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Review Article
Food allergy
Youngshin Han, Jihyun Kim, Kangmo Ahn
Clin Exp Pediatr. 2012;55(5):153-158.   Published online May 21, 2012

Food allergy is an important public health problem affecting 5% of infants and children in Korea. Food allergy is defined as an immune response triggered by food proteins. Food allergy is highly associated with atopic dermatitis and is one of the most common triggers of potentially fatal anaphylaxis in the community. Sensitization to food allergens can occur in the gastrointestinal...

Nutritional approach to failure to thrive
Su Jin Jeong
Clin Exp Pediatr. 2011;54(7):277-281.   Published online July 31, 2011

Failure to thrive (FTT) is a term generally used to describe an infant or child whose current weight or rate of weight gains is significantly below that expected of similar children of the same age, sex and ethnicity. It usually describes infants in whom linear growth and head circumference are either not affected, or are affected to a lesser degree...

Case Report
Misdiagnosis of fetus-in-fetu as meconium peritonitis
Yoon Joo Kim, Se Hyung Sohn, Ju Young Lee, Jin A Sohn, Eun Hee Lee, Ee Kyung Kim, Chang Won Choi, Han Suk Kim, Beyong Il Kim, Jung Hwan Choi
Clin Exp Pediatr. 2011;54(3):133-136.   Published online March 31, 2011

Fetus-in-fetu (FIF) is a rare congenital condition in which a fetiform mass is detected in the host abdomen and also in other sites such as the intracranium, thorax, head, and neck. This condition has been rarely reported in the literature. Herein, we report the case of a fetus presenting with abdominal cystic mass and ascites and prenatally diagnosed as meconium...

Review Article
Renal fibrosis
Min Hyun Cho
Clin Exp Pediatr. 2010;53(7):735-740.   Published online July 31, 2010

Renal fibrosis, characterized by tubulointerstitial fibrosis and glomerulosclerosis, is the final manifestation of chronic kidney disease. Renal fibrosis is characterized by an excessive accumulation and deposition of extracellular matrix components. This pathologic result usually originates from both underlying complicated cellular activities such as epithelial-to-mesenchymal transition, fibroblast activation, monocyte/macrophage infiltration, and cellular apoptosis and the activation of signaling molecules such as...

Original Article
Apoptosis and upregulation of TNF-α and TRAIL receptor 1 (DR4) in the pathogenesis of food protein-induced enterocolitis syndrome
Jin-Bok Hwang, Sang Pyo Kim, Yu Na Kang, Seong-Ryong Lee, Seong-Il Suh, Taeg Kyu Kwon
Clin Exp Pediatr. 2010;53(4):525-531.   Published online April 15, 2010
Purpose : Expression levels of tumor necrosis factor (TNF)-α expression on the mucosa of the small intestine is increased in patients with villous atrophy in food protein-induced enterocolitis syndrome (FPIES). TNF-α has been reported to induce apoptotic cell death in the epithelial cells. We studied the TNF family and TNF-receptor family apoptosis on the duodenal mucosa to investigate their roles in the pathogenesis...
Relationship between iron deficiency anemia and febrile convulsion in infants
Youn Soo Jun, Ho Il Bang, Seung Taek Yu, Sae Ron Shin, Du Young Choi
Clin Exp Pediatr. 2010;53(3):392-396.   Published online March 15, 2010
Purpose : The association between iron deficiency anemia and febrile convulsion in infants has been examined in several studies with conflicting results. Therefore, the authors aimed to evaluate the precise relationship involved. Methods : In this case-control study, the authors assessed 100 children with a diagnosis of febrile convulsion, aged between 9 months and 2 years, during January 2007 to...
Case Report
Two cases of Fabry disease identified in brothers
Ji Eun Cho, Yong Hee Hong, Yang Gyun Lee, Han Wook Yoo, Dong Hwan Lee
Clin Exp Pediatr. 2010;53(2):235-238.   Published online February 15, 2010
Fabry disease is a rare, X-linked inborn error of glycosphingolipid catabolism caused by a mutation in the gene encoding the α-galactosidase A (GLA) enzyme. We report two cases of Fabry disease in a 12-year-old boy who had acroparesthesia and in his elder brother with milder symptoms who were diagnosed by GLA activity assays and the presence of the GLA gene...
Two adolescent cases of Fitz-Hugh-Curtis syndrome
Ji Hye Kim, Sung Hee Oh
Clin Exp Pediatr. 2009;52(9):1038-1043.   Published online September 15, 2009
Two adolescent cases of Fitz-Hugh-Curtis syndrome, which has not been previously reported in Korean girls, presenting with right upper-quadrant abdominal pain, nausea, vomiting, and fever are reported here. A careful and thorough inquiry into the sexual history of the first patient, which was not done upon admission, led to a careful reassessment of the dynamic abdominal computed tomography scan revealing...
Original Article
Predictive factors for severe infection among febrile infants younger than three months of age
Eun Young Cho, Hwa Song, Ae Suk Kim, Sun Ju Lee, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Kwan Lee, Byoung Chan Park
Clin Exp Pediatr. 2009;52(8):898-903.   Published online August 15, 2009

