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- Original Article
- Neonatology (Perinatology)
- Predictive factors of death in neonates with hypoxic-ischemic encephalopathy receiving selective head cooling
- Behnaz Basiri, Mohammadkazem Sabzehei, Mohammadmahdi sabahi
- Clin Exp Pediatr. 2021;64(4):180-187. Published online August 27, 2020
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Question: What is the most important factor that increases mortality in infants with hypoxic-ischemic encephalopathy (HIE) who receive selective head cooling?
Finding: All cases of neonatal mortality were severe HIE (stage 3), and a severely abnormal amplitude-integrated electroencephalography and mortality were increased with the need for advanced neonatal resuscitation upon delivery.
Meaning: Advanced neonatal resuscitation affects HIE outcomes, and medical personnel should be prepared to provide the best intervention.
- Review Article
- Neurology
- Factors associated with seizure and cognitive outcomes after epilepsy surgery for low-grade epilepsy-associated neuroepithelial tumors in children
- Ara Ko, Joon Soo Lee
- Clin Exp Pediatr. 2020;63(5):171-177. Published online November 13, 2019
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Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are responsible for drug-resistant chronic focal epilepsy, and are the second-most common reason for epilepsy surgery in children. LEATs are extremely responsive to surgical treatment, and therefore epilepsy surgery should be considered as a treatment option for LEATs. However, the optimal time for surgery remains controversial, and surgeries are often delayed. In this review, we...
- How can neurological outcomes be predicted in comatose pediatric patients after out-of-hospital cardiac arrest?
- Hyo Jeong Kim
- Clin Exp Pediatr. 2020;63(5):164-170. Published online October 10, 2019
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The prognosis of patients who are comatose after resuscitation remains uncertain. The accurate prediction of neurological outcome is important for management decisions and counseling. A neurological examination is an important factor for prognostication, but widely used sedatives alter the neurological examination and delay the response recovery. Additional studies including electroencephalography, somatosensory-evoked potentials, brain imaging, and blood biomarkers are useful for...
- Original Article
- Risk factors for the occurrence and persistence of coronary aneurysms in Kawasaki disease
- Soo-kyeong Jeon, Geena Kim, Hoon Ko, Joung-Hee Byun, Hyoung Doo Lee
- Clin Exp Pediatr. 2019;62(4):138-143. Published online November 22, 2018
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Purpose: Prognostic factors of coronary aneurysms in Kawasaki disease have been investigated in many studies. The aim of this study was to identify risk factors associated with early and late coronary artery outcomes in treated patients with Kawasaki disease. Methods: A total of 392 patients diagnosed with Kawasaki disease from January 2012 to December 2015 in Pusan National University Children’s Hospital...
- Neonatology (Perinatology)
- Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit
- Se Jin Kim, Ga Eun Kim, Jae Hyun Park, Sang Lak Lee, Chun Soo Kim
- Clin Exp Pediatr. 2019;62(1):36-41. Published online September 27, 2018
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Purpose: In this study, we investigated the clinical features and prognostic factors of early-onset sepsis (EOS) in neonatal intensive care unit (NICU) patients. Methods: A retrospective analysis was conducted on medical records from January 2010 to June 2017 (7.5 years) of a university hospital NICU. Results: There were 45 cases of EOS (1.2%) in 3,862 infants. The most common pathogen responsible for...
- Neurology
- Clinical features and prognostic factors in drowning children: a regional experience
- Kyung Lae Son, Su Kyeong Hwang, Hee Joung Choi
- Clin Exp Pediatr. 2016;59(5):212-217. Published online May 31, 2016
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Purpose This study aimed to evaluate the clinical features of children who have survived a water submersion incident, and to identify risk factors for prognosis.
Methods We retrospectively reviewed the medical records of patients who experienced submersion between January 2005 and December 2014. The patients were classified into 2 groups, according to complications, and prognostic factors were evaluated.
Results During the study period, 29 children...
- Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapy
- Jinsup Kim, Na Hee Lee, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Jeong-Meen Seo, Suk-Koo Lee
- Clin Exp Pediatr. 2015;58(10):386-391. Published online October 21, 2015
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Purpose To evaluate the outcomes and prognostic factors in children with extracranial germ cell tumors (GCTs) treated at a single institution.
Methods Sixty-six children diagnosed with extracranial GCTs between 1996 and 2012 were included in the study. Primary treatment was surgical excision, followed by six cycles of cisplatin-based chemotherapy. The survival rates were compared according to the International Germ Cell Cancer Cooperative Group...
- The risk factors and prognosis associated with neonatal pulmonary hemorrhage
- Su Jin Park, Ki Tae Yun, Won Duck Kim, Sang Geel Lee
- Clin Exp Pediatr. 2010;53(4):503-509. Published online April 15, 2010
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Purpose : Although neonatal pulmonary hemorrhage is rare, it is associated with high mortality. We aimed to evaluate the risk factors associated with pulmonary hemorrhage in preterm infants and to describe the clinical course, including neonatal morbidity, of infants who developed pulmonary hemorrhage. Methods : We performed a retrospective case-control study of 117 newborn infants aged less than 37 gestational weeks admitted... -
- Analysis of prognostic factors of laparotomy for necrotizing enterocolitis in extremely low birth weight infants
- Jin Kyu Kim, Yi Sun Kim, Hye Soo Yoo, So Yoon Ahn, Hyun ju Seo, Seo Heui Choi, Soo Kyung Park, Yu Jin Jung, Myo Jing Kim, Ga Won Jeon, Soo Hyun Koo, Kyung-Hoon Lee, Yun Sil Chang, Won Soon Park
- Clin Exp Pediatr. 2010;53(2):167-172. Published online February 15, 2010
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Purpose : With improved survival of extremely low birth weight infants (ELBWI), there is an increase in the incidence of necrotizing enterocolitis (NEC) requiring laparotomy, and the risk of morbidity and mortality in these ELBWI is increased. Thus, we determined the prognostic factors in ELBWI who underwent laparotomy for NEC. Methods : We retrospectively reviewed the medical records of 35 ELBWI... -
- Case Report
- Partial trisomy of chromosome 18q11.2-q12: A case report
- Ah Ra Cho, Hye Ryoun Kim, Mi Kyung Lee, Sin Weon Yun, Jung Ju Lee
- Clin Exp Pediatr. 2009;52(10):1171-1174. Published online October 15, 2009
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Edwards syndrome, also called trisomy 18, is one of the most common autosomal anomalies. The survival rate of patients with Edwards syndrome is very low and its characteristic findings include cardiac malformations, mental retardation, growth retardation, specific craniofacial anomalies, clenched hands, rocker-bottom feet, and omphalocele. Compared with the classic Edwards syndrome, the symptom of partial duplication of chromosome 18 is... -
- Original Article
- Outcome of patients with neuroblastoma aged less than 1 year at diagnosis
- Jung Min Suh, Sang Goo Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Ju Youn Kim, Eun Joo Cho, Suk Koo Lee, Jhingook Kim, Do Hoon Lim
- Clin Exp Pediatr. 2009;52(1):93-98. Published online January 15, 2009
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Purpose : The purpose of this study was to evaluate the clinical characteristics and outcomes of patients with neuroblastoma aged less than 1 year. Methods : From January 1997 to December 2007, 41 patients aged less than 1 year were diagnosed with neuroblastoma. Patients were divided into 3 risk groups according to the stage of the disease and N-myc amplification. Low-risk... -
- Review Article
- Assessment of retinopathy of prematurity (ROP) revisited
- Jeong Hun Kim, Young Suk Yu
- Clin Exp Pediatr. 2009;52(1):22-27. Published online January 15, 2009
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Retinopathy of prematurity (ROP) is a major cause of blindness that affects premature infants. With advances in neonatology, ROP is likely to emerge as the most serious problem of vision loss in children even in developed countries; such a situation could be called the third epidemic of ROP. However, controversy and uncertainty still surround favorable outcomes of ROP. For successfully... -
