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Original Article
Neonatology (Perinatology)
Effect of red blood cell transfusion on short-term outcomes in very low birth weight infants
Eui Young Lee, Sung Shin Kim, Ga Young Park, Sun Hyang Lee
Clin Exp Pediatr. 2020;63(2):56-62.   Published online February 6, 2020
Question: Does RBC transfusion affect the short-term outcomes of VLBW infants?
Finding: The results showed that RBC transfusion was significantly related to the incidence of BPD (OR, 5.42; P<0.001) and NEC (OR, 3.40; P=0.009).
Meaning: Careful consideration of the patient’s clinical condition and appropriate guidelines is required before administering RBC transfusions.
Review Article
Neonatology (Perinatology)
Transfusion practice in neonates
Do-Hyun Kim
Clin Exp Pediatr. 2018;61(9):265-270.   Published online September 6, 2018
Neonates, especially extremely low birth weight infants, are among the groups of patients undergoing transfusion frequently. Since they are exposed to higher specific transfusion risks compared to the patients of other age groups, there are many special aspects that must be considered for transfusion therapy in neonates. The transfusion risks in neonates include adverse outcomes specific for preterm infants as...
Original Article
Genetics and Metabolism
Neonatal indirect hyperbilirubinemia and glucose-6-phosphate dehydrogenase deficiency
Hasan M. Isa, Masooma S. Mohamed, Afaf M. Mohamed, Adel Abdulla, Fuad Abdulla
Clin Exp Pediatr. 2017;60(4):106-111.   Published online April 25, 2017
Purpose

This study aimed to determine the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among infants with neonatal indirect hyperbilirubinemia (NIH); compare G6PD-deficient and G6PD-normal patients regarding hyperbilirubinemia and need for exchange transfusions (ET); and assess risk factors for ET and kernicterus.

Methods

This is a case-control retrospective study. Medical records of NIH patients admitted to the Pediatric Department, Salmaniya Medical Complex, Bahrain, between...

Analysis of the association between necrotizing enterocolitis and transfusion of red blood cell in very low birth weight preterm infants
Seon-Yeong Bak, Sihyoung Lee, Jae-Hong Park, Kyu-Hee Park, Ji-Hyun Jeon
Clin Exp Pediatr. 2013;56(3):112-115.   Published online March 18, 2013
Purpose

To investigate the association between necrotizing enterocolitis (NEC) and red blood cell transfusions in very low birth weight (VLBW) preterm infants.

Methods

We studied were 180 VLBW preterm infants who were admitted to the neonatal intensive care unit of CHA Gangnam Hospital from January of 2006 to December of 2009. The subjects were divided into 2 groups: an NEC group (greater than...

Case Report
Successful treatment by exchange transfusion of a young infant with sodium nitroprusside poisoning
Jong Geun Baek, Hoar Lim Jeong, Ji Sook Park, Ji Hyun Seo, Eun Sil Park, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Hee Shang Youn, Jung Sook Yeom
Clin Exp Pediatr. 2010;53(8):805-808.   Published online August 31, 2010

Although sodium nitroprusside (SNP) is often used in pediatric intensive care units, cyanide toxicity can occur after SNP treatment. To treat SNP-induced cyanide poisoning, antidotes such as amyl nitrite, sodium nitrite, sodium thiosulfate, and hydroxycobalamin should be administered immediately after diagnosis. Here, we report the first case of a very young infant whose SNP-induced cyanide poisoning was successfully treated by...

