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The purpose of this study was to determine the cerebral hemodynamic change in normal newborn infant before and after ductal closure. The measurements of cerebral blood flow velocity of internal carotid artery, middle cerebral artery and anterior cerebral artery were obtained using a 5 MHzpulsed wave Doppler and pulsatility indices were calculated from the Pourcelot index in 15 normal fullterm newborn infants. The newborn infants... |
We studied on leftventricular Cardiac output on the 25 normal newborn infants by using pulse Doppler echocardiography, before & after closure of ductus arteriosus, we also made closing time of ductus arteriousus by using pulsed & color Doppler echocardiography. The results were as follows; 1) The closure of ductus arteriosus was noted before 24hr of age in 3 cases (12%), 48hr of age in 19 cases... |
LDH which are widely distributed in mammalian tissues, being rich in myocardium, kidney, liver and muscle, and which is well known to catalyzes the reversible oxidation of lactate to pyruvate. We investigated serum LDH & Isoenzyme changes in 317 cases of children with respiratory disease and in 117 cases of healthy children as control. The objectives of this study were to ascertain whether serum... |
Hypophosphatemic rickets is a disorder characterized by a normal or slightly reduced serum calcium level, a moderately reduced serum phosphorus level and elevated alkaline phosphatase activity. The usual mode of inheritance is X-linked dominant and postulated mechanism is a selective disorder of tubular reabsorption of phosphate, defective conversion of 21-hydroxyvitamin D3 to calcitriol and increased catabolism of calcitriol. In children with renal hypophosphatemic rickets, growth... |
A clinical study was performed on 145 patients admitted to the Departement of Pediatrics, Yong Dong Severance Hospital between July, 1984 and June, 1987 with the diagnosis of Mycoplasmal pneumonia. This diagnosis was done when chest X-ray or auscultation of the chest showed signs of pneumonia. Patients with cold agglutinin titrations of 1:64 or titrations with four fold increase during follow up had Indirect... |
To determine the frequency, severity, time course and relations of exercise induced changes in lung function, forty-one asthmatic children and fifteen control children were subjected to free running and forced vital capacity (FVC), one-second forced expiratory volume (FEV1), maximum mid-expiratory flow rate (FEF 25-75%), and peak expiratory flow rate (PEFR) were measured before and serially for 60 minutes following exercise. The results were as follows. 1) Significant... |
Blood pressure measurements were done in 9,346 school children in Seoul area in May, June and September, 1987. Korin BP 103N (automated oscillometric method) was used for blood pressure measurements. The results were as follows. 1) Blood pressure increased according to both increasing age and height. 2) Mean systolic pressure (MSP) increased from 100 mmHg at 6 to 124 mmHg at 18 years of age in boys. On... |
To determine the incidence of cardiac arrhythmias of the school children, we have performed heart screening by the questionare and EKG and physical examination from September 1984 to October 1987 in Seoul. 1) The incidence of the cardiac arrhythmias was 1.27%. 2) There were 449 cases of heart diseases detected. Among these heart diseases there were congeni- tal heart diseases in 82 cases (0.31%), acquired heart diseases... |
Ventricular septal defect is the most common cardiac malformation, accounting for 25% of congenital heart disease. The electrocardiogram is becoming more useful as a tool in estimating the size of the ventricular septal defect and the type of pulmonary vascular response. This report comprises 210 patients in whom the diagnosis of isolated ventricular septal defect was made by cardiac catheterization and angiocardiography at Dong San... |
Human atrial myocytes secrete atrial natriuretic peptides (ANP) into the plasma, which causes rapid and marked natriuresis, diuresis and vasorelaxation. The releases of renin, aldosterone, and antidiuretic hormone are inhibited by ANP in vivo and in vitro experiments. Various atrial natriur- etic peptides were isolated and synthesized. Plasma ANP concentrations usually elevated in conges- tive heart failure, chronic renal failure, pulmonary arterial hypertension, tachyarrhythmia,... |
