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Original Article
Serum EosinophilCationic Protein Levelsin Patients with Recurrent Croup
Moon Kil Bahng, Do Yoon Lee, Mee Kyung Namgoong, Jong Soo Kim
Clin Exp Pediatr. 1997;40(2):194-198.   Published online February 15, 1997
Purpose : Most patients suffer from croup only once in a life time. However, a small group of patients suffer from it several times. A type of croup from which they suffer more than 3 times is called recurrent croup. The cause of recurrent croup has not been clearly described, but in recent years the allergic reaction is considered as a...
The Characteristics of Insulin-like Growth Factor Binding Protein-3(IGFBP-3) in Serum; The Diagnostic Utility of IGFBP-3 in Growth Hormone Deficiency
Ki-Joong Kim, Jeh-Hoon Shin, Young-Ik Lee
Clin Exp Pediatr. 1996;39(11):1594-1599.   Published online November 15, 1996
Purpose : For diagnosis of growth hormone(GH) deficiency in short stature, peak growth hormone levels after pharmacologic stimulation are usually used. In this study, we measured serum IGFBP-3, which is a major binding protein in serum and is considered to be GH-IGF-I axis dependent, levels by radioimmuno assay(RIA) in sera from normal short stature(NSS) children, and patients with GH deficiency children to clarify the...
Diagnosis and Treatment of Fetal Cardiac Anomalies
Nam Su Kim, Myung Kul Yum, Hahng Lee, Sung Ro Jung, Jung Bae Yoo, Jae Ek Lee
Clin Exp Pediatr. 1996;39(10):1395-1404.   Published online October 15, 1996
Purpose : Fetal echocardiography is used for the prenatal diagnosis of congenital heart disease. Fetal echocardiography allows decisions to be made in advance where the fetal abnormality is not compatible with life after delivery or where early correction is required. Our fetal echocardiographic experience was analysed retrospectively to guide future clinical application. Methods : 138 mothers had fetal echocardiography from April 1992 to December...
Surfactant Protein SP-A, B, and C: Purification and Biochemical Characterization
Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Kil Lyong Kim, Kyung Soo Hahn
Clin Exp Pediatr. 1996;39(2):218-229.   Published online February 15, 1996
Purpose : Several kinds of exogenous pulmonary surfactants (SF), either synthetic or animalderived, are being used for the replacement therapy in respiratory distress syndrome (RDS) of newborn, especially in premature infants, and improved the neonatal mortality and morbidity. Because synthetic preparations are lack of surfactant protein (SP) and animal-derived preparations cause immunogenecity of heterogenous SP, there have been great necessity for the development of next...
Case Report
A Case of the Renal Artery Aneurysm Associated with the Dysplastic Kidney
Tae Hee Park, Soo Hee Chang, Young Min Han, Soo Chul Cho, Dae Yeol Lee
Clin Exp Pediatr. 1995;38(11):1571-1576.   Published online November 15, 1995
Multicystic dysplastic kidney is the most frequent cause of abdominal mass in the neonate. It is frequently associated with contralateral genitourinary tract abnormalities and the most common abnormality is vesicoureteral reflux. Renal artery aneurysm is very rare in the children. Furthermore the case associated with the renal artery aneurysm has not been reported yet. We experienced a case of the left...
Original Article
A Follow-Up Study of Intractable Diarrhea in Early Infancy: Clinical Features of Cow's Milk Allergy and Cow Milk-Sensitive Enteropathy
Young Rak Kwon, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Chung, Young Dae Kwon
Clin Exp Pediatr. 1995;38(11):1515-1524.   Published online November 15, 1995
Purpose : The multiplicity of poorly defined illnesses and the variability of clinical and laboratory features elicited by milk ingestion in sensitized infants has made it difficult to differentiate them from the more common forms of cow milk intolerance. Following up the cases of intractable diarrhea in early infancy(illI), We investigated the clinical features of cow's milk allergy(CMA) and cow...
