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Original Article
The Growth Hormone-Binding Proteins in Human Serum: Partial characterization and Regulation
Ji Young Suh, Bu Hun Lee, Jeh Hoon Shin, Hang Lee, Seong Ryul Jang
Clin Exp Pediatr. 1994;37(10):1427-1436.   Published online October 15, 1994
We assessed abotu growth homone binding proteins(GHP|BP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus(IDDM), short stature due to growth hormone deficiency(GHD), chronic renal failure, short stature due to nutritional deficiency. Hypothyroidism, and noraml control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1)...
A Study on Evolution of Lipoportein(a) in Newborns
Keun Haeng Cho, Young Sook Hong, Soo Won Lee, Soon Kyum Kim, Young Chang Tockgo, Han Kyeom Kim
Clin Exp Pediatr. 1994;37(8):1078-1091.   Published online August 15, 1994
Lipoprotein(a) [Lp(a)] is considered an additional, independent and largely genetically determined risk factor for the development of premature coronary heart disease. Furthermore abnormal plasma lipoprotein patterns have been associated with increased risk for developing coronary heart disease. Among these lipoproteins, an increased concentration of serum Apo B and decreased level of Apo A are considered as major risk factors, together...
Eosinophil Cationic Protein in Relation to Bronchial Hyperresponsiveness in Asthmatic Children
Jin Tack Kim, Joon Sung Lee
Clin Exp Pediatr. 1993;36(12):1707-1715.   Published online December 15, 1993
The eosinophil is the major cell responsible for the inflammatory reaction in bronchial asthma. Secretion of granular components is probably of considerable importance for the inflammatory effects of the eosinophils, Eosinophil cationic protein (ECP) is the one of the secretory components of the eosinophil granule and is considered as an activation marker of eosinophil, Blood eosinophil count, serum concentration of...
Cow Milk Allergy in Infant Who Neonatal Onset
Seung Hee Park, Myung Ik Lee, Don Hee Ahn, Seung Hee Park
Clin Exp Pediatr. 1993;36(10):1383-1388.   Published online October 15, 1993
Cow milk allergy can be defined as an adverse immunologic reactions to cow milk protein. The term is often mistakenly applied to other causes of milk intolerence, such as lactase deficiency and galactosemia, which must be differenciated and excluded. We have experienced 10 children of cow milk allergy at neonatal onset who had suffered from G-I symtons, such as diarrhea, irritability,...
Effect of Different Levels of the Dietary Protein on Long Term Prognosis of Experimental Renal Damage
Choon Haeng Lee, Sang Joo Han, Hong Jin Lee, Won Il Park, Kyung Ja Lee, Young Eui Park, Min Chul Lee, Tae Heon Yoon
Clin Exp Pediatr. 1993;36(6):820-829.   Published online June 15, 1993
We examined the effect of various levels of dietary protein on long term prognosis of Adriamycinephropathy of S-D rat, fed with high protein(30%), intermediately low(10%), and strictly low(5%) protein diet for 15 weeks 1) In rats fed with strictly low protein diets(5%), proteinuria and serum creatinine decreased and creatinine clearance and histological changes were relatively well preserved. But hypoproteinmia and weight...
Serum Eosinophil Cationic Protien(ECP) in Children with Atopic Astham
Dae Cheol Kim, Ha Baik Lee
Clin Exp Pediatr. 1993;36(6):810-819.   Published online June 15, 1993
Eosinophils play a major role in the airway inflammation in asthma. To werify an association between airway responsiveness of asthmatics and eosinophil and/or ECP, we measured serum ECP in 23 children with atopic asthma during acute attacks and stable, and in 10 normal healthy controls. Peak flows were monitored in 15 children. The data suggest that serum ECP levels were higher...
The Usefulness of Measuring Serum α-fetoprotein and Thyroxine-binding Globulin to Differentiate between Neonatal Hepatitis and Congenital Extrahepatic Biliary Atresia
Soo Kyoung Lee, Ki Sup Chung
Clin Exp Pediatr. 1993;36(4):512-520.   Published online April 15, 1993
Together, neonatal hepatitis and biliary atresia make up approximately 70 to 80% of the causes of neonatal cholestasis. Biliary atresia must be differentiated from neonatal hepatitis as soon as possible in order to institute early surgical intervention. We performed this study to examine whether the measurement of the serum α-fetoprotein(AFP) and thyroxine-binding globulin(TBG) was useful for differentiating these two conditions....
Case Report
Characterization of the Novel Late T Cell Activation Proteins, 519 and 520
Dae-Yeol Lee, Alan M Krensky
Clin Exp Pediatr. 1993;36(3):409-416.   Published online March 15, 1993
The late T cell activation gene, 519, is expressed in antigen specific, growth factor dependent T cell lines and clones but not in T or B cell tumors, other hematopoietic cells, tonsil, muscle, lung, or liver. Resting peripheral blood ymphocytes(PBLs)express little or no 519mRNA, but levels increase dramatically 5~7 days after activation with alloantigen or mitoen. Four alternatively spliced transcripts...
