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Volume 44(1); Jan 2001
Review Article
The Present Status of Neonatology in Korea
Soo-Young Pi
J Korean Pediatr Soc. 2001;44(1):1-9.   Published online January 15, 2001
Clinical Lecture
Emergent Diseases in Neonate
Beyong Il Kim
J Korean Pediatr Soc. 2001;44(1):10-16.   Published online January 15, 2001
Erratum
Distribution of Anti-Mumps IgM Antibody in Children Presumptively Diagnosed of Mumps
Sung Hee Oh, Do Hack Yum, Jin Han Kang, Young Mo Sohn, Hoan Jong Lee, Bok Yang Pyun, Young Jin Hong, Chang Hwi Kim
J Korean Pediatr Soc. 2001;44(1):17-25.   Published online January 15, 2001
Purpose : Outbreaks of mumps continue to occur, even though the number of patients diagnosed of mumps has decreased considerably with the widespread use of vaccine. The accurate diagnosis of mumps is needed to understand the epidemiology of mumps and analyse the safety and effectiveness of vaccine. Therefore, we attempted to appraise the accuracy of provisional diagnosis of mumps in...
Original Articles
The Correlation Between the TSH Level in Neonatal Screening Test and the Prognosis of Congenital Hypothyroidism
Hong Sun Park, Kye Shik Shim, Kyuchul Choeh
J Korean Pediatr Soc. 2001;44(1):25-31.   Published online January 15, 2001
Purpose : It is important to diagnose and treat newborn patients with congenital hypothyroidism as soon as possible because of neurodevelopmental outcome. If we can detect more severe forms of congenital hypothyroidism with neonatal screening test, the results of treatment will improve. Methods : Sixty-four term infants whose TSH levels in neonatal screening test had been higher than 20μIU were recalled....
A Comparative Study of the Effects of Intravenous Indomethacin and Oral Mefenamic Acid in the Treatment of Premature Infants with Patent Ductus Arteriosus
Hae Jung Park, Yoon Suk Jung, Nam Soo Kim, Chang Ryul Kim, Hyuk Kim, Soo Jee Moon
J Korean Pediatr Soc. 2001;44(1):32-39.   Published online January 15, 2001
Purpose : For the management of patent ductus arteriosus(PDA) in premature infants, fluid restriction, correction of anemia, mechanical ventilation, diuretics, and surgery have been used, and the closure rate of PDA has improved significantly since the introduction of indomethacin and mefenamic acid as pharmacologic treatments of PDA. We studied to evaluate and compare the therapeutic effects of indomethacin and mefenamic...
Assessment of Endogenous Nitric Oxide Formation in the Neonate : Measurement of Urinary Nitrite and Citrulline Concentrations
Young Ho Kim, Ki Hwan Yu, Young Sook Hong, Sun Kyum Kim
J Korean Pediatr Soc. 2001;44(1):40-45.   Published online January 15, 2001
Purpose : At birth, as the fetus adjusts to the “new world”, the fetal pulmonary circulation undergoes a striking transition, characterized by an immediate rise in pulmonary blood flow and a sustained decrease in pulmonary vascular resistance(PVR). In the factors which reduce PVR after birth, are ventilation of the lung by gas, increase of oxygen tension in pulmonary vascular system,...
Influence of Epstein-Barr Virus Infection on Outcome of Coronary Artery Lesions in Patients with Kawasaki Disease
Hye-Yung Ahn, Hyang-Sook Kim, Jo-Won Jung, Ki-Soo Pai
J Korean Pediatr Soc. 2001;44(1):46-53.   Published online January 15, 2001
Purpose : Kawasaki disease(KD) may be linked to primary infection by certain common viruses. KD concurrent with Epstein-Barr virus(EBV) suggests the possibility of an etiologic agent related to the KD rather than to the EBV infection itself, but, the influence on coronary complication is unclear. To establish whether infection with EBV contributed to the outcome of coronary artery lesions in...
Risk Factors of Renal Scar After Acute Pyelonephritis in Children
Chur Woo You
J Korean Pediatr Soc. 2001;44(1):54-61.   Published online January 15, 2001
Purpose : In this study we re-evaluated the known risk factors of pyelonephritic scarring in children. Methods : A prospective study was performed on 36 acute pyelonephritis(APN) patients who were diagnosed as first acute pyelonephritis on 99mTc-DMSA scan between September 1998 and March 2000 in Masan Samsung Hospital. According to the prescence of remnant lesions on the 99mTc-DMSA scan performed...
