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- Original Article
- Neonatology (Perinatology)
- Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures
- Jae Won Shin, Yun Seob Jung, Kyungsoo Park, Soon Min Lee, Ho Seon Eun, Min Soo Park, Kook In Park, Ran Namgung
- Clin Exp Pediatr. 2017;60(2):50-54. Published online February 27, 2017
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Purpose The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM.
Methods A retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was performed. The mean loading dose was 20 mg/kg, followed by...
- Usefulness of serum cystatin C to determine the dose of vancomycin in neonate
- Jeong Eun Shin, Soon Min Lee, Ho Seon Eun, Min Soo Park, Kook In Park, Ran Namgung
- Clin Exp Pediatr. 2015;58(11):421-426. Published online November 22, 2015
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Purpose The vancomycin dosage regimen is regularly modified according to the patient's glomerular filtration rate (GFR). In the present study, we aimed to assess the usefulness of serum cystatin C (Cys-C) concentration, compared with serum creatinine (SCr) concentration, for predicting vancomycin clearance (CLvcm) in neonates.
Methods We retrospectively analyzed the laboratory data of 50 term neonates who were admitted to the neonatal intensive...
- The efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia
- Sang Bum Kim, Jang Hoon Lee, Juyoung Lee, Seung Han Shin, Ho Sun Eun, Soon Min Lee, Jin A Sohn, Han Suk Kim, Byung Min Choi, Min Soo Park, Kook In Park, Ran Namgung, Moon Sung Park
- Clin Exp Pediatr. 2015;58(9):347-353. Published online September 21, 2015
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Purpose The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD).
Methods The Interventional study was designed as a multicenter, prospective, and randomized trial, with open labeled and parallel-experimental groups, 66 infants were enrolled and allocated to either the case group (n=30) or the control group (n=36) based on gestational age (GA)....
- Serological investigation of
Ureaplasma urealyticum in Korean preterm infants - Ho Seon Eun, Soon Min Lee, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee
- Clin Exp Pediatr. 2013;56(11):477-481. Published online November 27, 2013
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Purpose Ureaplasma colonization is related with perinatal complications in preterm infants. Little is known about the difference in virulence among variousUreaplasma urealyticum serovars. The aim of this study was to determineU. urealyticum serovars of preterm infants in order to assess whether any of the serovars were associated with bronchopulmonary dysplasia (BPD).Methods Three hundred forty-four preterm infants with a gestational age...
- Case Report
- Successful pleurodesis with OK-432 in preterm infants with persistent pleural effusion
- Jeong Eun Kim, Chul Lee, Kook In Park, Min Soo Park, Ran Namgung, In Kyu Park
- Clin Exp Pediatr. 2012;55(5):177-180. Published online May 21, 2012
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OK-432 (picibanil) is an inactivated preparation of
Streptococcus pyogenes that causes pleurodesis by inducing a strong inflammatory response. Intrapleural instillation of OK-432 has recently been used to successfully treat neonatal and fetal chylothorax. Here we report a trial of intrapleural instillation of OK-432 in two preterm infants who were born with hydrops fetalis and massive bilateral pleural effusion. Both cases...
- Acute treatment of hyperammonemia by continuous renal replacement therapy in a newborn patient with ornithine transcarbamylase deficiency
- Hyo Jeong Kim, Se Jin Park, Kook In Park, Jin Sung Lee, Ho Sun Eun, Ji Hong Kim, Jae Il Shin
- Clin Exp Pediatr. 2011;54(10):425-428. Published online October 31, 2011
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Ornithine transcarbamylase (OTC) deficiency is well known as the most common inherited disorder of the urea cycle, and 1 of the most common causes of hyperammonemia in newborns. We experienced a case of a 3-day-old boy with OTC deficiency who appeared healthy in the first 2 days of life but developed lethargy and seizure soon afterwards. His serum ammonia level...
