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Original Article
The immunogenicity and reactogenicity of Td booster vaccination in Korean preadolescents, aged with 11-12 years old
Soo Young Lee, Ga Young Kwak, Hye Rin Mok, Jong Hyun Kim, Jae Kyun Hur, Kyung Il Lee, Park Joon Su, Sang Hyuk Ma, Hwang Min Kim, Jin Han Kang
Clin Exp Pediatr. 2008;51(11):1185-1190.   Published online November 15, 2008
Purpose : This study was undertaken to evaluate the immunogenicity and reactogenicity of Td booster immunization in early preadolescents of Korea. Methods : Healthy preadolescents, who had been vaccinated with 4 or 5 doses of DTaP vaccines until 6 years old age, were enrolled in this study from August 2006 to April 2007. Diphtheria and tetanus anti-toxoid antibodies in sera were...
Transforming growth factor-β gene promoter polymorphism : its association with renal involvement in Henoch-Sch lein Purpura in childhood
Seung Ho Lee, Hwa Young Jee, Hwang Min Kim, Byung Il Yeh
Clin Exp Pediatr. 2008;51(5):523-527.   Published online May 15, 2008
Purpose : Several cytokines play important roles in the inflammatory process of Henoch-Sch lein Purpura (HSP). It is likely that transforming growth factor-β (TGF-β) is involved in the pathogenesis of HSP. The purpose of this study is to investigate whether TGF-β promoter polymorphism is associated with the renal involvement of childhood HSP. Methods : Thirty-four patients younger than 15 years, who...
Clinical analysis of acute drug intoxication and foreign body ingestion in Wonju: comparison between the 1990s and the 2000s
Joo Pil Eum, Jin Suk Suh, Hwang Min Kim
Clin Exp Pediatr. 2007;50(2):138-142.   Published online February 15, 2007
Purpose : The purpose of this study is to find out the changing pattern of drug or foreign body ingestion between 1990s and 2000s in Wonju Christian Hospital, which is located in one of the most rapidly urbanizing cities in Korea. Methods : We retrospectively reviewed the medical records of patients with acute drug intoxication and foreign body ingestion from January...
Different Clinical Courses of Henoch-Sch nlein Purpura in Children, Adolescents and Adults
Joo Hee Hong, Hyung Joon Na, Mee Kyung Namgoong, Seung Ok Choi, Byng Geun Han, Soon Hee Jung, Hwang Min Kim
Clin Exp Pediatr. 2005;48(11):1244-1251.   Published online November 15, 2005
Purpose : Henoch-Sch nlein purpura(HSP) is the most common and benign systemic vasculitis in children. Few reports have focused on worse outcomes of HSP in adults. The age of onset is suggested as a main risk factor. We assessed the characteristics of adolescent-onset HSP. Methods : We retrospectively analyzed 205 cases presented from Aug. 1993 to Oct. 2003. Patients were classified...
Clinical Lecture
Treatment of Immue Thrombocytopenic Purpura in Childhood
Hwang Min Kim
Clin Exp Pediatr. 2004;47(12):1262-1265.   Published online December 15, 2004
Childhood immune thrombocytopenic purpura(ITP) is a typically benign self-limiting bleeding disorder of not fully known autoimmune etiology. Chronic ITP, which is defined by duration of more than 6 months, occurs in approximately 20% of children. Neither the risk of bleeding nor the type of disease, acute or chronic, can be predicted at initial presentation. The indication of treatment, choice...
Original Article
The Incidence and Risk Factors of Posttraumatic Seizure in Children
Sue Youn, Mi A Lee, Hwang Min Kim, Byung Ho Cha
Clin Exp Pediatr. 2004;47(11):1198-1204.   Published online November 15, 2004
Purpose : The goal of our study was to identify the incidence and clinical, neurophysiological and neuroradiological variables with predictive value for posttraumatic seizure(PTS). Methods : The medical records of 625 children with head traumas under 15-year-old who were admitted to the Wonju Christian Hospital, from January, 1993 to January, 2002 were retrospectively reviewed. Among them, 472 patients were included...
