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Original Article
Prevalence of Diabetes Mellitus and Glycosuria in School children
Jae Ho Lee, Kwang Wook Ko
Clin Exp Pediatr. 1994;37(7):986-993.   Published online July 15, 1994
An epidemiological survey on the glycosuria was conducted on the senier students of middle and hign school in Seoul, from March 1981 to March 1982. Selected examinee totalled to 254,835 of which 138,116 were male & 116,719 were female. The initial, second and third urine sugar test were done with Combur-test strip? Glucose tolerance test was performed on those who...
Nephrotic Syndrome under 2 Years of Age
Jae Sung Ko, Kang Mo Ahn, Hye Won Park, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1993;36(10):1395-1401.   Published online October 15, 1993
There had been total 20 patients with early onset (4 months~2 years) primary nephrotic syndrome in the Deparment of Pediatrics, Seoul National University Children's Hospital, during the period from March 1987 to February 1993. We analysed clinical courses, response to treatment, pathological findings and prognosis of the patients And the results were as follows; 1) The initial responders to steroid treatment...
Acute Renal Failure Following Cardiac Surgery
Kang Yong Park, Yeon Ho Choi, Tae Sun Ha, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Joon Ryang Rho
Clin Exp Pediatr. 1992;35(9):1198-1209.   Published online September 15, 1992
A retrospective study of 452 patients who undertook cardiac surgery was performed to determine the pevalence, etiology, and clinical features of postoperative acute renal failure(ARF). The overall incidence of ARF following cardiac surgery was 4.65%(21/452). The incidence of ARF following open heart surgery(OHS) was 5.11%, and that following closed heart surgery was 2.50%. Preoperactive risk factors noted in the development...
Acquired Renal Cystic Disease in Childhood Chronic Renal Failure
Tae Sun Ha, Seong Hoon Ha, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Woo Sun Kim, Kim In One
Clin Exp Pediatr. 1992;35(8):1044-1050.   Published online August 15, 1992
The authors evaluated 19 childrenwith chronic renal failure patients diagnosed and followed up at the Department of Pediatrics, Seoul National University Hospital for the detection of acquired renal cystic disease (ARCD) with two radiologists by the means of ultrasonography. The results were as follows: 1) Of the 19 patients, male to femals ratio was 14:5 and of them, hemodialysis and peritoneal dialysis...
A Clinical Aspect of the Hemolytic Uremic Syndrome
Hye Won Park, Tae Sun Ha, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1992;35(7):909-920.   Published online July 15, 1992
We reviewed the medical records of 14 children (8 girls, 6 boys), diagnosed as hemolytic uremic syndrome at Seoul National University Children뭩 Hospital from 1981 to 1990. The age at presentation ranged from 1 month to 10 years, with a mean age of 2.7 years. Only eight (57.1%) of the children had diarrheal prodrome and five (35.7%) had grossly bloody...
A comparison between remission and nonremission groups of hepatitis B virus-associated membranous nephropathy in children.
Kang Yong Park, Hye Won Park, Yon Ho Choe, Tae Sun Ha, Il Soo Ha, Yong Choi, Kwang Wook Ko, Hyun Soon Lee, Yong Il Kim
Clin Exp Pediatr. 1991;34(11):1512-1518.   Published online November 30, 1991
We analyzed medical records of 35 patients with Hepatitis B virus-associated Membranous Nephropathy proven by kidney biopsy at SNUCH from Jan. 1975 to Jun. 1990. Clinical presentation, laboratory and pathologic findings were compared between remission group (who are free of proteinuria and edema in current status) and nonremission group (who have either proteinuria or edema). Age at onset was younger in remission group (4.51 ±2.93...
Production and characterization of monoclonal antibodies against human albumin.