Serum 2-microglobulin and Retinol Binding Protein and Urine 2-microglobulin and 1-microglobulin in Early Neonatal Period
Jong Duck Kim, Jae Kak Choi, Yong Hwoe Moon
Clin Exp Pediatr. 1995;38(9):1176-1184.   Published online September 15, 1995
Purpose : For evaluation of usefulness of the serum .2-microglobulin(B2MG), retinol binding protein(RBP), urine 1-microglobulin(A1MG), and B2MG on neonatal renal function and renal tubular injuries, we detected and compared these values in 20 neonates. Methods : They were grouped into premature neonate, gestational age was 30-50 weeks(group Ⅰ), and full term neonate, gestational age was 38-40 weeks(group Ⅱ), The group Ⅱ...
Intractable Diarrhea in Early Infancy : Clinical Features on Admission and A Nutritional Management
Jong Won Shin, Kyung Won Hwang, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Chung, Young Dae Kwon
Clin Exp Pediatr. 1995;38(7):936-945.   Published online July 15, 1995
Purpose : We studied to assess the value of clinical findings on admission in screening of intractable diarrhea in early infancy(IDI) and the efficiency of early trial of semi-elemental form-ula (protein hydrolysate) as a nutritional management in IDI. Methods : We carried out a retrospective review of medical records of twenty-eight early infants with diarrhea and malnutrition who were diagnosed as...
Plasma Lipid Alteration in Leukemia and Solid Tumor
Eun Sik Kang, Myoung Soon Song, Hea Jin Cheoh, Kyu Chul Choeh
Clin Exp Pediatr. 1995;38(4):529-536.   Published online April 15, 1995
Purpose : A sensitive, specific blood test to detect cancer would be of great value but the search for such a test has been fruitless so far. In actual practice, there is often a considerable interval between the point at which a tumor could have been detected and the point at which it produces symptoms as a result of tumor...
Case Report
A Case of Type V Hyperlipoproteinemia
Yo Ahn Rho, Jong Kwang Lee, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(12):1752-1756.   Published online December 15, 1994
The hyperlipoproteinemias are the disturbance of lipid transport resulted from accelerated synthesis or retarded degradation of lipoproteins that transport cholesterol and trigycerides through plasma. These diseases are classified as type I, type IIa, type IIb, type III, type IV, type V, and hyper-α-triglyceride levels due to increases in both VLDL and chylomicrons and lipoprotein electrophoresis shows increases pre-β, β, and...
Original Article
Characteristics of Insulin-Like Growth Factor I in Serum; Pattern of Insulin-Like Growth Factor Binding Protein (Large Complex) in Short Stature Patients with Complete Growth Hormone Deficiency
Jin Nyoung Park, Byung Deok Seo, Jeh Hoon Shin, Soo Ji Moon, Sung Yeoul Chang
Clin Exp Pediatr. 1994;37(11):1548-1559.   Published online November 15, 1994
To elucidate the complex of insulin-like growth factor binding proteins (IGF-BPs) in short stature patients, we carried out a prospective study on three patients who were diagnosed as complete GH deficiency at the department of pediatrics form July 1992 to June 1993. The results were summarized as follows: 1) Two circulating IGFs complexed to specific binding protein existed in normal serum. Binding...
The Growth Hormone-Binding Proteins in Human Serum: Partial characterization and Regulation
Ji Young Suh, Bu Hun Lee, Jeh Hoon Shin, Hang Lee, Seong Ryul Jang
Clin Exp Pediatr. 1994;37(10):1427-1436.   Published online October 15, 1994
We assessed abotu growth homone binding proteins(GHP|BP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus(IDDM), short stature due to growth hormone deficiency(GHD), chronic renal failure, short stature due to nutritional deficiency. Hypothyroidism, and noraml control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1)...
