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Case Report
Infection
Scabies mimicking graft versus host disease in a hematopoietic cell transplant recipient
Dongsub Kim, Soo-Han Choi, Dong Youn Lee, Juyoun Kim, Eunjoo Cho, Keon Hee Yoo, Hong Hoe Koo, Yae-Jean Kim
Clin Exp Pediatr. 2018;61(11):371-373.   Published online November 9, 2018
Scabies is a highly contagious skin infestation caused by the mite, Sarcoptes scabiei var. hominis. Complex responses to scabies mites in the innate, humoral, and cellular immune systems can cause skin inflammation and pruritus. Diagnosis can be challenging because scabies resembles other common skin conditions. We report the first Korean case of scabies in a hematopoietic cell transplant (HCT) recipient,...
Original Article
Oncology
Excellent treatment outcomes in children younger than 18 months with stage 4 MYCN nonamplified neuroblastoma
Chiwoo Kim, Young Bae Choi, Ji Won Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
Clin Exp Pediatr. 2018;61(2):53-58.   Published online February 28, 2018
Purpose

Although the prognosis is generally good in patients with intermediate-risk neuroblastoma, no consensus has been reached on the ideal treatment regimen. This study analyzed treatment outcomes and toxicities in patients younger than 18 months with stage 4 MYCN nonamplified neuroblastoma.

Methods

We retrospectively analyzed 20 patients younger than 18 months newly diagnosed with stage 4 MYCN nonamplified neuroblastoma between January 2009 and...

Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapy
Jinsup Kim, Na Hee Lee, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Jeong-Meen Seo, Suk-Koo Lee
Clin Exp Pediatr. 2015;58(10):386-391.   Published online October 21, 2015
Purpose

To evaluate the outcomes and prognostic factors in children with extracranial germ cell tumors (GCTs) treated at a single institution.

Methods

Sixty-six children diagnosed with extracranial GCTs between 1996 and 2012 were included in the study. Primary treatment was surgical excision, followed by six cycles of cisplatin-based chemotherapy. The survival rates were compared according to the International Germ Cell Cancer Cooperative Group...

Case Report
A fatal case of acute pulmonary embolism caused by right ventricular masses of acute lymphoblastic lymphoma-leukemia in a 13 year old girl
Yu Mi Ko, Soo Hyun Lee, June Huh, Hong Hoe Koo, Ji Hyuk Yang
Clin Exp Pediatr. 2012;55(7):249-253.   Published online July 17, 2012

We report a case of a 13-year-old girl with acute lymphoblastic lymphoma-leukemia, who presented with a cardiac metastasis in the right ventricle, resulting in a pulmonary embolism. At the time of her leukemia diagnosis, a cardiac mass was incidentally found. The differential diagnosis for this unusual cardiac mass included cardiac tumor, metastasis, vegetation, and thrombus. Empirical treatment was initiated, including...

Review Article
Umbilical cord blood transplantation
Hong Hoe Koo, Hyo Seop Ahn
Clin Exp Pediatr. 2012;55(7):219-223.   Published online July 17, 2012

Since the first umbilical cord blood transplantation (CBT) in 1998, cord blood (CB) has now become one of the most commonly used sources of hematopoietic stem cells for transplantation. CBT has advantages of easy procurement, no risk to donor, low risk of transmitting infections, immediate availability and immune tolerance allowing successful transplantation despite human leukocyte antigen disparity. Several studies have...

Original Article
Successful and safe treatment of hemangioma with oral propranolol in a single institution
Sun Hee Chung, Dong Hyuk Park, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park, Hong Hoe Koo
Clin Exp Pediatr. 2012;55(5):164-170.   Published online May 21, 2012
Purpose

Dramatic improvement of hemangioma to propranolol has been recently reported; however, details on dose and duration of treatment, potential risks, and monitoring have not been determined. The objective of this study is to describe and analyze the use of propranolol as a first-line treatment or as a single therapy in management of complicated hemangioma.