A Case of Intestinal Lymphangiectasia
Yae Kyung Suh, Kyung Hee Park, Chul Ho Jang, Bum Soo Park, Jeong Kee Seo, Sung Hae Park, Je Geun Chi, Kyung Mo Yeon, Kwi Won Park
Clin Exp Pediatr. 1992;35(12):1737-1743.   Published online December 15, 1992
Intestinal lymphangiectasia is a primary or secondary disorder of the gastrointestinal tract, which is associated with lymphatic dysfuction and protein-losing enteropathy. It's clinical manifestations vary widely, but the main symptoms are abdominal distention, edema, abdominal pain and growth failure. We described a 15-yr-old boy, who suffered from above symptoms since third year of his age and diagnosed by duodenal endoscopy which...
Primay Endodermal Sinus Tumor of the Common Bile Duct
Kyeong Hee Cho, Se Jung Sohn, Kil Hyun Kim, Hak Soo Lee
Clin Exp Pediatr. 1992;35(9):1298-1302.   Published online September 15, 1992
The endodermal sinus tumors are rare and highly malignant germ cell origin tumors occuring in both gonadal and extragonadal tissue. We have experienced a case of endodermal sinus tumor mixed with benign teratoma occuring in the common bile duct. It is a very rare site for endodermal sinus tumor. Serum α-fetoprotein was well correlated with clinical course.
Neonatal Purpura Fulminans due to Homozygous Protein C Deficiency
Jae-Hong Park, Sung-Sub Sim, Soo-Young Kim, Hee-Joo Jeon, Chan-Yung Kim, Hong Keun Oh, Jin-Yeong Jeong
Clin Exp Pediatr. 1992;35(5):696-703.   Published online May 15, 1992
Homozygous protein C deficiency is a rare herediatary disorder of blood coagulation resulting in microvascular and venous thromboses, usually purpura fulminans, starting shortly after birth. Protein C serves to inactivate the active forms of factor V and VIII, and increase the rate of fibrin degradation. For confirmation of homozygous protein C deficiency, the infant should have undetectable protein...
Original Article
A study on the immune reaction to the milk protein antigens in the postpartum mother, newborn baby, and children.
Soo chul Cho, Ju Hyung Kim, Hong Ro Lee, Jong San Lee, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1991;34(11):1547-1558.   Published online November 30, 1991
There is continuing interest in the isotype response of human serum antibodies reactive with dietary proteins. This study was performed to clarify the humoral immune responses against cow’s milk proteins, 分-lactoglobulin and a-lactalbumin. Milk protein specific IgG, IgA, IgM, and IgG subclasses were measured using ELISA in the blood of various groups of age. The results were as follows: 1) Milk protein specific immunoglobulins were higher...
Prevalence of asymptomatic hematuria, proteinemia and glucosuria in primary school children in Chonju area.
Jin Oh Kim, Joseph Choi, Soo Cheol Cho, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1991;34(2):223-229.   Published online February 28, 1991
The present study was performed to define the prevalene of asymptomatic hematuria, proteinuria,and glucosuria. A total of 5011 primary school children in Chonju city were examined with test strip urinalysis during the period of one month from June to July 1989. Test strip (Hema-Combistix) was used in this examination. The results were as. follows: 1) Prevalence of hematuria, proteinuria and glucosuria were 0.8% (40 children), 0.78%...
IgA Nephropathy in Childhood.
Yong Choi, Dong Woo Son, Ja Wook Koo, Dong Kyu Jin, Hae Il Cheong, Kwang Wook Ko, Hyun Soon Lee, Yong Il Kim
Clin Exp Pediatr. 1990;33(9):1237-1243.   Published online September 30, 1990
In this study we compared between the patients with recurrent gross hematuria (group 1, n=45) and * with nephrotic range proteinuria (group 2, n=21) in IgA nephropathy who were admitted to Seoul National University Children’s Hospital during the period from January, 1980 to December, 1989. The results of the study were as follows. 1) Age of onset and sex ratio were not different between the...
A Study of C-Reactive Protein in Acute Infectious Diseases in Children.
H K Choi, Y H Chung
Clin Exp Pediatr. 1990;33(6):762-771.   Published online June 30, 1990
The C-reactive protein is an abnormal protein, which is reacted to various non-specific stmuli such as infection, tissue necrosis, trauma, neoplasm and granuloma formation. Hence, C-reactive protein was index of infection and its allied diseases. Serum C-reactive protein determination on total 207 patients with infectious disease and allied conditions were done in the pediatric ward of Chungnnam National Hospital during the period from Jan, 1988...