This experiment was carried out to investigate the morphological changes of cardiac tissue in Adriamycin treated rats. Adriamycin was administered (2.5 mg/kg/wk) for 5 weeks, subcutaneously. Cardiac tissue stained by H-E and Trichrom’s method. Clinical findings of congestive heart failure were also observed during experiment. The results were as follows ; 1) Symptoms and signs of congestive heart failure (tachypnea, ascites, hepatomegaly) were appeared in 43% (6 out... |
Common variable immunodeficiency, as defined by World Health Organization classification of primary immunodeficiency, is a heterogenous group of disorders with hypogammaglobulinemia, decreased ability to produced antibody following antigenic challenge, and increased incidence of infections. The disorder was often familial, but no mode of inheritance has been discerned. Clinical fingings are recurrent bacterial infections, particularly respiratory infection. Laboratory evaluations in common variable immunodeficiency demonstrate decrease in... |
Fetus papyraceus is a rare complication in multiple pregnancy. Intrauterine death of one fetus of the twin usually occurs before second trimester and remained in place compressed between uterine wall and membrane of living twin until the end of the pregnancy. A case of surviving infant bom with fetus papyraceus is presented with brief review of literatures. |
Doxorubicin is one of the most effective chemotherapeutic agents in the treatment of leukemia, lymphoma and various solid tumors. Because of dose-dependent degenerative cardiomyopathy, however, doxorubicin theraphy may be discontinued ineffectively early. Doxorubicin-induced conges- tive heart failure carries a very poor prognosis since it is lethal in 60% of patients. Various methods for evaluating the cardiotoxic effect have been employed such as EKG, systolic... |
Generally, infant of diabetic mother (IDM) have complex multisystems disease resulting in a high incidence of perinatal morbidity and mortality. Hypertrophic cardiomyopathy (HCM)-IDM appears as the early onset, transient and non-familial cariomyopathy in neonatal period. The etiology of the left ventricular outflow obstruction in these neonates is not clear. But, it is possible that the asymmetrical septal hypertrophy was a manifestation of the generalized... |
Ulcerative colitis is a chronic inflammatory bowel disease of unknown etiology affecting the mucosa of colon and rectum. We have recently experienced a case of ulcerative colitis in a 13 year-old girl. The diagnosis was established by clinical feature, barium enema, colonoscopy and rectal biopsy. |
We experienced a case of Potter syndrome type I characterized by polycystic kidney, pulmomnary hypoplasia and abnormal face in a 1 day-old male neonate with respiratory distress. Diagnosis was made with autopsy findings. A brief review of literature was made. |
Juvenile nephronophthisis is a chronic tubulo-interstitial renal disease characterized by an early onset of polyuria and polydipsia, decreased urinary concentrating ability, anemia, growth retardation and progressive renal disease. It is recognized as an important cause of chronic renal failure in the childhood. However only one case was reported in the Korean literatures. In this paper we have reported the second documented case of juvenile... |
Recurrent bacterial meningitis is a rare disease which is associated with congenital or acquired anatomical defects of CNS and surround structures, or it may be due to parameningeal foci of infection, defects in immune response, and post-operative state of shunt procedure in hydrocephalus. We experienced the patient of recurrent bacterial meningitis with CSF rhinorrhea due to structural defect which was not defined exactly. We identified... |
Metatropic dwarfism is rare skeletal dysplasia characterized by short extremities, bulbous enlarge- ment of the joints, joint limitation and progressive and ultimately severe kyphoscoliosis. We have experienced one case of metatropic dwarfism. The diagnosis was established by clinical, radiological and pathologic findings. The patient was died six days after delivery. A brief review of literature was made. |
A hermaphrodite in an individual in whom both testicular and ovarian tissues are present. A 15-year old boy presented with breast development and hypospadias. On physical examination, his height, weight, and arm span were normal. He had stage 4 breast development and normal pubic (stage 4) and axillary hair. He also had hypospadias in spite of corrective surgery 2 times. And his karyotype was... |