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Original Article
Influence of histologic chorioamnionitis and funisitis on the level of peripheral blood C-reactive protein at birth in preterm infants
Do-Hyun Kim, Heun Ji Lee, Hee Sup Kim, Byoung Hoon Yoo
Clin Exp Pediatr. 2010;53(1):33-40.   Published online January 15, 2010
Purpose : The objective of this study is to determine the change of C-reactive protein (CRP) levels in the peripheral blood of preterm infants at birth according to the stage of intrauterine inflammation. Methods : A total of 187 infants (<32 weeks of gestation) were divided into a “no histologic chorioamnionitis” [HCAM (-), n=85] group and a “histologic chorioamnionitis” [HCAM...
Review Article
Hypertension in children and adolescents
Jo Won Jung
Clin Exp Pediatr. 2009;52(7):745-751.   Published online July 15, 2009
Hypertension is a major risk factor for myocardial infarction, stroke, and cardiovascular mortality in adults; its treatment reduces the risk of cardiovascular events. In recent times, attention is being paid to monitoring of blood pressure from childhood to adulthood. Childhood hypertension is associated with hypertension in later life, and early intervention is important. In the Korean socioeconomic background, a rapid...
Original Article
Effects of soy-based formula on infants` growth and blood laboratory values spanning 3 years after birth
Ji Eun Yoon, Mi-Jung Kim, Heon-Seok Han
Clin Exp Pediatr. 2009;52(1):28-35.   Published online January 15, 2009
Purpose : We compared body growth, blood cell counts, and chemistry among infants receiving soy-based formula (SF), breast milk (BM), and casein-based formula (CF). Methods : Full-term neonates delivered at our hospital from June 2001 to August 2003 were recruited and divided into 3 feeding groups (BM=20, SF=19, CF=12) according to the parents wishes. Breast feeding or artificial formulae were...
Normal blood pressure values and percentile curves measured by oscillometric method in children under 6 years of age
Jin A Sohn, Hee Sook Lee, Kyoung Aha Lim, So Young Yoon, Jo Won Jung, Nam Su Kim, Chung Il Noh, Soon Young Lee, Young Mi Hong
Clin Exp Pediatr. 2008;51(9):998-1006.   Published online September 15, 2008
Purpose : Hypertension is defined as average systolic blood pressure and/or diastolic blood pressure that is ≥95th percentile for gender, age, and height on ≥three occasions. Knowing that blood pressure values increase in children as they grow older, the purposes of this study were to measure blood pressure by an oscillometric device and to determine normal values and percentile curves...
Relationship between cord blood level of IL-12 in preterm newborns and development of wheezing
Hyo Jung Yu, Eun Ae Park, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye Sook Park, Eun Hee Ha
Clin Exp Pediatr. 2008;51(7):754-759.   Published online July 15, 2008
Purpose : Abnormal activation patterns of Th1/Th2-cells have been suggested to increase the prevalence of allergic diseases. Prevention is regarded as an important corner stone in the management of allergic diseases. In this study, we have investigated the relationship between cord blood levels of IL-4, IL-10, and IL-12 in preterm newborns and the development of allergic respiratory diseases in infancy Methods...
The utility of ambulatory blood pressure monitoring in obese children
Myung Jin Kim, Jin Young Song
Clin Exp Pediatr. 2008;51(6):604-609.   Published online June 15, 2008
Purpose : Obesity in children and adolescence is highly correlated with adult obesity, which can provoke hypertension. Therefore, it is important to evaluate the blood pressure of obese children regularly. In this study, the results of ambulatory blood pressure monitoring (ABPM) in obese children and adolescents were evaluated. Methods : ABPM was conducted for selected patients who visited Handong University...
