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Volume 48(8); Aug 2005
Clinical Lecture
Hypothyroidism
Jong Duck Kim
Korean J Pediatr. 2005;48(8):779-805.   Published online August 15, 2005
Hypothyroidism is a deficiency in thyroid hormone secretion by the thyroid gland and a defect in thyroid hormonal receptor activity. It is categorized by the two major forms in children, the one is congenital hypothyroidism and the other is acquired hypothyroidism. Congenital hypothyroidism is one of the commonest treatable causes of mental retardation and occurs in 1 in 3,000-4,000 infants...
Medical Lecture Course
Endogenous Neurogenesis in Postnatal Brain
Yun Sil Chang
Korean J Pediatr. 2005;48(8):806-812.   Published online August 15, 2005
Repair mechanisms in the postnatal and mature central nervous system(CNS) have long been thought to be very limited. However recent works have shown that the mature CSN contains neural progenitors, precursors, and stem cells that are capable of generating new neurons, astrocytes, and oligodendrocytes especially in germinative areas such as the subventricular zone of the lateral ventricles, the dentate gyrus...
Original Articles
Medicolegal Problems in Pediatric Area
Soo Jeong Kwon, Ji Young Jang, Nam Su Kim, Myung Kul Yum, In Joon Seol, Ku Won Jung
Korean J Pediatr. 2005;48(8):813-819.   Published online August 15, 2005
Purpose : Medicolegal problems start when the patient asserts the mistake of doctor and doctor does not accept it. The purpose of this study is to assess the actual condition of medicolegal problems and to provide solutions of medicolegal problems in the pediatric field. Methods : There is not official statistical data about medicolegal problems in our country. We gathered...
A Study for Accuracy and Usefulness of Tympanic Membrane and Forehead Thermometers
Ki Wook Yun, In Seok Lim
Korean J Pediatr. 2005;48(8):820-825.   Published online August 15, 2005
Purpose : The presence and degree of fever in children is a useful indicator of illness. This project aimed to assess the accuracy and usefulness of infrared tympanic membrane(TM) & forehead feverscan thermometers for measuring children's temperatures. Methods : Data were obtained from 1,050 children with a median age of 4.5 years. They visited the pediatric clinics at Chung-Ang University Yongsan...
The Developmental Outcome of Fetal Mild Isolated Ventriculomegaly
Myung Sook Jeong, Jung Mi Chun, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin, Eu Ree Lee
Korean J Pediatr. 2005;48(8):826-831.   Published online August 15, 2005
Purpose : This study is directed to evaluate standardized developmental test performances of infants and children who, as fetuses, had mild isolated cerebral ventriculomegaly diagnosed by ultrasound. Methods : All prenatal sonographic findings from 2001 to 2002 were evaluated. Live isolated mild ventriculomegaly(IMVM) of 10-15 mm were observed in 95 cases(1.1 percent). Standardized developmental testing of 40 cases of IMVM and...
Hepatitis Complicated with Mycoplasma pneumoniae Infection in Children
Seung Min Lee, Sung Moon Lee, Hann Tchah, In Sang Jeon, Eell Ryoo, Kang Ho Cho, Yong Han Seon, Dong Woo Son, Hee Joo Hong
Korean J Pediatr. 2005;48(8):832-838.   Published online August 15, 2005
Purpose : Mycoplasma pneumoniae infection is relatively common in childhood. Its extrapulmonary manifestations have been reported so much, but hepatitis associated with it has been reported rarely in Korea. Methods : A clinical study was performed on 556 patients of M. pneumoniae pneumonia diagnosed serologically at Gil hospital from January 2001 to December 2004. We reviewed 65 cases among these patients,...
Clinical Evaluation of Tissue Biopsy for Children with Neck Mass; A Single Center Study
You Sook Youn, Hye Won Yoon, Sun Young Kim, Ji Young Sul, Chang Jun Song, Jin Man Kim, Kyung Duk Park
Korean J Pediatr. 2005;48(8):839-845.   Published online August 15, 2005
Purpose : Neck masses, in pediatric population, derive from a multitude of congenital, inflammatory, or neoplastic diseases. The majority of these masses represent benign conditions. However, thorough clinical evaluation is required to rule out malignant diseases. We evaluated the causes, clinical characteristics and outcomes of children with neck masses who underwent tissue biopsy. Methods : A total of 28 medical records...
Quantitative Assessment of Myocardial Tissue Velocity in Normal Children with Doppler Tissue Imaging : Reference Values, Growth and Heart Rate Related Change
Se Young Kim, Myung Chul Hyun, Sang Bum Lee
Korean J Pediatr. 2005;48(8):846-856.   Published online August 15, 2005
Purpose : To measure the peak myocardial tissue velocities and patterns of longitudinal motion of atrioventricular(AV) annuli and assess body weight and heart rates-related changes in normal children. Methods : Using pulsed wave Tissue Doppler Imaging(TDI), we measurpeak systolic, early and late diastolic myocardial velocities in 72 normal children at six different sites in apical-4 chamber (A4C) view and at...
Relationship between the Body Fat Mass Measured by Bioelectrical Impedance Analysis(BIA) and Dual Energy X-ray Absorptiometry(DEXA), and by the Indices of Insulin Sensitivity
In Seok Lim, Ki Wook Yun
Korean J Pediatr. 2005;48(8):857-864.   Published online August 15, 2005
Purpose : The objectives of this study was to evaluate the correlations between the indices of insulin sensitivity using fasting glucose and insulin level, and the body fat mass measured by bioelectrical impedance analysis(BIA) and dual energy X-ray absorptiometry(DEXA), and to determine the clinical usefulness of insulin sensitivity indices when obese children were followed up. Methods : In this study, 28...
