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Original Article
Factors which contribute to time of first stool and first urine passage in Newborns
Hye Jin Lee, Hyun Gon Jae, Sang Hee Son
Clin Exp Pediatr. 2006;49(5):482-488.   Published online May 15, 2006
Purpose : To evaluate the factors which contribute to the time of the first stool and the first urine passage. Methods : We retrospectively reviewed a chart of 1,221 infants ≥34 weeks of gestational age admitted to the normal newborn nursery of Il Sin Christian Hospital, Busan, from November 2004 to April 2005. We compared the time to first stool and...
Fas/FasL expression in the hippocampus of neonatal rat brains follwing hypoxic-ischemic injury
Young Pyo Chang, Myeung Ju Kim, Young Il Lee, Ik Je Im, Jae Ju Cho, Jong-Wan Kim, Sung Moon Yeo
Clin Exp Pediatr. 2006;49(2):198-202.   Published online February 15, 2006
Purpose : Fas is a cell surface receptor that transduces apoptotic death signals. Interaction of extracelluar domain of Fas with Fas ligand(FasL) triggers the apoptotic process in many diseases. We investigated the expression of Fas and FasL in the hippocampus of 7-day-old newborn rat brains following hypoxia-ischemia injury. Methods : The 7-days-old newborn rats were exposed to 8 percent oxygen...
Fine needle aspiration cytology of enlarged lymph nodes in children and adolescents
Seung Min Lee, Yoon Jung Oh, Yong Hoon Jun, Young Jin Hong, Byong Kwan Son, Soon Ki Kim, Jee Young Han, Young Chae Chu
Clin Exp Pediatr. 2006;49(2):167-172.   Published online February 15, 2006
Purpose : Palpable lymph nodes are common in the pediatric population, and most of them are either inflammatory or congenital. As the diagnostic evaluation, fine needle aspiration cytology (FNAC) is known to be more convenient and economical than tissue biopsy. We evaluated the usefulness of FNAC in children and adolescents. Methods : Four hundred and thirteen FNAC samples(M : F=1...
N-terminal Pro-B-type Natriuretic Peptide as a Predictive Risk Factor in Fontan Operation
Gi Young Jang, Jae Young Lee, Soo Jin Kim, Woo Sup Shim
Clin Exp Pediatr. 2005;48(12):1362-1369.   Published online December 15, 2005
Purpose : This study aimed to investigate the correlation between the plasma level of N-terminal pro-B-type natriuretic peptide(pro-BNP) and several known risk factors influencing outcomes after Fontan operations, and to assess whether pro-BNP levels can be used as predictive risk factors in Fontan operations. Methods : Plasma pro-BNP concentrations were measured in 35 patients with complex cardiac anomalies before catheterization....
Outcomes and Management of Fetal Infants with Birth Weight Below 500 g at a Tertiary Center
Yun Sil Chang, Yu Jin Kim, Soo Hyun Koo, Jang Hoon Lee, Jong Hee Hwang, Chang Won Choi, Jae Won Shim, Sung Shin Kim, Sun Young Ko, Eun Kyung Lee, Won Soon Park
Clin Exp Pediatr. 2005;48(9):939-945.   Published online September 15, 2005
Purpose : The purpose of this study was to report outcome of fetal infants with birth weight below 500 g known as lower limit of viability and to evaluate treatment characteristics and short-term morbidity of their survivors. Methods : We retrospectively analyzed the medical records of all fetal infants with birth weight below 500 g who were delivered at Samsung Medical...
A Study for Accuracy and Usefulness of Tympanic Membrane and Forehead Thermometers
Ki Wook Yun, In Seok Lim
Clin Exp Pediatr. 2005;48(8):820-825.   Published online August 15, 2005
Purpose : The presence and degree of fever in children is a useful indicator of illness. This project aimed to assess the accuracy and usefulness of infrared tympanic membrane(TM) & forehead feverscan thermometers for measuring children's temperatures. Methods : Data were obtained from 1,050 children with a median age of 4.5 years. They visited the pediatric clinics at Chung-Ang University Yongsan...