Effect of Delayed Intensification on Survival of Childhood Acute Lymphoblastic Leukemia
Jie Yeon Lee, Sue Youn, Byoung Chul Kwon, Chuhl Joo Lyu, Hwang Min Kim
Clin Exp Pediatr. 2003;46(12):1260-1265.   Published online December 15, 2003
Purpose : In 1970, the Berlin-Frankfurt-Munster(BFM) group introduced an intensification therapy after remission induction to reduce relapse of acute lymphoblastic leukemia(ALL) in childhood. Delayed intensification(DI) phase has been included for treatment of ALL in our hospital since the mid-1990s. The purpose of this study is to evaluate the outcome with vs. without DI phase and the outcome with two vs....
Case Report
Hemophagocytic Syndrome with Kawasaki Disease and Peripheral Gangrene
Hwa Jun Yun, Ko Woon Jeon, Hwang Min Kim, Seok Won Park, Young Uh
Clin Exp Pediatr. 2002;45(5):664-668.   Published online May 15, 2002
A twenty six months-old boy developed hemophagocytic syndrome during the course of Kawasaki disease. Despite the appropriate treatment modalities for Kawasaki disease, he developed thrombocytopenia, hepatomegaly, high-grade fever, hypertriglyceridemia, peripheral gangrene, and evidence of hemophagocytosis in bone marrow biopsy. Although the course was stormy, he responded well to a combination therapy of corticosteroid and etoposide.
Original Article
Effects of Obesity on Pulmonary Functions in Children
Seok Won Park, Hwang Min Kim, Jong Soo Kim, Jae Kuk Cha, Hae Ran Lee
Clin Exp Pediatr. 2002;45(5):588-595.   Published online May 15, 2002
Purpose : The incidence of obesity has increased in Korea recently. Obesity leads to higher risks of hypertension, hyperlipidemia and insulin resistance. It also leads to risks of respiratory complications. This study was performed to see the effects of obesity on children's pulmonary functions and on developed bronchospasm after exercise loading according to their obesity degrees. Methods : 257 obese...
Case Report
A Case of Vascular Leak Syndrome During Induction Chemotherapy of Acute Lymphoblastic Leukemia(T Cell Type)
Kye Wool Kang, Hwang Min Kim, Won Kyu Choi, Baek Keun Lim, Chang Hun Lee
Clin Exp Pediatr. 2001;44(9):1041-1046.   Published online September 15, 2001
Vascular leak syndrome(VLS) is characterized by endothelial damage, which causes extravasation of plasma proteins and fluid from capillaries into the extravascular space. It has been suggested that the increased vascular permeability is the result of an IL-2-induced suppression of endothelin- 1 secretion by endothelial cells, an IL-2-induced activation of the complement cascade or TNF-αrelease from IL-2-activated T-cells. A 13-year-old male patient visited our hospital...
Original Article
Mean Corpuscular Hemoglobin Concentration as a Discriminating Tool between Hereditary Spherocytosis and Intravascular Hemolysis
Hae Young Park, Hwang Min Kim, Kyoung Ah Lee, Dong Il Won, Sei Myeng Park, Seok Won Park, Baek Keun Lim, Kil Young Kim
Clin Exp Pediatr. 2001;44(6):664-668.   Published online June 15, 2001
Purpose : The purposes of this study were to elucidate the diagnostic significance of mean corpuscular hemoglobin concentration(MCHC) for various kinds of hemolytic anemia, the mechanism of elevated MCHC in hereditary spherocytosis(HS). Methods : The subjects consisted of 39 cases of HS(group 1), 31 cases of intravascular hemolysis (IH) such as DIC, snake bite or hemolytic uremic syndrome(group 3), and sex...
Survey on Upper Respiratory Tract Infections in Children
Seok Won Park, Hwang Min Kim, Jong Soo Kim, Kyu Earn Kim
Clin Exp Pediatr. 2001;44(6):642-653.   Published online June 15, 2001
Purpose : Recently, the numbers of non-pediatric doctors' giving medical treatment to children has shown a tendency to increase, especially in case of upper respiratory infection(URI) and it's complications such as tonsillitis, sinusitis and otitis media. Therefore we surveyed parents on children's URI and complications to find out parents' general understandings on pediatric treatment, what kind of pediatric treatment they...