Review Article
Normative blood pressure references for Korean children and adolescents
Chong Guk Lee, Jin Soo Moon, Joong-Myung Choi, Chung Mo Nam, Soon Young Lee, Kyungwon Oh, Young Taek Kim
Clin Exp Pediatr. 2008;51(1):33-41.   Published online January 15, 2008
Purpose : It is now understood that blood pressure (BP) measurement in the routine pediatric examination is very important because of the relevance of childhood BP to pediatric health care and the development of adult essential hypertension. There hasn't been a reference table of BP for Korean children and adolescents up to now. This study was to make normative BP...
The methodology for developing the 2007 Korean growth charts and blood pressure nomogram in Korean children and adolescents
Soon Young Lee, Youn Nam Kim, Yeon Ji Kang, Myoung-Jin Jang, Jinheum Kim, Jin Soo Moon, Chong Guk Lee, Kyungwon Oh, Young Taek Kim, Chung Mo Nam
Clin Exp Pediatr. 2008;51(1):26-32.   Published online January 15, 2008
Purpose : This study was to provide the methods of developing the growth charts and the blood pressure nomogram among Korean children and adolescents. Methods : The growth charts were developed based on the data from the national growth surveys for children and adolescents in 1998 and 2005. The percentile charts were developed through two stages. At the first stage, the...
Original Article
Effect of intravenous deferoxamine in multiply transfused patients
Sang Min Oh, Joon Won Kang, Sun Young Kim
Clin Exp Pediatr. 2007;50(12):1225-1230.   Published online December 15, 2007
Purpose : Multiple transfusions in patients with chronic anemia can result in excessive iron deposition in tissues and organs. Effective iron chelation therapy in chronically transfused patients can only be achieved when iron chelators remove sufficient amounts of iron equivalent to those accumulated in the body from transfusions, thus leading to maintain body iron load at a non-toxic level. This...
Pulse wave velocity and ankle brachial index in obese adolescents
Ji Hye Kim, Hee Sun Koo, Young Mi Hong
Clin Exp Pediatr. 2007;50(11):1078-1084.   Published online November 15, 2007
Purpose : The prevalence of childhood obesity has doubled over the last 30 years. Obesity-associated sequelae in the vasculature begins in the early stages of life. The purpose of this study was to investigate how pulse wave velocity (PWV) and ankle brachial index (ABI) change with height, weight and body mass index (BMI) in obese adolescents. Methods : Seventy-nine obese...
Review Article
Intensive management of acute right heart failure
Gi Beom Kim, Chung Il Noh
Clin Exp Pediatr. 2007;50(11):1041-1048.   Published online November 15, 2007
Not a few patients in children and adolescents are suffering from right ventricular (RV) dysfunction resulting from various conditions such as chronic lung disease, left ventricular dysfunction, pulmonary hypertension, or congenital heart defect. The RV is different from the left ventricle in terms of ventricular morphology, myocardial contractile pattern and special vulnerability to the pressure overload. Right ventricular failure (RVF)...
Original Article
A pilot study of neuroprotection with umbilical cord blood cell transplantation for preterm very low birth weight infants
Kyu Young Chae, Kyu Hyung Lee, So-Hee Eun, Byung Min Choi, Baik-Lin Eun, Hoon-Chul Kang, Myung Jae Chey, Nam Keun Kim, Doyeun Oh
Clin Exp Pediatr. 2007;50(9):882-890.   Published online September 15, 2007
Purpose : Preterm very low birth weight infant have high rate of adverse neurodevelopmental sequale. Recently, there have been lots of reports that human umbilical cord blood transplantation ameliorates functional deficits in animal models as hypoxic ischemic injury. This pilot study was undertaken to determine the clinical efficacy and safety of autologous umbilical cord blood cell transplantation for preventing neurodevelopmental...
Pulse wave velocity and ankle brachial index in normal adolescents
Ji Hye Kim, Tae Young Gil, Hee Woo Lee, Young Mi Hong
Clin Exp Pediatr. 2007;50(6):549-555.   Published online June 15, 2007
Purpose : Pulse wave velocity (PWV) and ankle brachial index (ABI) are simple, non-invasive methods to assess arterial stiffness. These parameters are also known to be closely related to cardiovascular risk factors and diseases. The purposes of this study were to measure blood pressure, PWV, ABI in healthy Korean adolescents, set up their normal values and assess their correlations. Methods...
