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Case Report
Two cases of female hydrocele of the canal of nuck
Yu Mi Choi, Gyu Min Lee, Jung Bin Yi, Kyung Lim Yoon, Kye Shik Shim, Chong Woo Bae, Sung Il Choi, Hyun Cheol Kim
Clin Exp Pediatr. 2012;55(4):143-146.   Published online April 30, 2012

The processus vaginalis within the inguinal canal forms the canal of Nuck, which is a homolog of the processus vaginalis in women. Incomplete obliteration of the processus vaginalis causes indirect inguinal hernia or hydrocele of the canal of Nuck, a very rare condition in women. Here, we report 2 cases of hydrocele of the canal of Nuck that were diagnosed...

A case of partial trisomy 3p syndrome with rare clinical manifestations
Dong Hoon Han, Ji Young Chang, Woo In Lee, Chong Woo Bae
Clin Exp Pediatr. 2012;55(3):107-110.   Published online March 16, 2012

Partial trisomy 3p results from either unbalanced translocation or de novo duplication. Common clinical features consist of dysmorphic facial features, congenital heart defects, psychomotor and mental retardation, abnormal muscle tone, and hypoplastic genitalia. In this paper, we report a case of partial trisomy 3p with rare clinical manifestations. A full-term, female newborn was transferred to our clinic. She had cleft...

Original Article
Impact factor of Korean Journal of Pediatrics on Korean Medical Citation Index and Science Citation Index of Web of Science
Chong Woo Bae, Sun Hee Choi, Man Yong Han, Yeong Ho Rha, Young Jin Lee
Clin Exp Pediatr. 2011;54(4):152-156.   Published online April 30, 2011
Purpose

The total number of times a paper is cited, also known as the impact factor (IF) of a medical journal, is widely implied in evaluating the quality of a research paper. We evaluated the citation index data as an IF of Korean J Pediatr in Korean Medical Citation Index (KoMCI) and JCI of Web of Science.

Methods

We calculated the IF of...

Complete rooming-in care of newborn infants
Yoo Min Lee, Kang Hoon Song, Young Mi Kim, Jin Sun Kang, Ji Young Chang, Hyun Joo Seol, Yong Sung Choi, Chong Woo Bae
Clin Exp Pediatr. 2010;53(5):634-638.   Published online May 31, 2010
Purpose

In Kyung Hee East-West Neo Medical Center, Seoul, Korea, efforts to raise rooming-in care success rate have been undertaken since when the hospital was established in 2006. We intended to analyze our experience over the past 3 years of period and to discuss the advantages of rooming-in.

Methods

We analyzed the rooming-in practice rate, failure rate, and the breast feeding rate. Subjects...

