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Original Article
Pulmonology
Increased procalcitonin level is a risk factor for prolonged fever in children with Mycoplasma pneumonia
Ji Eun Jeong, Ji Eun Soh, Ji Hee Kwak, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Moon Soo Park, Jung Yeon Shim
Clin Exp Pediatr. 2018;61(8):258-263.   Published online August 15, 2018

Purpose: Macrolide-resistant Mycoplasma pneumoniae pneumonia (MPP) is characterized by prolonged fever and radiological progression despite macrolide treatment. Few studies have examined serum procalcitonin (PCT) level in children with MPP. We aimed to investigate the association of acute inflammation markers including PCT with clinical parameters in children with MPP. Methods: A total of 147 children were recruited. The diagnosis of MPP...
Case Report
Case of seropositive allergic bronchopulmonary aspergillosis in a 10-year-old girl without previously documented asthma
Jeong Eun Shin, Jae Won Shim, Deok Soo Kim, Hae Lim Jung, Moon Soo Park, Jung Yeon Shim
Clin Exp Pediatr. 2015;58(5):190-193.   Published online May 22, 2015

Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease due to bronchial colonization of Aspergillus fumigatus that occurs in susceptible patients with asthma or cystic fibrosis. A 10-year-old girl was referred to the Department of Pediatric Pulmonology for persistent consolidations on chest radiography. Pulmonary consolidations were observed in the right upper and left lower lobes and were not resolved with...

Original Article
Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children
Bo Ram Cheon, Jeong Eun Shin, Yun Ji Kim, Jae Won Shim, Deok Soo Kim, Hye Lim Jung, Moon Soo Park, Jung Yeon Shim
Clin Exp Pediatr. 2015;58(3):96-101.   Published online March 20, 2015
Purpose

Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD.

Methods

We enrolled 91...

Increased risk of refractory Mycoplasma pneumoniae pneumonia in children with atopic sensitization and asthma
Jeong Eun Shin, Bo Ram Cheon, Jae Won Shim, Deok Soo Kim, Hae Lim Jung, Moon Soo Park, Jung Yeon Shim
Clin Exp Pediatr. 2014;57(6):271-277.   Published online June 30, 2014
Purpose

A nationwide outbreak of Mycoplasma pneumoniae pneumonia (MP) refractory to macrolide antibiotics occurred in Korea during 2011. Steroid therapy has been reported to be both efficacious and well tolerated in pediatric patients with refractory MP. We compared clinical features and laboratory characteristics between children with refractory MP requiring steroid treatment and those with macrolide-responsive MP and evaluated the risk factors...

Prevalence of respiratory viral infection in children hospitalized for acute lower respiratory tract diseases, and association of rhinovirus and influenza virus with asthma exacerbations
Jang-Mi Kwon, Jae Won Shim, Deok Soo Kim, Hye Lim Jung, Moon Soo Park, Jung Yeon Shim
Clin Exp Pediatr. 2014;57(1):29-34.   Published online January 31, 2014
Purpose

In this study, we aimed to investigate the prevalence of year-round respiratory viral infection in children with lower respiratory tract infection (LRTI) and the relationship between respiratory viral infection and allergen sensitization in exacerbating asthma.

Methods

We investigated the sources for acute LRTIs in children admitted to our hospital from May 2010 to April 2011. The 6 most common respiratory viruses were...

Case Report
Klebsiella pneumoniae liver abscess in an immunocompetent child
Jang-Mi Kwon, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park
Clin Exp Pediatr. 2013;56(9):407-410.   Published online September 30, 2013

Klebsiella pneumoniae has emerged as a leading pathogen that causes pyogenic liver abscesses (PLAs) in Korea. K. pneumoniae liver abscess (KLA) is potentially life threatening, and the diagnosis is difficult. In developed countries, PLA is rarely observed in children and is frequently associated with disorders of granulocyte function and previous abdominal infection. We observed a case of KLA in a...

