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Original Article
Treatment of Kawasaki Disease with Single High-dose Intravenous Gammaglobulin
Mi Koo Kang, Eun Young Cho, Young Hwue Kim, Ki Soo Kim, Young Seo Park, In Sook Park, Hyung Nam Moon, Chang Yee Hong
Clin Exp Pediatr. 1992;35(3):342-348.   Published online March 15, 1992
Kawasaki disease is an acute febrile illness of unknown origin and most frequently affects infants and children under 5 years of age. Coronary aneurysms are the most serious complications and 15-20% of patient develop coronary aneurysm. We studied 50 children who wre diagnosed as Kawasaki disease and treated simultaneously with single high-dose gammaglobulin (2 gm/kg/day) and aspirin at Asan Medical Canter...
A comparative study of therapeutic effect of combined treatment with aspirin and intravenous gammaglobulin versus aspirin alone in Kawasaki disease.
Sang Bong Lee, Eui Tak Oh, Kang Youl Bae, Hong Ja Kang, Woo Sik Chung, Kil Soo Kim
Clin Exp Pediatr. 1991;34(12):1664-1670.   Published online December 31, 1991
We compared the therapeutic effect of intravenous gamma globulin plus aspirin with that of aspirin alone in reducing the coronary aneurysms and changes of clinical courses in 57 children with Kawasaki disease who were admitted in Dae Dong hospital from Jul. 1987 to Jun. 1990 These 57 cases were divided into two groups: Group A:High dose aspirin (100 mg/kg/day) during febrile stage and then...
A study on the immune reaction to the milk protein antigens in the postpartum mother, newborn baby, and children.
Soo chul Cho, Ju Hyung Kim, Hong Ro Lee, Jong San Lee, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1991;34(11):1547-1558.   Published online November 30, 1991
There is continuing interest in the isotype response of human serum antibodies reactive with dietary proteins. This study was performed to clarify the humoral immune responses against cow’s milk proteins, 分-lactoglobulin and a-lactalbumin. Milk protein specific IgG, IgA, IgM, and IgG subclasses were measured using ELISA in the blood of various groups of age. The results were as follows: 1) Milk protein specific immunoglobulins were higher...
Early detection of gentamicin nephrotoxicity using urinary beta2-microglobulin in neonates.
Mi Kyung Kim, Seung Joo Lee
Clin Exp Pediatr. 1991;34(7):940-948.   Published online July 31, 1991
Gentamicin, commonly used antibiotics in neonatal care, has a nephrotoxicity, but it is difficulto to assess renal function in early stage. This study evaluated the renal function and urinary β2-microglobulin excretion in 17 gentamicin treated and 11 control neonates. The results are as follows. 1) Urinary 02-M in gentamicin treated neonates were 0.84±0.17mg/L at postnatal day 1 and increased to 5.99±1.15mg/L at day 4, 14.17±2.39mg/L at day...
A clinical study of Graves' disease in children.
Kee Young Park, Ho Kyung Choi, Jong Jin Seo, Young Hun Chung
Clin Exp Pediatr. 1991;34(6):812-819.   Published online June 30, 1991
The authors analyzed the clinical manifestations, laboratory results, and relationship between the presence of antithyroid autoantibodies and response of short-term antithyroid medication in 20 children with Graves* disease who were diagosed at the Department of Pediatarics, Chungnam National Universtiy Hospital from March 1985 to February 1990. The results were as follows; 1) The ratio of male to female was 1:9. 2) The age distribution of patients ranged from...
Effect of immune globulin on the prevention of coronary artery aneurysm in Kawasaki disease.
Mi Jin Jung, Chung Il Noh, Jung Yun Choi, Yong Soo Yun
Clin Exp Pediatr. 1991;34(5):668-676.   Published online May 31, 1991
We compared the efficacy of each modality of treatment group in reducing the frequency of coronary artery aneurysm in children with Kawasaki syndrome. Group 1 (26 cases)-aspirin alone: Group 2 (26 cases)-intravenous gamma globulin, 400 mg per kilogram of body weight per day for five consecutive days, plus aspirin; Group 3 (21 cases)-intravenous gamma globulin, single dose of 2.0 g per kilogram of body...