- Original Article
- Clinical characteristics and prognostic factors for survival in hemophagocytic lymphohistiocytosis
- Khi Joo Kim, Ki Hwan Kim, Taek Jin Lee, Jin-Kyong Chun, Chuhl Joo Lyu, Dong Soo Kim
- Clin Exp Pediatr. 2008;51(3):299-306. Published online March 15, 2008
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Purpose : Hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by fever, splenomegaly, pancytopenia, and hemophagocytosis in the bone marrow and other tissues. In this study, we investigated the clinical manifestations and prognostic factors in patients with HLH. Methods : We retrospectively analyzed the data from 29 patients who were diagnosed whit HLH in the Severance Children's Hospital from... -
- Incidence, clinical features and prognosis of Bell's palsy in children
- Yoo Jong Won, Kyung Hee Moon, Wan Soo Lee, Seung Woon Keum, Taek Yu, Gyung Jae Oh, Chang Woo Lee
- Clin Exp Pediatr. 2007;50(3):272-276. Published online March 15, 2007
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Purpose : Bell's palsy is defined as an idiopathic facial nerve paralysis of sudden onset. In spite of intensive clinical and experimental investigation, there is still uncertainty in the incidence, etiology, and preferred mode of treatment in children. The objective of this study was to analyze clinical outcome and prognosis of children with Bell' palsy. Methods : We analyzed 61 cases... -
- Clinical features of congenital muscular torticollis
- Ji Eun Jun, Hye Kyeong Ryu, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-Soo Kim
- Clin Exp Pediatr. 2007;50(3):241-247. Published online March 15, 2007
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Purpose : Congenital muscular torticollis (CMT) is a common and benign congenital disorder of the musculoskeletal system in neonates and infants. The pathophysiology is that the sternocleidomastoid muscle (SCM) is shortened on the involved side by fibrosis, leading to ipsilateral tilt and contralateral rotation of the face and chin. In this study, we investigated the clinical features of CMT, the... -
- Clinicopathologic features and prognosis of childhood IgA nephropathy
- Sung Il Woo, Keun Wook Bae, Joo Hoon Lee, Young Seo Park, Yong Mee Cho
- Clin Exp Pediatr. 2007;50(2):170-177. Published online February 15, 2007
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Purpose : Clinicopathological features were investigated to clarify the outcome and prognostic indicators for patients with IgA nephropathy in Korean children. Methods : We reviewed the outcomes of 61 patients in whom IgA nephropathy was diagnosed before the age of 15 years from 1991 to 2005 and followed-up at least for one year. All patients were confirmed by renal biopsy. Results... -
- Clinical significance of cerebrospinal fluid pleocytosis in pediatric refractory status epilepticus
- Jung Mi Kim, Young Mi Kim, Soon Hak Kwon
- Clin Exp Pediatr. 2006;49(10):1086-1092. Published online October 15, 2006
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Purpose : Refractory status epilepticus(RSE) is a serious neurological emergency in children. The mortality is high and the neurological outcome is not good. This study aimed to evaluate the clinical significance of cerebrospinal fluid(CSF) pleocytosis in refractory status epilepticus in children. Methods : From January 1999 to January 2006, 25 out of 37 children with refractory status epilepticus had... -
- Difference of Clinical Features according to Hypoalbuminemia in the Children with Pleural Effusion
- Min-Jung Sung, Hee-ju Park
- Clin Exp Pediatr. 2005;48(5):523-526. Published online May 15, 2005
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Purpose : Hypoalbuminemia is a rare cause of pleural effusion. The relationship between the severity of hypoalbuminemia and the clinical course of pleural effusion is unclear. The aim of this study was to evaluate the change of clinical course according to the severity of hypoalbuminemia due to pleural effusion in children. Methods : A total of 96 patients admitted to Pusan... -