- Original Article
- Survival analysis of spinal muscular atrophy type I
- Hyun Bin Park, Soon Min Lee, Jin Sung Lee, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee
- Clin Exp Pediatr. 2010;53(11):965-970. Published online November 30, 2010
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Purpose The life expectancy of patients with spinal muscular atrophy (SMA) type I is generally considered to be less than 2 years. Recently, with the introduction of proactive treatments, a longer survival and an improved survival rate have been reported. In this study, we analyzed the natural courses and survival statistics of SMA type I patients and compared the clinical characteristics...
- Effect of severe neonatal morbidities on long term outcome in extremely low birthweight infants
- Kyo Yeon Koo, Jeong Eun Kim, Soon Min Lee, Ran Namgung, Min Soo Park, Kook In Park, Chul Lee
- Clin Exp Pediatr. 2010;53(6):694-700. Published online June 23, 2010
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Purpose To assess the validity of individual and combined prognostic effects of severe bronchopulmonary dysplasia (BPD), brain injury, retinopathy of prematurity (ROP), and parenteral nutrition associated cholestasis (PNAC).
Methods We retrospectively analyzed the medical records of 80 extremely low birthweight (ELBW) infants admitted to the neonatal intensive care unit (NICU) of the Severance Children's Hospital, and who survived to a postmenstrual age of...
- Case Report
- A case of postoperative nasopharyngeal reflux associated with retropharyngeal lymphangioma in newborn infant
- Kyo Yeon Koo, Jun Seok Lee, Soon Min Lee, Min Soo Park, Ran Namgung, Kook In Park, Chul Lee, Choon Sik Yoon, Woo Hee Jung, Hong Shik Choi
- Clin Exp Pediatr. 2010;53(2):258-261. Published online February 15, 2010
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Lymphangioma is a rare benign congenital tumor of the lymphatic system, which is commonly diagnosed before 2 years of age. In the natronal report, cystic lymphangioma was usually reported as a huge translucent mass located in the head and neck area. It's occurrence in retropharyngeal space with respiratory obstruction and swallowing difficulty in neonate is extremely rare and postoperative nasopharyngeal... -
- Original Article
- Clinical experience of therapeutic effect of peritoneal drainage on intestinal perforation in preterm infants
- Jun Seok Lee, Kyo Yeon Koo, Soon Min Lee, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee, Seung Hoon Choi
- Clin Exp Pediatr. 2009;52(11):1216-1220. Published online November 15, 2009
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Purpose : To analyze and compare various cases in which peritoneal drainage was used as the primary treatment method in preterm infants with intestinal perforation. Methods : Among the preterm infants of less than 28 weeks of gestation who were admitted to the neonatal intensive care unit (NICU) at the Gangnam Severance Hospital from April 2006 to April 2009, 7 who... -
- Case Report
- De novo interstitial direct duplication 8 (p21.3p23.1) with Pierre Robin sequence
- Soon Min Lee, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee, Jin Seong Lee, Kyung A Lee, Jong-Rak Choi
- Clin Exp Pediatr. 2009;52(5):603-606. Published online May 15, 2009
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The Pierre Robin sequence (PRS) is the nonrandom association of micrognathia, cleft palate, and glossoptosis, leading to respiratory and feeding difficulties that appear neurogenic rather than mechanical in causation. Genetic determinants are thought to underlie this functional and morphological entity, based on the existence of Mendelian syndromes with PRS. Here, we demonstrate the association of PRS with trisomy 8p due... -
- Original Article
- Montelukast as an add-on therapy in bronchopulmonary dysplasia
- He Min Kim, Ji Eun Song, Soon Min Lee, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee
- Clin Exp Pediatr. 2009;52(2):181-186. Published online February 15, 2009
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Purpose : Inflammation plays a potential role in the pathogenesis of bronchopulmonary dysplasia (BPD). Strategies for preventing BPD include respiratory management, antioxidants, nutritional treatment, and others such as anti-inflammatory agents. We aimed to assess the safety, tolerability, and efficacy of montelukast (MK), a cysteinyl leukotriene 1 receptor antagonist, as an add-on therapy in BPD. Methods : In addition to currently available... -