Purpose:This study investigated the predictive factors for identifying infection-prone febrile infants younger than three months. Methods:We conducted a retrospective study of 167 infants younger than three months with an axillary temperature >38℃ who were hospitalized between 2006 and 2008. If they met any of the following criteria, positive blood culture, CSF WBC ≥ 11/mm3 or positive CSF culture, urinalysis WBC ≥6/HPF and positive...
Case Report
Facial palsy as the presenting symptom of acute myeloid leukemia in children: Three cases with stem cell transplantatio
Hee Jo Baek, Dong Kyun Han, Young Ok Kim, Ic Sun Choi, Tai Ju Hwang, Hoon Kook
Clin Exp Pediatr. 2009;52(6):713-716.   Published online June 15, 2009
Facial palsy as the presenting symptom of leukemia is very rare, especially in acute myeloid leukemia. A review of the medical literature identified reports on 8 children with AML who had facial paralysis as the presenting sign. Whole brain irradiation (WBI) has been applied in most cases. We present the cases of 3 such children. Achieving a remission without WBI,...
Familial systemic lupus erythematosus in two Korean male siblings
Hyun Sik Kang, Hyun Ju Oh, Young Ree Kim, Jae-Wang Kim, Kyung-Sue Shin
Clin Exp Pediatr. 2009;52(5):611-614.   Published online May 15, 2009
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of a wide range of autoantibodies, resulting in tissue damage. Although the susceptibility to SLE has been attributed to complex interactions between genetic and environmental factors, the influence of a genetic predisposition to SLE is supported by observations of familial aggregations. Family studies have found that siblings...
Review Article
Diagnosis and therapy for functional urinary incontinence in childhood
Ju Hyung Kang
Clin Exp Pediatr. 2008;51(11):1147-1151.   Published online November 15, 2008
Functional urinary incontinence, the absence of any neurologic or structural abnormality as a cause of urinary incontinence in children, is one of the most common clinical problems encountered in pediatric and urologic departments, and it can be socially and emotionally distressing for the affected children. The prevalence rates of functional urinary incontinence in school-aged children are not very high and...
The use of fluoroquinolone in children
Jae Kyun Hur
Clin Exp Pediatr. 2008;51(10):1042-1046.   Published online October 15, 2008
The fluoroquinolones are an important group of antibiotics widely used in the treatment of various infectious diseases in adults, as a result of an excellent spectrum of activity, good tissue penetration and convenient ways of administration. In recent decades, there has been extensive development, clinical investigation, licensure and use of fluoroquinolone antibiotics. However, the use of fluoroquinolones in children has...
Original Article
Analysis on the association between EEG and 2-deoxy-2-[18F]-D-glucose (FDG)-PET findings in children with epilepsy
Yun Jung Hur, Joon Soo Lee, Jong Doo Lee, Heung Dong Kim
Clin Exp Pediatr. 2008;51(3):286-292.   Published online March 15, 2008
Purpose : We performed EEG and PET on children with epilepsy concomitantly in order to evaluate the effects of epileptiform and non-epileptiform discharge of EEG on glucose metabolism. Methods : Seventy three children with epilepsy who had PET and EEG simultaneously were included in our study. The subjects were classified in two ways: (1) based on the frequency of epileptiform...
Serum levels of free insulin-like growth factor-I and clinical value in healthy children
Young Hee Chung, Woo Yeong Chung
Clin Exp Pediatr. 2008;51(1):47-53.   Published online January 15, 2008
Purpose : The serum levels of total insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)- 3 reflect endogenous growth hormone (GH) secretion in healthy children. Free form of IGF-I which is suggested to have more potent biological action than complex form of IGF-I. The aim of this study is to investigate the serum levels of free IGF-I and its...
Case Report
Epidural emphysema and pneumoscrotum caused by bronchial foreign body aspiration
Dong-Yeon Kim, Woo-Yeon Choi, Young-Kuk Cho, Jae-Sook Ma
Clin Exp Pediatr. 2007;50(8):785-788.   Published online August 15, 2007
Epidural emphysema and pneumoscrotum with subcutaneous emphysema are rare in a child past the neonatal period. Their most common causes are bronchial asthma and respiratory infection. Here, we report an 18-month-old boy who was presented with severe air leak, consisting of epidural emphysema, pneumoscrotum, subcutaneous emphysema, and pneumomediastinum, complicated by a bronchial foreign body. The air leak was resolved dramatically...