Clinical Utilities of Serum Ferritin as a Marker of Disease Activity and Prognostic Factor in Childhood Tumors
Eun Seok Roh, Jung Hyun Lee, Yu Ra Hong, Jae Sun Park, Jong Shin Kim
Clin Exp Pediatr. 2004;47(12):1319-1324.   Published online December 15, 2004
Purpose : In order to assess the usefulness of serum ferritin as a marker of disease activity and prognostic factor in pediatric malignancy, serum ferritin levels were measured. Methods : Peripheral blood samplings for ferritin level were made at presentation, in remission following therapy, and in relapse in 95 children with malignancy admitted to the Department of Pediatrics, Kosin University Gospel...
Case Report
A Case of Fetal Alcohol Syndrome with Persistent Pulmonary Hypertension of the Newborn
Jin-Ha Chang, Ran Namgung, Min-Soo Park, Kook In Park, Jin-Sung Lee, Chul Lee
Clin Exp Pediatr. 2004;47(11):1220-1224.   Published online November 15, 2004
Fetal alcohol syndrome can be suspected in infants born to mothers with a prenatal history of alcohol abuse if the child exhibits characteristic facial features, together with intrauterine growth retardation, multiple neurological abnormalities, and multiorgan defects. If only a few of the above criteria are satisfied, the term fetal alcohol effects is used. We experienced a neonate who presented with...
Original Article
The Levels of Zinc and Neuron-specific Enolase in Febrile Convulsion
Hong Sang Cho, Jun Hun Shin, Ji Yeoung Seo, Cho Ae Lee, Se Hyun Kim, Kyu Young Chae
Clin Exp Pediatr. 2004;47(10):1087-1092.   Published online October 15, 2004
Purpose : To determine the role of zinc in febrile convulsion and to evaluate whether febrile convulsion causes neuronal damage, serum and cerebrospinal fluid(CSF), zinc and CSF neuron-specific enolase(NSE) levels were measured in patients with febrile convulsion, epilepsy and aseptic meningitis. Methods : Three groups were formed as follows : group I : 53 children with febrile convulsion; group II :...
CSF Examination in the First Febrile Seizure
Joseph Jo, Sun Hee Yu, Young Taek Jang
Clin Exp Pediatr. 2004;47(7):762-767.   Published online July 15, 2004
Purpose : This study was launched to classify subjects of the CSF examination and improve early diagnosis of meningitis and its treatment in children who have had a first febrile seizure. Methods : From March 1995 to September 2003, children aged 3 months to 5 years who had had treatment for febrile seizure were analyzed as to their age at first...
Evaluation of Intrauterine Growth in Neonates with Congenital Heart Disease
Ji Hyun Yeo, Hee Jung Lee, Eun Sil Lee, Young Hwan Lee
Clin Exp Pediatr. 2004;47(7):746-750.   Published online July 15, 2004
Purpose : Intrauterine growth retardatation(IUGR) is very important because of high mortality and morbidity in the neonatal period. We studied the intrauterine growth retardation pattern in neonates with congenital heart disease(CHD). Methods : One hundred seventeen cases with CHD(acyanotic, 73 cases; cyanotic, 44 cases) who had no other congenital malformation or maternal diseases that might affect fetal growth were enrolled in...
Effect of a Flavon Extracted from Artemisia absinthium on Collagen Induced Arthritis in Mice
Kyong Min Choi, Dae Hwan Hwang, Kyung Mi Shin, Do-Young Yoon, Dong Soo Kim
Clin Exp Pediatr. 2004;47(6):677-684.   Published online June 15, 2004
Purpose : In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated. Methods : DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies...