Clinical Study of Effectiveness Topiramate in Children with Intractable Epilepsy
Young Mi Choi, Sa Jun Chung
J Korean Pediatr Soc. 2001;44(1):62-67.   Published online January 15, 2001
Purpose : Topiramate(TPM) is a new anticonvulsant with multiple action mechanisms which should theoretically represent a wide therapeutic spectrum. However, there is still little clinical experience of its use in Asian children with epilepsy. Methods : The patients were total 96 children who were treated with more than 2 anticonvulsants but poorly controlled seizure activity. TPM was given as add-on therapy...
Tumor Vaccine Effect by IL-16 Gene Transfer into Murine Neuroblastoma Model
Hyun-Sang Cho, Chong Young Park
J Korean Pediatr Soc. 2001;44(1):68-74.   Published online January 15, 2001
Purpose : Interleukin(IL)-16 is a potent chemoattractant factor for CD4＋ T cells, monocytes, and eosinophils. It up-regulates IL-2R on CD4＋ T lymphocytes and regulates the function of antigen presenting cells. We used retrovirus-mediated gene transfer of the human IL-16 gene into the neuro-2a cells, which is the murine neuroblastoma cell lines, to investigate whether locally secreted IL-16 might generate anti-tumor...
Factors Affecting the Presence of Menarche and Final Adult Height in Adult Female Patients with Congenital Adrenal Hyperplasia of 21-Hydroxylase Deficiency
Seong Yong Lee, Chae Kyoung Song, Min Ho Jung, Jin Soon Hwang, Sei Won Yang
J Korean Pediatr Soc. 2001;44(1):75-82.   Published online January 15, 2001
Purpose : Amenorrhea and short stature are serious complications in patients with congenital adrenal hyperplasia of 21-hydroxylase deficiency(CAH). We analysed several factors influencing the presence of menarche and final adult height in these patients. Methods : We retrospectively reviewed medical records of 24 female patients with CAH. We analysed possible factors affecting the menarche and final adult height, such as clinical...
A Case of Xp21 Contiguous Gene Deletion Syndrome with Hyperglycerolemia, Congenital Adrenal Hypoplasia and Duchenne Muscular Dystrophy
Dae-Won Shin, Jun Huh, Hong-Jin Lee, Won-Ill Park, Kyung-Ja Lee, Yoon-Sook Shin, D.R. Sjarif, B.T. Poll-The
J Korean Pediatr Soc. 2001;44(1):83-88.   Published online January 15, 2001
On Xp21 region several genes such as adrenal hypoplasia congenita(AHC) gene, glycerol kinase (GK) gene and Duchenne muscular dystrophy(DMD) gene are located contiguously. If there is a long deletion in that region, various combination of genetic defect can be occurred from one kind of genetic defect to all three kinds of genetic defect simultaneously. In case of more than two...
Case Reports
A Case of Distal Renal Tubular Acidosis Associated with Medullary Sponge Kidney
Sung Jun Jang, Jo Yun Jung, Jun Sik Kim, Heung Sik Kim, Hee Jung Lee
J Korean Pediatr Soc. 2001;44(1):89-93.   Published online January 15, 2001
Renal tubular acidosis is a clinical state of systemic hyperchloremic acidosis resulting from impaired urine acidification. Medullary sponge kidney is a renal parenchymal malformation characterized by cystic dilatation of the collecting ducts. Although medullary sponge kidney is a congenital disease, it is rarely identified in childhood and is usually discovered in adulthood. Medullary sponge kidney patients may have defects in...
A Case of Maple Syrup Urine Disease Controlled by Peritoneal Dialysis and Diet
Ju Wan Kim, June Huh, Won Il Park, Kyung Ja Lee, Hong Jin Lee
J Korean Pediatr Soc. 2001;44(1):94-98.   Published online January 15, 2001
Maple syrup urine disease is an autosomal recessive disease caused by a deficiency of the branched-chain α-ketoacid dehydrogenase complex. The disease is often suspected because of the peculiar odor of maple syrup in urine. Maple syrup urine disease is usually confirmed by amino acid analysis and urine organic acid analysis showing marked elevations of leucine, isoleucine, valine, and respective ketoacids in...
A Case of Congenital Nasal Pyriform Aperture Stenosis
Hyoung Sik Oh, Sang Hee Kim, Gil Hyun Kim, Hak Soo Lee, Il Hwan Jang, Ji Hae Kim
J Korean Pediatr Soc. 2001;44(1):99-102.   Published online January 15, 2001
The cause of congenital nasal pyriform aperture stenosis is unclear. The development of the facial skeleton occurs between the fifth and the eighth week of gestation. It is at this stage that the stenosis occurs due to overgrowth of the ossification of the maxilla. Infants are obligate nasal breathers. Incomplete and milder forms of nasal airway obstruction may be present...