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Case Report
Two Cases of Paragonimiasis in Young Siblings Presenting with Pleural Effusion and Subcutaneous Nodules
Moon Young Jeong, Hee Jo Baek, Duck Cho, Jin Kim, Chan Kyoo Hwang, Dong Kyun Han, Jae Sook Ma, Hoon Kook
Clin Exp Pediatr. 2005;48(12):1385-1388.   Published online December 15, 2005
Paragonimiasis is the infestation of lung flukes of the trematode genus Paragonimus. This disease is common in Asia, and the southern part of Korea has been known as one of the endemic areas of Paragonimiasis westermanii in Korea. Human infection is associated with specific dietary habits, such as eating freshwater crawfish or crabs. In a 6 1/2-year-old boy with pleural...
Original Article
The Preventive Effect of Dexrazoxane and Pentoxifylline on Adriamycin Induced Cardiomyopathy
Ling Zhu, Eun-Jung Bae, Il-Soo Ha, Jung-Wook Seo, Chung-Il Noh, Jung-Yun Choi, Yong-Soo Yun
Clin Exp Pediatr. 2005;48(12):1378-1384.   Published online December 15, 2005
Purpose : We hypothesized dexrazoxane(DXR) and pentoxifylline(PTX) may prevent myocardial damage in adriamycin(ADR)-induced cardiomyopathic rat model. We also investigated their effects on the myocardial apoptosis and fibrosis in ADR induced cardiomyopathy. Methods : The six-week old female Spregue-Dawley rats were divided into control group(CNT, n= 4), ADR group(n=6), ADR＋DXR group(DXR, n=5), ADR＋PTX group(PTX, n=6), ADR＋DXR＋PTX group(DXPT, n=5). ADR(5 mg/week, twice) was...
Changes of Lipid and Lipoprotein Compositions in Kawasaki Disease and its Impact on Cardiac Complications
Sin Weon Yun, Ho Seok Lee, Dong Woon Kim, Kang Won Rhee, Young Soo Jung
Clin Exp Pediatr. 2005;48(12):1370-1377.   Published online December 15, 2005
Purpose : Delineation of serum lipid and lipoprotein values in children after Kawasaki disease(KD) is important because of the predilection of this disease for the coronary arteries. Methods : The KD group was composed of 51 patients who were hospitalized from Jan. 2002 to Dec. 2003. Control was 25 patients with non-KD febrile illness. The levels of total lipid, phospholipid,...
N-terminal Pro-B-type Natriuretic Peptide as a Predictive Risk Factor in Fontan Operation
Gi Young Jang, Jae Young Lee, Soo Jin Kim, Woo Sup Shim
Clin Exp Pediatr. 2005;48(12):1362-1369.   Published online December 15, 2005
Purpose : This study aimed to investigate the correlation between the plasma level of N-terminal pro-B-type natriuretic peptide(pro-BNP) and several known risk factors influencing outcomes after Fontan operations, and to assess whether pro-BNP levels can be used as predictive risk factors in Fontan operations. Methods : Plasma pro-BNP concentrations were measured in 35 patients with complex cardiac anomalies before catheterization....
Therapeutic Effect of Anti-Rotavirus Chicken Egg Yolk Immunoglobulin(IgY) on Diarrhea by Infection of Rotavirus
In Seok Lim, Ho Seok Lee, Wonyong Kim, Eung Sang Choi, Dong Hyuk Jung, Hoo Kil Jung, Sung Seob Yun, Ho Nam Chun
Clin Exp Pediatr. 2005;48(12):1354-1361.   Published online December 15, 2005
Purpose : Rotavirus is an enteric pathogen that affects millions of children globally each year. But no specific therapy is available for the management of rotavirus diarrhea. Due to the clear need to define improved modality for treatment of rotavirus diarrhea, we evaluated the efficacy of anti- rotavirus IgY in the treatment of infants and children with gastroenteritis. Methods : First,...