- Effect of surfactant lavage in severe meconium aspiration syndrome
- Soon Min Lee, He Min Kim, Ji Hyun Jeon, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee
- Clin Exp Pediatr. 2008;51(4):367-371. Published online April 15, 2008
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Purpose : The surfactant dysfunction may play an important role in meconium aspiration syndrome (MAS). We aim to evaluate the effect of surfactant lavage in the treatment of term infants with MAS. Methods : The medical records of 15 neonates with severe MAS admitted at Yongdong Severance Hospital from 2005 to 2007 were reviewed and analyzed. Seven infants with severe... -
- Oxygenation index as a respiratory parameter of respiratory distress syndrome in preterm infants
- Ji Hyun Jeon, Ran Namgung, Min Soo Park, Kook In Park, Chul Lee
- Clin Exp Pediatr. 2008;51(2):145-149. Published online February 15, 2008
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Purpose : To examine whether changes of oxygenation index (OI) by postnatal age were different by the number of surfactant administration, and different between subgroups of survival and death. Methods : From January 2005 to June 2006, preterm infants (n=84) diagnosed as respiratory distress syndrome (RDS) and treated with surfactant and ventilator were included. They were divided into two groups: Group... -
- The effect of restricted fluid intakes in the first week of life on the risk of bronchopulmonary dysplasia and patent ductus arteriosus in very low birth weight infants
- Hoe Kyoung Koo, Eun Na Choi, Ran Namgung, Min Soo Park, Kook In Park, Chul Lee
- Clin Exp Pediatr. 2007;50(6):536-542. Published online June 15, 2007
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Purpose : We investigated the effects of restricted fluid in the first 7 days of life on the risk of bronchopulmonary dysplasia (BPD) or patent ductus arteriosus (PDA) in very low birth weight (VLBW) infants. Methods : Eighty three VLBW infants who lived more than 28 days were selected. The amount of daily maintenance fluid was determined by calculation of insensible... -
- Case Report
- A Case of Fetal Alcohol Syndrome with Persistent Pulmonary Hypertension of the Newborn
- Jin-Ha Chang, Ran Namgung, Min-Soo Park, Kook In Park, Jin-Sung Lee, Chul Lee
- Clin Exp Pediatr. 2004;47(11):1220-1224. Published online November 15, 2004
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Fetal alcohol syndrome can be suspected in infants born to mothers with a prenatal history of alcohol abuse if the child exhibits characteristic facial features, together with intrauterine growth retardation, multiple neurological abnormalities, and multiorgan defects. If only a few of the above criteria are satisfied, the term fetal alcohol effects is used. We experienced a neonate who presented with... -
- Original Article
- Clinical Trial of Domestically Developed Bovine Lung Surfactant YY-38 in Neonatal Respiratory Distress Syndrome
- Chul Lee, Jeong Nyun Kim, Min-Soo Park, Moon Sung Park, Shin Won Yoon, Wook Chang, Ran Namgung, Kook In Park, Dong-Gwan Han
- Clin Exp Pediatr. 1999;42(4):472-483. Published online April 15, 1999
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Purpose : We previously reported modified bovine lung surfactant YY-38(NewfactanⓇ) had a low surface tension, good hysteresis, and exhibited good pressure-volume curve in animal experiment (J Korean Pediatr Asso 1997;40:771-85). We performed multicenter clinical trial of NewfactanⓇ in neonatal RDS. Methods : Seventy-seven infants with RDS(GA 31.8¡¾2.9 wks and BW 1,809¡¾592 gm) in 4 NICU were enrolled. After administration of... -
- Physical and Biological Activity of Domestic Product of Modified Bovine Lung Surfactant
- Chul Lee, Min Soo Park, Moon Sung Park, Jung Nyeon Kim, Jong Wook Lee, Kwang Hyun You, Won Jae Kwag, Kook In Park, Ran Nam gung, Dong Gwan Han
- Clin Exp Pediatr. 1997;40(6):771-785. Published online June 15, 1997
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Purpose : Neonatal respiratory distress syndrome is caused by the deficiency of lung surfactant in premature babies. For the treatment of RDS at present surfactants such as Surfacten․ (Tokyo-Tanabe Co., Japan) and Exosurf․ (Wellcome Co., USA) are used. As awarded the grant from the Ministry of Science and Technology for a model research project of Medium-Technology program, we have modified (supplemented) the bovine lung... -