Effects of Growth Hormone Therapy in Children with Idiopathic Short Stature
Kyong A Lee, Heon Seok Han
Korean J Pediatr. 2005;48(8):865-870.   Published online August 15, 2005
Purpose : The use of growth hormone(GH) to promote growth in normal short children without classical GH deficiency is controversial. Numerous foreign studies have shown the effects of GH therapy in children with idiopathic short stature(ISS) whereas few has been interested in Korea. Therefore, this study is designed to investigate the effects of GH therapy on ISS by observing correlations...
Tumor Necrosis Factor and Lymphotoxin-α Gene Polymorphism in Korean Children with Type 1 Diabetes
Jin Soon Suh, So Young Park, Min Ho Jung, Byung Kyu Suh, Tae Gyu Kim, Byung Churl Lee
Korean J Pediatr. 2005;48(8):871-876.   Published online August 15, 2005
Purpose : Recently, it was reported that tumor necrosis factor(TNF) and lymphotoxin-α(LT-α) gene regions might be a susceptible loci to type 1 diabetes in Japanese. The purpose of this study was to investigate the association of TNF and LT-α gene polymorphisms with disease susceptibility in Korean children with type 1 diabetes. Methods : Forty-nine Korean children with type 1 diabetes(29...
Clinical Findings of Genotypes in Korean Patients with Glycogen Storage Disease Type Ia
Jae Sung Ko, Hye Ran Yang, Jong Won Kim, Jeong Kee Seo
Korean J Pediatr. 2005;48(8):877-880.   Published online August 15, 2005
Purpose : Glycogen storage disease type Ia(GSD Ia) is an autosomal recessive disorder caused by the deficiency of glucose-6-phosphatase(G6Pase). The aim of the study was to investigate the spectrum of G6Pase gene mutations and relationship between genotype and clinical findings in Korean patients with GSD Ia. Methods : Genomic DNA was extracted from peripheral leukocytes of 20 patients with GSD...
Effects of Hyperosmolar Stimuli on Activation of Human Eosinophilic Leukaemia EoL-1 Cells
Byoung Chul Kwon, Eun Soo Kim, Kyung Won Kim, Tae Won Song, Myung Hyun Sohn, Myeong Heon Shin, Kyu-Earn Kim
Korean J Pediatr. 2005;48(8):881-885.   Published online August 15, 2005
Purpose : Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction. The aim of this study was to establish if a hyperosmolar challenge could induce activation of eosinophils. Methods : Human eosinophilic leukaemic cell lines, EoL-1 cells were incubated with hyperosmolar solutions for 15 minutes. Activation of EoL-1 cells was monitored by degranulation and superoxide...
Inhibition of Vascular Endothelial Growth Factor-induced Endothelial Cell Differentiation by Intravenous Immunoglobulin and Methylprednisolone
Hyoun Ah Choi, Kyung Hwa Ha, Jong Seo Yoon, Yoon Lee, Joon Sung Lee, Ji Whan Han
Korean J Pediatr. 2005;48(8):886-893.   Published online August 15, 2005
Purpose : Kawasaki disease is the most common cause of systemic vasculitis in children less than 5 years of age. Recent immunohistochemistry findings suggest that many vascular growth factors play a role in the formation of the coronary artery lesions. Active remodeling of the coronary artery lesions in Kawasaki disease continues in the form of intimal proliferation and neoangiogenesis for...
Ex vivo Expansion and Clonal Maintenance of CD34＋ Selected Cells from Cord Blood and Peripheral Blood
Soon Ki Kim, Hye Yoon Ghil, Sun U. Song, Jong Weon Choi, Sang Kyu Park
Korean J Pediatr. 2005;48(8):894-900.   Published online August 15, 2005
Purpose : Because of the unavailability of marrow transplantation, umbilical cord blood (CB) is increasingly being used. We evaluated the potential of ex vivo expansion and clonality in CD34＋ cells separated from cord blood source and mobilized peripheral blood (PB) in a serum-free media. Methods : The CD34＋ cells, selected from CB and mobilized PB, were expanded with hematopoietic growth...
Case Reports
Giant Coronary and Axillary Aneurysms in an Infant with Kawasaki Disease Associated with Thrombocytopenia
Sei Young Seo, Jin Hee Oh, Jong-Hyun Kim, Ji-Whan Han, Kyung-Yil Lee, Dae Kyun Koh
Korean J Pediatr. 2005;48(8):901-906.   Published online August 15, 2005
Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Yet the etiology of KD is still unknown and diagnosis depends on the exclusion of other diseases and the clinical manifestations meeting the defined criteria. Young infants frequently show atypical clinical courses and are frequently complicated with coronary aneurysms. Some cases show thrombocytopenia, which is known as...
A Case of Intussusception Caused by Meckel's Diverticulum in a Newborn
Seung Taek Yu, Yeon Kyun Oh, Won Churl Park, Eun A Kim, Chang Woo Lee, Hyang Suk Yoon
Korean J Pediatr. 2005;48(8):907-910.   Published online August 15, 2005
Intussusception and Meckel's diverticulum are very rare disorders in intrauterine or neonatal periods, which are causes of intestinal obstruction. We experienced a case of intussusception due to Meckel's diverticulum which caused intestinal obstruction in the neonate who had bilious vomiting a few hours after birth. We report this case with a brief review of the literature.