Clinical Outcomes of Infants with Failure to Gain Weight among Out-patients
Byoung Cheol Lee, Hae Rim Kim, Chan Lack Sohn, Sin Kam, Jin-Bok Hwang
Clin Exp Pediatr. 2004;47(6):604-610.   Published online June 15, 2004
Purpose : The three categories of failure to thrive are based on anthropometric measurements of weight, length, and head circumference for age. Type 1 is a failure to gain weight(FGW) due mainly to malnutrition. This study was performed to observe the clinical outcomes of infants with FGW, Type 1, among out-patients. Methods : Between October 2002 and July 2003, data from...
Erratum
A Clinical Approach to Failure to Gain Weight in Infants
Jin-Bok Hwang
Clin Exp Pediatr. 2004;47(4):355-361.   Published online April 15, 2004
Failure to thrive is a term used to describe growth failure in infants and young children that may be accompanied by retarded social and motor achievements. The three categories of failure to thrive is based on anthropometric measurements of weight, length, and head circumference for age. Type 1 category, inadequate growth or loss of body weight with relatively normal height...
Clinical Lecture
Food Allergy
Soo-Young Lee
Clin Exp Pediatr. 2004;47(3):240-246.   Published online March 15, 2004
Food allergy is one of the clinical clusters due to food-induced allergic inflammation against dietary proteins which induced by IgE-mediated and/or non-IgE mediated mechanisms. Food allergic reactions are responsible for a variety of clinical symptoms involving the skin, gastrointestinal tract, and respiratory tract. Sometimes the life threatening anaphylactic reactions would be induced, especially by peanuts, tree nuts and buckwheat allergy....
Case Report
Familial Adenomatous Polyposis Improved by COX-2 Inhibitor in a Child
Ki Won Oh, Se Young Kim, Hwan Suk Lee, Myung Hoon Lee, Byung Ho Choe
Clin Exp Pediatr. 2002;45(12):1591-1595.   Published online December 15, 2002
Familial adenomatous polyposis(FAP) is an autosomal dominant disease characterized by numerous adenomas in the colorectum. Patients with FAP are always at risk of malignant transformation, so that colectomy is unavoidable. NSAID, such as sulindac, and selective COX-2 inhibitor, such as celecoxib, have shown a positive effect on FAP by causing polyp regression in some patients. We report a case of...
A Case of Fetal Valproate Syndrome Associated with Both Elbow Joint Contractures
Yun Chang Choi, Eun Young Kim, Kynug Rye Moon, Young Il Rho
Clin Exp Pediatr. 2002;45(10):1288-1292.   Published online October 15, 2002
Fetal valproate syndrome has been described as a distinctive pattern of minor anomalies of the face and digits. This pattern has not been delineated completely but appears to involve brachycephaly with a high forehead, shallow orbit, ocular hypertelorism, small nose, small mouth, low set posteriorly rotated ears, long overlapping fingers and toes, and hyperconvex fingernail. Cleft palate and congenital heart disease have occasionally been...
Original Article
Post-natal Outcome of Fetal Hydronephrosis Detected with Prenatal Ultrasonography
Youn Jin Park, Soon Jung Mun, Chong Woo Bae, Bum Ha Lee, Jin Il Kim
Clin Exp Pediatr. 2002;45(10):1213-1218.   Published online October 15, 2002
Purpose : Hydronephrosis constitutes a great portion of fetal anomalies screened by prenatal sonogram. The present authors made an attempt to access its natural courses through follow up neonatal hydronephrosis diagnosed by prenatal sonogram. Methods : The study was composed of 23 neonates(36 renal units) who were diagnosed with hydronephrosis through prenatal sonogram screening and confirmed 3-7 days after birth with sonographic evaluation at Kyung...