A case of hyperimmunoglobulin E syndrome.
Myeong Cheol Shinn, Sung Dong Choi, Byung Gyu Suh, Jin Han Kang, Joon Sung Lee
Clin Exp Pediatr. 1991;34(2):292-298.   Published online February 28, 1991
The hyperimmunoglobulin E syndrome is a primary immunodeficiency disorder characterized by serious recurrent bacterial infections of the skin and respiratory system in early life, and markedly elevated serum IgE level. These recurrent infections are generally subcutaneous abscesses caused by Staphylococcus aureus. Also, additional characteristrics of this syndrome include coarse facial appearance, chronic pruritic dermatitis and eosinophilia. The baisic immunologic defect mechanism in hyperimmunoglobulin E syndrome is...
Changes of PPD-Specific Immunoglobulin in Pulmonary Tuberculosis After Treatment.
Ja Young Kim, Mun Hwan Lee, Pyoung Han Hwang, Chan Uhng Joo, Jung Soo Kim
Clin Exp Pediatr. 1990;33(12):1647-1655.   Published online December 31, 1990
The definite diagnosis and precise assessment of response to therapy is still a problem in childhood tuberculosis because these patients rarely produce sputum and if obtained it may be negative. For this reason, diagnosis rely largely on the clinical and X-ray examination, which have a low specificity and high proportion of false positive results. Recently immunologic diagnosis of tuberculosis using enzyme-linked immunosorbent assay (ELISA) was...
Changes of beta-lactoglobulin Specific Immunoglobulins According to the Age and the Onset of Cow's Milk Feeding.
Jong San Lee, Soo Young Cho, Pyoung Han Hwang, Soo Cheol Cho, Jung Soo Kim
Clin Exp Pediatr. 1990;33(12):1639-1646.   Published online December 31, 1990
It is not yet possible to explain in detail the pathogenesis of the diverse types of food allergy encountered clinically. This generalization applies to milk allergy in spite of the large number of studies reporting the immune responses to cow’s milk proteins, both in healthy subjects and in milk sensitive patients. This study was performed to define the changes of circulating immunoglobulins against milk protein...
Comparison between Treatment with Aspirin Alone and the Combined Treatment with Aspirin and Intravenous gamma-Globulin in Kawasaki Disease.
Sang Yoon Ahn, Sun Yang Hong, Nam Soo Kim, Ha Baik Lee, Soo Jee Moon, Hahng Lee
Clin Exp Pediatr. 1990;33(10):1380-1387.   Published online October 31, 1990
Out of a total of 140 children hospitalized with the diagnosis of Kawasaki disease at the Depart- ment of Pediatrics, Hanyang University Hospital during the period of 9 years from July 1980 to July 1989, 68 cases were subjected to echcocardiographic examination at 10 to 15 days after the onset of illness, and these 68 cases were divided into two groups according the...
Immunologic Changes in Bronchial Asthma on Immunotherapy.
Joon Sung Lee, Kyung Tai Whang, Sung Hoon Cho
Clin Exp Pediatr. 1990;33(9):1255-1261.   Published online September 30, 1990
The best treatment of allergic disease is to avoid exposure to known allergen. Immunotherapy has been attempted in IgE-mediated allergic patients who didn’t show any responses to pharmacologic therapy or couldn’t avoid allergen. There have been many enthusiastic claims for symptomatic relief of allergic disease by various forms of hyposensitization, first introduced by Noon and Freeman (1911) in the treatment of hay fever. The mechanism of...
An Experience of High Dose Intravenous Immunoglobulin Therapy in Refractory Evans Syndrome.