Original Article
Effect of intravenous deferoxamine in multiply transfused patients
Sang Min Oh, Joon Won Kang, Sun Young Kim
Clin Exp Pediatr. 2007;50(12):1225-1230.   Published online December 15, 2007
Purpose : Multiple transfusions in patients with chronic anemia can result in excessive iron deposition in tissues and organs. Effective iron chelation therapy in chronically transfused patients can only be achieved when iron chelators remove sufficient amounts of iron equivalent to those accumulated in the body from transfusions, thus leading to maintain body iron load at a non-toxic level. This...
The Prevalence of Transfusion-Transmitted Virus Infection in Children
Ju Young Chung, Tae Hee Han, Eung Su Hwang
Clin Exp Pediatr. 2004;47(2):183-186.   Published online February 15, 2004
Purpose : Transfusion-transmitted virus(TTV) is an newly described nonenveloped human virus, with a circular, negative stranded DNA genome. Although a high prevalence of TTV infection in the normal population has been demonstrated, there is a still possibility of association with hepatitis according to the genotype of TTV. The aim of this study is to investigate the prevalence of TTV infection...
Frequency of Platelet Transfusions and Outcome in Neonates with Thrombocytopenia
Suk-Hwan Lim, Jin-Hwa Kook, Chang-Yee Cho, Young-Youn Choi, Tai-Ju Hwang
Clin Exp Pediatr. 2002;45(8):961-966.   Published online August 15, 2002
Purpose : We compared the underlying or associated diseases according to the frequency of platelet transfusions in neonates with thrombocytopenia to know the factors predicting which patients will require multiple platelet transfusions. We also compared mortality. Methods : A retrospective study was performed in 72 neonates who received the platelet transfusions in neonatal intensive care unit(NICU) between August 1996 and July...
The Change of White Blood Cell Count Following Transfusion in Preterm Neonates
Soo Young Yoon, Gum Joo Lee, Gui Young Jung
Clin Exp Pediatr. 2002;45(3):325-330.   Published online March 15, 2002
Purpose : We intended to find out how the red cell transfusion would change the white cell count in preterm neonates under treatment in the intensive care unit. We also speculated whether the magnitude of such a change could indicate a potential neonatal infection. Methods : Total white blood cell count, total neutrophil count, and band count were compared and analyzed...
The Use of Quadruple Blood Bags Transfusion of Low Birth Weight Neonates
Sang Hoon Lee, Jean Yoon, Yang Park, Sung Kyu Lee, Hee Chung Kim, Woo Sup Shim
Clin Exp Pediatr. 1999;42(8):1122-1129.   Published online August 15, 1999
Purpose : Low-birth-weight(LBW) neonates often need multiple transfusions during their neonatal period. The routine use of the 500ml mono-bag system in Korea, even in neonatal transfusions, results in a great waste of blood and exposes the neonate to multiple blood donors. To reduce the waste of blood and the number of exposures, we used quadruple blood bags in the transfusion...
The Relationship between IL-1β, TNFα, IL-6 and Factors Associated with Febrile Reactions to Transfused Blood
Hae Shin Kyung, Kyung Ha Ryu, Kyung Hyo Kim, Young Mi Hong, Kyung Hi Kim, Keun Lee
Clin Exp Pediatr. 1999;42(1):108-114.   Published online January 15, 1999
Purpose : Aggressive chemotherapy and bone marrow transplantation have a large demand for platelet concentrate and packed RBC transfusion. Febrile nonhemolytic transfusion reactions are an immunologically mediated reaction involving plasma in the recipient and the white blood cells in the donor. This study was performed to understand the role of cytokines and factors associated with febrile nonhemolytic transfusion reaction to...
Case Report
A Case of Secondary Hemosiderosis and Hepatic Fibrosis in a Pateint with Acute Myelogenous Leukemia
Hyoung No Kim, Jae Won Huh, Jae Sun Park
Clin Exp Pediatr. 1998;41(3):420-424.   Published online March 15, 1998