Ja Wook Koo, Dong Kyu Jin, Yong Choi, Kwang Wook Ko, Suhnggwon Kim, Jung Sang Lee, Chung Gyu Park, Chang Yong Cha
Clin Exp Pediatr. 1991;34(8):1070-1079.   Published online August 31, 1991
Hybridoma technology를 이용하여 human albumin에 선택적으로 반응하는 4 종류의 단세포군 항 처 1(HSA-1，HSA-2, HSA-3, HSA-4) 를 개발하였다. 단세포군의 isotype 및 subclass를 효소 결합 면역 측정법으로 검색한 결과 IgGi 이었다. 단세포군 항체 HSA-1 을 제외한 HSA-2, HSA-3, HSA-4 모두 human albumin에 선택적으로 반 응함을 효소 결합면역 측정 법과 Western blot immunoassay로 알아내 었다. HSA-1, HSA-2, HSA-3는 albumin의 reduction 여부와 관계 없이 albumin molecule과 반응하였 으나，HSA-4는 albumin을 reduction하지...
Weight and morphologic development of prenatal human thymus.
Il Soo Ha, Kwang Wook Ko, Je Geun Chi
Clin Exp Pediatr. 1991;34(8):1057-1069.   Published online August 31, 1991
Thymus is a primary lymphoid organ which has an important role in maturation of immune competence. This organ matures earlier than the other organs, and the informations about its prenatal development are essential to understand the maturation of human immunity. To delineate the weight and morphologic development of prenatal thymus, the authors measured the weight of 221, and observed gross and histologic features of...
Morphological study on the development of human fetal kidney.
Hee Young Shin, Kwang Wook Ko, Je Geun Chi
Clin Exp Pediatr. 1991;34(8):1045-1056.   Published online August 31, 1991
A total of 293 human fetal kidneys, including those of 42 embryos are studied for the elucidation of temporal development of the kidney. These specimens were interpreted as normal by thorough postmortem examinations. The age of the specimens was determined by developmental horizon criteria in embryos and by correlating crown-rump length in fetuses. Embryos were embedded in toto, cut in various planes and reconstructed...
Acute renal failure with back pain after exercise.
Hae Jung Park, Mi Jung Kim, Dong Kyu Jin, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Jung Mi Park, Kyung Mo Yeun
Clin Exp Pediatr. 1991;34(6):863-868.   Published online June 30, 1991
We have experienced one case of acute renal failure without clinical rhabdomyolysis characterized by preceding exercise and back pain. This patient showed patch renal increased uptakes in bone scan with 99mTechnetium-methylene diphosphonate, and delayed wedge-shaped contrast enhancements in renal computed tomography. These findings can be explained by focal renal vasoconstriction of interlobar arteries or arcuate arteries, which may be considered as one of the...
A clinical study of continuous ambulatory peritoneal dialysis in childhood.
Tae Sun Ha, Hye Won Park, Ja Wook Koo, In Seok Lim, Hae Il Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1991;34(3):363-370.   Published online March 31, 1991
A retrospective analysis of clinical with findings in 24 children continuous ambulatory peritoneal dialysis (CAPD) who were admitted to the Department of Pediatrics, Seoul National University Children’s Hospital from March, 1987 till August, 1990 was performed and the results were as follows; 1) The male to female ratio was 16:8, and the age distribution at the beginning of CAPD was from 59 days to 16.5...
IgA Nephropathy in Childhood.
Yong Choi, Dong Woo Son, Ja Wook Koo, Dong Kyu Jin, Hae Il Cheong, Kwang Wook Ko, Hyun Soon Lee, Yong Il Kim
Clin Exp Pediatr. 1990;33(9):1237-1243.   Published online September 30, 1990
In this study we compared between the patients with recurrent gross hematuria (group 1, n=45) and * with nephrotic range proteinuria (group 2, n=21) in IgA nephropathy who were admitted to Seoul National University Children’s Hospital during the period from January, 1980 to December, 1989. The results of the study were as follows. 1) Age of onset and sex ratio were not different between the...