Original Article
Expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ in the lung tissue of obese mice and the effect of rosiglitazone on proinflammatory cytokine expressions in the lung tissue
Seung Lok Ryu, Jae Won Shim, Duk Soo Kim, Hye Lim Jung, Moon Soo Park, Soo-Hee Park, Jinmi Lee, Won-Young Lee, Jung Yeon Shim
Clin Exp Pediatr. 2013;56(4):151-158.   Published online April 22, 2013
Purpose

We investigated the mRNA levels of peroxisome proliferator-activated receptor (PPAR)-α, PPAR-γ, adipokines, and cytokines in the lung tissue of lean and obese mice with and without ovalbumin (OVA) challenge, and the effect of rosiglitazone, a PPAR-γ agonist.

Methods

We developed 6 mice models: OVA-challenged lean mice with and without rosiglitazone; obese mice with and without rosiglitazone; and OVA-challenged obese mice with and...

Successful and safe treatment of hemangioma with oral propranolol in a single institution
Sun Hee Chung, Dong Hyuk Park, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park, Hong Hoe Koo
Clin Exp Pediatr. 2012;55(5):164-170.   Published online May 21, 2012
Purpose

Dramatic improvement of hemangioma to propranolol has been recently reported; however, details on dose and duration of treatment, potential risks, and monitoring have not been determined. The objective of this study is to describe and analyze the use of propranolol as a first-line treatment or as a single therapy in management of complicated hemangioma.

Methods

A retrospective chart review of eight patients...

