(3):115-116. Published online February 5, 2020

Web of Science 7 Crossref 5

DOI: https://doi.org/10.3345/cep.2019.01277

Original Article

Endocrinology

Influence of subclinical hypothyroidism on metabolic parameters in obese children and adolescents

Ozlem Kara

Clin Exp Pediatr. 2020;63(3):110-114. Published online March 6, 2020

Web of Science 6 Crossref 7

Question: Does subclinical hypothyroidism in obese children and adolescents affect metabolic parameters?
Finding: Insulin, HOMA-IR, and TG levels were higher and the HDL-C level was lower in patients with SH.
Meaning: A clear association is observed between SH, and insulin resistance and dyslipidemia in obese children. It can be said that the TSH may be evaluated as a metabolic risk factor in obese patients.

DOI: https://doi.org/10.3345/cep.2019.01536

Allergy

Asthma predictive index as a useful diagnostic tool in preschool children: a cross-sectional study in Korea

Dong Hyeon Lee, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Hyo-Bin Kim, So-Yeon Lee, Gwang-Cheon Jang, Dae-Jin Song, Woo Kyung Kim, Young-Ho Jung, Soo-Jong Hong, Jung Yeon Shim

Clin Exp Pediatr. 2020;63(3):104-109. Published online November 8, 2019

Web of Science 9 Crossref 8

Question: Is physician-diagnosed current asthma in preschool children associated with the asthma predictive index, atopic sensitization, or pulmonary function test?
Finding: Physician-diagnosed current asthma in preschool children was associated with the asthma predictive index, but not with spirometry, methacholine provocation test, fractional expiratory nitric oxide level, and atopic sensitization.
Meaning: Physician-diagnosed asthma in preschool children may be different from classic atopic asthma in school children or adolescents.

DOI: https://doi.org/10.3345/kjp.2019.00640

Editorial

Allergy

Is the predictive model for asthma development useful as a tool for diagnosing pediatric asthma?

Bong-Seong Kim

Clin Exp Pediatr. 2020;63(3):102-103. Published online February 5, 2020

DOI: https://doi.org/10.3345/cep.2019.01557

Neurology

Guideline for advanced neuroimaging in pediatric epilepsy

Yun Jung Hur

Clin Exp Pediatr. 2020;63(3):100-101. Published online March 6, 2020

Web of Science 2 Crossref 1

DOI: https://doi.org/10.3345/cep.2019.01403

Hematology

When to suspect inherited platelet disorders and how to diagnose them

Eun Sil Park

Clin Exp Pediatr. 2020;63(3):98-99. Published online February 5, 2020

Web of Science 1 Crossref 1

DOI: https://doi.org/10.3345/cep.2019.01207

Cardiology

Can the accurate epidemiological study help to search the etiology of Kawasaki disease?

Ji Whan Han

Clin Exp Pediatr. 2020;63(3):96-97. Published online August 7, 2019

DOI: https://doi.org/10.3345/kjp.2019.00367

Review Article

Neurology

Advanced neuroimaging techniques for evaluating pediatric epilepsy

Yun Jeong Lee

Clin Exp Pediatr. 2020;63(3):88-95. Published online February 6, 2020

Web of Science 12 Crossref 11

Accurate localization of the seizure onset zone is important for better seizure outcomes and preventing deficits following epilepsy surgery. Recent advances in neuroimaging techniques have increased our understanding of the underlying etiology and improved our ability to noninvasively identify the seizure onset zone. Using epilepsy-specific magnetic resonance imaging (MRI) protocols, structural MRI allows better detection of the seizure onset zone,...

DOI: https://doi.org/10.3345/kjp.2019.00871

Hematology

Genetic classification and confirmation of inherited platelet disorders: current status in Korea

Ye Jee Shim

Clin Exp Pediatr. 2020;63(3):79-87. Published online February 6, 2020

Web of Science 5 Crossref 9

Inherited platelet disorders (IPDs), which manifest as primary hemostasis defects, often underlie abnormal bleeding and a family history of thrombocytopenia, bone marrow failure, hematologic malignancies, undefined mucocutaneous bleeding disorder, or congenital bony defects. Wide heterogeneity in IPD types with regard to the presence or absence of thrombocytopenia, platelet dysfunction, bone marrow failure, and dysmegakaryopoiesis is observed in patients. The individual...