Case Report
A Case of Severe Hypertensive Pulmonary Edema Associated with Neuroblastoma during Chemotherapy
Hee Suk Cho, Hwang Min Kim, Seok Won Park, Jong Soo Kim, Yoon Mi Kim, Kwang Kil Lee
Clin Exp Pediatr. 2000;43(4):573-577.   Published online April 15, 2000
The authors report a 7-year-old boy with neuroblastoma complicated by severe hypertension and pulmonary edema. Abdominal computed tomographic scan revealed a huge mass surrounding the aorta. After administration of cancer treatment, there was a marked increase in serum catecholamines level and hypertension, which resulted in pulmonary edema and heart failure. Alpha adrenergic blocking agents(prazocin, terazocin) were administrated, successfully controlling the...
A Case of Idiopathic Hypoparathyroidism Associated with Graves' Disease
Eun Young Jang, Hwang Min Kim, Baek Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 1999;42(5):716-721.   Published online May 15, 1999
Graves' disease is a relatively rare endocrinologic disorder in childhood age and often associated with other endocrinologic disorders such as type I diabetes mellitus and Addison's disease etc. Also, it is associtated with non-endocrinologic autoimmune diseases such as systemic lupus erythematosus, myasthenia gravis, idiopathic thrombocytopenic purpura, vitiligo and pernicious anemia. However, idiopathic hypoparathyroidism associated with Graves' disease is very...
Original Article
Diagnostic Value of Reticulated Platelet in Thrombocytopenia
Song Hee Park, Hwang Min Kim, Baek Keun Lim, Young Hak Shim, Chang Hoon Lee, Myung Seo Kang
Clin Exp Pediatr. 1997;40(6):850-856.   Published online June 15, 1997
Purpose : We performed this study to determine the diagnostic significance and useful cut-off value of reticulated platelet, which can be used for discriminating the destructive thrombocytopenia from underproductive thrombocytopenia. Methods : We evaluated 37 patients with thrombocytopenia who were admitted to the Wonju christian hospital from March to July, 1995. All patients were evaluated with bone marrow megakaryocyte count. We divided them into two...
Case Report
A Case of Lymphocytic Interstitial Pneumonia
Ho Young Lee, Hwang Min Kim, Mee Kyung Namgoong, Jong Soo Kim, Soon Hee Jung, Dong Jin Kim
Clin Exp Pediatr. 1997;40(4):572-577.   Published online April 15, 1997
Lymphoid interstitial pneumonia(LIP) is an uncommon process in childhood, and is characterized by interstitial accumulation of mature lymphocytes, plasma cells and reticuloendothelial cells. LIP is believed to have autoimmune or immunologic pathogenesis, because it is frequently associated with acquired immune deficiency syndrome, Epstein-Barr virus infection, common variable immunodeficiency. The patient described in this report had idiopathic thrombocytopenic purpura, Evans syndrome...
Medical Lecture Course
Molecular Biological Aspects of Neuroblastoma
Hwang Min Kim
Clin Exp Pediatr. 1996;39(11):1493-1497.   Published online November 15, 1996
Case Report
A Case of Acyclovir Induced Acute Tubular Necrosis
Mi Ya Park, Mee Kyung Namgoong, Hwang Min Kim, Baek Keun Lim, Sun Hee Jung
Clin Exp Pediatr. 1995;38(9):1283-1287.   Published online September 15, 1995
Acyclovir is generally regarded as a safe and highly effective antiviral agent in normal, as well as in immunocompromised hosts. Major renal complication was unusual. However, reversible renal dysfunction has been reported. The impairment of renal nephropathy resulting from crystal formation in the renal tubules or the collecting ducts. But we experienced a case of immunocompetent patient who developed severe...