The clinical evaluation for children with orthostatic proteinuria.
Chan Sung Lee, Chong Guk Lee, Sang Woo Kim
Clin Exp Pediatr. 1989;32(11):1520-1525.   Published online November 30, 1989
Total of eighteen children with orthostatic proteinuria were evaluated for clinical characteristics. The development of renal or urologic diseases were monitored on these subjects for 1 year. The results were as following; 1) The number of children with transient orthostatic proteinuria and fixed orthostatic proteinuria were 7(39%) and 11(61%), respectively. 2) In children with fixed and reproducible orthostatic proteinuria, mild proteinuria were noted in 73% but no massive...
Analysis of Asymptomatic Proteinuria in School Children.
Chong Guk Lee, Tae Sub Shim, Dong Hwan Lee, Yong Soo Yun, Chang Jun Ko, Sa Jun Chung, Hyun Soon Lee, Sung Jae Suh, Pyung Nam Kim
Clin Exp Pediatr. 1989;32(9):1187-1194.   Published online September 30, 1989
Uriary mass screening program for the detection of proteinuria had been performed for a school- age population in the city of Seoul since 1981. Annually, about half million students, who comprised 3 different age group, corresponding to the averages of 11，14, and 17 years, had been examined. A systematic clinical evaluation was designed for students with proteinuria identified in the mass screening through ’87...
Serum C-Reactive Protein in Differential Diagnosis of Meningitis in Children.
Hae Lim Chung, Hoan Jong Lee, Yong Seung Hwang
Clin Exp Pediatr. 1988;31(12):1588-1593.   Published online December 31, 1988
CSF findings such as cell count, differential count, protein, glucose and serum CRP determined by capillary precipitin method evaluated in 90 patients of meningitis admitted to the pediatric ward of Seoul National University Children’s Hospital, in terms of differential diagnosis of meningitis. The results are as follows; 1) There was considerable overlap of CSF findings and hematQlogic values between bacterial, aseptic and tuberculous meningitis groups. 2) All 9...
Lipoproteinelectropheresis pattern in Nephrotic Syndrome.
Soon Don Hong, Byung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1988;31(9):1163-1170.   Published online September 30, 1988
This study was undertaken to eluidate lipoprotein patterns in patients with childhood nephrotic syndrome by response to initial steroid therapy, serum albumin level in MCNS and other histologic classifications. The result were summerized as follows. 1) There were 19 cases (52.8%) of abnormal lipoprotein patterns by Fredrickson classifications, type Ila were 6 cases (16.7%), type lib were 1 cases (2.8%) and type IV were 12 cases...
A Case of Iron Deficiency Anemia with Hypoproteinemia.
Seong Ho Kim, Woo Kill Lee
Clin Exp Pediatr. 1988;31(8):1054-1058.   Published online August 31, 1988
Severe iron deficiency anemia is occasionally accompanied by hypoproteinemia and edema. There is evidence that the hypoproteinemia is caused by increased intestinal loss of serum protein. We experienced a case, 1 year and 6 months old female patient with generalized edema, diagnosed as iron deficiency anemia with hypoproteinemia. After treatment with ferrous iron preparation, generalized edema was subsided, and hemoglobin value and serum protein...
Clinical Observation and Study for Cerebrospinal Fluid Protein Levels in Aseptic Meningitis.
D H Chee, M I Lee, S H Kim, K C Sohn
Clin Exp Pediatr. 1987;30(10):1107-1114.   Published online October 31, 1987
Observation for clinical findings and laboratory findings, especially for cerebrosipinal fluid protein level has been done in 57 cases of aseptic meningitis who had been admitted to pediatric dept, of National Medical Center from Jan. ’81 to May ’85. The results were as follows; 1) The ratio of male to female was 1.7:1, and the cases were distributed relatively evenly through ...
Clinical Value of Urinary β₂ -Microglobulin in Patients with Urianry Tract Infection.
Nak Uk Sung, Chang Ryul Kim, Jeh Hoon Shin, Woo Gill Lee
Clin Exp Pediatr. 1987;30(9):1014-1020.   Published online September 30, 1987
Urinary tract infection (UTI) in children is relatively common infectious disease and it may be the forerunner of severe renal diseases in adulthood. The site of infection is an important factor in the evaluation of the clinical course, treatment and prognosis of patients with UTI, because patients with bacteriuria of renal origin (pyelonephritis) are probably at risk of developing the renal parenchymal reduction seen...
Cord Plasma Alpha-Fetoprotein Values and Neonatal Jaundice.