Clinical Usefulness of Rapid Antigen Test on the Diagnosis of Influenza
Jae Seon Kim, Hyon Joo Choi, Young Min Ahn, Young Ok Hwang
Clin Exp Pediatr. 2005;48(12):1348-1353.   Published online December 15, 2005
Purpose : Influenza is a respiratory disease which prevails widely every year and shows high morbidity and mortality among not only chronic invalids and the old, but also among infants and young children. To prevent community-acquired influenza infection, to facilitate prompt antiviral therapy and to avoid unnecessary use of antibiotics, an easy, rapid diagnostic method for the influenza virus is...
Clinical Characteristics of Neonatal Status Epilepticus
Kyeong Hun Jung, Yun Hee Kim, Young Se Kwon, Yong Hoon Jun, Soon Ki Kim, Byong Kwan Son
Clin Exp Pediatr. 2005;48(12):1342-1347.   Published online December 15, 2005
Purpose : Among perinatal risk factors, neonatal seizures are one of the strongest independent discriminators of adverse outcome, representing high risks of mortality and neurologic morbidity. This study was undertaken to evaluate the neurologic outcome of neonatal status epilepticus according to underlying etiology, seizure pattern, onset time, and duration. Methods : We reviewed retrospectively 36 neonates(19 males, 17 females) with status...
Usefulness of Korean Infant Developmental Screening Test in Premature Infants
Dong Han Shin, Hee Sun Lee, Jee Yeon Lee, Byung Min Choi, Baik-Lin Eun, Young Sook Hong, Joo Won Lee
Clin Exp Pediatr. 2005;48(12):1337-1341.   Published online December 15, 2005
Purpose : This study aimed to evaluate the usefulness of Korean Infant Development Screening Test in predicting delayed development in premature infants. Methods : A total of 74 children with histories of prematurity, who visited the pediatric neurology clinic of Korean University Ansan Hospital from August, 2002 to July, 2004, were examined, using the Korean Infant Development Screening Test. They were...
Development of Periventricular Leukomalacia and Severe Intraventricular Hemorrhage in Very Low Birth Weight Newborns and Relationship with Ventilator Care (Study of Ventilator Care as a Risk Factor of PVL and PV-IVH)
Hak Sung Lee, Sae Kyu Lee, Yeong Jin Kim, Sang Geel Lee
Clin Exp Pediatr. 2005;48(12):1330-1336.   Published online December 15, 2005
Purpose : It has been suggested that changes in cerebral blood flow by ventilator care could be a risk factor in periventricular leukomalacia(PVL) and severe periventricular-intraventricular hemorrhage(PV-IVH). The study aims to assess the relationship between perinatal clinical events, including ventilator care, and the development of PVL and severe PV-IVH; especially, whether ventilator care could be causers of PVL and severe...
Evaluation of Perinatal and Management Factors Associated with Improved Survival in Extremely Low Birth Weight Infants
Sung Eun Park, Ga Won Jeon, Chang Won Choi, Jong Hee Hwang, Soo Hyun Koo, Yu Jin Kim, Chang Hoon Lee, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2005;48(12):1324-1329.   Published online December 15, 2005
Purpose : The aim of this study was to evaluate recent improvements in the survival rate of extremely low birth weight (ELBW) infants and to identify perinatal and management factors that are associated with improved survival. Methods : Two groups of ELBW infants who were admitted to our neonatal intensive care unit (NICU) during two distinct eras : November 1994-December...
A Cytogenetic Study in Patients with Sex Chromosome Abnormalities
Hyun Ji Seo, Ji Hye Lee, Heung Kyo Lee, Seung Hee Jung, Kun Soo Lee
Clin Exp Pediatr. 2005;48(12):1317-1323.   Published online December 15, 2005
Purpose : This study was performed to evaluate the recent frequency of karyotypes in different sex chromosome abnormalities and to evaluate the age and clinical manifestations at diagnosis. Methods : Peripheral blood leukocytes were obtained from subjects who were clinically suspected to have sex chromosome abnormalities and referred to the cytogenetic laboratory in the Department of Pediatrics, Kyungpook National University Hospital...