Methods

A retrospective chart review of eight patients...

Hematopoietic stem cell transplantation in children with acute leukemia: similar outcomes in recipients of umbilical cord blood versus marrow or peripheral blood stem cells from related or unrelated donors
Eun Sang Yi, Soo Hyun Lee, Meong Hi Son, Ju Youn Kim, Eun Joo Cho, Su Jin Lim, Hee Won Cheuh, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
Clin Exp Pediatr. 2012;55(3):93-99.   Published online March 16, 2012
Purpose

This study compared outcomes in children with acute leukemia who underwent transplantations with umbilical cord blood (UCB), bone marrow, or peripheral blood stem cells from a human leukocyte antigen (HLA)-matched related donor (MRD) or an unrelated donor (URD).

Methods

This retrospective study included consecutive acute leukemia patients who underwent their first allogeneic hematopoietic stem cell transplantation (HSCT) at Samsung Medical Center between...

The metabolic syndrome and body composition in childhood cancer survivors
Young Bae Sohn, Su Jin Kim, Sung Won Park, Se-Hwa Kim, Sung-Yoon Cho, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Jae Hoon Chung, Hong Hoe Koo, Dong-Kyu Jin
Clin Exp Pediatr. 2011;54(6):253-259.   Published online June 30, 2011
Purpose

Long-term survivors of childhood cancer appear to have an increased risk for the metabolic syndrome, subsequent type 2 diabetes and cardiovascular disease in adulthood compared to healthy children. The purpose of this study was to investigate the frequency of the metabolic syndrome and associated factors in childhood cancer survivors at a single center in Korea.

Methods

We performed a retrospective review of...

Responses and adverse effects of carboplatin-based chemotherapy for pediatric intracranial germ cell tumors
Suntae Ji, Hee Won Chueh, Ju Youn Kim, Su Jin Lim, Eun Joo Cho, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
Clin Exp Pediatr. 2011;54(3):128-132.   Published online March 31, 2011
Purpose

Cisplatin-based chemotherapy has been commonly used for the treatment of intracranial germ cell tumors (IC-GCTs). However, this treatment exhibits some adverse effects such as renal problems and hearing difficulty. Carboplatin-based chemotherapy was administered to pediatric patients with IC-GCTs from August 2004 at the Samsung Medical Center. In this study, we assessed the responses and adverse effects of carboplatin-based chemotherapy in...

Review Article
Philadelphia chromosome-positive acute lymphoblastic leukemia in childhood
Hong Hoe Koo
Clin Exp Pediatr. 2011;54(3):106-110.   Published online March 31, 2011

In pediatric patients with acute lymphoblastic leukemia (ALL), the Philadelphia chromosome translocation is uncommon, with a frequency of less than 5%. However, it is classified as a high or very high risk, and only 20-30% of Philadelphia chromosome-positive (Ph+) children with ALL are cured with chemotherapy alone. Allogeneic hematopoietic stem cell transplantation from a closely matched donor cures 60% of...

Original Article
International travel of Korean children and Dengue fever: A single institutional analysis
Soo Han Choi, Yae Jean Kim, Ji Hun Shin, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
Clin Exp Pediatr. 2010;53(6):701-704.   Published online June 23, 2010
Purpose

Dengue fever occurs in many popular tourist destinations and is increasingly imported by returning travelers in Korea. Since Korea is not an endemic country for dengue fever, pediatricians do not usually suspect dengue fever in febrile children even with typical presentation and exposure history. This study was performed to describe the international travel experiences and dengue fever in Korean children.

Methods

Travel...