Cord blood IL-10, IL-12 in preterm newborns as predictors of respiratory distress syndrome and bronchopulmonary dysplasia
Jee Yoon Park,, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye sook Park, Eun Hee Ha, Eun Ae Park
Clin Exp Pediatr. 2007;50(3):248-254.   Published online March 15, 2007
Purpose : Inflammation plays a major role in the pathogenesis of RDS and BPD in the immature lung. We investigated the possible role of IL-10 and IL-12 in the cord blood of preterm newborns with RDS or BPD. Methods : Forty preterm newborns whose mothers received antenatal care at Ewha Womans University Mokdong Hospital between January 2003 to June 2005, and...
The influence of some intrauterine growth variables on neonatal blood pressure
Jungwon Min, Eun Ae Park, Kyoungae Kong, Bohyun Park, Juhee Hong, Young Ju Kim, Hwayoung Lee, EunHee Ha, Hyesook Park
Clin Exp Pediatr. 2006;49(9):966-971.   Published online September 15, 2006
Purpose : ‘Programming’ describes the process that stimulus at a critical period of development has lifelong effects. The fact that low birth weight links to the risk of elevated blood pressures in adult life is well known. This study aims to examine whether this link is evident in the newborn by investigating the relationship of the intrauterine growth indices and...
Ex vivo Expansion and Clonal Maintenance of CD34＋ Selected Cells from Cord Blood and Peripheral Blood
Soon Ki Kim, Hye Yoon Ghil, Sun U. Song, Jong Weon Choi, Sang Kyu Park
Clin Exp Pediatr. 2005;48(8):894-900.   Published online August 15, 2005
Purpose : Because of the unavailability of marrow transplantation, umbilical cord blood (CB) is increasingly being used. We evaluated the potential of ex vivo expansion and clonality in CD34＋ cells separated from cord blood source and mobilized peripheral blood (PB) in a serum-free media. Methods : The CD34＋ cells, selected from CB and mobilized PB, were expanded with hematopoietic growth...
Perinatal Factors Affecting Thyroid Stimulating Hormone(TSH) and Thyroid Hormone Levels in Cord Blood
Eun Young Kim, Sang Kee Park, Chang Hun Song, Sung-Chul Lim
Clin Exp Pediatr. 2005;48(2):143-147.   Published online February 15, 2005
Purpose : The aim of the this study was to evaluate the effect of various perinatal conditions on TSH and thyroid hormone levels in cord blood. Methods : Cord blood samples were collected from 130 neonates immediately after birth. TSH, T3, and free T4 levels were measured by the radioimmunoassay(RIA) method. The effects of gestational age, sex, birth weight, delivery method,...
The Diagnostic Value of Gross Bloody Stool on Intussusception
Kyung Ah Nam, Sang Hee Lee, Sang Hee Son, Su Jin Jung, Son Sang Seo
Clin Exp Pediatr. 2004;47(8):851-854.   Published online August 15, 2004
Purpose : To evaluate the diagnostic value of gross bloody stools as a predictor of intussusception. Methods : We reviewed 159 cases retrospectively that had an ultrasound examination for diagnosis of intussusception from January 2001 to December 2003 at Ilsin Christian Hospital. We compared each symptom and assessed the diagnostic value of gross bloody stools in the patients with suspected intussusception. Results...
Prediction of Intravenous Immunoglobulin Non-responders in Patients with Kawasaki Disease
Gi Bum Lee, Ji-Won Lee, Kyung-Yil Lee
Clin Exp Pediatr. 2004;47(1):90-94.   Published online January 15, 2004
Purpose : We evaluated the effects of intravenous immunoglobulin(IVIG) on the levels of laboratory indices examined serially according to the responsiveness to IVIG therapy in children with Kawasaki disease(KD). Methods : Children with KD(n=63) who had been treated with IVIG at a dosage of 2.0 g/kg were classified into two groups : the IVIG-resistant(consistent fever over 48 hours after initiation...