Changes of Serum Fatty Acid and Carnitine Levels after Administration of L-carnitine in Rats
Jae Won Lee, Young Mi Hong
Clin Exp Pediatr. 2002;45(9):1075-1082.   Published online September 15, 2002
Purpose : Obesity is known to be associated with hypertension, dyslipidemia, and fatty liver and is thought to be associated with increased levels of free fatty acids. One of the strategies for decreasing free fatty acid levels is stimulation of hepatic lipid oxidation with L-carnitine. Carnitine is an essential cofactor for transport of long-chain fatty acid into mitochondria for oxidation....
Usefulness of Low Risk Criteria for Serious Bacterial Infection Among Febrile Infants Younger than Three Months of Age
So Hyun Kim, Ji Ah Jung, Hae-Soon Kim, Eun Sun Yoo, Sejung Sohn, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 2002;45(8):967-972.   Published online August 15, 2002
Purpose : A retrospective study was undertaken to evaluate the usefulness of low risk criteria for identifying febrile infants younger than three months unlikely to have serious bacterial infection. Methods : We conducted a retrospective study of 527 infants younger than three month with a axillary temperature ≥37.4℃. If they met the following all four criteria, appear well, WBC 5,000- 20,000/mm3,...
A Study of Receptor Expression in Leukocytes by Quantitative Fluorescence Measurement
Kyung Hyo Kim, Ju Young Seoh
Clin Exp Pediatr. 2002;45(5):637-645.   Published online May 15, 2002
Purpose : It is well known that the receptors for Fcγ moiety of IgG(FcγR) are instrumental in antibody-mediated clearance of microorganisms by granulocytes and monocytes, and immune regulation in lymphocytes. Furthermore, complement receptor-3(CR3) is also important in neutrophilic adhesion, diapedesis, and phagocytic functions. In an attempt to examine their roles in neonates, we compared the expressions of FcγRs and CR3...
A Review of Endoscopic Removal Methods in 127 Cases of the Esophageal Foreign Bodies
Jum Su Kim, Jung Soo Yang, Hae Sung Jung, Min Hye Lee, Chan-Hoo Park, Myoung Bum Choi, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2002;45(4):459-465.   Published online April 15, 2002
Purpose : The aim of this study was to evaluate the latest tendency of esophageal foreign body's extraction and to obtain a consensus from recent trends of indications and techniques of flexible endoscopy of esophageal FB in children. Methods : We retrospectively reviewed medical records of 127 cases with foreign bodies in esophagus at Dept. of Pediatrics and Otorhinolaryngology, Gyeongsang National...
Case Report
A False Diagnosis of Hypoplastic Left Heart Syndrome in a Fetus
Youn Jeong Shin, Sung Hee Jang, Jung Yun Choi, Eun Sook Han
Clin Exp Pediatr. 2002;45(2):267-272.   Published online February 15, 2002
Typical hypoplastic left heart syndrome(HLHS) is a distinct pathologic entity with aortic atresia, mitral atresia, very hypoplastic or absent left ventricle and thread like ascending aorta. Occasionally, the lesser degree of hypoplasia is found and is called hypoplastic left heart complex(HLHC) by some authors. This HLHC is often associated with critical aortic stenosis. Fetal echocardiography has enabled us to observe...
Original Article
The Amino Acid Compositions of Formula for Children with Inherited Metabolic Disorder
Kyung Hwa Ryu, Jong Soo Kim, Eun Ha Lee, Il Sun Kwon, Si Houn Hahn
Clin Exp Pediatr. 2002;45(1):37-43.   Published online January 15, 2002
Purpose : This study aimed to determine the amino acids composition, safety and efficacy of formulas recently developed by Korean dairy companies for children with inherited metabolic disorder. Methods : The determination of amino acids concentration was performed on eight Korean formula samples. The samples were hydrolyzed with 6N HCL or performic acid and analyzed by amino acid analyzer. Results : No phenylalanine, methionine or...