Outcome of patients with neuroblastoma aged less than 1 year at diagnosis
Jung Min Suh, Sang Goo Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Ju Youn Kim, Eun Joo Cho, Suk Koo Lee, Jhingook Kim, Do Hoon Lim
Clin Exp Pediatr. 2009;52(1):93-98.   Published online January 15, 2009
Purpose : The purpose of this study was to evaluate the clinical characteristics and outcomes of patients with neuroblastoma aged less than 1 year. Methods : From January 1997 to December 2007, 41 patients aged less than 1 year were diagnosed with neuroblastoma. Patients were divided into 3 risk groups according to the stage of the disease and N-myc amplification. Low-risk...
Review Article
Solid tumors in childhood: risk-based management
Hong Hoe Koo
Clin Exp Pediatr. 2007;50(7):606-612.   Published online July 15, 2007
Since the introduction of chemotherapy for the treatment of childhood leukemia more than 50 years ago, the results of childhood cancer have improved dramatically. The 5-year survival rate of disease, many of which were uniformly fatal in the prechemotherapy era, reached to more than 75%. This remarkable improvement in survival is a direct result of the incorporation of chemotherapeutics into...
Original Article
Factors affecting hematologic recovery and infection in high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk solid tumor
Jung Hyun Lee, Bo Lyun Lee, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hye Lim Jung, Eun Joo Cho, Hong Hoe Koo
Clin Exp Pediatr. 2006;49(10):1079-1085.   Published online October 15, 2006
Purpose : The purpose of this study was to evaluate factors affecting hematologic recovery and infection in high-dose chemotherapy(HDCT) and autologous stem cell transplantation(ASCT) in patients with high-risk solid tumor. Methods : From January 2004 to December 2005, 72 HDCTs and ASCTs were applied to children with high-risk solid tumor at Samsung Medical Center. Medical records of these 72 HDCTs and...
Responses and Toxicities of Risk-adapted Chemotherapy in Pediatric Intracranial Germ Cell Tumors
Dong Kil You, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Do Hoon Lim, Hyung Jin Shin, Hong Hoe Koo
Clin Exp Pediatr. 2005;48(2):186-190.   Published online February 15, 2005
Purpose : The purpose of this study was to evaluate the responses and toxicities of risk-adapted chemotherapy in pediatric intracranial germ cell tumors(IC-GCT). Methods : Fourteen patients who were diagnosed as IC-GCT from October 2002 to December 2003 received chemotherapy as an initial treatment modality. The low risk(LR) group was defined as follows : Pure germinoma and normal AFP level....
Allogeneic Hematopoietic Stem Cell Transplantation in Juvenile Myelomonocytic Leukemia
Keon Hee Yoo, Dong Kil You, Soo Hyun Lee, Ki Woong Sung, Eun Joo Cho, Hong Hoe Koo
Clin Exp Pediatr. 2005;48(2):178-185.   Published online February 15, 2005
Purpose : The purpose of this study was to evaluate the outcome of children with juvenile myelomonocytic leukemia(JMML) treated with allogeneic hematopoietic stem cell transplantation(allo- HSCT). Methods : Eleven JMML patients aged 8-39 months underwent allo-HSCT. The sources of grafts were unrelated donors(n=7), HLA-matched siblings(n=3) and an HLA 1-antigen mismatched familial donor. All patients had received chemotherapy ?13-cis-retinoic acid(CRA) before...
Case Report
A Therapeutic Experience of Congenital Bilateral Neuroblastoma
Yeon Kyong Seo, Heung Sik Kim, Kun Young Kwon, Hee Jung Lee, Hong Hoe Koo
Clin Exp Pediatr. 2003;46(12):1279-1282.   Published online December 15, 2003
Neuroblastoma is the most common intraabdominal malignant tumor of childhood, with 40% arising from the adrenal gland. Bilateral adrenal involvement from synchronous development or metastatic spread of tumor is rarely seen in children with neuroblastoma. The patient was born with a spontaneous vaginal delivery. Birth weight was 3,200 g. Fetal ultrasonography showed a left adrenal cystic mass. At two weeks...
Original Article
The Role of Neoadjuvant Chemotherapy for Advanced Stage Wilms Tumor
Chang Kyu Kang, Kwang Bin Moon, Keon Hee Yoo, Hong Hoe Koo, Hye Kyung Yoon, Kwan Hyun Park