Umbilical Cord Arterial Concentrations of Isoprostane(8-iso-PGF2α) in Newborn Infants
Kun Song Lee, Yoon Hee Ji, Young Pyo Chang
Clin Exp Pediatr. 2003;46(9):865-870.   Published online September 15, 2003
Purpose : We measured the umbilical cord arterial concentrations of isoprostane(8-iso-PGF2α) and intended to decide whether the umbilical cord arterial concentrations of isoprostane could be used as a useful parameter for lipid peroxidation in newborn infants. Methods : The isoprostane and malondialdehyde(MDA) concentrations of the umbilical cord were measured by enzyme immunoassay and TBARS(thiobarbituric acid reactive substance) assay in 33...
Increased Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Levels in the Cerebrospinal Fluid from Children with Aseptic Meningitis
Ju Hee Yang, Min Hyuk Park, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuck Keum
Clin Exp Pediatr. 2003;46(6):548-553.   Published online June 15, 2003
Purpose : Matrix metalloproteinase(MMP)-9 is known to breakdown the blood-brain barrier by degrading the extracellular matrix of the subendothelial basement membrane in meningitis. Tissue inhibitor of metalloproteinase(TIMP)-1, a known inhibitor of MMP-9, has been postulated to inhibit the proteolytic activity of MMP-9 by bindng to MMP-9, but their interaction has not been fully understood yet. So far, there have been...
Case Report
A Successful Transplant of HLA-3 Loci Mismatched Umbilical Cord Blood into a Patient with Acute Myeloid Leukemia from an Unrelated Donor
Byoung Chul Kwon, Kyung Mi Shin, Sung Chul Won, Chuhl Joo Lyu, Chang Hyun Yang, Hyun Ok Kim
Clin Exp Pediatr. 2002;45(7):912-916.   Published online July 15, 2002
Cord blood is a useful source of allogeneic hematopoietic stem cells for bone marrow reconstitution. The number of umbilical cord blood transplants is increasing worldwide. In this a case 15- month-old boy with acute myeloid leukemia was treated with umbilical cord blood transplant from an HLA-3 loci mismatched unrelated donor. Granulocyte recovery greater than 500/mm3 occurred at day 49, and...
Original Article
Availability of Capillary Blood Gas Analysis in Neonate
Jong Tae Jeong, Su Young Yun, Ran Lee, Jae Ho Hyun, Gyu Young Jung
Clin Exp Pediatr. 2002;45(4):449-453.   Published online April 15, 2002
Purpose : Arterial blood gas analysis is frequently performed in neonatal intensive care unit (NICU) to evaluate ventilation and the metabolic state of critically ill infants. In occasions when umbilical arterial catheterization is not available, frequent arterial puncture is mandatory. This requires some technical skill and may occasionally have side effects. So we studied the validity of capillary blood gas...
Case Report
A Mesenteric Lymphangioma Causing Billous Vomiting and Bloody Stool in a 3-day-old Infant
Jeum-Su Kim, Hae-Seoung Jung, Ki Su Kang, Yong-Suk Kim, Chan-Hoo Park, Myoung Bum Choi, Hyang-Ok Woo, Gyung-Hyuck Ko, Hee-Shang Youn
Clin Exp Pediatr. 2001;44(11):1316-1319.   Published online November 15, 2001
Mesenteric lymphangioma, which is rare and often diagnosed incidentally, is a benign tumor in infants and children. Most cases of lymphangioma are in the neck and axilla. About 5% of these lesions are in the mediastinum, mesentery or retroperitoneal region. Although most lymphangioma produce no symptoms, it may present an acute surgical condition suggesting acute intestinal obstruction. We report one...