Transforming growth factor-β promoted vascular endothelial growth factor release by human lung fibroblasts
Sang Uk Park, Joo Hwa Shin, Jae Won Shim, Deok Soo Kim, Hye Lim Jung, Moon Soo Park, Jung Yeon Shim
Clin Exp Pediatr. 2008;51(8):879-885.   Published online August 15, 2008
Purpose : The human lung fibroblast may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, which are important in airway remodeling. Vascular endothelial growth factor (VEGF) induces mucosal edema and angiogenesis. Thymus and activation regulated chemokine (TARC) induces selective migration of T helper 2 cells. We investigated whether human lung fibroblasts produced VEGF and TARC, and the...
Case Report
A case of idiopathic renal hypouricemia
Moon Hee Han, Sang Uk Park, Deok-Soo Kim, Jae Won Shim, Jung Yeon Shim, Hye Lym Jung, Moon Soo Park
Clin Exp Pediatr. 2007;50(5):489-492.   Published online May 15, 2007
Idiopathic renal hypouricemia is a disorder characterized by impaired urate handling in the renal tubules. This disease usually produces no symptoms, but hematuria, uric acid nephrolithiasis or acute renal failure may develop. A defect in the SLC22A12 gene, which encodes the human urate transporter, is the known major cause of this disorder. We describe a 10-month-old boy with idiopathic renal...
Original Article
Clinical features of congenital muscular torticollis
Ji Eun Jun, Hye Kyeong Ryu, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-Soo Kim
Clin Exp Pediatr. 2007;50(3):241-247.   Published online March 15, 2007
Purpose : Congenital muscular torticollis (CMT) is a common and benign congenital disorder of the musculoskeletal system in neonates and infants. The pathophysiology is that the sternocleidomastoid muscle (SCM) is shortened on the involved side by fibrosis, leading to ipsilateral tilt and contralateral rotation of the face and chin. In this study, we investigated the clinical features of CMT, the...
Relationship of serum IL-13 and eotaxin level with airway hyperresponsiveness in children with asthma
Eun Young Park, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
Clin Exp Pediatr. 2006;49(8):889-894.   Published online August 15, 2006
Purpose : Asthma is characterized by the presence of airway hyperresponsiveness(AHR) and inflammation. The extensive eosinophil infiltration into the lung is the hallmark of asthma and contributes to the damage of respiratory epithelium during late phase airway responses. Eotaxin is the major eosinophil chemoattractant found in bronchoalveolar lavage(BAL) fluid of allergic inflammation. IL-13 has been known to induce the...
A study of neuropeptides related to headaches in children with meningeal irritation signs
Bo Gil Seo, Myung Hwan Yoo, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-Soo Kim
Clin Exp Pediatr. 2006;49(5):533-538.   Published online May 15, 2006
Purpose : The headache, one of the symptoms of meningitis, is related to abrupt elevation of intracranial pressure(ICP) or stimulation of intracranial nociceptive structure. However, in cases of mild elevation of ICP or normal findings of cerebrospinal fluid(CSF) analysis, patients sometimes complain of headaches. Therefore, other pathways may contribute to the occurrence of headaches in aseptic meningitis or meningismus. We...
The significance of vascular endothelial growth factor(VEGF) in children with asthma and pneumonia
Seong Hwan Choi, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
Clin Exp Pediatr. 2006;49(2):192-197.   Published online February 15, 2006
Purpose : Vascular endothelial growth factor(VEGF) is a key cytokine for controlling vascular permeability and angiogenesis, which is one of the major findings in airway remodeling. However, it is not well known if it is associated with acute lower respiratory tract disease such as lobar pneumonia. The aim of this study is to compare serum VEGF levels in patients with...
A clinical study of migraines without aura in children : based on revised international headache society criteria
Bo Gil Seo, Myung Hwan Yoo, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-soo Kim
Clin Exp Pediatr. 2006;49(1):71-75.   Published online January 15, 2006
Purpose : Because migraine in children has different characteristics from that in adults, it is inappropriate to apply migraine criteria for adults to children. Recently, the International Headache Society(IHS) revised criteria regarding children's characteristics. Therefore, we reviewed the characteristics of childhood migraines without auras based on the revised criteria and compared the data with the findings of childhood migraine by...
Case Report
Two Cases of Lead Poisoning due to Herb Medicinal Pills
Seong Hwan Choi, Eun Young Park, Jung Yeon Shim, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
Clin Exp Pediatr. 2005;48(9):1009-1015.   Published online September 15, 2005