Mee Kyung Namgoong, Sei Hee Choi, Ae Sook Kim, Baek Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 1986;29(8):836-839.   Published online August 31, 1986
Alpha-fetoprotein(aFP) levels were studied in 20 neonatally hyperbilirubinemic children and 20 controls matched for gestational age. The mean aFP value of cord blood (119+58.2산g/ml) with hyperbilirubinemic children was significantly greater than that(79.6±40.8/zg/ml) for the control infants(P<0.001). At the age of 3 and 5 days the mean serum aFP in hyperbilirubinemic children were higher compared with the control group, the difference...
A Study on Changes of Serum Prootein, Immunoglobulins, and Electrolyte Metabolism in Childhood Nephrotic Syndrome after Steroid Therapy.
Kyung Rae Moon, Chang Soo Ra
Clin Exp Pediatr. 1986;29(1):32-44.   Published online January 31, 1986
The author determined serum and 24hr urine protein(total protein and albumin), immunoglobulins(lgG, IgA, and IgM) and serum electrolytes(Na, K, Ca, P, Mg, and Cl) in 5 cases of childhood nephrotic syndrome before and after steroid therapy, until urinary excretion of protein was negative (remission).The results observed are summarized as follows; 1) Serum protein; Before treatment, the mean serum total protein...
A Study on Serum Lipids and Lipoproteins in Acute Viral Hepatitis in Children.
Kyu Hyoung Han, Chang Soo Ra
Clin Exp Pediatr. 1985;28(7):642-652.   Published online July 31, 1985
Most of the lipids in serum are transported in the from of lipoproteins. A major portion of these lipoproteins is formed in the liver. The determination of serum lipoprotein patterns is a better index of liver abnormalities than determination of lipids alone. The authors determined serum lipid concentration and the patterns of serum lipoproteins in 40 cases of acute viral...
The Evolution of Serum Alpha-Fetoprotein Levels in the Newborn and Infants.
Gu Seok Jung, Chan Yung Kim
Clin Exp Pediatr. 1985;28(6):538-544.   Published online June 30, 1985
The author observed serum alpha-fetoprotein concentration in 112 cases of healthy, fullterm newborns and infants from March 1984 to September 1984. Among them, 9 cases were cord bloods of healthy, full-term newborns who were delivered at Pusan St. Benedict Hospital, the others were healthy infants under the age of 36 months who visited well-baby-clinic of Pusan St. Benedict Hospital. The...
Clinical Trial
Clinical trials of lactous free soy protein based formula for infantile diarrhea.
Soon Wha Kim, Keun Chan Sohn
Clin Exp Pediatr. 1985;28(5):463-469.   Published online May 31, 1985
We observed 50 infants admitted to the Dept, of Pediatrics, National Medical Center to determine the efficacy of lactose free soy protein based formula, domestic products, on the recovery of diarrhea from Sept. 1984 to Dec. 1984. Cases were divided into two groups, group 1 was consisted of 25 infants who were given lactose free soy protein formula, and group...
Original Article
A Study on Serum Alpha-fetoprotein Levels in Newborn Infants.
Sang Ki Min
Clin Exp Pediatr. 1984;27(3):224-228.   Published online March 31, 1984
The levels of alpha-fetoprotein (AFP) were measured in 32 newborn infants (Under 24 hours of age), who have no evidence of infection and hyperbilirubinemia (Total bilirubin: Below 6 mg/ml.). 2~3 ml of blood was sampled from femoral puncture and serum AFP levels were measured by radioimmunoassay (Amersham RIA Kit: Amersham International Co. U.K.). The results were summarized as follows: 1) There...
Urine Sediments and Protein in Healthy Newborn Infants.
Jeh Hoon Shin, Eui Soo Park, Woo Gill Lee, Chong Moo Park
Clin Exp Pediatr. 1983;26(12):1159-1167.   Published online December 31, 1983
h7Routine urine examination in neonatal period is one of the most basic laboratory examination for early diagnosis of various diseases such, as urinary tract infection, congenital anomalies, and renovascular disorders etc. There are many methods to collect urine, but each of these methods has a problem, that is, catheterization causes urethral injury and ascending infection; suprapublic puncture is the most...
Hyperlipidemia and Hyperlipoproteinemia in Focal Segmental Glomerulosclerosis Nephrotic Syndrome.
Heui Jeen Kim, Kwang Wook Ko
Clin Exp Pediatr. 1983;26(10):967-977.   Published online October 31, 1983
Sera obtained from 23 hospitalized patients with focal segmental glomerulosclerosis nephrotic syndrome which is confirmed by kidney biopsy, were analyzed for serum albumin, serum lipids, 24hr urine protein, creatinine clearance, HDL-cholesterol. In 19 of the patients lipoproteins were analyzed. the following results were obtained. 1) Serum phospholipid (PL) was increased whenever serum total cholesterol (TC) was increased but to a lesser degree. The ratio of TC/PL...