Clin Exp Pediatr. 2002;45(12):1534-1539.   Published online December 15, 2002
Purpose : This study was designed to exclude radiation in advanced(stage 3, 4) Wilms tumor (WT) by increasing the chance of complete surgical removal with preceding neoadjuvant chemotherapy, thereby reducing the incidence of late effects. Methods : Between December 1998 and July 2002, we conducted neoadjuvant chemotherapy after needle aspiration biopsy on patients who had advanced WT. If needle...
Central Diabetes Insipidus in Children Related to Craniotomy for a Brain Tumor
Seung Mi Song, Eun Jung Park, Jung Sim Kim, Hong Hoe Koo, Mun Hyang Lee, Hyung Jin Shin, Dong Kyu Jin
Clin Exp Pediatr. 1999;42(12):1702-1710.   Published online December 15, 1999
Purpose : Diabetes insipidus(DI) has been known to be a relatively common complication after craniotomy. We have investigated the incidence and clinical course of DI in children related to craniotomy for a brain tumor and determined the risk factors of postoperative DI. Methods : Sixty-two pediatric patients, who have undergone craniotomy for a brain tumor(including stereotactic biopsy) from February 1995 through...
Case Report
Mucoepidermoid Carcinoma of the Bronchus in A 9-year-old Child
Jin Ah Son, Hong Hoe Koo, Sang Il Lee, Jhingook Kim
Clin Exp Pediatr. 1998;41(6):837-840.   Published online June 15, 1998
The appearance of mucoepidermoid carcinoma of the lung during in childhood is an uncommon neoplasm. Symptoms of progressive bronchial obstruction proceed the recognition of this lesion. Adequate surgical resection precludes the need for further radiation therapy or chemotherapy. The patient underwent bronchoscopy to investigate the cause of chronic coughing, which revealed a tumor. Histological examination confirmed the diagnosis of mucoepidermoid...
Original Article
Results of Chemotherapy of Hepatoblastoma and Hepatocellular Carcinoma in Children
Kyung Duk Park, Gi Woong Seong, Jae Kyung Lee, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1995;38(2):195-206.   Published online February 15, 1995
Purpose : Surgical excision has been the primary treatment for hepatoblastoma and hepatocellular carcinoma. However, at presentation, only one third of such tumors are surgically resectable. Without operation, the disease is fatal. Therefore, neoadjuvant chemotherapy has been introduced for conversion of the unresectable tumors into the resectable ones. We studied th e effects of chemotherapy for hepatic malignancy in children. Methods...
A Prospective Study of Totally Implanted Venous Access System in 19 Children with Cancer
Kyung Duk Park, Eun Sil Dong, Seong Hoon Ha, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Seong Eun Jun, Gui Won Park
Clin Exp Pediatr. 1993;36(5):687-692.   Published online May 15, 1993
A totally implanted venous access system was inserted in 19 children with cancer. The devices were utilized for the administration of antineoplastic drug, parenteral fluids, antibiotics, and blood products. Total duration of implantation was 4,046 days for 23 implanted system (range 7-445 days). Complications included cather infection (0.247/100 catheter day), occlusion (0.692/100 catheter days), and dislodgement of needle (0.643/100 catheter...
Acute Megakaryoblastic Leukemia in Children
Hong Hoe Koo, Sang Kyu Park, Eun Sil Dong, Hye Jung Park, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1993;36(1):9-16.   Published online January 15, 1993
We analyzed the clinical and laboratory features of ten children with acute megakaryoblastic leukemia (M7) and compared the findings with those reported in the literature. The diagnosis was supported by ultrastructural examination of platelet peroxidase or immunophenotyping for glycoprotein Iib/IIIa. Of the ten children, five were girls and five were boys. The median age at diagnosis was 13 months. Two...
Carcinomas in Childhood -A 10-Year Experience in Seoul National University Hospital-
Hong Hoe Koo, Kyung Duk Park, Hye Lim Jung, Sang Kyu Park, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1992;35(10):1369-1376.   Published online October 15, 1992