Chronic iron overload is associated with life-threatening complications, such as cardiomyopathy, liver cirrhosis, diabetes, hypothyroidism, hypoparathyroidism and hypogonadism. We experienced a case of secondary hemosiderosis with hepatic fibrosis in a 8-year-old boy who had been transfused 56 pints of packed red blood cells for a supportive therapy of acute myelogenous leukemia for a 27-month period. Intramuscular injection of Desferroxamine(40mg/kg/day) was...
Original Article
Effect of Prophylactic Treatment of High Doses Recombinant Human Erythropoietin on Anemia in Premature Infants
Soon Seong Park, Seong Ho Hong, Hye Lime Jung, Dong Hyeok Keum
Clin Exp Pediatr. 1995;38(10):1384-1393.   Published online October 15, 1995
Purpose : This study was conducted to determine whether prophylatic treatment with recombinant human erythropoietin(rHuEPO) could prevent anemia and reduce the need for blood transfusion in premature infants. Methods : This study was conducted from May, 1992 to July 1994. We randomly assigned 24 premature infants with gestational age less than 34 weeks and birth weight less than 2.0kg. After having...
Case Report
A Case of Stillbirth Due to Fetomaternal Transfusion
Jin Min Choi, Myoung Bae Jeon, Byung Joo Park, Jung Hye Choi, Seoung Yul Lee, Dong Won Choi
Clin Exp Pediatr. 1994;37(12):1762-1766.   Published online December 15, 1994
Transfer of large quantities of fetal blood across the placental barrier to the maternal circulation is a rare occurrence which results in severe anemia in the newborn infants. This phenomenon is believed to occur most often during labor and delivery and apparently, is more frequent when abnormal obstetric conditions are present. However, fetal erythrocytes have been identified in the naternal...
Original Article
The Biochemical and Bacteriological Study of the Umbilical Venous Blood for Autologous Transfusion in Neonates
Son Moon Shin, Kwang Hae Choi, Hyun Mo Gu, Jeong Ok Hah
Clin Exp Pediatr. 1994;37(7):928-936.   Published online July 15, 1994
This study was conducted to investigate the safety of the umbilical venous blood for antologous transfusion in the premature newborn babies. Umbilical venous blood was collected with aseptic technique immediately after delivery from 270 healthy mothers admitted to the Yeungnam University Hospital between March 1, 1992 and August 31, 1992. The volume of the blood and the time taken for...
Packed Red Cell Transfusion in Neonate : Effects of Age of Red Cells on Serum Laboratory Values and Readjustment of Hematocrit Values after Transfusion
Dong Ha Lee, Jin Kyung Kim, Heng Mi Kim
Clin Exp Pediatr. 1994;37(4):452-456.   Published online April 15, 1994
Sick neonates often require periodic small volume transfusion(10mg/kg) to replace blood draw for laboratory monitoring during their hospital stay. The effect of packed red cell transfusion on the hematocrit, potassium, ionized calcium, acid base status, glucose and indirect bilirubin was investigated in 25 transfusions. Analysis of transfused blood by the age of the red cells, older red cells (more than...
Exchange Transfusion Using Percutaneous Femoral Vein Catheterization in Neonates: Comparison with Umbilical Vein Catheterization
Song-Ja Kim, Hyang-Ok Woo, Seung-Hwan Kim, Mi-Ryeong Kim, Sun-Kyeong Sin, Hee-Shang Youn
Clin Exp Pediatr. 1994;37(2):180-184.   Published online February 15, 1994
Traditionally umbilical vein has been used for exchange transfusion in neonates. This method is relatively safe and effective but with a few complications. So via percutaneous femoral vein catheters we tried exchange transfusion in 30 patients with neonatal hyperbilirubinemia admitted to GNUH from September 1990 to August 1992. Femoral vein catheterization succeeded in 2~3 trials. In all cases high bilirubin level...
Case Report
A Case of Transfusion-Associated Gragt-Verus-Host Disease in a Preterm Infant
Hye Jung Joo, Seung Mo Park, Ran Namgung, Kook In Park, Jin Sung Lee, Chul Lee, Dong Kwan Han, Kir-Young Kim, Kwang-Hoon Lee, Kwang-Gil Lee
Clin Exp Pediatr. 1993;36(11):1613-1620.   Published online November 15, 1993