A Case of Congenital Dyserythropoietic anemia Type IV
Hwa Young Jeon, Hwang Min Kim, Baek Keun Lim, Duk Woo Park, Myung Seo Kang, Young Kun Deung
Clin Exp Pediatr. 1995;38(5):702-706.   Published online May 15, 1995
Congenital dyserythropoietic anemia(CDA) is characterized by ineffective erythropoiesis an d increased numbers of multinucleated red cell precursors in the marrow. This syndrome has b een subdassified on the basis of morphologic and serologic differences in the red cell pecursors. There are some patients with congenital dyserythropoietic anemia who do not fit into the conventional classification of type I, II, or...
A Case of Intestinal Tuberculosis with Tuberculous Mesenteric Lymphadenitis Simulating Neoplasm
Jin Young Choi, Won Kyu Choi, Hwang Min Kim, Joong Soo Kim
Clin Exp Pediatr. 1995;38(3):404-408.   Published online March 15, 1995
The incidence of abdominal tuberculosis is decreasing due to more effective chemotherapy and pasteurization of milk and tuberculosis may nt be given serious consideration, especially when the primary pulmonary site is healed or not roentgenographically apparent. The clinical features of these infection are relatively nonspecific and the combination of abdominal mass, weight loss, anorexia and fever frequently lead to an...
Original Article
Analysis on the Cause of Eosinophilia in Premature Infants
Woo Sik Kang, Suck Kyu Hur, Mee Kyung Namgoong, Hwang Min Kim, Baek Keun Lim
Clin Exp Pediatr. 1994;37(1):47-53.   Published online January 15, 1994
Eosinophilia is a common finding in premature babies during the neonatal period. Serial eosinophil counts were determined in 94 hospitalized, appropriately grown premature infants whose gestational ages ranged from 28 to 36 weeks. The incidence, sseverity and etiologic factors of eosinophila were retrospectively studied in premature infants, who were divided into three groups according to their gestational age. The results were...
Diagnostic Significance of Red Cell Indices in Non-anemic Iron Deficiency and Iron Deficiency Anemia: Reevaluation with ROC Curve
Hwang Min Kim, Won Kyu Choi, Jae Seung Yang, Jong Soo Kim
Clin Exp Pediatr. 1994;37(1):33-39.   Published online January 15, 1994
To validate the diagnostic significance of red cell indices in non-anemic iron deficiency and iron deficiency anemia, complete blood count, serum iron, total iron binding capacity, and serum ferritin were measured in 208 middle school girls between 13 and 15 years age. We used Reciever Operating Characteristic (ROC) curve to compare the diagnostic significances of various red cell indices (MCV,...
Clinical Characteristics of Inborn and Outborn Infants Admitted to the NICU
Hyun Cheol Lee, Jin Young Choi, Hwang Min Kim, Baek Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 1993;36(12):1647-1655.   Published online December 15, 1993
Regionalization of high-risk perinatal care has been advocated because intensive care of small and ill newborn infants lowers mortality and morbidity. This report is based on analysis of admissions to the Neonatal Intensive Care Unit (NICU) at the Wonju Christian Hospital during the 4-year period from January, 1988 to December, 1991. There were 786 inborn infants and 1155 outborn...
Case Report
Two Cases of Virus Associated Hemophagocytic Syndrome
Jae Hee Han, Hyun Chul Lee, Hwang Min Kim, Jong Soo Kim, Kyung Won Lee
Clin Exp Pediatr. 1993;36(10):1458-1465.   Published online October 15, 1993
Virus associated hemophagocytic syndrome, class II histiocytoses, characterized by high fever, severe constitutional symptoms, abnormal liver function and coagulation, peripheral blood pancytopenia and histiocytic hyperplasis with prominent hemophagocytosis in bone marrow and lymph nodes has been reported and associated with active viral infection. It is non-malignant and reversible. It must be differentiated from histiocytic medullary reticuosis because of the inappropriateness...