A Study on Evolution of Lipoportein(a) in Newborns
Keun Haeng Cho, Young Sook Hong, Soo Won Lee, Soon Kyum Kim, Young Chang Tockgo, Han Kyeom Kim
Clin Exp Pediatr. 1994;37(8):1078-1091.   Published online August 15, 1994
Lipoprotein(a) [Lp(a)] is considered an additional, independent and largely genetically determined risk factor for the development of premature coronary heart disease. Furthermore abnormal plasma lipoprotein patterns have been associated with increased risk for developing coronary heart disease. Among these lipoproteins, an increased concentration of serum Apo B and decreased level of Apo A are considered as major risk factors, together...
Eosinophil Cationic Protein in Relation to Bronchial Hyperresponsiveness in Asthmatic Children
Jin Tack Kim, Joon Sung Lee
Clin Exp Pediatr. 1993;36(12):1707-1715.   Published online December 15, 1993
The eosinophil is the major cell responsible for the inflammatory reaction in bronchial asthma. Secretion of granular components is probably of considerable importance for the inflammatory effects of the eosinophils, Eosinophil cationic protein (ECP) is the one of the secretory components of the eosinophil granule and is considered as an activation marker of eosinophil, Blood eosinophil count, serum concentration of...
Cow Milk Allergy in Infant Who Neonatal Onset
Seung Hee Park, Myung Ik Lee, Don Hee Ahn, Seung Hee Park
Clin Exp Pediatr. 1993;36(10):1383-1388.   Published online October 15, 1993
Cow milk allergy can be defined as an adverse immunologic reactions to cow milk protein. The term is often mistakenly applied to other causes of milk intolerence, such as lactase deficiency and galactosemia, which must be differenciated and excluded. We have experienced 10 children of cow milk allergy at neonatal onset who had suffered from G-I symtons, such as diarrhea, irritability,...
Effect of Different Levels of the Dietary Protein on Long Term Prognosis of Experimental Renal Damage
Choon Haeng Lee, Sang Joo Han, Hong Jin Lee, Won Il Park, Kyung Ja Lee, Young Eui Park, Min Chul Lee, Tae Heon Yoon
Clin Exp Pediatr. 1993;36(6):820-829.   Published online June 15, 1993
We examined the effect of various levels of dietary protein on long term prognosis of Adriamycinephropathy of S-D rat, fed with high protein(30%), intermediately low(10%), and strictly low(5%) protein diet for 15 weeks 1) In rats fed with strictly low protein diets(5%), proteinuria and serum creatinine decreased and creatinine clearance and histological changes were relatively well preserved. But hypoproteinmia and weight...
Serum Eosinophil Cationic Protien(ECP) in Children with Atopic Astham
Dae Cheol Kim, Ha Baik Lee
Clin Exp Pediatr. 1993;36(6):810-819.   Published online June 15, 1993
Eosinophils play a major role in the airway inflammation in asthma. To werify an association between airway responsiveness of asthmatics and eosinophil and/or ECP, we measured serum ECP in 23 children with atopic asthma during acute attacks and stable, and in 10 normal healthy controls. Peak flows were monitored in 15 children. The data suggest that serum ECP levels were higher...
The Usefulness of Measuring Serum α-fetoprotein and Thyroxine-binding Globulin to Differentiate between Neonatal Hepatitis and Congenital Extrahepatic Biliary Atresia
Soo Kyoung Lee, Ki Sup Chung
Clin Exp Pediatr. 1993;36(4):512-520.   Published online April 15, 1993
Together, neonatal hepatitis and biliary atresia make up approximately 70 to 80% of the causes of neonatal cholestasis. Biliary atresia must be differentiated from neonatal hepatitis as soon as possible in order to institute early surgical intervention. We performed this study to examine whether the measurement of the serum α-fetoprotein(AFP) and thyroxine-binding globulin(TBG) was useful for differentiating these two conditions....