Erratum
Mechanical Ventilation of the Children
June Dong Park
Clin Exp Pediatr. 2005;48(12):1310-1316.   Published online December 15, 2005
Mechanical ventilation in children has some differences compared to in neonates or in adults. The indication of mechanical ventilation can be classified into two groups, hypercapnic respiratory failure and hypoxemic respiratory failure. The strategies of mechanical ventilation should be different in these two groups. In hypercapnic respiratory failure, volume target ventilation with constant flow is favorable and pressure target ventilation...
Medical Lecture Course
New Nutritional Concepts of Vitamins and Minerals
Hee-Shang Youn
Clin Exp Pediatr. 2005;48(12):1295-1309.   Published online December 15, 2005
Nowadays, the nutritional deficits are rarely seen in Korea. However, an increased availability of the highly palatable energy dense, nutrient-poor foods increases the risks of obesity and deficits of vitamins and minerals in the general population. Also, optimum intake of vitamins and minerals, which varies with age and genetic back ground, might not suffice the poor, young, obese, and elderly...
Clinical Lecture
Diagnosis and Management of Acute Otitis Media and Otitis Media With Effusion
Seong Hee Jang
Clin Exp Pediatr. 2005;48(12):1283-1294.   Published online December 15, 2005
The American Academy of Pediatrics and American Academy of Family Physicians developed the clinical practice guideline on the management of acute otitis media. The American Academy of Pediatrics, American Academy of Family Physicians, and American Academy of Otolaryngology-Head and Neck Surgery developed the clinical practice guideline on the diagnosis and management of otitis media with effusion. These two guidelines provide...
Case Report
Intervention with Balloon Valvuloplasty followed by Patent Ductus Arteriosus Stent in a Patient with Pulmonary Atresia with Intact Ventricular Septum
Han Hyuk Lim, Young Deuk Kim, Jae Hwan Lee, Mea Young Chang, Hong Ryang Kil
Clin Exp Pediatr. 2005;48(11):1256-1259.   Published online November 15, 2005
Pulmonary atresia with intact ventricular septum (PAIVS) is rare, less than 1% of congenital heart disease. It needs a therapeutic approach according to its individual morphologic feature. Surgical treatment of valvotomy and modified Blalock-Taussig shunt or non-surgical interventional catheter balloon valvuloplasty can be used for mild to moderate hypoplasia of right ventricle. Fontan operation can be considered for less optimum...
A Single Nucleotide Deletion resulting in Frameshift in Two Korean Neonates with Thyroxine-Binding Globulin Deficiency
Sang-Joon Park, Jin-Soon Suh, Min-Ho Jung, Hee-Jin Lee, Hee-Jin Lee, Won-Bae Lee, Byung-Churl Lee
Clin Exp Pediatr. 2005;48(11):1252-1255.   Published online November 15, 2005
Abnormalities in the levels of thyroxine-binding globulin (TBG) are not associated with clinical disease and they do not require treatment. Congenital TBG deficiency is inherited in an X-linked manner. To date, some complete and partial TBG variants and one polymorphism have been identified by analysis of the TBG gene. Two male neonates were referred to us because of their low...
Original Article
Different Clinical Courses of Henoch-Sch nlein Purpura in Children, Adolescents and Adults
Joo Hee Hong, Hyung Joon Na, Mee Kyung Namgoong, Seung Ok Choi, Byng Geun Han, Soon Hee Jung, Hwang Min Kim
Clin Exp Pediatr. 2005;48(11):1244-1251.   Published online November 15, 2005
Purpose : Henoch-Sch nlein purpura(HSP) is the most common and benign systemic vasculitis in children. Few reports have focused on worse outcomes of HSP in adults. The age of onset is suggested as a main risk factor. We assessed the characteristics of adolescent-onset HSP. Methods : We retrospectively analyzed 205 cases presented from Aug. 1993 to Oct. 2003. Patients were classified...