The factors associated with the efficacy of indomethacin treatment in premature infants with patent ductus arteriosus
Min Jeong Yoon, Hye Sun Yoon, Sung Hoon Chung, Mi Young Han, Chong Woo Bae
Clin Exp Pediatr. 2007;50(6):531-535.   Published online June 15, 2007
Purpose : Indomethacin treatment is successful in about 90% of patent ductus arteriosus (PDA) in premature infants, but in some, repeated administration or surgical closure is required. The object of the present study is to determine the factors affecting the efficacy of indomethacin treatment and to predict the treatment result. Method : The 29 preterm neonates, admitted to neonatal intensive...
Clinical characteristics and risk factors for staphylococcal infections in neonatal intensive care unit
Min Kook Chung, Jeong Ho Choi, Jin Keun Chang, Sung Hoon Chung, Chong Woo Bae, Sung Ho Cha
Clin Exp Pediatr. 2006;49(12):1287-1295.   Published online December 15, 2006
Purpose : The importance of staphylococcal infections in NICU has been emphasized in terms of increased resistant strains and increased incidence of morbidity and mortality. In this study, we inrestignted the clinical characteristics and risk factors for staphylococcal infections, and looked into sensitivity trends of antibiotics in the era of a high rate of methicillin-resistant staphylococcus aureus (MRSA) in our...
Comparison of Clinical Progress between Single- and Multiple-dose Surfactant Treatment in Neonatal Respiratory Distress Syndrome
Chang Hee Kil, Ho Sang Jeon, Chong Woo Bae
Clin Exp Pediatr. 2005;48(10):1090-1095.   Published online October 15, 2005
Purpose : In the case of serious respiratory distress syndrome(RDS) or relapse of clinical appearances after single treatment, we obtained more effective results with multiple-dose surfactant replacement therapy. We carried out this investigation for comparing and observing clinical progress between single-dose(group S) and multiple-dose(group M) pulmonary surfactant treatment group of neonatal RDS. Methods : We investigated 48 neonates who were...
Human Surfactant Protein-A(SP-A) Gene Locus Associated with Mycoplasma pneumoniae Pneumonia in Korean Children
Seung Soo Kim, In Kyu Lee, Jung Ho Ko, Myung Ho Oh, Chong Woo Bae
Clin Exp Pediatr. 2005;48(4):376-379.   Published online April 15, 2005
Purpose : Mycoplasama pneumoniae is a leading cause of pneumonia and exacerbates other respiratory conditions such as asthma. Surfactant protein A(SP-A) is involved in surfactant physiology and surfactant structure, and plays a major role in innate host defense and inflammatory processes in the lung. In this study, SP-A mediated mycoplasma cidal activity. The candidate-gene approach was used to study the...
Association between the Human Surfactant Protein-A(SP-A) Gene Locus and Respiratory Distress Syndrome in Korean Neonates
Jae Hoon Choe, Myung Ho Oh, Jung Ho Ko, Sun Young Kim, In Kyu Lee, Chong Woo Bae
Clin Exp Pediatr. 2004;47(7):735-739.   Published online July 15, 2004
Purpose : Respiratory distress syndrome(RDS) is caused by a deficiency of pulmonary surfactant, which is a lipoprotein complex. Both low levels of surfactant protein A(SP-A) and SP-A alleles have been associated with RDS. However, the genes underlying susceptibility to RDS are insufficiently known. The candidate-gene approach was used to study the association between the SP-A gene locus and RDS in...
The Effect of Post-natal Weight Changes on the Development of Bronchopulmonary Dysplasia in Infants with Respiratory Distress Syndrome
Hye One Jhon, Young Min Kim, Hee Joo Hong, Chong Woo Bae
Clin Exp Pediatr. 2004;47(3):269-274.   Published online March 15, 2004
Purpose : The subjects were compared and measured for differences in the aspects of weight changes between the groups that developed bronchopulmonary dysplasia(BPD) after treatment and those that did not, to analyze the relations between the patterns of early weight change after birth and the development of BPD. Methods : Retrospective analysis of medical records were performed for birth weight and...
Allele Distribution and Frequency of Human Surfactant Protein-A2 in Korean Neonates
Nyeon Cheon Kim, Hee Chul Yoon, Jung Su Suk, Jung Ho Ko, Ook Joon Yoo, In Kyu Lee, Myung Ho Oh, Chong Woo Bae
Clin Exp Pediatr. 2003;46(4):340-344.   Published online April 15, 2003