A Clinical Study on the Posterior Subcapsular Cataracts in Childhood Nephrotic Syndrome.
Dong Kyu Jin, Ja Wook Koo, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Jong Hoon Lee, Young Suk Yu
Clin Exp Pediatr. 1990;33(8):1097-1103.   Published online August 31, 1990
A clinical study was carried out in 73 children with nephrotic syndrome who had had regular ophthalmologic examination annually at Seoul National University Children’s Hospital from March 1976 to February 1990 with the aim of finding the relationship between the posterior subcapsular cataract (PSC) and the effect of corticosteroids. The results were summarized as follows: 1) The number of patients with PSC were 23 cases...
Recombinant Human Erythropoietin Therapy in Anemia Accompanied by Chronic Renal Failure.
Dong Kyu Jin, Hae Il Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1990;33(7):970-976.   Published online July 31, 1990
A clinical study was carried out to evaluate the efficacies of rHuEPO (recombinant human erythropoietin) in anemia of 7 chronic renal failure patients under dialysis at Seoul National University Children's Hospital from Feb. 1989 to Nov. 1989. The results were as follows; - 1) There was progressive increase of hematocrit levels in all 6 hemodialysis patients and mainte- nance dosage of rHuEPO to sustain hemoglobin...
Statistical Analysis of Patients in Seoul National University Children's Hospital (1985~1988).
Kyung Mo Kim, Kwang Wook Ko
Clin Exp Pediatr. 1990;33(6):744-753.   Published online June 30, 1990
Statistical analysis of outpatients and inpatients from 1985 to 1988 was assessed with aims to have an overal grasp of patterns and trends of childhood diseases at Seoul National University Children, s Hospital. 1) Number of outpatient visits were totally 458,390 with annual number of visits of 144,754 and average daily number of 461, including 241 visits in Department of Pediatrics. 2) Number of patients at Eemergency...
A Case of Acute Renal Failure Associated with Rhabdomyolysis in Carbon Monoxide Intoxication.
Kyung Hee Park, Sei Hee Hwang, Hae Il Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1990;33(5):690-694.   Published online May 31, 1990
We experienced a case of acute renal failure associated with rhabdomyolysis after Carbon Monoxide intoxication in a 12 year old Korean girl who had marked soft tissue swelling of the left thigh, reddish brown colored urine and oliguria. Diagnosis was made by clinical features, markedly elevated serum muscle enzymes and serum myoglobin, and Tc 99m-MDP bone scan which revealed increased radioactivity at the left...
Hypophosphatemic Rickets.
Kyung Mo Kim, Seong Hoon Ha, Dong Kyu Jin, Kwang Wook Ko
Clin Exp Pediatr. 1990;33(4):437-447.   Published online April 30, 1990
Seventeen patients who were diagnosed as primary hypophosphatemic rickets at Department of Pediatrics, Seoul National University Children’s Hospital were analyzed to assess its clinical aspect and effect of treatment, especially on height and growth velosity. The average age of onset was 2 years, and their chief complaints were bowleg and short stature. Sex ratio was l.l:l(male: female). Familial hypophoshatemic rickets was known as X-linked...
Selectivity Index of Proteinuria in Childhood Minimal Change Nephrotic Syndrome.
Cheol Ho Lee, Young Seo Park, Kwang Wook Ko
Clin Exp Pediatr. 1989;32(10):1384-1390.   Published online October 31, 1989
The selectivity indices (S.I.) of proteinuria in 120 biopsy proven minimal change nephrotic syn- drome (MCNS) children who were admitted to Seoul National University Childern’s Hospital from January 1976 to June 1988 and followed up for more than 1 year from onset of disease, were analyzed in relation to clinical findings, histopathologic features and steroid responsiveness. The results were as follows: 1) The mean age at...
Juvenile Nephronophyjisis in An Infant.