Serum Ferritin as a Risk Factor in Type 2 Diabetes Mellitus
Jung Hyun Kim, Ho Seong Kim, Duk Hee Kim
Clin Exp Pediatr. 2005;48(11):1239-1243.   Published online November 15, 2005
Purpose : Iron accumulation interferes with hepatic insulin extraction and affects insulin synthesis and secretion. The purpose of this study is to investigate the correlation between serum ferritin and type 2 diabetes mellitus. Methods : We compared the serum ferritin level among 18 patients in an impaired glucose tolerance (IGT) group, 36 in a type 1 diabetes group, eight in...
Lorenzo's Oil Treatment in X-linked Adrenoleukodystrophy
Hyo Jung Kim, Eun Young Kim, Young Jong Woo, Hoon Kook
Clin Exp Pediatr. 2005;48(11):1232-1238.   Published online November 15, 2005

Purpose: Though more than 15 years have passed after introduction of Lorenzo's oil therapy in X- linked adrenoleukodystrophy(ALD), its efficacy is still fully not known. In patients who already have neurologic symptoms, most reports indicate that the neurologic disability continues to increase. We evaluated its efficacy in X-linked ALD patients. Methods: Four patients who were treated with Lorenzo's oil for at...
Comparison of Epileptic Seizures between Preterm and Term-born Epileptic Children with Periventricular Leukomalacia
Hee Jeong Jeong, Eun Sil Lee, Han Ku Moon
Clin Exp Pediatr. 2005;48(11):1225-1231.   Published online November 15, 2005
Purpose : This study compares the first epileptic seizures between preterm and term-born children with periventricular leukomalacia and epilepsy. Methods : From 108 cases having lesions of high signal intensity around the ventricles in T2 weighted imaging of a brain magnetic resonance study, we selected 37 cases that showed epileptic seizures two times or more and divided them into the...
The Relation between Obesity and Glomerular Filtration Rate in Children and Adolescents
Youngsu Jung, Dongwoon Kim, Inseok Lim
Clin Exp Pediatr. 2005;48(11):1219-1224.   Published online November 15, 2005
Purpose : The prevalence of obesity in children and adolescents has been rising rapidly in Korea because of changes of diet and lifestyle. As with adults, obesity in children and adolescents can cause diabetes mellitus, hyperlipidemia, cardiovascular diseases and renal diseases. The aim of the present study is to examine the relation of obesity, glomerular filtration rate(GFR) and serum cystatin...
Clinical Features of Symptomatic Neonates with Ebstein's Anomaly
Hee Jin Cho, In Sil Lee, Jae Kon Ko
Clin Exp Pediatr. 2005;48(11):1212-1218.   Published online November 15, 2005
Purpose : Forward pulmonary blood flow may be absent in some neonates with Ebstein's anomaly by anatomical or functional pulmonary atresia in association with the elevated pulmonary vascular resistance, patent ductus arteriosus and tricuspid regurgitation. We reviewed the presentation and outcomes of symptomatic neonates with Ebstein's anomaly focusing on the pulmonary atresia. Methods : Clinical presentation and outcome of 15 symptomatic...
Pneumococcal Surface Protein A of Streptococcus pneumoniae Isolates from Koreans
Kyung Hyo Kim
Clin Exp Pediatr. 2005;48(11):1206-1211.   Published online November 15, 2005
Purpose : Pneumococcal protein vaccine based on pneumococcal surface protein A (PspA) is in development with the potential to offer a broad range of protection against different strains. PspA elicits protection in mice against fatal sepsis as well as carriage and lung infection. This study was performed to investigate the frequency of PspA families among Streptococcus pneumoniae recovered from Korean...