Graft-versus-host disease is commonly observed after allogeneic bone marrow transplantation but rarely recognized transfusion or solid-organ transplantation. Transfusion-associated graft-versus-host disease can occur in immunosuppressed recipients and immunocompetent transplant recipients. The clinical manifestations of gastrointestinal or hepatic dysfunction, rash and pancytopenia should heighten the physician's index of suspicion for GVHD. Among premature infants, only four cases have been reported to develop...
Original Article
A Clinical Study on Prematurity Who received Blood Transfusion
Chul Soon Park, Myung Ik Lee, Soon Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1993;36(10):1389-1394.   Published online October 15, 1993
A clinical study was made on 85 cases of prematurity under 37 weeks of gestational age who had history of blood transfusion during their admission at the National Medical Center from January 1989 to June 1992. The results were as follows: 1) Among 339 prematurity patients, 85 patients (25.1%) received blood transfusion once at least. 2) Male to female ration was 1.13:1 and...
A Clinical Study on Neonatal Exchange Transfusion
Eun Ju Park, Eun Wui Kim, Yang Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1993;36(4):469-477.   Published online April 15, 1993
Clinical observation was perfumed on 81 cases who were received exchange transfusion at Ilsin Christian Hospital from January, 1986 to December, 1990. The results obtained were as follows: 1) Among 6,388 cases of neonatal jaundice, the exchange transfusion was performed on 81 cases(1.27%) 2) There was no sex predominance (male 40, female 41). The birth weight of 75 cases(92.6%) ranged from 2,500 gm...
Case Report
Transfusion-Acquired Cytomegalovirus Infections in Two Premature Infants
Dong Wook Kim, Kyung Un No, Mi Jung Kim, Soon Mee Park, Hee Sup Kim, Young Pyo Chang, Hoan Jong Lee, Jung-Hwan Choi, Chong Ku Yun, Je Geun Chi
Clin Exp Pediatr. 1992;35(8):1141-1147.   Published online August 15, 1992
Transfusion-acquired perinatal cytomegalovirus (CMV) infection can cause significant morbidity and mortality, particularly in premature infants with a birth wight of less than 1,500 gm. This recognizable syndrome consisted of deterioration of respiratory function, hepatosplenogaly, unusual gray pallor with disturbing septic appearance, lymphocytosis, thrombocytopenia and hemolytic anemia. We experienced transfusion-acquired CMV infections in 2 premature infants with a birth weight of...
Original Article
The role of exchange transfusion as a therapy for neonatal DIC.
Jung Tak Kim, Kook In Park, Ran Namgung, Dong Gwan Han, Kir Young Kim
Clin Exp Pediatr. 1991;34(1):31-40.   Published online January 31, 1991
A clinical study on the effects of exchange transfusion on disseminated intravascular coagulation was conducted on 32 patients with DIC who were admitted to the pediatric department of YUMC from January 1984 to June 1989. We diagnosed DIC when symptoms were compatible to the diagnosis and there were more than 3 abnormal laboratory findings out of the following 5, which were platelet count, PT,...
A Clinical study on the Neonatal Exchange Transfusion.
S Y Song, W H Kwon, C H Han, H L Jeong, S Y Kim, Y D Kwon
Clin Exp Pediatr. 1990;33(2):162-169.   Published online February 28, 1990
A clinical observation was performed on patients with neonatal hyperbilirubinemia who were treated by exchange transfusion, and following results were obtained. Exchange transfusion was performed in 31 cases (8% of 383 csases admitted due to neonatal hyperbilirubinemia during the observation period). There was no sex predominance (male 16, female 15). Most common type of delivery was normal varginal delivery (22 cases, 71%). Birth weight of 17...
Acid-Base and Electrolyte Change Before and After Exchange Transfusion with ACD-B Blood in Hyperbilirubinemia of Newborn.
Ki Hong Park, Chong Woo Bae, Yong Mook Choi, Chang Ill Ahn, Jung Kook Lee
Clin Exp Pediatr. 1989;32(3):311-320.   Published online March 31, 1989