- The Therapeutic Effects of Dexamethasone Therapy in Neonate with Bacterial Meningitis
- Eun Gyung Lee, Kook In Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Kwan Han
- Clin Exp Pediatr. 1995;38(5):602-611. Published online May 15, 1995
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Purpose : In experimental models of meningitis and in children with meningitis, dexametha-sone has been shown to reduce meningeal inflammation and to improve the outcome of disea-se. We studied the effects of dexamethasone administration in neonates(<2 month-old) with b-acterial meningitis. Methods : We retrospectively reviewed the medical records of 30 neonates admitted to the nursery, the Yonsei University College of Medicine... -
- Case Report
- A Case of Antley-Bixler Syndrome
- Young Rae Kim, Kook In Park, Choon Sik Yoon, Ran Namgung, Chul Lee, Dong Gwan Han
- Clin Exp Pediatr. 1995;38(4):582-585. Published online April 15, 1995
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Antley-Bixler syndrome is a very rare disese of characteristic feature of craniosynostosis, brachycephaly, midface hypoplasia, depressed nasal bridge, radiohumeral synostosis and bowing femur. We presented a case of Antley-Bixtler syndrome with brief review of lituratures. -
- A Case of Hemimegalencephaly with Intraventricular Hemorrhage and Multifocal Intraparenchymal Hemorrage on Deep White Matter of Periventricular Area
- Jin Sung Ko, Kook In Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwang Han, Choon Sik Yoon
- Clin Exp Pediatr. 1995;38(4):561-566. Published online April 15, 1995
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Hemimegalencephaly is a rare congenital anomaly characterized by a intractable seizure an infantile death. This disease is a migrational disorder with enlargement of unilateral hemisphere, abnormal gyration of the cortex, the presence of large and atypical neuron, hetero trophic neuron at subcortical area and proliferation of astrocyte ect. We observed a neonate with neonatal seizure, and the radiological evaluation revealed abnormal... -
- Original Article
- Neonatal Neurosonographic Findings, Cerebral Doppler and Electrophysiological Findings in Infants with Motor Idsturbance
- Jae Kwang Kim, Kook In Park, Chang Il Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Kwan Han
- Clin Exp Pediatr. 1995;38(4):445-460. Published online April 15, 1995
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Purpose : Neurosonography, cerebral doppler and electrophysiological study are valuable in predicting neurodevelopmental outcome. The purpose of this study was to analyze characteristics of neonatal neurosonographic findigs, cerebral doppler and electrophysiological findings in infants withmotor disturbance. Methods : The subjects were 33 infants hospitalized at Yonsei Severance Medical Center NICU from January, 1990 to December, 1992. 19 of these patients underwent... -
- Evaluation of Development of Normal Infants Using Bayley Developmental Test
- Young Mi Chung, Chul Lee, Kook In Park, Ran Namgung, Dong Gwan Han
- Clin Exp Pediatr. 1994;37(11):1508-1518. Published online November 15, 1994
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From April to September 1992, 40 infants with age 6 months to 8 months who had been born in Yongdong Severanve Hospital were studied for evaluation of their development using Bayley developmental test. The result obtained were as follow: 1) Mean mental developmental index(MDI) is higher than mean psychomotor developmental index (PDI) and the values are 101.9¡¾8.2 and 105.5¡¾9.8 respectively. 2) As... -
- Clinical and Ultrasonographic Study on Prenatal Brain Damage in Newborn Infants
- Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee
- Clin Exp Pediatr. 1994;37(10):1364-1375. Published online October 15, 1994
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To determine the incidence of prenatal brain damage, and evaluate the clinical and neurosonographical characteristics, we prospectively examined 508 newborn infants with intracranial ultrasound within the first day of life who admitted to the NICU of Severance Hospital from June 1990 to January 1992 and reviewed maternal or neonatal medical records. We found 12 cases(2.4%) of fetal brain... -
- Risk Factors of Bronchopulmonary Dysplasia in Premature Infants Treated with Mechanical Ventilation and Restrictive Fluid Therapy
- Min Soo Park, Kook In Park, Hye Jung Choo, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