Purpose : We evaluated allele frequencies and distribution of surfactant protein A2(SP-A2) in Korean neonates in order to estimate the prevalence of RDS, to find out new SP-A alleles, and to establish new steroid therapy. Methods : Genomic DNA was extracted from 71 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations...
Differential Response of Surfactant Protein-A Genetic Variants to Dexamethasone Treatment
Eul Soon Kim, In Kyu Lee, Myung Ho Oh, Chong Woo Bae
Clin Exp Pediatr. 2003;46(4):335-339.   Published online April 15, 2003
Purpose : Surfactant protein A(SP-A) is involved in surfactant physiology and structure, and plays a major role in innate host defense and inflammatory processes in the lung. Steroid therapy is widely used for mothers who threaten to deliver prematurely and also used commonly in the management of preterm infants with chronic lung disease. Two SP-A genes(SP-A1, SP-A2) and several alleles...
Case Report
A Case of Neonatal Tetanus Cured with Neuromuscular Blocking Agent and Ventilatory Support
Hyeon Joo Lee, Ji Young Jeong, Sa Jun Jung, Yong Mook Choi, Chong Woo Bae
Clin Exp Pediatr. 2003;46(2):192-194.   Published online February 15, 2003
A neonate born at 38 gestational weeks was admitted due to generalized tonic-clonic seizure and cyanosis. The neonate was born six days previously at home through normal delivery and the umbilical cord was cut using scissors sterilized in boiling water. The neonate weighed 3,180 g at admission. Physical examination revealed cyanosis, opisthotonus, trismus and reactive muscle spasms. Laboratory exam, brain...
Original Article
Allele Distribution and Frequency of Human Surfactant Protein-A1 in Korean Neonates
Kyung Shin Lee, Young Hee Kim, Jung Su Suk, Jung Ho Ko, Ook Joon Yoo, In Kyu Lee, Myung Ho Oh, Chong Woo Bae
Clin Exp Pediatr. 2002;45(12):1497-1502.   Published online December 15, 2002
Purpose : We evaluated allele frequencies and distribution of surfactant protein A1(SP-A1) in Korean neonates in order to estimate prevalence of RDS to find out new SP-A alleles, and to establish new steroid therapy. Methods : Genomic DNA was extracted from 100 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations were...
Post-natal Outcome of Fetal Hydronephrosis Detected with Prenatal Ultrasonography
Youn Jin Park, Soon Jung Mun, Chong Woo Bae, Bum Ha Lee, Jin Il Kim
Clin Exp Pediatr. 2002;45(10):1213-1218.   Published online October 15, 2002
Purpose : Hydronephrosis constitutes a great portion of fetal anomalies screened by prenatal sonogram. The present authors made an attempt to access its natural courses through follow up neonatal hydronephrosis diagnosed by prenatal sonogram. Methods : The study was composed of 23 neonates(36 renal units) who were diagnosed with hydronephrosis through prenatal sonogram screening and confirmed 3-7 days after birth with sonographic evaluation at Kyung...
Comparison of Diagnostic and Therapeutic Efficacy between Ultrasound Guided Hydrostatic Saline Reduction and Fluoroscopic Barium Reduction in Children with Intussusception
Chi Hyung Park, Ho Seok Lee, Chong Woo Bae, Sa Jun Chung, Young Mook Choi, Sun Wha Lee, Yup Yun
Clin Exp Pediatr. 1995;38(12):1664-1670.   Published online December 15, 1995
Purpose : Several studies recently have emphasized the value of sonography as an new therapeutic method for hydrostatic reduction of intussusception by using a saline enema under ultrasound guidance. The purpose of this study was to asses the diagnostic screening efficacy of sonography in suspected childhood intussusception and the value of ultrasound guidance in hydrostatic reduction performed with saline enema. Methods...
A Study of Relation between Stable Microbubble Rating and Pulmonary Surfactant Concentration in vitro
Seong Yong Jung, Thi Hyung Park, Chong Woo Bae, Chang Il Ahn
Clin Exp Pediatr. 1994;37(8):1048-1054.   Published online August 15, 1994
Respiratory distress syndrome (RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventilatory techniques. After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement produced exellent...
Clinical Study and Availability of Ultrasonography in Hemorrhagic Cystitis
Jin Park, Chi Hyung Park, Chong Woo Bae, Sung Ho Cha, Byoung Soo Cho, Chang Il Ahn, Young Tae Ko, Sun Wha Lee