Bronchial foreign body aspiration diagnosed with MDCT
Hye Kyung Cho, Ky Young Cho, Sung Yoon Cho, Sejung Sohn
Clin Exp Pediatr. 2007;50(8):781-784.   Published online August 15, 2007
Foreign body aspiration (FBA) is a common accident in young children. Undiagnosed and retained foreign bodies may result in severe early and late complications such as asphyxia, pneumonia, atelectasis and bronchiectasis. Moreover, because it can mimic bronchiolitis, croup or asthma, an accurate history and a high index of suspicion are of paramount importance for early diagnosis. With our experience on...
A familial case report of paroxysmal kinesigenic dyskinesia in three brothers
Oh Dae Kwon, Sung Jin Hwang, Jun Hwa Lee, Ji Eun Kim, Kyung Jib Kim, Eul Ju Seo
Clin Exp Pediatr. 2007;50(7):694-697.   Published online July 15, 2007
Paroxysmal kinesigenic dyskinesia (PKD), previously referred to as movement-provoked seizures, is a rare neurological condition that is characterized by short duration dystonic or choreoathetotic movements precipitated by sudden movement, a change in position or hyperventilation. It can be difficult to distinguish this syndrome from seizures. We reported on three brothers in one family all of whom developed abnormal involuntary dystonic...
Original Article
Characteristics of functional gastrointestinal disorders in children with chronic abdominal pain
Ji Hyun Uhm
Clin Exp Pediatr. 2007;50(7):655-659.   Published online July 15, 2007
Purpose : The aim of this study was to document the causes of chronic abdominal pain in children referred to a hospital setting and evaluate the frequency and characteristics of functional gastrointestinal disorder (FGID) classified by Rome III criteria. Methods : One hundred thirty two patients with chronic abdominal pain were evaluated. Examinations were performed in order to find organic...
Fluconazole prophylaxis in high-risk, very low birth weight infants
Soo Young Kim, Soon Joo Lee, Mi Jeong Kim, Eun Song Song, Young Youn Choi
Clin Exp Pediatr. 2007;50(7):636-642.   Published online July 15, 2007
Purpose : Fluconazole prophylaxis for very low birth weight (VLBW) infants has been shown to reduce invasive fungal infection and its mortality. This study aims to evaluate the effect of fluconazole prophylaxis in VLBW infants on the incidence and mortality of fungal infection. Methods : VLBW infants with endotracheal intubation and central vascular access admitted to the Neonatal Intensive Care...
Prenatal diagnosis and clinical course of restrictive foramen ovale in otherwise normal heart
Ji Joung Lee, Min A Lee, Yun ee Rhee, Mea Young Chang, Hong Ryang Kil
Clin Exp Pediatr. 2007;50(3):268-271.   Published online March 15, 2007
Purpose : Premature narrowing of the foramen ovale is rare but serious clinical entity. Prenatal narrowing or obstruction of the foramen ovale shows symptoms such as right heart failure, fetal hydrops, triscupid regurgitation, left heart obstructive disease, and supraventricular tachycardia. This study aimed to assess the prenatal diagnosis and postnatal clinical course of restrictive foramen ovale in utero in otherwise...
Review Article
Fever and rash
Jin Han Kang
Clin Exp Pediatr. 2007;50(2):132-137.   Published online February 15, 2007
Patients with febrile illness and skin rashes need full and immediate attention. In general, these diseases show mild manifestations and good prognosis. However, causalities of some diseases with fever and rash may be life threatening or trivial. So, the differential diagnosis for those patients is extensive. A through history, a careful physical examination and close observation of clinical progress are...
Diagnostic approach to the fever of unknown origin in children - Emphasis on the infectious diseases -
Eun Hwa Choi
Clin Exp Pediatr. 2007;50(2):127-131.   Published online February 15, 2007
Fever of unknown origin (FUO) has been a convenient term used to classify patients who warrant a particular systemic approach to diagnostic evaluation and management. The greatest clinical concern in evaluating FUO is identifying patients whose fever has a serious or life-threatening cause when a delay in diagnosis could jeopardize successful intervention. Thorough history and complete physical examination are critical...
Fever