Hee Sup Kim, Won Sup Shin, Sang Il Lee, Sang Woo Kim
Clin Exp Pediatr. 1990;33(5):701-707.   Published online May 31, 1990
Evans syndrome, a combination of autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura, relapses freguently and is refractory to conventional treatment such as corticosteroid, immunosuppressive agents, splenectomy and plasma exchange. Recently Oda et al applied high dose immunoglobulin (400/kg/day for 4 days repeated 2 weeks later) to 5 month-old infant with refractory Evans syndrome, and was successful in maintaining remission for five years and nine...
A Comparative Study of Therapeutic Effect of Intravenous Gammaglobulin plus Aspirin Versus Aspirin Alone in Kawasaki Syndrome.
Boung Yul Leem, Chong Sung Chung, Sung Ho Cha, Yong Mook Choi, Chang Il Ahn
Clin Exp Pediatr. 1989;32(10):1408-1415.   Published online October 31, 1989
We compared the efficacy of intravenous gamma globulin plus aspirin with that of aspirin alone in reducing the frequency of coronary artery abnormahties and changes of clinical coures in children with acute kawasaki syndrome in the children of 44 cases who were admitted in K.H.U.H from Mar. 1986 to Fab. 1988. Group A: High dose aspirin (60〜90 mg/kg/D) during febrile stage and then switched...
Specific Antibody Response in House Dust Mite Asthmatics on Immunotherapy.
Won Sup Shin, Bub Sung Kim, Sang Il Lee
Clin Exp Pediatr. 1989;32(9):1282-1287.   Published online September 30, 1989
The immunotherapy has become a useful and effective method to treat allergic respiratory diseases. It is a logical assumption that immunotherapy produces symptom relief as a result of immunologically specific response. This study was performed to delineate the IgE, IgG and IgG4 responses to immunotherapy, and their relationships. We selected the six asthmatic children on immunotherapy with Dermatophagoides pteronyssinus (Dp). A set of samples from each...
Serum IgE Levels in Bronchiolitis Patients.
Seong Hee Choi, Keun Lee
Clin Exp Pediatr. 1989;32(6):749-755.   Published online June 30, 1989
Bronchiolitis is a virus.caused lower respiratory disease resulting from inflammatory obstruction of the small airways. The condition may develop to asthma anddifferential diagnosis is not clearcut between two diseases during infancy. Measurement of the serum IgE concentration has been used as an aid in the differential diagnosis. The purpose of this study is to compare the serum IgE levels between control groups and bronchiolitis patients,...
Non-specific Immunotherapy with Histamine-Gammalobulin Preparations in Chronic Respiratory Group Patients and Non-atopic Asthmatic Children.
Byeung Ju Jeoung, Kyu Earn Kim, Ki Young Lee
Clin Exp Pediatr. 1988;31(10):1308-1314.   Published online October 31, 1988
We evaluated the therapeutic effect of non-specific immunotherapy with Histamine- gammahlobulin in 60 patients. Among them 22 patients were chronic respiratory group patients who were under 2 years of age and suffered from frequent respiratory tract infections, and 38 patients were as follows: 1) Excluding the patients who received 9 weeks therapy for the test period, the mean duration of Histamine-gammaglobulin therapy in the chronic respiratory...
Changes of Specific Immunogloblins Against Dihperia Toxoid After DPT Vaccination.
Byung Sook Park, Byung An Shim, Kyung Jin Shin, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1988;31(9):1126-1132.   Published online September 30, 1988
The present study was performed to define the humoral immune responses after DPT vaccination changes of diphteria specific IgG and IgM were evaluated suing ELISA method on 196 cases of 6 groups which were divided according to the frequency of DPT vaccination. Alum-precipitated diphtheria toxoid was used as antigen for ELISA. The results were as follows; 1) IgG was mainly involed in humoral immune responses against...
A Prospective Study of Urinary beta2 -Microglobulin in Infants with Meconium-Stained Amniotic Fluid.