- Clinical Utilities of Serum Ferritin as a Marker of Disease Activity and Prognostic Factor in Childhood Tumors
- Eun Seok Roh, Jung Hyun Lee, Yu Ra Hong, Jae Sun Park, Jong Shin Kim
- Clin Exp Pediatr. 2004;47(12):1319-1324. Published online December 15, 2004
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Purpose : In order to assess the usefulness of serum ferritin as a marker of disease activity and prognostic factor in pediatric malignancy, serum ferritin levels were measured. Methods : Peripheral blood samplings for ferritin level were made at presentation, in remission following therapy, and in relapse in 95 children with malignancy admitted to the Department of Pediatrics, Kosin University Gospel... -
- Cause and Prognosis of Pediatric Acute Respiratory Failure by Intrapulmonary Lesion
- Hye-Young Lee, Ji-Suk Park, Hee-Ra Choi, Ji-Hyun Seo, Jeum-Su Kim, Jae-Young Lim, Myoung-Bum Choi, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
- Clin Exp Pediatr. 2004;47(5):555-560. Published online May 15, 2004
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Purpose : Respiratory failure arises from derangements in pulmonary gas exchange. The causes may be classified as due to either lung disease or respiratory pump dysfunction. Problems with lung mechanics is an important cause of acute respiratory failure in children clinically. The aims of this study were to survey the cause and prognosis of children diagnosed with acute respiratory failure... -
- A Clinical Study of Childhood Henoch-Sch nlein Purpura
- Tae-Sun Ha, Hyun-Hoe Koo
- Clin Exp Pediatr. 2003;46(11):1118-1123. Published online November 15, 2003
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Purpose : Henoch-Sch nlein purpura(HSP) is a systemic vasculitis, characterized by cutaneous purpura, abdominal pain, arthralgia and renal involvement. The clinical features of HSP have been reasonably well documented but there are still many gaps in our understanding of HSP. The aim of this study was to present the clinical features of 125 children with HSP and compare them with... -
- Pathologic Change and Prognosis after Combination Therapy in Advanced Neuroblastoma
- Yeon Kyong Seo, Yu Jin Jung, Joon Sik Kim, Heung Sik Kim, Woo Hyun Park, Soon Ok Choi, Byung Yook Lee, Kun Young Kwon
- Clin Exp Pediatr. 2003;46(11):1107-1111. Published online November 15, 2003
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Purpose : Neuroblastoma is a malignant neoplasm which arises from primitive sympathetic neuroblasts, and occasionally can matured from a malignant neuroblastoma into a benign ganglioneuroma. It has the highest rate of spontaneous regression of any pediatric tumor. We performed a retrospective study of pathologic features after combination therapy in advanced neuroblastoma. Prognostic effects of the individual morphologic feature and prognostic... -
- A Study on the Disease Course and Prognosis of Cyclic Vomiting Syndrome
- Hye Ran Yang, Jae Sung Ko, Jeong Kee Seo
- Clin Exp Pediatr. 2001;44(10):1141-1156. Published online October 15, 2001
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Purpose : To describe clinical features of cyclic vomiting syndrome(CVS), managements during episodes, prophylactic drugs as long term therapy and to investigate the disease course and prognostic factors of CVS. Methods : Thirty two children who fulfilled the diagnostic criteria of CVS and who presented to Seoul National University Children's Hospital from March 1989 to December 2000, were included. Data were... -
- Long-term Clinical Follow-up of Korean Children with Wilson Disease; Twenty Years` Experience
- Jin Soo Moon, Jae Sung Ko, Jeong Kee Seo
- Clin Exp Pediatr. 2001;44(2):127-138. Published online February 15, 2001
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Purpose : To investigate the clinical features of long-term follow-up, and the treatment responses in Korean children with Wilson disease(WD). Methods : The clinical data from ninety-two children with WD, diagnosed at Seoul National University Hospital from 1976 to 1999, were reviewed. Mean duration of follow-up was 5¡¾4.5 years. We analysed the patient's records based on the clinical manifestations, laboratory findings,... -