We encountered two children with lead poisoning who were administered herb medicinal pills recommended by their clergyman. These patients presented anemia and severe coliky abdominal pain, but no neurologic symptoms. For this reason, they were initially misdiagnosed with gastrointestinal hemorrhagic disease. However, we got a clue that they took herb medicinal pills. Finally, based on the assay of blood lead...
Original Article
Evaluation of Serum Insulin-Like Growth Factor(IGF)-I, Insulin-Like Growth Factor Binding Protein(IGFBP)-2 and IGFBP-3 Levels in Healthy Korean Children
Gi Hoon Yang, Hye Lim Jung, Deok Soo Kim, Jae Won Shim, Jung Yeon Shim, Moon Soo Park
Clin Exp Pediatr. 2005;48(3):298-305.   Published online March 15, 2005
Purpose : We performed this study to evaluate the mean serum levels of insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 in healthy Korean children according to age and sex. Methods : Ninety two healthy children, consisting of 42 boys and 50 girls, were classified into five groups according to age : neonate; infancy; early childhood; late childhood;...
Clinical Significance of Immature Reticulocyte Fraction and Reticulocyte Cellular Indices in Pediatric Anemia Patients
Young Seo, Hye Lim Jung, Jae Won Shim, Deok Su Kim, Jeong Yeon Shim, Moon Soo Park
Clin Exp Pediatr. 2005;48(3):284-291.   Published online March 15, 2005
Purpose : Flow cytometric automated reticulocyte analysis is a superior method to manual reticulocyte counting, with respect to precision and sensitivity. Furthermore, flow cytometric analysis is able to measure immature reticulocyte fraction(IRF) and reticulocyte cellular indices(RCI : cell hemoglobin content : CHr, mean cell volume : MCVr, cell hemoglobin concentration mean : CHCMr, distribytion width : RDWr, HDWr, CHDWr). In...
Serum and Cerebrospinal Fluid(CSF) Nitric Oxide, Macrophage Inflammatory Protein-1α and Lactoferrin Levels in Aseptic Meningitis
Young Seo, Jung Yeon Shim, Jae Won Shim, Deok Su Kim, Hye Lim Jung, Moon Soo Park
Clin Exp Pediatr. 2005;48(1):48-54.   Published online January 15, 2005
Purpose : The pathologic mechanisms of central nervous system(CNS) injuries in human meningitis are not yet completely understood. Recent studies indicate that the host inflammatory responses are as important in brain damage as the infecting organisms and toxins. There have been some reports on the relationship of nitric oxide(NO), macrophage inflammatory protein-1α(MIP-1α), and lactoferrin in bacterial meningitis, but few reports...
Serum Vascular Endothelial Growth Factor as a Predictive Risk Factor for the Occurrence of Coronary Artery Lesions in Kawasaki Disease
Min Hyuk Park, Hye Lim Jung, Ju Hee Yang, Jung-Yeon Shim, Deok Soo Kim, Jae Won Shim, Moon Soo Park
Clin Exp Pediatr. 2003;46(8):811-816.   Published online August 15, 2003
Purpose : Kawasaki disease is an acute systemic vasculitis of unknown etiology with a predilection for the coronary arteries. Vascular endothelial growth factor(VEGF) is a cytokine which promotes vascular permeability and angiogenesis. We investigated serum VEGF(sVEGF) levels in Kawasaki disease to determine whether sVEGF level can be used as a risk factor to predict the occurrence of coronary artery lesions(CAL)...
Increased Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Levels in the Cerebrospinal Fluid from Children with Aseptic Meningitis
Ju Hee Yang, Min Hyuk Park, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuck Keum
Clin Exp Pediatr. 2003;46(6):548-553.   Published online June 15, 2003
Purpose : Matrix metalloproteinase(MMP)-9 is known to breakdown the blood-brain barrier by degrading the extracellular matrix of the subendothelial basement membrane in meningitis. Tissue inhibitor of metalloproteinase(TIMP)-1, a known inhibitor of MMP-9, has been postulated to inhibit the proteolytic activity of MMP-9 by bindng to MMP-9, but their interaction has not been fully understood yet. So far, there have been...
Case Report
Two Cases of Gitelman's Syndrome Diagnosed by Renal Clearance Study
Tae Hwa Kim, Seung Jun Kim, Yu Kyung Seo, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuk Kum
Clin Exp Pediatr. 2002;45(3):413-417.   Published online March 15, 2002
Gitelman's syndrome is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria that has recently been reported to be linked to thiazide-sensitive Na-Cl cotransporter gene mutation. In this study, we performed renal clearance studies to differentiate Gitelman's from Bartter's syndrome and to confirm the diagnosis in two patients clinically diagnosed with Gitelman's syndrome. Each patient was hydrated...
Original Article
Changes of Interleukin-10 and Granulocyte Colony-Stimulating Factor in Cerebrospinal Fluid of Children with Aseptic Meningitis
Byeong Chan Park, Jung-Yeon Shim, Jeong Mi Lee, Jin-Young Park, Myung Ja Yoon, Hye Rim Jung, Moon Soo Park, Dong Hyeuk Keum, Dong Keug Keum
Clin Exp Pediatr. 1999;42(12):1676-1682.   Published online December 15, 1999