- Clin Exp Pediatr. 1994;37(10):1357-1363. Published online October 15, 1994
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In addition to many of the widely accepted risk factors of bronchopulmonary dysplasia(BPD), such as prematurity, oxygen toxicity, barotrauma, and infection, the amount of fluid intake during the early phase of life has recently been reported to be an important factor, especially the amount of colloid. Forty-one premature infants who were admitted to the NICU of Severance Hospital, Yonsei University... -
- Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with Perinatal Asphyxia and Hypoxic-Ischemic Encephalopathy with Doppler Technique
- Kook In Park, Dong Kwan Han, Joon Soo Lee, Ran Namgung, Chul Lee
- Clin Exp Pediatr. 1994;37(9):1196-1204. Published online September 15, 1994
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Fifty-three full-term, preterm, term-SGA newborn infants with perinatal asphyxia and 16 full-term infants with hypoxic-ischemic encephalopathy were studied with color Doppler songraphy to assess the postnatal change of the cerebral blood flow velocity(CBFV) longitudinally. A control group of 81 healthy infants also had CBFV recordings during the 1st week of life. Pourcelot Resistance index(PI) and area under the velocity curve(AUVC)... -
- Case Report
- A Case of Phakomatosis Pigmentovascularis
- Seung Mo Park, Kook In Park, Hye Jung Joo, Ran Namgung, Chul Lee, Dong Gwan Han, Soo Il Chun
- Clin Exp Pediatr. 1994;37(8):1156-1161. Published online August 15, 1994
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In 1947, Ota et al. First reported a case of phakomatosis pigmentovascularis and defined a subgroup of this disease having a congenital generalized hemangioma and pigmented lesions including anmongolian spot-like lesion, nevus pigmentosus and nevus of Ota. We experienced a case of phakomatosis pigmentovascularis type Iib in a 10-day old male baby, who since birth, had generalized nevus flammeus and... -
- Original Article
- Effect of Glucocorticoid-Induced Hyperglycemia on Preventing Hypoxic-Ischemic Brain Damage by Dexamethasone in Neonatal Rat
- Kook In Park, Tae Seung Kim, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
- Clin Exp Pediatr. 1994;37(8):1035-1047. Published online August 15, 1994
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Purpose : We evaluated the protective effect of dexamethasone (DX) administration on brain damage produced in a perinatal model of cerebral hypoxia-ischemia in the rat. Since hyperglycemia has been shown to reduce hypoxic-ischemic brain injury (HI) in immature rat, we investigated the role of glucocorticoid-induced hyperglycemia in the neuroprotective mechanism of DX. Methods : Hypoxic-ischemic brain injury in 7-day-old rats was... -
- Intraventricular Hemorrhage in Full-Term Neonate
- Myoung Bae Jeon, Kook In Park, Choon Sik Yoon, Ran Namgung, Chul Lee, Dong Gwan Han
- Clin Exp Pediatr. 1994;37(6):776-785. Published online June 15, 1994
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Intraventricular hemorrhage is a common hemorrhagic cerebral disorder in premature, but occurs much less frequently in the full-term newborn. In order to obtain documentation of clinical and ultrasonographic characteristics of intraventricular hemorrhage in full-term, we performed cerebral ultrasonography on 602 newborn infants who had been admitted to neonatal intensive care unit at the Deppartment of Pediatrics, Yonsei University College of... -
- Case Report
- A Case of Brain Damage in Surviving Monozygotic Twin After Intrauterine Death of Co-Twin
- Jae Young Choi, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han, Tae Sub Chung
- Clin Exp Pediatr. 1994;37(5):701-706. Published online May 15, 1994
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Various anatomical defects have been described in the surviving twin who had a stillborn, macerated monozygotic co-twin Disseminated Intravascular Coargulation. The etiology is thought to be placental transfer of emboli or thromboplastic material through placental vascular anastomoses. We experienced a case of monozygotic twin with deceased co-twin at 30 weeks of gestation and confirmed to have antenatal periventricular germinal matrix and... -
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Impact Factor3.2
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8.02023CiteScore94th percentilePowered by
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