A Case of Primary Pulmonary Hypertension
Sang Woo Lew, Hae Yong Lee, Hwang Min Kim, Jae Seung Yang, Jong Soo Kim
Clin Exp Pediatr. 1993;36(10):1452-1457.   Published online October 15, 1993
We have experienced a 14 year old female patient who had suffered from headache, dizziness, exertional dyspnea and chest pain during 6 months. She was diagnosed as primary pulmonary hypertension by ultrasonogram and cardiac catheterization. On the cardiac catheterization, there was elevated pulmonary artery pressure and normal pulmonary wedge pressure. We report this case with related literature review.
Three Cases of Purpura Fulminans
Sun Hee Suh, Hwang Min Kim, Jae Seung Yang, Baek Keun Lim
Clin Exp Pediatr. 1993;36(5):725-732.   Published online May 15, 1993
Purpura fulminans is one of rare consumptive coagulopathy in children. The most common prediasposing conditions of purpura fulminans are infectious disease like streptococcal infection and chickenpox. This disease is characterized by ecchymotic lesions that are usually distributed symmetrically on the lower extremities and buttocks. These ecchymotic lesions undergo necrosis, unless there is effective treatment. We experienced 3 cases of purpura fulminans...
2 Cases of Acute Disseminated Encephalomyelitis
Hyun Cheol Lee, Mee Kyung Namgoong, Hae Yong Lee, Hwang Min Kim, Jae Seung Yang, Jong Soo Kim
Clin Exp Pediatr. 1993;36(4):568-573.   Published online April 15, 1993
Acute disseminated encephalomyelitis(ADEM) is an acute inflammatory demyelinating disease of the central nervous system. It is thought to be an autoimmune mediated disorder which occurs usually after viral or bacterial infections, or after immunization. The clinical manifestations reflect sudden onset of the diffuse involvement of the brain, spinal cord and the meninges. We experienced two cases of acute disseminated encephalomyelitis. The...
Original Article
The Significance of Nucleated Red Blood Cell Counts in Various Conditions Associated with Acute or Chronic Perinatal Asphyxia
Suck Kyu Hur, Moon Sang Park, Mee Kyung Namgoong, Hwang Min Kim, Jae Seung Yang, Baek Keun Lim, Jong Soo Kim, Myung Seo Kang
Clin Exp Pediatr. 1992;35(11):1514-1519.   Published online November 15, 1992
This study was conducted to find out the significance of nucleated red blood cell (NRBC) in neonates, especially associated with acute or chronic perinatal asphyxia. So, we compared NRBC counts in various neonatal groups, such as normal newborn, small for gestational age (SGA), premature, acute perinatal asphyxia, & hyaline membrane disease (HMD). In the first day of life, we examined...
A Study on the Diagnostic Value of Cerebrospinal Fluid Adenosine Deaminase Activity in Children with Tuberculous Meningitis
Won Kyu Choi, Mee Kyung Namgoong, Hae Yong Lee, Hwang Min Kim, Jae Seung Yang, Jong Soo Kim
Clin Exp Pediatr. 1992;35(1):88-97.   Published online January 15, 1992
Tuberculous meningitis is still relatively common infectious disease of central nervous system in korea. The prognosis of tuberculous meningitis is closely related to the state at which treatment if started. Adenosine deaminase (ADA) is an enzyme which irreversibly hydrolyzes adenosine into inosine and ammonia. Recent investigations have suggested that the measurement of ADA activities in cerebrospinal fluid is useful in the...
The Comparision of Brain Computed Tomography and Isotope Cisternography in Communicating Hydrocephalus
Jong Chan Kim, Hwang Min Kim, Jae Seung Yang, Baek Keun Lim, Chul Hu, Soon Ki Hong, Young Hyuk Lee
Clin Exp Pediatr. 1992;35(1):9-16.   Published online January 15, 1992
Brain computed tomograpy is particularly accurate in defining cerebrospinal fluid (CSF) space because of the relatively great density difference between CSF and brain parenchyma. This noninvasive procedure has very quickly become definitive in the diagnosis of hydrocephalus. However, while the typical clinical and radiological picture of a hydrocephalic patient leaves no doubt as to the need for adequate surgical treatment....