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Original Article
Transplacental transmission of hepatitis B virus from carrier nothers to neonates.
Soh Yeon Kim, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1991;34(2):190-196.   Published online February 28, 1991
Neonates bom to hepatitis B carrier mothers at Yongdong Severance Hospital, Yonsei University College of Medicine were sampled for hepatitis B viral markers using venous blood drawn from external jugular vein within 3 hours after birth and the following results were obtained. Two thousand nine hundred and seventy two pregnant women who received prenatal care at Yongdong Severance Hospital, Yonsei University College of Medicine...
The Effect of Low-Dosage Alpha-Interferon Therapy in Children with Chronic Active Hepatitis B.
Hee Kyung Kim, Sung Min Choi, Cheol Woo Ko, Kun Soo Lee, Ja Hoon Koo, Doo Hong Ahn
Clin Exp Pediatr. 1990;33(7):915-922.   Published online July 31, 1990
A clinical trial was conducted to determine the effect of low-dosage recombinant a-interferon therapy in children with HBs Ag and HBe Ag positive chronic active hepatitis. Studied patients consist of 7 biopsy-proven children (aged 6.5-11.5 yr). After 16 weeks of therapy, following results were obtained. Out of 7 HBe Ag positive cases, 5 cases (71.4%) were converted to HBe Ag negative state. One of two...
The Change of Anti-HBs Titer after Hepatitis B Vaccination in Newborn.
Ji Hye Kang, Young Mi Hong, Seung Joo Lee
Clin Exp Pediatr. 1990;33(5):598-605.   Published online May 31, 1990
Hepatitis B vaccination is an accepted preventive measure for all newborn as well as the risk group. However, there is some uncertainty about the persistence of anti-HBs and the timing of booster vaccination. We studied anti-HBs titer, positive rate and minimum protective rate in relation to time interval after the third vaccination in 102 infants bom to HBsAg negative mother (Group I) and 52...
A Study on Periphral T Cell Subsets in Asymptomatic HBsAg Carriers and Children with Chronic Hepatitis B and Hepatitis B vaccine Inoculated Infants.
Hee Joo Jeon, Chan Yung Kim
Clin Exp Pediatr. 1989;32(9):1248-1258.   Published online September 30, 1989
To elucidate the characteristics of immunoregulatory system of children with chronic active hepatitis B and hepatitis B vaccine inoculated infant, the authors examined T cell subsets of the peripheral blood in 16 children with asymptomatic HBsAg carriers, 19 children with chronic hepatitis B (11 chronic persistent hepatitis (CPH) and 8 chronic active hepatitis (CAH) and 21 hepatitis B vaccine inoculated infants as well as...
The Effect of Hepatitis B Vaccination on Newborns of Hepatitis B Carrier Mothers.
Ho Taek Kom, Pyung Kil Kim, Chang Ho Hong, Chul Lee
Clin Exp Pediatr. 1987;30(11):1228-1235.   Published online November 30, 1987
The transmission of hepatitis B virus (HBV) from carrier mothers to their infants is a serious problem in many countries and the transmission rate is reported to be as high as 60%. The best preventive method of perinatal transmission is hepatitis B immune globulin (HBIG) which confers a passive immunity and HB vaccine which confers an active immunity. However, the exact dosage and the...
Immunogenecity of Low-Dose Administration of Hepatitis B Virus Vaccine in School Aged Group.
Young Mo Sohn, Pyung Kin Kim, Kyung Soon Song
Clin Exp Pediatr. 1987;30(11):1221-1227.   Published online November 30, 1987
For evaluation of immunogenecity of low-dose of hepatitis vaccine-prepared by Korea Green Cross Corporation 74 school aged children were given routine schedule (0, 1, 6 months). A dose of 5 microgram was administered intramuscullary in the cases of age under 10 yrs of age and 10 microgram was administered in the cases over 11 yrs of age. An adequate follow-up observation of antibody titer...
Chronic Hepatitis B in Children.
Don Gyu Yang, Jong Kyun Lee, Pyung Kil Kim, Chang Ho Hong, Chul Lee
Clin Exp Pediatr. 1987;30(10):1115-1123.   Published online October 31, 1987
We reviewed 19 cases of chronic hepatitis B confirmed by liver biopsy during the 3 years and 5months from March 1983 to July 1986 at Young Dong Severance Hospital. The following results were obtained: 1) There were 16 boys and 3 girls with ages ranging from 7 months to 14 years old (mean+S.D.; 6.5 ±0.9 years). 2) There were 2 cases (10.5%) of chronic persistent...
The relationship between Dose of Hepatitis B Vaccine and Seroconversion Rate in Infants.
Jung Hye Choi, Ki Sup Chung, Dong Gwan Han
Clin Exp Pediatr. 1986;29(10):1080-1086.   Published online October 31, 1986
After the discovery of Australia antigen by Blumberg et al in 1965, subsequent studies revealed that Australia antigen is identical with surface antigen of hepatitis B virus. The infants born to HBsAg positive mother can be protected from perinatal hepatitis B virus infection with hepatitis B vaccine and hepatitis B immunoglobulin. If the dose of vaccine can be reduced from...