- The Correlation Between the TSH Level in Neonatal Screening Test and the Prognosis of Congenital Hypothyroidism
- Hong Sun Park, Kye Shik Shim, Kyuchul Choeh
- Clin Exp Pediatr. 2001;44(1):25-31. Published online January 15, 2001
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Purpose : It is important to diagnose and treat newborn patients with congenital hypothyroidism as soon as possible because of neurodevelopmental outcome. If we can detect more severe forms of congenital hypothyroidism with neonatal screening test, the results of treatment will improve. Methods : Sixty-four term infants whose TSH levels in neonatal screening test had been higher than 20μIU were recalled.... -
- On the Significance of Blood Sampling Time in Neonatal Neurologic Prognosis Using Creatine Kinase BB
- Heung Taek Kim, Mi Kyung Son, Eun Ju Kim, Kyuchul Choeh
- Clin Exp Pediatr. 1998;41(5):669-676. Published online May 15, 1998
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Purpose : To investigate the cut-off value of creatine kinase(CK) BB according to blood sampling time in predicting neonatal prognosis, we studied the time-related releasing pattern of CK isoenzymes after birth asphyxia. Methods : CK was measured within 1 hour and at 6-10 hours after birth from 45 newborn infants who were suspected to be perinatal asphyxia or fetal distress. The... -
- Childhood Near-Drowning in Chinju
- Hyang Ok Woo, Chan-Hoo Park
- Clin Exp Pediatr. 1997;40(11):1588-1595. Published online November 15, 1997
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Purpose : Drowning is the second most common cause of accidental death in children, exceeded only by motor vehicle accidents. The purpose of the present study was to investigate the prognostic factors of near-drowning in children, such as age, sex, season, site of submersion, and initial clinical or laboratory manifestrations, and to formulate preventive strategies for decreasing injuries by drowning. Methods : Sixty-one near-drowning children... -
- Erratum
- A Case of Joubert Syndrome
- Hye-Young Kim, Sun-Jun Kim, Jung-Soo Kim
- Accepted January 1, 1970
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Joubert syndrome is frequently associated with developmental delay and mental retardation, neonatal tachypnea and apnea, abnormal eye movements, and ataxia. It is inherited by an autosomal recessive trait. The most significant and constant neuropathological finding is partial or total agenesis of cerebellar vermis. Absence of the vermis results in a triangular-shaped mid-fourth ventricle and a "bat-wing" shaped fourth ventricle superiorly. The superior cerebellar peduncles... -
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- Original Article
- Ischemic Hepatitis in Children after Cardiac Operation -Analysis of Clinical Characteristics, Risk Factors and Outcome-
- Kyung Mo Kim, Jeong Kee Seo
- Clin Exp Pediatr. 1995;38(11):1540-1546. Published online November 15, 1995
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Purpose : We have experienced frequently the ischemic hepatitis after cardiac operations which shows rapid striking rise of transaminase. But the ischemic hepatitis in children after cardiac operation is not defined yet in Korea. We examined the clinical characteristics and analyzed the risk factors and outcome in 20 children who showed typical clinical course of ischemic hepatitis after cardiac operation. Methods... -
- Clinical Characteristics of Childhood Cerebrovascular Disease and Analysis on the Prognostic Factors
- Yong Seung Hwang, Moon Sun Yang
- Clin Exp Pediatr. 1995;38(3):353-365. Published online March 15, 1995
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Purpose : Cerebrovascular disease in children is more common than was once recognized and the etiology and prognosis of the disease in children are quite different from those of adults. Recently according to medical reports and clinical experiences, the incidence of childhood cerebrovascular disease is increasing in Korea. To clarify the clinical features of childhood cerebrovascular disease and to analyze its... -
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