Young Seo Park, Chang Youn Lee, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Je Geun Chi, Chang Bin Im
Clin Exp Pediatr. 1989;32(8):1155-1160.   Published online August 31, 1989
Juvenile nephronophthisis is a chronic tubulo-interstitial renal disease characterized by an early onset of polyuria and polydipsia, decreased urinary concentrating ability, anemia, growth retardation and progressive renal disease. It is recognized as an important cause of chronic renal failure in the childhood. However only one case was reported in the Korean literatures. In this paper we have reported the second documented case of juvenile...
Urinary Tract Anomalies in Congenital Heart Disease.
Chang Youn Lee, Young Seo Park, Hae Il Cheong, Jung Yun Choi, Young Soo Yun, Yong Choi, Kwang Wook Ko, In One Kim, Kyung Mo Yeun, Kwang Myung Kim, Hwang Choi
Clin Exp Pediatr. 1989;32(6):804-808.   Published online June 30, 1989
A variety of urinary tract anomalies were detected in 1,569 children with congenital heart disease during their cardiac evaluation with cardiac cineangiography in the Department of Pediatrics, Seoul National University Children’s Hospital within a period from October 1985 to April 1988. The incidence, nature and course of these urinary tract anomalies were analyzed and the results were as follows; 1) The number of male children...
Hypercalciuria in Children with Hematuria.
Tae Sung Ko, Chang Youn Lee, Young Seo Park, Hae Il Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1989;32(5):644-652.   Published online May 31, 1989
Ten children with gross hematuria were diagnosed as hypercalciuria in the Department of Pediatrics, Seoul National University Children’s Hospital during the period from June 1983 to Aug. 1987. We reviewed their clinical data, retrospectively, and could obtain the following results. 1) The age at the onset of gross hematuria ranged from 4 months to 10 7/12 years, and the male to female ratio was...
Continuous Arteriovenous Hemofiltration in Children.
Hae Il Cheong, Dong Kyu Jin, Young Seo park, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1989;32(2):230-238.   Published online February 28, 1989
Among those who were admitted to the Pediatric Intensive Care Unit (PICU), Seoul National University Children’s Hospital and developed acute renal failure (ARF) during the disease course, 11 children received continuous arteriovenous hemofiltration (CAVH) by pediatricians during a 3-year- period from Nov. 85 to Oct. 88. Their clinical findings were analyzed retrospectively, and the results were as follows; 1) They were 5 boys and 6...
Childhood Renal Diseases.
Tae Sung Ko, Hae Il Cheung, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1988;31(11):1468-1474.   Published online November 30, 1988
1978년 1월부터 1987년 12월까지 만 10년간 서울대학교 소아병원 소아과에 입원한 환자중 신질환 환아를 대상으로 후향적 인 임상통계학적 고찰을 시 행하여 다음과 같은 결과를 얻었다. 1) 10년기간중 신질환 환아는 총 2,023명으로 이는 동일기간 전체 소아과 입원환아(28,611)의 7.1 %에 해당하였고，전체 환아에 대한 신질환 환아의 비는 매년 거의 일정하였다. 2) 전체 신질환 환아의 남여 비 는 2.2 : 1이 었다. 3) 신증후군(38.8%), 요로감염(18.0%), 급성사구체신염(12.1%) 이 3대 질병을 이루었으며 다음 으로는 반복성 혈뇨(7.6%),...
Urinary Red Blood Cell Morphology in Hematuria.
Hong Jin Lee, Chang Yeon Lee, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Myung Hee Park
Clin Exp Pediatr. 1988;31(11):1460-1467.   Published online November 30, 1988
We have studied morphological alterations in urinary RBC as a tool for the differential diagnosis of hematuria in children, that is, differentiation of glomerular bleeding from nonglomerular bleeding, and the results were as follows; 1) Urinary RBCs from glomerular diseases showed higher rate of dysmorphism (84.3±16.8%), and those from nonglomerular diseases did lower one (15.2 ±12.9%) with phase contrast microscopic examination. 2) Simple light microscopic examination after Wright’s...