Exchange transfusion is being used widely to correct anemia and control existing hyperbilirubinemia for the prevention of kernicterus in newborn. But the blood used for exchange transfusion is stored blood containing anticoagulants and other substances. So many metabolic changes can be developed after exchange transfusion. This study was undertaken to evaluate the acid-base and electrolyte change after exchange transfusion using the ACD-B blood. In...
Case Report
A case of Congenital Factor X III Deficiency.
Sei Woo Chung, Myung Ik Lee, Don Hee Ahn, Keun Chan Sohn, Jin Sook Hong, Dong Hun Yoon
Clin Exp Pediatr. 1986;29(5):553-559.   Published online May 31, 1986
A 4 year and 7 month old male patient was admitted with the chief complaint of subgaleal hematoma and recurrent bleeding episodes. The first episode was umbilical cord bleeding on the third day of life. Routine coagulation study including factor assay at that time was within normal limit. The bleeding cleared after whole blood transfusion. He had been admitted...
Original Article
Clinical Studies on Neonatal Jaundice and Exchange Transfusion.
Byoung Hun Kim, Soo Yup Lee, Jeh Hoon Shin, Kyu Hwan Lee, Soo Jee Moon, Chong Moo Park
Clin Exp Pediatr. 1986;29(5):535-542.   Published online May 31, 1986
Jaundice occurs rather frequently in neonatal period, and yet the irreversible complication, kernicterus, may occur in severe cases with pathologic jaundice, from which the patients are at high risk for mental retardation, cerebral palsy, and even death. To prevent this complication, aggressive measures have been used for the neonatal janudice, such as phototherapy and exchange transfusion. Exchange transfusion has been...
The Influence of Hepatitis B Virus to Neonates.
Dong Hak Shin, Rac Kyun Ro, Sung Do Yoon
Clin Exp Pediatr. 1986;29(1):51-57.   Published online January 31, 1986
To evaluate the influence of HBV to fetus, authors studied 817 pregnant women and neonates who were admitted to delivery room of Keimyung University Dongsan medical center from 1882 to 1984. The results were as follows; 1) Percent of HBsAg positive mother was 6.8% (50/817) and child bearing age was 7.8% (72/917). Percent of Anti-HBs positive was 33.9% and...
Clinical Study of the role of Exchange Transfusion for Treatment in Neonatal DIC.
Myung Shik Lee, Jin Sung Lee, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1984;27(12):1151-1161.   Published online December 31, 1984
This study was made of 9 cases of neonatal septicemia complicated with DIC and sclerema, who were admitted to the pediatric department of YUMC from January 1981 to June 1983. The following results were obtained; 1) A higher incidence was observed in males(77.8%), low birth weight(66.7%) and1 pretnature(77.8%). 2) The mean onset of sepsis was noticsd on 4.4 days of life. The most common presenting symptoms...
A Study of 60 Cases of Exchange Transfusion.
Si Bok Jo, Im Ju Kang, Jae Keun Yoon, Hae Jin Suh
Clin Exp Pediatr. 1984;27(11):1055-1062.   Published online November 30, 1984
Clinical study was made of 60 cases who were received blood exchange transfusion at Taegu Fatima Hospital from January, 1978 to December, 1980 with the following results. 1) Among 1,387 cases of neonatal hyperbilirubinemia, the exchange transfusion was performed on 60 ases(4.3%). 2) The most predominant delivery type was normal vertex delivery at local clinics. 3) The most common cause of performed exchange transfusion was unknown...
The Response of Leukocytes in the Peripheral Blood Following Exchange Transfusion in the Newborn.
Young Mo Sohn, Yu Young Chang, Young Ho Kim, Kir Young Kim
Clin Exp Pediatr. 1983;26(11):1049-1054.   Published online November 30, 1983
We have studied the hemoglobin level and. leukocyte count of 23 fullterm and 1 premature jaundiced babies soon after exchange transfusion and daily thereafter until 7 days. The resixlts are: 1) One exchange transfusion was enough in 16 patients but 8 were required more than 2times of exchange transfusion. The maximum is 6 times. 2) The postnatal age was...