Clin Exp Pediatr. 1992;35(12):1722-1727.   Published online December 15, 1992
Acute hemorrhagic cystitis characterized by gross hematuria and symptoms of bladder irritation occurs in children as a self-limited disease that must be differentiated from serious renal disease. We analyzed 22 cases of hemorrhagic cystitis which were managed in the Dept. of pediatrics, Kyung Hee university hospital and present the availability of bladder sonography for diagnosis of hemorrhagic cystitis and for follow-up. The...
Hypercalciuria Associated with Nephropathy (diagnosis by renal biopsy)
Hyun Ho Shin, Jae Yoon Kim, Chong Woo Bae, Sung Ho Cho, Byoung Soo Cho, Chang Il Ahn, Young Tae Ko, Moon Ho Yang
Clin Exp Pediatr. 1992;35(11):1509-1513.   Published online November 15, 1992
Idiopathic hypercalciuria is defined as excessive urinary excretion of calcium in normocalcemia without any primary cause. We performed the sono-guided percutaneous renal biopsy for patients of recurrent hematuria, persistent microscopic hematuria, proteinuria and RBC cast to evaluate underlying nephropathy. We could obtained the following results 1) The age at the renal biopsy ranged from 3 years to 14 years. Sex ratio is 1.9:1...
Surfactant replacement therapy in neonatal respiratory distress syndrome.
Chan Ok Park, Boung Yul Lim, Byeong Gie Yeo, Ji Ho Song, Eun Kyung Sohn, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1991;34(9):1211-1222.   Published online September 30, 1991
Respiratory distress syndrome (RDS) in tiny infants remains a major medical challenge as they are less tolerant of supportive care. In 1959, after identification of the pulmonary surfactant (S), S replacement therapy were used to treat RDS. This idea was first successfully tested on RDS infants by Fujiwara, et. al” in 1980. Now the trial and use of S for the treatment in RDS...
Diagnosis and hydrostatic saline reduction of intussusception under ultrasonographic guidance.
Jong Yul Jeon, Jae Yun Kim, Chong Woo Bae, Sung Ho Cha, Chang Il Ahn, Sun Wha Lee, Jae Hoon Lim
Clin Exp Pediatr. 1991;34(6):771-778.   Published online June 30, 1991
Recently, a new technique of reduction for intussusception using saline solution and ultrasonogram instead of barium enema is being used in several centers. In order to evaluate its efficacy, we have conducted the clinical observation in 40 patients with intussusception who were treated by hydrostatic saline reduction under the ultrasonographic guidance in Kyung-Hee University Hospital from June 1989 to July 1990. We have observed...
Accuracy of anorectal manometry in the diagnosis of congenital megacolon.
Jong Yul Jeon, Byeong Gie Yeo, Chong Woo Bae, Yong Mook Choi, Chang Il Ahn, Young Woon Chang
Clin Exp Pediatr. 1991;34(5):614-620.   Published online May 31, 1991
Thirty-seven patients with clinical impression of congenital megacolon were studied with anorectal manometry for the evaluation of its diagnostic accuracy. Including 12 neonates, their age ranged form 3 days to 8 years and barium enema was performed to all of them except one. The results of rectosphincteric reflex (RSR) of anorectal manometry was compared with the final diagnosis, which was obtained by clinical course,...
A clinical study on the idiopathic respiratory distress syndrome of the newborn: comparison of radiographic and clinical findings.
Byoung Yul Lim, Chong Woo Bae, Yong Mook Choi, Chang Il Ahn, Sun Wha Lee
Clin Exp Pediatr. 1991;34(1):16-23.   Published online January 31, 1991
Idiopathic respiratory distress syndrome (IRDS) of the newborn remains an important and signifi- cant cause of morbidity and mortality despite of improvement in neonatal care. The clinical and radiologic features observed are the results of surfactant deficiency combined with a highly compliant chest wall. We have been applied the clinical and radiologic features in the diagnosis of IRDS. In 1974, Bomsel et al reported the...
Changes in Auditory Brainstem Reponses (ABR) in Severe Hyperbilirubinemic Neonates with Transient Bilirubin Encephalopathy.
Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1990;33(9):1216-1222.   Published online September 30, 1990