Evaluation of Antibody Formation After Hepatitis B Vaccination in Children.
Pyung Kil Kim, Ho Taek Kim, Kyu Earn Kim, Kyung Soon Song
Clin Exp Pediatr. 1986;29(10):1072-1079.   Published online October 31, 1986
Hepatitis B virus infection is a serious problem in many countries, especially Africa, Southeast Asia and Korea. As we know, vaccination against hepatitis B virus is the most effective method to prevent hepatitis B and the rate of anti-HBs formation after hepatitis B vaccination is known to be 91 〜99%. We studied the titer of anti-HBs after 3 times of...
Epidemiologic Study on Hepatitis B Virus Infection in Childhood.
Byoung Tae Kim
Clin Exp Pediatr. 1986;29(6):613-625.   Published online June 30, 1986
We conducted HBsAg, HBsAb and HBcAb determinations by the method of radioimmunoassay on 329 healthy children who visited for the purpose of immunization with HB vaccine, or had been admitted because of miscellaneous diseases except for liver disease from July 1984 to December 1984. The following results were obtained; 1) Among the 329 children, 16(4.9%) were positive for HBsAg. There was...
Intrafamilial Spread of Hepatitis B virus Ifection.
Kew Keun Hwang
Clin Exp Pediatr. 1985;28(3):242-250.   Published online March 31, 1985
The authors evaluated serologic markers of Hepatitis B on 205 cases in families of HB marker positive 67 patients who were admitted to pediatric ward of St. Benedict Hospital from April, 1983 to April, 1984, to determine the intrafamilial spread of hepatitis B virus infection. The results were as follows; 1)Intrafamilial positive rate of HB marker was 52.7%. HB marker...
Hepatitis B Serologic Markers at Birth in Babies of HBsAg-Positive Mothers.
Jeoung Wan Seo, Hye Seung Kim, Keun Lee
Clin Exp Pediatr. 1985;28(3):236-241.   Published online March 31, 1985
It has been established that hepatitis B virus may be transmitted from mothers to infants in the perinatal period. A study was undertaken to identify HBsAg in neonates born to mothers who were asymptomatic carriers of HBsAg. From Jan. 1 ’83 to June 30 ’84, total 4,044 cases of pregnant women and 131 babies were studied for serologic markers of hepatitis...
The Frequency of HBsAg and HBsAb Positive in Hospitalized Children and Preschool Children in Kindegarten From Busan Area.
Kew Keun Hwang, Won Kyung Kim, Kyung Tae Kim, Jung Hee Lee
Clin Exp Pediatr. 1984;27(1):61-67.   Published online January 31, 1984
The authors evaluated HBsAg and Anti-HBs on 434 cases who were admitted to pediatric ward of St. Benedict Hospital and HBsAg on 656 cases of 6 kindegartens in Busan area from January to April in 1983. The results were as follows. 1)Among 434 cases of hospitalized children (male; 256, female; 178), 24(5.53%) were HBsAg positive and 13(2.98%) were HBsAb positive. 2)Among...
A Survey of HBs Antigenemia Among Healthy Primary and Middle Children, Pregnant Women in Kyungpook Province.
G H Jun, J J Kim, D H Shin, S D Yoon
Clin Exp Pediatr. 1983;26(12):1188-1195.   Published online December 31, 1983
The prevalence of hepatitis B surface antigen in various regions of the world is estimated to range from 0.1% low to 15% high. The area with high prevalence is the west pacific region. The carrier rate of hepatitis B surface antigen among 897 healthy primary and middle school children in Taegu City, Korea was investigated in November, 1982. Another sample of 729...
A Prospective Study of Intrafamilial Spread in Hepatitis B Viral Infection.
Ki Sub Chung, Jong Wie Choi
Clin Exp Pediatr. 1982;25(12):1210-1217.   Published online December 31, 1982
The pediatric liver disease involves primarily viral infection of type A or type B. Presently the hepatitis incidences are on the rising trend in Korea, especially the type B viral hepatitis. It is estimated that approximately 4〜5% of the school children are HBsAg chronic carriers which are posing threat to citizens health status. We examined 264 patients admitted to Severance hospital at Yonsei medical...
Case Report
A Case of Vertically Transmitted Neonatal Hepatitis B with Pancytopenia.
Young Chang Kim, Jae Oak Park
Clin Exp Pediatr. 1982;25(7):737-742.   Published online July 31, 1982
A newborn infant, who was low-birth weight(1,780gm), showed severe degree of jaundice on second day of life and skin color became dark greenish-yellow and moderate hepatosplenomegaly was noted on physical examination. Results of liver function test & radioimmuniassay for hepatitis B antigen of both infant and mother suggested that neonatal hepatitis B seemed to occure transplacentally during pregnancy from infected...