Taek Jin Lee, Dong Soo Kim
Clin Exp Pediatr. 2007;50(2):121-126.   Published online February 15, 2007
Fever has been recognized as a cardinal feature of disease since antiquity, but only recently has the pathophysiology of fever come to be understood. It became clear that the ultimate cause of fever is not a bacterial product (a so-called exogenous pyrogen) but a product of host inflammatory cells (i.e., an endogenous pyrogen). Many studies have demonstrated that mononuclear phagocytes...
Original Article
Long term prognosis of patients who had a Fontan operation
Hyun-Jung Kim, Eun-Jung Bae, Jung-Il Noh, Jung-Yun Choi, Yong-Su Yun, Wong-Hwan Kim, Jung-Yeul Lee, Yong-Jin Kim
Clin Exp Pediatr. 2007;50(1):40-46.   Published online January 15, 2007
Purpose : This study assessed the long term survival rate and long term complications of patients who had a modified Fontan operation for functionally univentricular cardiac anomaly. Methods : Between June 1986 and December 2000, 302 patients with a functional single ventricle underwent surgical interventions and were followed up until February 2006. The mean follow-up period was 8.3?.3 years (range 3.5-18...
Investigation of causes of FUO (fever of unknown origin) in children
Hyun Seok Park, Sun Ju Im, Su Eun Park
Clin Exp Pediatr. 2006;49(12):1282-1286.   Published online December 15, 2006
Purpose : The causes of prolonged fever have changed during the years and are influenced by age, geographic location and availability of diagnostic facilities/techniques. The aim of the present study was to determine the causes of prolonged fever, to know the proportion and outcomes of undiagnosed children. Methods : We reviewed patients with fever persisting for more than 2 weeks in...
Diagnostic classification and clinical aspects of floppy infants in the neonatal and pediatric intensive care units
Eun Sun Kim, Kyung Eun Jung, Sang Duk Kim, Eo Kyung Kim, Jong Hee Chae, Han Suk Kim, June Dong Park, Ki Joong Kim, Beyong Il Kim, Yong Seung Hwang, Jung-Hwan Choi
Clin Exp Pediatr. 2006;49(11):1158-1166.   Published online November 15, 2006
Purpose : The purpose of this study is to make a diagnostic classification and discuss a diagnostic strategy of floppy infants by investigating clinical, neurological, electrophysiological, and genetic analysis of infants admitted to intensive care units with the complaint of hypotonia. Methods : A retrospective study was performed from Jan. 1993 to Dec. 2005 in neonatal and pediatric intensive care units...
Impact of fetal diagnosis of congenital heart disease on parents
Eun Young Choi, Chang Hoon Lee, Myung Ja Yoon, Eun Sook Han, Joon Suk Hong, Yun Sook Jung, Jung Yun Choi
Clin Exp Pediatr. 2006;49(10):1073-1078.   Published online October 15, 2006
Purpose : This study was performed to assess how a fetal diagnosis of congenital heart disease affects parents, as regards pregnancy management and care of infants after birth. Methods : Database search to find out abnormal fetal echocardiography performed at Seoul National University Children's Hospital from July 1988 to June 2003 revealed 370 examinations. After excluding both arrhythmias without structural cardiac...
Clinical analysis of febrile infants and children presenting to the pediatric emergency department
Byeong Gon Kwak, Hyun Oh Jang
Clin Exp Pediatr. 2006;49(8):839-844.   Published online August 15, 2006
Purpose : We studied clinical patterns of the febrile infants and children presenting to the Pediatric Emergency Department(ED) in the general pediatric population. Method : We analyzed 1,764 infants and children who had a history of measured body temperature of 38.3℃ or higher, before or after arrival at Pediatric ED of Ilsan Paik Hospital from September 2004 to August 2005....
Effect of maternal thyroxine treatment on the offspring's brain development with fetal alcohol effects in the rats
Jin Fu, Yoon Young Chung, Sang Kee Park
Clin Exp Pediatr. 2006;49(6):677-685.   Published online June 15, 2006
Purpose : This study aimed to investigate whether exogenous thyroxine(T4) treatment to alcohol-fed dams would ameliorate the detrimental effects of alcohol on the postnatal development of neuropeptide-Y(NPY)-containing neurons of the cerebral cortex and hippocampus of the offspring. Methods : Time-pregnant rats were divided into three groups. An alcohol-fed group A received 35 calories of liquid alcohol diet daily from gestation day...


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