Case Report
Characterization of the Novel Late T Cell Activation Proteins, 519 and 520
Dae-Yeol Lee, Alan M Krensky
Clin Exp Pediatr. 1993;36(3):409-416.   Published online March 15, 1993
The late T cell activation gene, 519, is expressed in antigen specific, growth factor dependent T cell lines and clones but not in T or B cell tumors, other hematopoietic cells, tonsil, muscle, lung, or liver. Resting peripheral blood ymphocytes(PBLs)express little or no 519mRNA, but levels increase dramatically 5~7 days after activation with alloantigen or mitoen. Four alternatively spliced transcripts...
A Case of Intestinal Lymphangiectasia
Yae Kyung Suh, Kyung Hee Park, Chul Ho Jang, Bum Soo Park, Jeong Kee Seo, Sung Hae Park, Je Geun Chi, Kyung Mo Yeon, Kwi Won Park
Clin Exp Pediatr. 1992;35(12):1737-1743.   Published online December 15, 1992
Intestinal lymphangiectasia is a primary or secondary disorder of the gastrointestinal tract, which is associated with lymphatic dysfuction and protein-losing enteropathy. It's clinical manifestations vary widely, but the main symptoms are abdominal distention, edema, abdominal pain and growth failure. We described a 15-yr-old boy, who suffered from above symptoms since third year of his age and diagnosed by duodenal endoscopy which...
Primay Endodermal Sinus Tumor of the Common Bile Duct
Kyeong Hee Cho, Se Jung Sohn, Kil Hyun Kim, Hak Soo Lee
Clin Exp Pediatr. 1992;35(9):1298-1302.   Published online September 15, 1992
The endodermal sinus tumors are rare and highly malignant germ cell origin tumors occuring in both gonadal and extragonadal tissue. We have experienced a case of endodermal sinus tumor mixed with benign teratoma occuring in the common bile duct. It is a very rare site for endodermal sinus tumor. Serum α-fetoprotein was well correlated with clinical course.
Neonatal Purpura Fulminans due to Homozygous Protein C Deficiency
Jae-Hong Park, Sung-Sub Sim, Soo-Young Kim, Hee-Joo Jeon, Chan-Yung Kim, Hong Keun Oh, Jin-Yeong Jeong
Clin Exp Pediatr. 1992;35(5):696-703.   Published online May 15, 1992
Homozygous protein C deficiency is a rare herediatary disorder of blood coagulation resulting in microvascular and venous thromboses, usually purpura fulminans, starting shortly after birth. Protein C serves to inactivate the active forms of factor V and VIII, and increase the rate of fibrin degradation. For confirmation of homozygous protein C deficiency, the infant should have undetectable protein...
Original Article
A study on the immune reaction to the milk protein antigens in the postpartum mother, newborn baby, and children.
Soo chul Cho, Ju Hyung Kim, Hong Ro Lee, Jong San Lee, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1991;34(11):1547-1558.   Published online November 30, 1991
There is continuing interest in the isotype response of human serum antibodies reactive with dietary proteins. This study was performed to clarify the humoral immune responses against cow’s milk proteins, 分-lactoglobulin and a-lactalbumin. Milk protein specific IgG, IgA, IgM, and IgG subclasses were measured using ELISA in the blood of various groups of age. The results were as follows: 1) Milk protein specific immunoglobulins were higher...
Prevalence of asymptomatic hematuria, proteinemia and glucosuria in primary school children in Chonju area.
Jin Oh Kim, Joseph Choi, Soo Cheol Cho, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1991;34(2):223-229.   Published online February 28, 1991
The present study was performed to define the prevalene of asymptomatic hematuria, proteinuria,and glucosuria. A total of 5011 primary school children in Chonju city were examined with test strip urinalysis during the period of one month from June to July 1989. Test strip (Hema-Combistix) was used in this examination. The results were as. follows: 1) Prevalence of hematuria, proteinuria and glucosuria were 0.8% (40 children), 0.78%...