Sung Oh Kim, Jeh Hoon Shin, Woo Gill Lee, Soo Jee Moon, Keun Soo Lee
Clin Exp Pediatr. 1988;31(8):968-976.   Published online August 31, 1988
We studied prospectively whether events that result in meconium staining may be associated with additional abnormalities that are not clinically apparent associated by measurements of urinary concentrations of β₂-microglobulin indicating renal proximal tubular functions. Among 61 fullterm, healthy neonates delivered at Hanyang University Hospital during the period of September 1986 through April 1987, urinary concentration of β₂-microglobulin and creatinine were measured during the immediate perinatal...
The Role of Anitiplatelet Antibody and the Therapeutic Effect of High-Dose I.V. gamma-globulin in Childhood Idiopathic Thrombocytopenic Purpura.
Kyu Chul Choi, Sang Ho Park, Yong Mook Choi
Clin Exp Pediatr. 1988;31(2):212-219.   Published online February 28, 1988
Among 48 children with I.T.P (26 acute, 10 chronic and 12 undetermined), the antiplatelet antibody test (APA) was qualitatively studied by indirect immunofluorescent method in 34 patients of which only 25 patients (18 acute and 7 chronic) were able to follow-up. The overall positivity of APA was 36% and there was no relationship with disease chronicity. Intravenous r-globulin was given at a dose of...
Clinical Value of Urinary β₂ -Microglobulin in Patients with Urianry Tract Infection.
Nak Uk Sung, Chang Ryul Kim, Jeh Hoon Shin, Woo Gill Lee
Clin Exp Pediatr. 1987;30(9):1014-1020.   Published online September 30, 1987
Urinary tract infection (UTI) in children is relatively common infectious disease and it may be the forerunner of severe renal diseases in adulthood. The site of infection is an important factor in the evaluation of the clinical course, treatment and prognosis of patients with UTI, because patients with bacteriuria of renal origin (pyelonephritis) are probably at risk of developing the renal parenchymal reduction seen...
Immunologic Function in Early Phase of Various Glomerulonephritis.
Soon Don Hong, Hyoung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1987;30(7):735-741.   Published online July 31, 1987
Abnormal lymphocyte function has been postulated to have a pathogenetic role in nephrotic syndrome. To assess immunologic parameters in the pathogenesis of various glomerulonephritis in early phase, in prdiatric department of Kyung Hee University Hospital from September 1985 to June 1986, serum immunoglobulin concentration and T cell subsets were measured in 32 children and compared with normal control group (n=30). Further studies are needed to...
Specific Immunoglobulin Responses Against Tetanus Toxoid after DPT Vaccination.
Kyung Jin Shin, Sng Nam Chun, Heon Seob Song, Dae Yeal Lee, Jung Soo Kim
Clin Exp Pediatr. 1987;30(6):625-632.   Published online June 30, 1987
DPT vaccination has successfully been applied to the prevention of tetanus infection. Edsall (1949) reported the presence of serum tetanus antitoxin after tetanus toxoid immunization. Gill et al (1983) also demonstrated that the values of tetanus specific IgM were increased on neonates after maternal tetanus toxiod immunization. The present study was performed to define the humoral immune responses after DPT vaccination. Changes of tetanus specific...
Clinical Study of Acute Glomerulonephritis in Children.
Kyeong Rae Moon, Choon Ho Park, Sang Kie Kim, Jin Heon Kim, Chang Soo Ra
Clin Exp Pediatr. 1986;29(2):178-185.   Published online February 28, 1986
From January 1979 to June 1984, 96 cases of acute glomerulonephritis were clinically investigated at the Department of Pediatrics, Chosun University Hospital, and following results were obtained: 1) Male to female ratio was 1.7 : 1, and the age incidence was highest in children from 7 to 9 years (35.4%), with a seasonal peak in Autumn and Winter (66.8%). 2) The most common...
A Study on Serum Immuoglobulins and Complements in Newborn Infants.
Song Soo Moon, Chang Soo Ra
Clin Exp Pediatr. 1986;29(1):58-71.   Published online January 31, 1986
The author investigated serum immunoglobulins (IgG, IgA, and IgM) and complements (C3and C4) of cord blood in 29 cases of normal fullterm infants, 14 cases of low birth weight infants (8 cases of premature infants) and 43 cases of their mothers at delivery. Serum immunoglobulin and complement levels were measured by the single radial immuno diffusion method (NISSUI, Japan). The...