Many authors have reported alterations in the ABR in severe hyperbilirubinemia and ABR is an effective non-invasive method of assessing the functional status of the auditory nerve and brainstem sensory pathway in the management of neonatal hyperbilirubinemia. Perlman et al reported that jaundice in the early neonatal period is associated with significant transient aberration of ABR, suggestive of a transient bilirubin encephalopathy (TBE). And...
A Case of (21q 21q) Translocation Down Syndrome Inherited from a t(21q 21q) Balanced Carrier Mother.
Byeong Gie Yeo, Chong Woo Bae, Yong Mook Choi, Chang Il Ahn, Bo Hoon Oh
Clin Exp Pediatr. 1990;33(7):1004-1008.   Published online July 31, 1990
Vast majority of t(21q 21q) Down syndrome occur de novo and familial cases are extremely rare. In familial translocation Down syndrome, One of the parent show 45 chromosomes. In general, the carrier parent carrying (21q 21q) translocation is phenotypically normal because significant amount of genetic material has not been lost in the translocation process. Homologous Robertsonian translocation can be produced either by abnormal gametogenesis...
Change of Auditory Brainstem Response(ABR) on Neonatal Asphyxia.
Jeong Sam Jeon, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1989;32(10):1391-1396.   Published online October 31, 1989
Neonatal asphyxia is insult to the newborn due to lack of oxygen or perfusion to various organs. It is associated with tissue hypoxia, especially brain. So hypoxic-ischemic brain injury is the most important complication known as hypoxic-ischemic encephalopathy. The EEG as well as various evoked potentials (auditory, visual and somatosensory) may assist in evaluating the severity of the damage. This study was undertaken to...
The Effect of Oxytocin in Induced Labour on Neonatal Jaundice.
Seung Koog Kim, Chong Woo Bae, Young Mook Choi, Chang Il Ahn
Clin Exp Pediatr. 1989;32(10):1337-1344.   Published online October 31, 1989
This study was undertaken to evaluate the relationship between oxytocin which was administered to pregnant women during delivery or pregnancy and hyperbilirubinemia of newborn. Among new- borns who were delivered in KHUH from Feb. 1987 to Sep. 1987 and showed hyperbilirubinemia whithin 1 week after birth without definite etiologies of hyperbilirubinemia of newborn, 30 newborns delivered by induced labour and 30 newborns delivered by...
Two Case of Transient Bilirubin Encephalopathy in Newborn.
Eun Kyoung Sohn, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1989;32(9):1295-1299.   Published online September 30, 1989
More recently, several studies have been repotted about the abnormalities of auditory brainstem response (ABR) in hyperbilirubinemia of newborn. By using of ABR, visual evoked potenital and nuclear magnetic resonance techniques, some investigators suggested that transient alteration in ABR in severely jaundiced neonates indicated reversible transient subclinical or clinical bilirubin induced neurotoxicity. They thought it would be the early stage of kernicterus. We experienced two...
A Study of Milk β-Glucuronidase Activity in Breast Milk Associating with Neonatal Jaundice.
Soo Chun Kim, Chong Woo Bae, Yong Mook Choi, Chang Il Ahn
Clin Exp Pediatr. 1989;32(9):1202-1209.   Published online September 30, 1989
Since the 1960s, several reports have been presented to explain how the ingestion of human milk is related to neonatal jaundice. Recently, the jaundiced neonates whose mother’s milk contain sub- stances (eg, pregnane 3a, 20β-diol, lipoprotein lipase, free fatty acid, β-glucuronidase etc) facilitating the reabsorption of unconjugated bilirubin in the neonatal intestine through the enhancement of the enterohepatic circulation, were called the breast milk...
Hypertrophic Cardiomyopathy in Infant of Diabetic Mother.
Jeong Sam Jeon, Soo Chun Kim, Chong Woo Bae, Sung Ho Cha, Chang Il Ahn
Clin Exp Pediatr. 1989;32(8):1138-1143.   Published online August 31, 1989
Generally, infant of diabetic mother (IDM) have complex multisystems disease resulting in a high incidence of perinatal morbidity and mortality. Hypertrophic cardiomyopathy (HCM)-IDM appears as the early onset, transient and non-familial cariomyopathy in neonatal period. The etiology of the left ventricular outflow obstruction in these neonates is not clear. But, it is possible that the asymmetrical septal hypertrophy was a manifestation of the generalized...