The Study of Clinical Characteristic Changes in Acute Poststreptococcal Glomerulonephtritis - Comparision of Clinical Manifestations between Recent 5 Years and Past 5 Years -
Hye Won Yoon, Kyung Soo Park, Jae Ho Lee
Clin Exp Pediatr. 2005;48(11):1201-1205.   Published online November 15, 2005
Purpose : The purpose of this study is to evaluate the clinical characteristic changes of acute poststeptococcal glomerulonephritis(APSGN) in recent. The cases of APSGN occurred for the last ten years were divided into group I and II by the unit of 5 years and clinical manifestations and laboratory findings of each groups were analyzed. Methods : Total of 74 cases...
Clinical Entities and Etiology of Invasive Bacterial Infections in Apparently Healthy Children
Joon Ho Lee, Eun Kyoung Song, Jin A Lee, Nam Hee Kim, Dong Ho Kim, Ki Won Park, Eun Hwa Choi, Hoan Jong Lee
Clin Exp Pediatr. 2005;48(11):1193-1200.   Published online November 15, 2005
ilus influenzae has been declined to 4% each from 23% and 14%, respectively, compared to previous study. S. agalactiae was the most common isolate in the infants ≤3 months. Among the infants and children aged 3 months to 2 years and children of 2-5 years, S. pneumoniae(57%, 52%, respectively, in each group) was the most common isolates followed by S....
The Effectiveness of Intravenous Immunoglobulin for Clinically Suspected Neonatal Sepsis
Hyun Jung Na, Ji Young Kim, Gyeong Hoon Lee, Jun Hwa Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Woo Taek Kim
Clin Exp Pediatr. 2005;48(11):1187-1192.   Published online November 15, 2005
Purpose : The purpose of this study is to determine the effectiveness of intravenous immunoglobuin (IVIG) administration in fullterm neonates having clinically suspected neonatal sepsis. Methods : Forty full-term neonates admitted to the neonatal intensive care unit with clinically suspected neonatal sepsis, who had at least two positive diagnostic criteria were enrolled. Twenty neonates were enrolled into the IVIG arm and...
Birth Weight Distribution by Gestational Age in Korean Population : Using Finite Mixture Modle
Jung-Ju Lee, Chang Gi Park, Kwang-Sun Lee
Clin Exp Pediatr. 2005;48(11):1179-1186.   Published online November 15, 2005
Purpose : A universal standard of the birth weight for gestational age cannot be made since girth weight distribution varies with race and other sociodemographic factors. This report aims to establish the birth weight distribution curve by gestational age, specific for Korean live births. Methods : We used the national birth certificate data of all live births in Korea from January...
Serum Insulin, Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 Levels in Obese Adolescents
Jung Hyun Kwon, Hyun Jin Kim, Young Mi Hong
Clin Exp Pediatr. 2005;48(11):1172-1178.   Published online November 15, 2005
Purpose : Childhood Obesity is increasing throughout the world, and it is known to incur many diseases especially in later life such as diabetes and cardiovascular disorders. The purpose of this study was to investigate the association between obesity and insulin, insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3(IGFBP-3) and know if these factors are useful in predicting cardiovascular...
A Study on the Relationship between School-age Obesity and Type of Feeding in Infant Period
Kyung Lae Cho, Soo Young Kim
Clin Exp Pediatr. 2005;48(11):1166-1171.   Published online November 15, 2005
Purpose : The aim of this study was to evaluate whether breast milk feeding at infancy has the effect of a programming agent preventing school-age obesity, or whether formula milk feeding is the cause of elementary school-age obesity. Methods : We randomly selected 4 elementary school in Masan and Changwon city. We calculated the BMI and obesity degree from height...
Current Understanding and Practices of Breast feeding by Mothers
Eun Young Park, Su Jin Cho, Keun Lee
Clin Exp Pediatr. 2005;48(11):1162-1165.   Published online November 15, 2005
Purpose : The objective of this survey was to develop an operational plan for breast feeding education. In order to comprehend current breast feeding patterns, we aimed to examine the knowledge, attitude and practices regarding breast feeding of mothers and to compare the data with a similar study done 6 years ago. Methods : A total of 127 mothers who delivered...
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