A Study on Changes of Serum Prootein, Immunoglobulins, and Electrolyte Metabolism in Childhood Nephrotic Syndrome after Steroid Therapy.
Kyung Rae Moon, Chang Soo Ra
Clin Exp Pediatr. 1986;29(1):32-44.   Published online January 31, 1986
The author determined serum and 24hr urine protein(total protein and albumin), immunoglobulins(lgG, IgA, and IgM) and serum electrolytes(Na, K, Ca, P, Mg, and Cl) in 5 cases of childhood nephrotic syndrome before and after steroid therapy, until urinary excretion of protein was negative (remission).The results observed are summarized as follows; 1) Serum protein; Before treatment, the mean serum total protein...
Primary Peritonitis in Children with Nephrotic Syndrome.
Hae Il Cheong, Whan Jong Lee, Jeong Kee Seo, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1985;28(7):695-704.   Published online July 31, 1985
Thirty episodes of primary peritonitis in 22 children with nephrotic syndrome who had admitted in the Department of Pediatrics, Seoul National University Hospital from Jan. *81 to Sept. ’84 were studied, and the results were as follows; 1)Among 22 children, male to female ratio was 16 : 6 and the mean age at the onset of peritonitis was 7.80 years (average...
The Effect of Intravenous Gammaglobulin for Acute Idiopathic Thrombocytopenic Purpura in Children.
Seung In Baek, Geum Joo Kim, Kuhn Soo Lee, Sang Bum Lee, Doo Hong Ahn
Clin Exp Pediatr. 1985;28(5):483-491.   Published online May 31, 1985
A clinical study was conducted to determined the effectiveness of intravenous gammaglobulin on childhood acute ITP. Study group consisted of 8 children who were treated with IV Globulin(0.4 gm/kg/d, 5 days) only or combined with steroid, and control group of 19 children who were treated with steroid only. Study period was from January 1980 to June 1984, and following results...
Clinical and Immunologic Studies on Epidemic Encephalitis.
Cheul Woo Park, Kwang Rhun Koo, Song Soo Moon, Ho Seung Yoo, Chang Soo Ra
Clin Exp Pediatr. 1983;26(6):545-552.   Published online June 30, 1983
Epidemic encephalitis in the Korea is caused by arbovirus (Japanese encephalitis virts). And this acute illness occurs annually during the late summer and early autumn months and is more prevalent among children under 15 years with high mortality. 130 cases of epidemic encephalitis were hospitalized at the Department of Pediatrics, Chosun University Hospital, during the period of August-October, 1982. Authors investigated hemaggulutination...
Quantitative Determination of Immunologlobulins in Breast Milk During the Period of Lactation.
Sung Ee Kim, Chang Soo Ra
Clin Exp Pediatr. 1982;25(12):1203-1209.   Published online December 31, 1982
It has been established by many investigations that immunoglobulins in breast milk, par- ticularly secretory IgA, are important in. protecting the infant, not only through the colostrum but through milk from birth to the early months of life. In order to determine the levels of immunoglobulins in breast milk and the alterations of levels of immunoglobulins during the period of lactation, the authors studied...
A prospective study on immunoglobulins and ESR in acute viral hepatitis patients.
Jong Wie Choi, Sung Seek Lee, Ki Sup Chung
Clin Exp Pediatr. 1982;25(9):914-921.   Published online September 30, 1982
This study was carried out in 78 subjects of both sexes who were affected by acute viral hepatitis and admitted to Severance Hospital attached to Yonsei Medical College from Oct. 1980 to June. 1981. Hepatitis B markers, serum immunoglobulins and ESR were respectively examined in all patients. The results were as follows. 1. In all patients, regardless of positivity of HB markers, IgG, IgA and IgM levels...
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