Carcinomas in childhood differ from those in adults in their frequency, histologic type, and distribution of primary sites. In children, carcinomas are rare and few series have been published containing sufficient mumbers of cases to permit a reliable account of the incidence and survival of children with carcinoma. During a 10-year period, 1982-1991, we observed 40 patients less than 16...
Case Report
Three Cases of Brain Tumors with Bone Metastasis
Eun Joo Kim, Kyung Duk Park, Eun Sil Dong, Hye Jung Park, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Je Geun Chi
Clin Exp Pediatr. 1992;35(3):381-389.   Published online March 15, 1992
Medulloblastoma and primitive neuroectodermal tumor(PNET) are relatively common intracranial neoplasms in childhood. Their extracranial metastasis were thought to be rare occurrences. But they are more frequent compared to other intracranial tumors. The most frequent site of metastasis deposits in medulloblastoma is bone, and metastasis to lymph node, peritoneum, liver or lung have been reported infrequently. The authors experienced three cases...
Original Article
Clinical Considerations of the Mediastinal Tumors in Children
Eun Joo Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1992;35(1):98-107.   Published online January 15, 1992
Mediastinal tumors of children constitute a heterogeneous group of malignant and benign neoplasms because they originated from a variety of structures. But they show some characteristics in type of tumor according to location, relative frequency of masses, clinical manifestations. Management and long-term reusult. We observed 82 patients less than 16 years of age who were evaluated and treated for a...
Incidence Estimation of Leukemia among Korean Children
Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Yoon-Ok Ahn
Clin Exp Pediatr. 1992;35(1):80-87.   Published online January 15, 1992
Leukemia is a neoplasm arising from the malignant transformation of hematopoietic cells. The incidence data of leukemia have not been available for Korean as a whole. The present study was therefore undertaken in order to estimate the incidence of childhood leukemia among Korean. The study population of this investigation was the beneficiaries of the Korea Medical Insurance Corporation(KMIC) during the period...
A case of bone marrow necrosis in acute lymphoblastic leukemia.
Mee Ran Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(8):1163-1168.   Published online August 31, 1991
Bone marrow necrosis is a rare complication most commonly encountered in patients with leuke- mia, metastatic tumor in marrow, sickle cell disease, DIC and severe infections. Recently it is regarded as a more common finding frequently overlooked and carrying not so poor prognosis. We reported here a boy with ALL who showed marrow necrosis on biopsy at the time of diagnosis and achieved complete...
A case of acute lymphoblastic leukemia complicating neuroblastoma in remission.
Dong Woo Son, Bum Soo Park, Jun Jae Kim, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(5):720-729.   Published online May 31, 1991
As childhood cancer survivors are now increasing in number owing to the improvements in diagnosis, staging, and treatment, concerns have been raised regarding the quality of survival of these patients. One of the limitation to quality and length of survival has been the development of second malignant neoplasm (SMN). In Korea, only one case of SMN has been reported. However, one can expect that...
Malignant Schwannomas in children.
Joon Jai Kim, Dong Joo Shin, Dong Won Son, Hong Hoe Koo, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(4):525-531.   Published online April 30, 1991
Six pediatric patients who were diagnosed as malignant Schwannoma and treated at Seoul National University Children’s Hospital from Aug. 1981 to Jun. 1990 were reviewed. Mean age was 11 years and 1 month and all cases except one were over 10 years old. Of six cases, three (50%) were associated with von Recklinghausen’s disease. Overall male to female ratio was 1 : 2. In...
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