Purpose : Interleukin(IL)-10 is an antiinflammatory cytokine produced by monocytes/macrophages. Granulocyte colony-stimulating factor(G-CSF) plays an important role, not only as a hemopoietic factor but also as a regulating factor for a biologic defense system by neutrophils, in the foci of infection. We studied G-CSF and IL-10 levels in the serum and cerebrospinal fluid(CSF) of patients with aseptic meningitis and investigated...
A Seroepidemiologic Study on Hepatitis A in Seoul, Korea
Dong Woon Yang, Young Ah Lee, Jung Yeon Shim, Jin Young Park, Hye Lim Jung, Moon Soo Park, Dong Hyeuk Keum
Clin Exp Pediatr. 1999;42(2):180-185.   Published online February 15, 1999
Purpose : The prevalence of hepatitis A(HAV) in a certain community reflects that community’s living standard and hygienic condition. And the pattern of HAV infection differs over time and geography, with varying widely from country to country and even within the same city. Recently a shift in prevalence has been observed in cases from childhood to adulthood. We studied HAV...
Acute Renal Failure in Children : Underlying Disease and Management according to Age
Eun Joung Park, Joung Sim Kim, Jai Bok Yoo, Joung Sook Sul, Si Whan Koh, Phil Soo Oh, I Suk Kang, Moon Soo Park, Heung Jae Lee, Dong Kyoo Jin
Clin Exp Pediatr. 1998;41(5):654-662.   Published online May 15, 1998
Purpose : It has been stressed that age itself as well as multiple organ failure are important prognostic factors in acute renal failure(ARF) in children. This study was performed to find out the significance of age factor and underlying disease of ARF in children. Methods : We tried to review 58 pediatric ARF cases, retrospectively, in the pediatric intensive care unit(excluding...
The Prevalence of A985G Mutation in Medium Chain Acyl-Coenzyme A Dehydrogenase(MCAD) Gene in Neonates Determined from Guthrie Card
Baeck Hee Lee, Hye Won Park, Moon Soo Park, Ho Jin Park, Yong Choi, Hae Il Cheong
Clin Exp Pediatr. 1997;40(12):1645-1650.   Published online December 15, 1997
Purpose : Medium chain acyl-CoA dehydrogenase(MCAD) deficiency is an autosomal recessive disoder of β oxidation of fatty acids and characterized by episodic hypoglycemia, vomiting, convulsion, encephalopathy, apnea, and sudden death related to fasting or infection resembling Reye syndrome or sudden infant death syndrome. In acute stage, mortality rate is very high and survivors have significant risk of developmental disability and chronic somatic illness. However,...
Case Report
A Case of17α-Hydroxylase Deficiency
Yong Kyu Lee, Yun Jong Kang, Chan Young Pak, Soo Young Choi, Moon Soo Park
Clin Exp Pediatr. 1996;39(4):577-584.   Published online April 15, 1996
A 12-year-old girl with hypertension, hypokalemia, cystic ovaries and absence of secondary sexual development is presented. Hormonal study revealed very low levels of cortisol, testosterone, estrogen, and high levels of progesterone, deoxycorticosterone, corticosterone, FSH and ACTH. Following treatment with dexamethasone and estrogen, the levels of the latter group remarkably decreased. Serum potassium level and blood pressure also became normal. With...
Original Article
A case of idiopathic precocious puberty treated with a luteinizing hormone relaeasing hormone analog.
Keun Hee Chung, Yoo Mi Kim, Mi Won Kim, Soon Ki Kim, Moon Soo Park, Jin Keun Chang
Clin Exp Pediatr. 1991;34(8):1132-1138.   Published online August 31, 1991
We experienced a 4 year girl with idiopathic precocious puberty treated with a long acting LHRH analog (Buserelin). As an indction therapy she received LHRH analog for 6 months in subcutaneous route. After then she was maintained by intranasal therapy for 6 months. One month after the induction therapy began, we observed prepunbertal pattern of LHRH stimulation test and significant suppression of 17B-estradiol level....
A Case of Acute Interstitial Nephritis Associated with Yersinia Pseudotuberculosis Infection.
Keun Hee Chung, Yoo Mee Kim, Mee Won Kim, Soon Gi Kim, Moon Soo Park, Jin Keun Chang
Clin Exp Pediatr. 1990;33(8):1123-1128.   Published online August 31, 1990
Authors recently experienced a case of acute interstitial nephritis associated with Yersinia pseudotuberculosis infection in 10-8/12 year old boy, who was admitted to prolonged high fever. On 3rd hospital day, puffy face and oliguria were noted. BUN and serum creatinine rose to peak level, 94.1 mg/dl and 10.1 mg/dl, respectively on 7th hospital day. After then renal functions were normal- ized gradually without specific...
A case of Erythema Nodosum due to Yersinia Pseudotuberculosis.
Keun Hee Chung, Hong Jong Joo, Yoo Mi Kim, Soon Ki Kim, Moon Soo Park, Jin Keun Chang, Sung Woo Shin
Clin Exp Pediatr. 1990;33(4):528-533.   Published online April 30, 1990
Yersinia pseudotuberculosis infection is one of the common causes of erythema nodosum in Europe, but in Korea only 2 cases have been reported. Recently authors experienced a 6 year old boy who suffered from erythematous painful skin lesions on the shin and calf, and was diagnosed serologically as erythema nodosum due to Yersinia pseudotuberculosis infection. So we report here the clinical findings of this...