DOI: https://doi.org/10.3345/kjp.2019.00052

Letter to the Editor

Neonatology (Perinatology)

Risk factors for BiPAP failure as an initial management approach in moderate to late preterm infants with respiratory distress

Heekwon Son, Eui Kyung Choi, Kyu Hee Park, Jeong Hee Shin, Byung Min Choi

Clin Exp Pediatr. 2020;63(2):63-65. Published online February 15, 2020

Web of Science 2 Crossref 2

Question: Which factors can predict BiPAP failure as the initial management approach for moderate to late preterm infants with respiratory distress?
Finding: RDS aggravation and increased oxygen and frequency requirements during BiPAP support were associated with BiPAP failure.
Meaning: Early changes to invasive ventilator care should be considered for moderate to late preterm infants showing RDS aggravation and increased oxygen and frequency requirements during BiPAP support.

DOI: https://doi.org/10.3345/kjp.2019.01361

Original Article

Neonatology (Perinatology)

Effect of red blood cell transfusion on short-term outcomes in very low birth weight infants

Eui Young Lee, Sung Shin Kim, Ga Young Park, Sun Hyang Lee

Clin Exp Pediatr. 2020;63(2):56-62. Published online February 6, 2020

Web of Science 18 Crossref 19

Question: Does RBC transfusion affect the short-term outcomes of VLBW infants?
Finding: The results showed that RBC transfusion was significantly related to the incidence of BPD (OR, 5.42; P<0.001) and NEC (OR, 3.40; P=0.009).
Meaning: Careful consideration of the patient’s clinical condition and appropriate guidelines is required before administering RBC transfusions.

DOI: https://doi.org/10.3345/kjp.2019.00990

Gastroenterology

Thyroid disturbances in children treated with combined pegylated interferon-alpha and ribavirin for chronic hepatitis C

Yasser K. Rashed, Fatma A. Khalaf, Sobhy E. Kotb

Clin Exp Pediatr. 2020;63(2):52-55. Published online September 27, 2019

Web of Science 4 Crossref 4

Background: Immunomodulatory properties of interferon (IFN) have been documented. It may induce autoimmune diseases such as autoimmune thyroiditis with hypo- or hyperthyroidism. In addition, it may impair thyroid hormone synthesis through affecting iodide organification in thyroid gland.
Purpose: The aim of this study was to describe thyroid function tests disturbances in children with chronic hepatitis C (CHC) receiving pegylated interferon-alpha (PEG...

DOI: https://doi.org/10.3345/kjp.2018.07150

Neonatology (Perinatology)

Placental histopathology in late preterm infants: clinical implications

Kristina Ericksen, Joshua Fogel, Rita P. Verma

Clin Exp Pediatr. 2020;63(2):48-51. Published online August 19, 2019

Web of Science 1 Crossref 2

Question: Placental histopathology and its clinical implications in late preterm infants.
Finding: Placental vascular anomalies are more, and placental inflammation less common in late preterm infants compared to term. Higher maternal age, magnesium sulfate therapy and hypertension are clinical risk factors associated with late preterm delivery.
Meaning: Prevention and aggressive management of hypertension, and conception before 30 years of age might be effective in preventing late preterm births.

DOI: https://doi.org/10.3345/kjp.2019.00038

Editorial

Gastroenterology

Strategies for treating and managing chronic hepatitis C in children in the direct-acting antiviral era

Suk-Jin Hong, Byung-Ho Choe

Clin Exp Pediatr. 2020;63(2):46-47. Published online February 6, 2020

DOI: https://doi.org/10.3345/kjp.2019.01116

Pulmonology

Are alternative antibiotics needed for antibiotic-nonresponsive Mycoplasma pneumoniae pneumonia?

Eun-Ae Yang, Kyung-Yil Lee

Clin Exp Pediatr. 2020;63(2):44-45. Published online February 15, 2020

Web of Science 1 Crossref 1

DOI: https://doi.org/10.3345/kjp.2019.00332

Systematic review and meta-analysis

Genetics and Metabolism

Global prevalence of classic phenylketonuria based on Neonatal Screening Program Data: systematic review and meta-analysis

Hamid Reza Shoraka, Ali Akbar Haghdoost, Mohammad Reza Baneshi, Zohre Bagherinezhad, Farzaneh Zolala

Clin Exp Pediatr. 2020;63(2):34-43. Published online February 6, 2020

Web of Science 44 Crossref 46

Question: What is the global prevalence of classic phenylketonuria based on Neonatal Screening Program Data?
Finding: The overall worldwide prevalence of the disease is 6.002 per 100,000 neonates. The highest prevalence (38.13) was reported in Turkey, while the lowest (0.3) in Thailand.
Meaning: This difference in the prevalence may be due to differences in the number of consanguineous marriages among the different regions, phenylalanine cutoff points, and sample sizes.