Original Article
The Relationship of Maternal Disorder with Neonatal Cord Blood Leptin - Preeclampsia, Diabetes Mellitus, Antenatal Steroid Treatment -
Seon Mi Park, Eun Young Kim, Yeong Bong Park, Sang Kee Park
Clin Exp Pediatr. 2001;44(10):1119-1126.   Published online October 15, 2001
Purpose : Leptin, the product of the ob gene is primarily by adipose tissue but also by the human placenta. Leptin may also have a role as a regulator of fetal growth and development during normal pregnancy as well as in pregnancies associated with anomalous fetal growth. Our study aimed to discover whether or not leptin concentration in neonatal cord...
The Effectiveness of Propofol on Pediatric Cardiac Catheterization and Electrophysiologic Study
Woo Saeng Park, Myung Chul Hyun
Clin Exp Pediatr. 2001;44(7):773-777.   Published online July 15, 2001
Purpose : Our purpose was to evaluate the effectiveness of propofol on pediatric cardiac catheterization or radiofrequency catheter ablation. Methods : We measured the serial changes of arterial oxygen saturation, heart rate, systolic and diastolic blood pressure at 4 stages, a baseline(during normal sleep), stage 1(just after loading of propofol 2 mg/kg over 10 minutes), stage 2(10-15 minutes after propofol continuous...
Whole Blood and Plasma Vitamin C Concentrations in Children of 1-6 Years of Age in the Chinju Area
Hyang-Ok Woo, Jin-Su Jun, Ji-Hoe Park, Young-Suk Kim, Eun-A Kim, Jae-Young Lim, Myoung-Bum Choi, Chan-Hoo Park, Hee-Shang Youn, Gyung-Hyuck Ko, Chan-Hoo Park, Woo-Kon Lee, Myung-Je Cho, Kwang-Ho Rhee
Clin Exp Pediatr. 2001;44(5):501-508.   Published online May 15, 2001
Purpose : Vitamin C among antioxidants in human is a physiological antioxidant for protection against diseases. We measured the vitamin C concentrations of whole blood and plasma among children in early childhood at normal condition in order to know the presence of vitamin C deficiency. Methods : The venous blood was collected from 471 subjects at 1-6 years of ages in...
The Relationship between Change of Cardiac Function and Systemic Oxygen Consumption according to the Dose of Dopamine in the Rabbit
Hee Ju Park, Seok Ho Yoon, Bong Seok Choi, Jung Hwoi Cho, Ku Tae Kim, Sun Young K, Sang Ook Nam, Bok Luel Lee
Clin Exp Pediatr. 2001;44(2):177-184.   Published online February 15, 2001
Purpose : We'd like to know the relationship between the changes of cardiac function and systemic O2 consumption according to the increasing dose of dopamine. Methods : Ten rabbits(from 2kg to 2.8kg) were used in this experiment. Anesthesia was induced with intraperitoneal pentobarbital sodium(35mg/kg) and tracheostomy was done. It was maintained by ventilation with a mixture of 1-3% halothane and 67-69%...
Effect of Granulocyte-macrophage Colony-stimulating Factor in Neonatal Infection
Il-Young Jo, Sang-Hyun Byun
Clin Exp Pediatr. 2000;43(12):1552-1557.   Published online December 15, 2000
Purpose : Neutrophils are central to the defences against bacterial infection, and in neonates the number of neutrophils are decreased due to inhibited production and phagocytic function. This induces high mortality rates in infants suffering from neonatal sepsis. Exogenous GM-CSF can increase the number of neutrophils and improve the phagocytic function. To establish the most cost effective dose of exogenous...
Oscillometric Blood Pressure Values of Infants and Children
Hae In Suh, Young Mi Hong
Clin Exp Pediatr. 2000;43(8):1029-1036.   Published online August 15, 2000
Purpose : Automated oscillometric blood pressure measurement is not used universally, but has a tendency to be used more frequently in pediatric areas. Reference values of blood pressure by this method were not reported on infants and children under 5 years of age in Korea. This study was performed to study normative blood pressure values by using oscillometric method, presenting...