Plasma Renin Activity (PRA) in Peripheral Vein and Renal Veins in Normotensive Children with Cyanotic Congenital Heart Disease.
Sang Kyu Park, Hae Il Cheong, Chung Il Noh, Yong Soo Yun, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1988;31(8):1021-1027.   Published online August 31, 1988
PRA’s in peripheral vein, both renal veins, and inferior vena cava (IVC) were measured in 25 normotensive children without renal disease undergoing cardiac catheterization for their underlying cyanotic congenital heart disease. And we presented the results as reference values/ranges of PRA in children. 1) There was no significant difference in PRA between both side renal veins at any absolute PRA levels with a mean ratio (RT/LT)...
A Clinicopathologic Study on Postinfectious Glomerulonephritis.
Hong Jin Lee, Kwang Wook Ko
Clin Exp Pediatr. 1988;31(6):723-730.   Published online June 30, 1988
38 biopsy proven postinfectious glomerulonephritis patients were analyzed retrospectively in view of clinicopathological correlation. 1) Of the 38 patient reviewed, 23 cases were male and 15 female and the male to female ratio was 1.5:1. The mean age of onset was 9.8±3.2 years old with 2 peaks at 7 and 12 years of age. 2) The clinical presentations on admission were acute nephritic syndrome (15 cases,...
Clinical Observation on Hemodialysis in Children with Chronic Renal Failure.
Hae Il Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1988;31(5):590-596.   Published online May 31, 1988
There had been total 21 children with end stage renal disease in whom hemodialysis was done in the pediatric dialysis unit of Seoul National University Children’s Hospital during the period from 1986. 3. 31 to 1987. 11. 30. And we took a retrospective review of their clinical data, and the results were as follows 1) Primary glomerular disease, H enoch-Schdnlein nephritis, and reflux nephropathy were...
A Study on Minimal Change Nephrotic Syndrome in Children.
Yong Choi, Hong Jin Lee, Hae Il Cheong, Kwang Wook Ko, Hyun Soon Lee, Yong Il Kim
Clin Exp Pediatr. 1988;31(2):220-226.   Published online February 28, 1988
To assess the clinical significance of histopathologic variants of minimal change nephrotic syn- drome (MCNS) by light microscopic findings, 148 biopsy proven MCNS patients, who were admitted to Seoul National University Hospital between the period from January 1976 to December 1986, were analyzed according to clinical findings, steroid responsiveness, and follow up status in relation to the pathologic variants. The followings are summary and conclusion. 1) Significantly...
A Clinical Observation on Systemic Lupus Erythematosus in Children.
Han Wook Yoo, Hae Il Cheong, Hoan Jong Lee, Yong Choi, Kwang Wook Ko, Yong Il Kim
Clin Exp Pediatr. 1987;30(5):527-535.   Published online May 31, 1987
To elucidate the clinical characteristics of childhood onset systemic lupus erythematosus (SLE), we carried out a retrospective review on medical records of sixteen patients who were diagnosed as SLE on the base of “the 1982 revised criteria for the SLE” (by American Rheumatism Association) at the Department of Pediatrics, Seoul National University Children’s Hospital between January 1976 and July 1986. The results were summarized...
A Retrospective Study on the Effect of Cyclophosphamide in Children with Minmal Change Nephrotic Syndrome.
Il Soo Ha, Kwang Wook Ko, Yong Il Kim
Clin Exp Pediatr. 1987;30(2):158-174.   Published online February 28, 1987
Thirty one children associated with biopsy-proven minimal change nephrotic syndrome with frequent relapse, were placed on cyclophosphamide, and its effect was analyzed. Cyclophosphamide was given with the dosage of 2.46±0.42 mg/kg/day for 58±7 days along with the alternate day corticosteroid. Sixty three percent of the patients showed complete remission and twenty seven percent of the patients resulted in partial remission after the treatment. Those...