Case Report
Fanconi-Bickel Syndrome Presented with Diabetes Mellitus and Galactosemia : Identification of a Novel Mutation in the GLUT2 Gene
You-Jeong Kim, Sun-Hee Rim, Young-Lim Shin, Han-Wook Yoo
Clin Exp Pediatr. 2001;44(10):1201-1205.   Published online October 15, 2001
Fanconi-Bickel syndrome is a rare autosomal recessive disorder of the carbohydrate metabolism recently demonstrated to be caused by mutations in GLUT2, the gene for the glucose transporter protein 2 expressed in the liver, pancreatic β islet-cells, intestine and kidney. Typical clinical and laboratory findings of Fanconi-Bickel syndrome are hepatomegaly secondary to glycogen accumulation, glucose and galactose intolerance, fasting hypoglycemia, a...
Original Article
Clinical Efficacy of Selective Fetal Echocardiography
Su Young Hong, Ji Eun Ban, Young Seok Lee, Hyoung Doo Lee
Clin Exp Pediatr. 2001;44(10):1127-1134.   Published online October 15, 2001
Purpose : The aims of this study was to assess the indication, diagnostic, accuracy and prognostic influence of fetal echocardiography. Methods : From 1995 to 1999, 283 pregnancies were evaluated with fetal echocardiography at Dong-A University Hospital. We reviewed medical records included indication, fetal echocardiographic findings, postnatal echocardiographic findings, methods of treatment and outcome of prenataly diagnosed patients. Results : Family...
Clinical Features of Food Protein-Induced Enterocolitis Syndrome
Jeong Sik Seo, Hai Lee Chung
Clin Exp Pediatr. 2001;44(7):758-763.   Published online July 15, 2001
Purpose : Food protein-induced enterocolitis syndrome(FPIES) is a symptom complex of severe vomiting and diarrhea which is known as a food-related gastrointestinal hypersensitivity disorder without evidence of IgE-mediated sensitivity. We described the clinical characteristics of FPIES in young infants. Methods : Twenty-eight patients, aged 7 to 120 days, were included who were diagnosed as FPIES by clinical criteria and food challenges....
The Optimum Dose of Oral Diazepam to Reduce Seizure Attack in Febrile Seizure Patients During Febrile Illness
Im Jeong Choi, Je Eun Choi, Jung A Lee, Pil Ju Jeong, Sung Mi Kim, Jin Hwa Jeong, Jeong Ho Lee
Clin Exp Pediatr. 2001;44(6):677-682.   Published online June 15, 2001
Purpose : Febrile seizure is the most common type of seizure affecting 3-4% of children. The recurrence rate of febrile seizure is approximately 33%. About 16% of children with a febrile seizure during the febrile illness have a recurrent seizure attack within 24 hours. This study aimed to investigate the optimum dose of diazepam to reduce the recurrence of febrile...
Surgically Treated Intractable Child Epilepsy with Focal Cortical Dysplasia : Clinical and Electroencephalographic Findings
So Hee Chung, Ho Young Lee, Mun Hyang Lee, Hye Kyung Yoon, Bo Kyung Kim, Seung Chyul Hong
Clin Exp Pediatr. 2001;44(5):552-561.   Published online May 15, 2001
Purpose : Widespread use of MRI now gives us increased insights into the different expressions of cortical malformations. We carried out this study to characterize the clinical and EEG features of focal cortical dysplasia(FCD) which also caused intractable epilepsy requiring surgical treatment. Methods : A retrospective analysis was conducted in 8 children. The history of seizures, imaging studies, electroencephalographic findings,...
Studies on Functional Differentiation of Small Intestinal Epithelial Cells
Ho Keun Yi, Su Mi Oh, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2001;44(5):523-532.   Published online May 15, 2001
Purpose : We investigated compounds from food sources given to children that may induce the differentiation of small intestinal epithelial cells in order to signal pathways that induce the proliferation and differentiation of small intestinal epithelial cells. Methods : We analyzed small intestinal epithelial cell differentiation using in vitro IEC-6 cells model. The growth curve of IEC-6 cells was obtained...
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