IgA Nephropathy in Childhood.
Yong Choi, Dong Woo Son, Ja Wook Koo, Dong Kyu Jin, Hae Il Cheong, Kwang Wook Ko, Hyun Soon Lee, Yong Il Kim
Clin Exp Pediatr. 1990;33(9):1237-1243.   Published online September 30, 1990
In this study we compared between the patients with recurrent gross hematuria (group 1, n=45) and * with nephrotic range proteinuria (group 2, n=21) in IgA nephropathy who were admitted to Seoul National University Children’s Hospital during the period from January, 1980 to December, 1989. The results of the study were as follows. 1) Age of onset and sex ratio were not different between the...
A Study of C-Reactive Protein in Acute Infectious Diseases in Children.
H K Choi, Y H Chung
Clin Exp Pediatr. 1990;33(6):762-771.   Published online June 30, 1990
The C-reactive protein is an abnormal protein, which is reacted to various non-specific stmuli such as infection, tissue necrosis, trauma, neoplasm and granuloma formation. Hence, C-reactive protein was index of infection and its allied diseases. Serum C-reactive protein determination on total 207 patients with infectious disease and allied conditions were done in the pediatric ward of Chungnnam National Hospital during the period from Jan, 1988...
The clinical evaluation for children with orthostatic proteinuria.
Chan Sung Lee, Chong Guk Lee, Sang Woo Kim
Clin Exp Pediatr. 1989;32(11):1520-1525.   Published online November 30, 1989
Total of eighteen children with orthostatic proteinuria were evaluated for clinical characteristics. The development of renal or urologic diseases were monitored on these subjects for 1 year. The results were as following; 1) The number of children with transient orthostatic proteinuria and fixed orthostatic proteinuria were 7(39%) and 11(61%), respectively. 2) In children with fixed and reproducible orthostatic proteinuria, mild proteinuria were noted in 73% but no massive...
Analysis of Asymptomatic Proteinuria in School Children.
Chong Guk Lee, Tae Sub Shim, Dong Hwan Lee, Yong Soo Yun, Chang Jun Ko, Sa Jun Chung, Hyun Soon Lee, Sung Jae Suh, Pyung Nam Kim
Clin Exp Pediatr. 1989;32(9):1187-1194.   Published online September 30, 1989
Uriary mass screening program for the detection of proteinuria had been performed for a school- age population in the city of Seoul since 1981. Annually, about half million students, who comprised 3 different age group, corresponding to the averages of 11，14, and 17 years, had been examined. A systematic clinical evaluation was designed for students with proteinuria identified in the mass screening through ’87...
Serum C-Reactive Protein in Differential Diagnosis of Meningitis in Children.
Hae Lim Chung, Hoan Jong Lee, Yong Seung Hwang
Clin Exp Pediatr. 1988;31(12):1588-1593.   Published online December 31, 1988
CSF findings such as cell count, differential count, protein, glucose and serum CRP determined by capillary precipitin method evaluated in 90 patients of meningitis admitted to the pediatric ward of Seoul National University Children’s Hospital, in terms of differential diagnosis of meningitis. The results are as follows; 1) There was considerable overlap of CSF findings and hematQlogic values between bacterial, aseptic and tuberculous meningitis groups. 2) All 9...
Lipoproteinelectropheresis pattern in Nephrotic Syndrome.
Soon Don Hong, Byung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1988;31(9):1163-1170.   Published online September 30, 1988
This study was undertaken to eluidate lipoprotein patterns in patients with childhood nephrotic syndrome by response to initial steroid therapy, serum albumin level in MCNS and other histologic classifications. The result were summerized as follows. 1) There were 19 cases (52.8%) of abnormal lipoprotein patterns by Fredrickson classifications, type Ila were 6 cases (16.7%), type lib were 1 cases (2.8%) and type IV were 12 cases...
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