DOI: https://doi.org/10.3345/kjp.2019.00465

Perspective

General Pediatrics

Integrative care for children with medical complexity

Jung Lee, Min Sun Kim, Hee Young Shin

Clin Exp Pediatr. 2020;63(2):32-33. Published online November 14, 2019

Web of Science 1 Crossref 1

DOI: https://doi.org/10.3345/kjp.2019.00717

Clinical Note

Allergy

Complement 4 levels of a 4-year-old girl with angioedema

Soyoung Shin, Yoon Tae Lee, Kyung Yil Lee, Joonhong Park, Jae Ho Lee, Eun Ae Yang

Clin Exp Pediatr. 2020;63(1):30-31. Published online November 8, 2019

Web of Science 1

DOI: https://doi.org/10.3345/kjp.2019.00241

Original Article

Neonatology (Perinatology)

Effectiveness of various nonpharmacological analgesic methods in newborns

Pancham Kumar, Rakesh Sharma, Sukhdev Rathour, Sunidhi Karol, Mohit Karol

Clin Exp Pediatr. 2020;63(1):25-29. Published online August 16, 2019

Web of Science 16 Crossref 15

Question: Can nonpharmacological methods be used for neonatal pain management.
Finding: Nonpharmacological methods like Sucrose, breastfeeding etc have shown to significantly reduce the pain caused by intramuscular hepatitis B vaccination.
Meaning: Nonpharmacological methods are the safe and cheap potential modalities of analgesia which can be used during mild to moderate pain in newborns.

DOI: https://doi.org/10.3345/kjp.2017.05841

Critical Care Medicine

Comparative validity of microalbuminuria versus clinical mortality scores to predict pediatric intensive care unit outcomes

Shifa Nismath, Suchetha S. Rao, B.S. Baliga, Vaman Kulkarni, Gayatri M. Rao

Clin Exp Pediatr. 2020;63(1):20-24. Published online August 12, 2019

Web of Science 1 Crossref 1

Question: Does microalbuminuria predict mortality in pediatric intensive care unit?
Finding: Positive correlation was found between albumin-creatinine ratio and pediatric intensive care unit stay, organ dysfunction and need of inotropes. Area under the receiver operating characteristic curve for albumin-creatinine ratio was comparable to mortality scores.
Meaning: Microalbuminuria is a good predictor of outcome in pediatric intensive care unit and is comparable with mortality scores.

DOI: https://doi.org/10.3345/kjp.2018.07220

Editorial

Allergy

Hereditary angioedema in childhood

Young Min Ahn

Clin Exp Pediatr. 2020;63(1):18-19. Published online January 15, 2020

Web of Science 1 Crossref 1

DOI: https://doi.org/10.3345/kjp.2019.01165

Neonatology (Perinatology)

Prevention and management of pain in the neonatal intensive care unit

Sung Shin Kim

Clin Exp Pediatr. 2020;63(1):16-17. Published online January 15, 2020

Web of Science 6 Crossref 5

DOI: https://doi.org/10.3345/kjp.2019.01200

Genetics and Metabolism

Considerations for evaluating the effectiveness and long-term outcome of enzyme replacement therapy in Pompe disease

Chong Kun Cheon

Clin Exp Pediatr. 2020;63(1):14-15. Published online August 7, 2019

Web of Science 2 Crossref 2

DOI: https://doi.org/10.3345/kjp.2018.07402

Systematic review and meta-analysis

Neurobehavior

Association between neonatal jaundice and autism spectrum disorders among children: a meta-analysis

Ensiyeh Jenabi, Saeid Bashirian, Salman Khazaei

Clin Exp Pediatr. 2020;63(1):8-13. Published online November 7, 2019

Web of Science 22 Crossref 25

Autism spectrum disorder is a common neurodevelopmental disorder with an unknown etiology. The correlation between neonatal jaundice and the risk of developing autism spectrum disorder was investigated previously. Some studies showed significant associations, whereas others demonstrated no association. In this meta-analysis, we pooled the results of observational studies to examine the association between neonatal jaundice and the risk of autism...

DOI: https://doi.org/10.3345/kjp.2019.00815

Review Article

Pulmonology

High-flow nasal cannula oxygen therapy in children: a clinical review

Ji-Won Kwon

Clin Exp Pediatr. 2020;63(1):3-7. Published online October 28, 2019

Web of Science 51 Crossref 59

High-flow nasal cannula (HFNC) is a relatively safe and effective noninvasive ventilation method that was recently accepted as a treatment option for acute respiratory support before endotracheal intubation or invasive ventilation. The action mechanism of HFNC includes a decrease in nasopharyngeal resistance, washout of dead space, reduction in inflow of ambient air, and an increase in airway pressure. In preterm...

DOI: https://doi.org/10.3345/kjp.2019.00626

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